{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:37:49Z","timestamp":1765604269141,"version":"3.48.0"},"reference-count":43,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:p>This study compares the incidence rates of histologically confirmed gastric carcinoma in Oxfordshire in two five year periods (1960-64, 1984-88). Data were available for 215 patients in the first period, and 200 in the second. The overall incidence fell from 18\/100,000 to 15\/100,000 but when analysed for site, the incidence of antral tumours fell from 10 to 4.5\/100,000. In contrast, there was an increase from 2.8 to 5.2\/100,000 of tumours of the cardia. These changes were more pronounced in men. There was a marked association between smoking and tumours of the cardia (relative risk 4.5). Helicobacter pylori was associated with 37.5% of tumours in the 1960s series compared with 25% in the later series. The changing patterns of incidence of gastric carcinoma may, in part, be related to changes in smoking habits and perhaps a change in incidence of H pylori infection.<\/jats:p>","DOI":"10.1136\/gut.33.10.1312","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1312-1317","source":"Crossref","is-referenced-by-count":39,"title":["Changing pattern of gastric cancer in Oxfordshire."],"prefix":"10.1136","volume":"33","author":[{"given":"E","family":"Rios-Castellanos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"ref_1","article-title":"Cancer mortality statistics in the world","author":"Kurihara, M.; Aoki, K.; Tominaga, S.","year":"1981","unstructured":"Kurihara M, Aoki K, Tominaga S. 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