{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:23:01Z","timestamp":1760782981039},"reference-count":37,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,10,1]]},"DOI":"10.1136\/gut.33.10.1353","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:41:31Z","timestamp":1190151691000},"page":"1353-1357","source":"Crossref","is-referenced-by-count":22,"title":["Inhibition of binding of interferon-gamma to its receptor by salicylates used in inflammatory bowel disease."],"prefix":"10.1136","volume":"33","author":[{"given":"B","family":"Crotty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"29","article-title":"Structure and function of","volume-title":"HLA molecules. Transplant Proc","volume":"19","author":"Thorsby, E.","year":"1987","unstructured":"Thorsby E. Structure and function of HLA molecules. Transplant Proc 1987; 19: 29-35."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00007890-198409000-00019","article-title":"The detailed distribution of MHC class II antigens in normal human organs","volume":"38","author":"Daar, A.S.; Fuggle, S.V.; Fabre, J.W.; Ting, A.; Morris, P.J.","year":"1984","unstructured":"Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ. The detailed distribution of MHC class II antigens in normal human organs. Transplantation 1984; 38: 293-8.","journal-title":"Transplantation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1146\/annurev.iy.08.040190.003341","article-title":"Regulation of major histocompatability complex class-II genes: X, Y and other letters ofthe alphabet","volume":"8","author":"Benoist, C.; Mathis, D.","year":"1990","unstructured":"Benoist C, Mathis D. Regulation of major histocompatability complex class-II genes: X,Y and other letters ofthe alphabet. Ann Rev Immunol 1990; 8: 681-715.","journal-title":"Ann Rev Immunol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-3083.1988.tb01460.x","article-title":"Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by tumour necrosis factor-a and gamma interferon","volume":"28","author":"Kvale, D.; Brandtzaeg, P.; Lovhaug, D.","year":"1988","unstructured":"Kvale D, Brandtzaeg P, Lovhaug D. Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by tumour necrosis factor-a and gamma interferon. ScandJ Immunol 1988; 28: 351-7.","journal-title":"ScandJ Immunol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.4049\/jimmunol.137.9.2853","article-title":"Effects of interferon-y and tumour necrosis factor-a on the expression of an la antigen on a murine macrophage cell line","volume":"137","author":"Chang, R.J.; Lee, S.H.","year":"1986","unstructured":"Chang RJ, Lee SH. Effects of interferon-y and tumour necrosis factor-a on the expression of an la antigen on a murine macrophage cell line. J Immunol 1986; 137: 2853-6.","journal-title":"J Immunol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-3083.1980.tb00043.x","article-title":"HLA-DRlike antigens in the epithelium of the human small intestine","volume":"12","author":"Scott, H.; Solheim, B.G.; Brandtzaeg, P.; Thorsby, E.","year":"1980","unstructured":"Scott H, Solheim BG, Brandtzaeg P, Thorsby E. HLA-DRlike antigens in the epithelium of the human small intestine. ScandJr Immunol 1980; 12: 77-82.","journal-title":"ScandJr Immunol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gut.31.6.647","article-title":"Relationship between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa","volume":"31","author":"Valnes, K.; Huitfeldt, H.S.; Brandtzaeg, P.","year":"1990","unstructured":"Valnes K, Huitfeldt HS, Brandtzaeg P. Relationship between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa. Gut 1990; 31: 647-52.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0016-5085(86)80018-X","article-title":"Increased HLA-DR expression by enterocytes in children with celiac disease","volume":"91","author":"Arnaud-Battandier, F.; Cerf-Bensussan, N.; Amsellem, R.; Schmitz, J.","year":"1986","unstructured":"Arnaud-Battandier F, Cerf-Bensussan N, Amsellem R, Schmitz J. Increased HLA-DR expression by enterocytes in children with celiac disease. Gastroenterology 1986; 91: 1206-12.