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In these two groups, none of the animals developed colorectal cancer over 100 day period. In a group treated for 180 days, seven of the eight animals had dysplasia, and one had two adenomas. Furthermore, four of the eight animals had adenocarcinoma in the transverse colon; they were protruding well differentiated adenocarcinoma in one and non-protruding lesions infiltrating into the musclaris propria in three. The three non-protruding infiltrating adenocarcinomas were classified to be well differentiated adenocarcinoma in one and mucinous adenocarcinoma in two, resembling the type of cancer which complicates ulcerative colitis in man.<\/jats:p>","DOI":"10.1136\/gut.33.11.1521","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1521-1527","source":"Crossref","is-referenced-by-count":78,"title":["Occurrence of dysplasia and adenocarcinoma after experimental chronic ulcerative colitis in hamsters induced by dextran sulphate sodium."],"prefix":"10.1136","volume":"33","author":[{"given":"M","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ohkusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Okayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0016-5085(19)31501-X","article-title":"Cancer in colitis: Assessment of the individual risk by clinical and histological criteria","volume":"73","author":"Lennard-Jones, J.E.; Morson, B.C.; Ritchie, J.K.; Shove, D.C.; Williams, C.B.","year":"1977","unstructured":"Lennard-Jones JE, Morson BC, Ritchie JK, Shove DC, Williams CB. 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