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/293150a0","article-title":"Graft-versus-host disease induces expression of la antigen in rat epidermal cells and gut epithelium","volume":"293","author":"Mason, D.Y.; Dallman, M.; Barclay, A.N.","year":"1981","unstructured":"Mason DY, Dallman M, Barclay AN. Graft-versus-host disease induces expression of la antigen in rat epidermal cells and gut epithelium. Nature 1981; 293: 150-1.","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/jcp.40.3.312","article-title":"Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon","volume":"40","author":"McDonald, G.B.; Jewell, D.P.","year":"1987","unstructured":"McDonald GB, Jewell DP. Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon.J Clin Pathol 1987; 40: 312-7.","journal-title":"J Clin Pathol"},{"key":"ref_11","first-page":"614","article-title":"Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease","volume":"53","author":"Selby, W.S.; Janossy, G.; Mason, D.W.; Jewell, D.P.","year":"1983","unstructured":"Selby WS, Janossy G, Mason DW, Jewell DP. Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 1983; 53: 614-8.","journal-title":"Clin Exp Immunol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1042\/cs0780119","article-title":"Mechanism of action of 5-animosalicylic acid and its derivatives","volume":"78","author":"Ireland, A.; Jewell, D.P.","year":"1990","unstructured":"Ireland A, Jewell DP. Mechanism of action of 5-animosalicylic acid and its derivatives. Clin Sci 1990; 78: 119-25.","journal-title":"Clin Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/gut.33.1.59","article-title":"Salicylates used in inflammatory bowel disease and colchicine impair Interferon-y induced HLA-DR expression","volume":"33","author":"Crotty, B.; Hoang, P.; Dalton, H.R.; Jewell, D.P.","year":"1992","unstructured":"Crotty B, Hoang P, Dalton HR, Jewell DP. Salicylates used in inflammatory bowel disease and colchicine impair Interferon-y induced HLA-DR expression. Gut 1992; 33: 59-64.","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0016-5085(84)80164-X","article-title":"Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis","volume":"86","author":"Lauritsen, K.; Hansen, J.; Ryde, M.; Rask-Madsen, J.","year":"1984","unstructured":"Lauritsen K, Hansen J, Ryde M, Rask-Madsen J. Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterology 1984; 86: 1496-500.","journal-title":"Gastroenterology"},{"issue":"4","key":"ref_15","first-page":"111","article-title":"Clinical pharmacokinetics of intravenous and oral prednisolone","volume":"1979","author":"Pickup, M.E.","unstructured":"Pickup ME. Clinical pharmacokinetics of intravenous and oral prednisolone. Clin Pharmacokinet 1979;-4: 111-28.","journal-title":"Clin Pharmacokinet"},{"key":"ref_16","article-title":"Molecular cloning laboratory manual","author":"Sainbrook, J.; Fritsch, E.F.; Maniatis, T.","year":"1989","unstructured":"Sainbrook J, Fritsch EF, Maniatis T. Molecular cloning laboratory manual. 2nd ed. New York: Cold Spring Harbour Laboratory Press, 1989.","edition":"2nd ed"},{"key":"ref_17","first-page":"156","article-title":"Single-stage method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski, P.; Sacchi, N.","year":"1987","unstructured":"Chomczynski P, Sacchi N. Single-stage method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.","journal-title":"Anal Biochem"},{"key":"ref_18","first-page":"1060","volume":"i:","author":"Interferons, Balkwill FR.","year":"1989","unstructured":"Balkwill FR. Interferons. Lancet 1989; i: 1060-3.","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0140-6736(89)92640-8","article-title":"Interleukins and the immune system 2","volume":"i:","author":"O'Garra, A.","year":"1989","unstructured":"O'Garra A. Interleukins and the immune system 2. Lancet 1989;i: 1003-5.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","article-title":"Adhesion receptors of the immune system","volume":"346","author":"Springer, T.A.","year":"1990","unstructured":"Springer TA. Adhesion receptors of the immune system. Nature 1990; 346: 425-34.","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI113938","article-title":"Interferon-y directly affects barrier function of cultured intestinal epithelial monolayers","volume":"83","author":"Madara, J.L.; Stafford, J.","year":"1989","unstructured":"Madara JL, Stafford J. Interferon-y directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989; 83: 724-7.","journal-title":"J Clin Invest"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0167-5699(88)91241-8","article-title":"Interferon receptors","volume":"9","author":"Langer, J.A.; Pestka, S.","year":"1988","unstructured":"Langer JA, Pestka S. Interferon receptors. Immunol Today 1988; 9: 393-400.","journal-title":"Immunol Today"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/gut.24.3.213","article-title":"Inhibition of prostaglandin synthetase in human rectal mucosa","volume":"24","author":"Hawkey, C.J.; Truelove, S.C.","year":"1983","unstructured":"Hawkey CJ, Truelove SC. Inhibition of prostaglandin synthetase in human rectal mucosa. Gut 1983; 24: 213-7.","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1172\/JCI110474","article-title":"Sulphasalazine inhibits the synthesis of chemotactic lipids by neutrophils","volume":"69","author":"Stenson, W.F.; Lobos, E.","year":"1982","unstructured":"Stenson WF, Lobos E. Sulphasalazine inhibits the synthesis of chemotactic lipids by neutrophils. J Clin Invest 1982; 69: 494-7.","journal-title":"J Clin Invest"},{"key":"ref_25","first-page":"1167","article-title":"Role of platelet-activating factor","volume-title":"ulcerative colitis. Gastroenterology 1988; 95","author":"Eliakim, R.; Karmeli, F.; Razin, E.; Rachmilewitz, D.","unstructured":"Eliakim R, Karmeli F, Razin E, Rachmilewitz D. Role of platelet-activating factor in ulcerative colitis. Gastroenterology 1988; 95: 1167-72."},{"key":"ref_26","first-page":"1167","article-title":"Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species","volume":"28","author":"Miyachi, Y.; Yashioka, A.; Immamura, S.; Niwa, Y.","year":"1987","unstructured":"Miyachi Y, Yashioka A, Immamura S, Niwa Y. Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species. Gut 1987; 28: 1167-72.","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0006-2952(84)90233-8","article-title":"Sulphasalazine inhibits the binding of formylmethionylleucylphenylalanine (FLMP) to its receptor on human neutrophils","volume":"33","author":"Stenson, W.F.; Mehta, J.; Spilberg, J.","year":"1984","unstructured":"Stenson WF, Mehta J, Spilberg J. Sulphasalazine inhibits the binding of formylmethionylleucylphenylalanine (FLMP) to its receptor on human neutrophils. Biochem Pharmacol 1984; 33: 407-12.","journal-title":"Biochem Pharmacol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-2999(85)90071-8","article-title":"Inhibition of IgE mediated mast cell degranulation by sulphasalazine","volume":"107","author":"Barrett, K.E.; Tachof, T.L.; Metcalfe, D.D.","year":"1985","unstructured":"Barrett KE, Tachof TL, Metcalfe DD. Inhibition of IgE mediated mast cell degranulation by sulphasalazine. Eur3J Pharmacol 1985; 107: 279-81.","journal-title":"Eur3J Pharmacol"},{"key":"ref_29","first-page":"811","article-title":"Sulphasalazine metabolites and dapsone attenuate formyl-methionyl-leucylphenylalanine induced mucosal injury","volume-title":"rat ileum. Gastroenterology 1989; %","author":"C, Von Ritter; MB, Grisham; DN, Granger","unstructured":"Von Ritter C, Grisham MB, Granger DN. Sulphasalazine metabolites and dapsone attenuate formyl-methionyl-leucylphenylalanine induced mucosal injury in rat ileum. Gastroenterology 1989; %: 811-6."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0016-5085(89)91569-2","article-title":"Inhibition of antibody secretion by 5-aminosalicylic acid","volume":"96","author":"MacDermott, R.P.; Schloemann, SR, Bertovich; MJ, Nash; GS, Peters; M, Stenson; W.F.","year":"1989","unstructured":"MacDermott RP, Schloemann SR, Bertovich MJ, Nash GS, Peters M, Stenson WF. Inhibition of antibody secretion by 5-aminosalicylic acid. Gastroenterology 1989; 96: 442-8.","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/gut.32.1.50","article-title":"5-Aminosalicylic acid is a potent inhibitor of interleukin 1, B production in organ culture of biopsy specimens from patients with inflammatory bowel disease","volume":"32","author":"Mahida, Y.R.; Lamming, C.E.D.; Gallagher, A.; Hawthorne, A.B.; Hawkey, C.J.","year":"1991","unstructured":"Mahida YR, Lamming CED, Gallagher A, Hawthorne AB, Hawkey CJ. 5-Aminosalicylic acid is a potent inhibitor of interleukin 1,B production in organ culture of biopsy specimens from patients with inflammatory bowel disease. Gut 1991;32:50-4.","journal-title":"Gut"},{"key":"ref_32","first-page":"96","article-title":"Sulphasalazine inhibits cytokine production in human mononuclear cells: a novel anti-inflammatory mechanism","volume":"96","author":"Cominelli, F.; Zipser, R.D.; Dinarello, C.A.","year":"1989","unstructured":"Cominelli F, Zipser RD, Dinarello CA. Sulphasalazine inhibits cytokine production in human mononuclear cells: a novel anti-inflammatory mechanism. Gastroenterology 1989; 96: A96.","journal-title":"Gastroenterology"},{"key":"ref_33","first-page":"1471","article-title":"Acetylation of 5-amino salicylic acid by human colonic epithelial cells","volume":"90","author":"Ireland, A.; Priddle, J.D.; Jewell, D.P.","year":"1986","unstructured":"Ireland A, Priddle JD, Jewell DP. Acetylation of 5-amino salicylic acid by human colonic epithelial cells. Gastroenterology 1986; 90: 1471.","journal-title":"Gastroenterology"},{"key":"ref_34","first-page":"1122","article-title":"A controlled study of 5acetaminosalicylic acid as enema in ulcerative colitis","volume":"16","author":"Binder, V.; Halskov, S.; Hviderg, E.","year":"1981","unstructured":"Binder V, Halskov S, Hviderg E, et al. A controlled study of 5acetaminosalicylic acid as enema in ulcerative colitis. Scand J Gastroenterol 1981; 16: 1122.","journal-title":"Scand J Gastroenterol"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2036.1988.tb00668.x","article-title":"Double-blind comparison of 5-aminosalicylic acid and acetyl 5-aminosalicylic acid suppositories in patients with idiopathic proctitis","volume":"2","author":"PAM, Van Hogezand R.A.Van Hess; JPWM, Van Gorp","year":"1988","unstructured":"Van Hogezand RA. Van Hess PAM, Van Gorp JPWM, et al. Double-blind comparison of 5-aminosalicylic acid and acetyl 5-aminosalicylic acid suppositories in patients with idiopathic proctitis. Aliment Pharmacol Ther 1988; 2: 33-40.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_36","first-page":"715","article-title":"The effect of topical N-acetyl-5-aminosalicylic acid in ulcerative colitis","volume":"15","author":"Willoughby, C.P.; Piris, J.; Truelove, S.C.","year":"1980","unstructured":"Willoughby CP, Piris J, Truelove SC. The effect of topical N-acetyl-5-aminosalicylic acid in ulcerative colitis. ScandJ7 Gastroenterol 1980; 15: 715-9."},{"key":"ref_37","first-page":"1447","article-title":"A comparison of the uptake of 5-aminosalicylic acid and N-acetaminosalicylic acid in the isolated colonic epithelial cell","volume":"92","author":"Ireland, A.; Priddle, J.P.; Jewell, D.P.","year":"1987","unstructured":"Ireland A, Priddle JP, Jewell DP. A comparison of the uptake of 5-aminosalicylic acid and N-acetaminosalicylic acid in the isolated colonic epithelial cell. Gastroenterology 1987; 92: 1447.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.10.1353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T23:44:43Z","timestamp":1708213483000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.10.1353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,1]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1992,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/gut.33.10.1353","relation":{},"ISSN":["0017-5749"],"issn-type":[{"value":"0017-5749","type":"print"}],"subject":[],"published":{"date-parts":[[1992,10,1]]}}}