{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:00:15Z","timestamp":1765645215780,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specimens were taken to determine H pylori status (Gram and Giemsa staining, urease test, and cultures). The NSAID group comprised: group I, patients without mucosal damage (n = 28); group II, patients with gastropathy (n = 26); and group III, patients with bleeding associated with NSAID induced gastropathy (n = 12). Control patients had neither dyspeptic symptoms nor endoscopic lesions. There were no differences in age, sex ratio, or presence of H pylori (26% v 24%) between the NSAID and the control groups. Among patients taking NSAIDs, H pylori infection was more frequently (p &lt; 0.02) diagnosed in those who presented with gastropathy (groups II and III: 37%) than in those without lesions (group I: 11%). The frequency of H pylori infection increased significantly with the severity of gastropathy (group I = 11%; group II = 31%; group III = 50%; p &lt; 0.03). H pylori infection was associated with chronic active gastritis (group I = 21%; group II = 35%; group III = 67%; p &lt; 0.05). These data suggest that H pylori may be a risk factor of NSAID induced gastropathy.<\/jats:p>","DOI":"10.1136\/gut.33.12.1608","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1608-1611","source":"Crossref","is-referenced-by-count":49,"title":["Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy."],"prefix":"10.1136","volume":"33","author":[{"given":"D","family":"Heresbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Raoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Bretagne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Minet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P Y","family":"Donnio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Ram\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Siproudhis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gosselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/gut.28.5.527","article-title":"Nonsteroidal anti-inflammatory drugs and life threatening complications ofpeptic ulceration","volume":"28","author":"Armstrong, C.P.; Blower, A.L.","year":"1987","unstructured":"Armstrong CP, Blower AL. Nonsteroidal anti-inflammatory drugs and life threatening complications ofpeptic ulceration. Gut 1987; 28: 527-32.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archinte.1987.00370010087021","article-title":"The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding","volume":"147","author":"Carson, J.L.; Strom, B.L.; Soper, K.A.; West, S.L.; Morse, M.L.","year":"1987","unstructured":"Carson JL, Strom BL, Soper KA, West SL, Morse ML. The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding. Arch Intern Med 1987; 147: 85-8.","journal-title":"Arch Intern Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/gut.28.5.515","article-title":"NSAIDs: should every prescription carry a government health warning","volume":"28","author":"Cockel, R.","year":"1987","unstructured":"Cockel R. NSAIDs: should every prescription carry a government health warning. Gut 1987; 28: 515-8.","journal-title":"Gut"},{"key":"ref_4","first-page":"647","article-title":"Toward an epidemiology of gastropathy associated with non-steroidal anti-inflammatory drug use","volume":"%:","author":"Fries, J.F.; Miller, SR, Spitz; PW, Williams; CA, Hubert; HB, Bloch; D.A.","year":"1989","unstructured":"Fries JF, Miller SR, Spitz PW, Williams CA, Hubert HB, Bloch DA. Toward an epidemiology of gastropathy associated with non-steroidal anti-inflammatory drug use. Gastroenteroloy 1989; %: 647-55.","journal-title":"Gastroenteroloy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1001\/archinte.1989.00390050025005","article-title":"Risk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs","volume":"149","author":"Bloom, B.S.","year":"1989","unstructured":"Bloom BS. Risk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs. Arch Intern Med 1989; 149: 1019-22.","journal-title":"Arch Intern Med"},{"key":"ref_6","first-page":"675","article-title":"Prevention of gastroduodenal injury induced by chronic nonsteroidal anti-inflammatory drug therapy","volume-title":"Gastroenterology 1989; %","author":"Graham, D.Y.","unstructured":"Graham DY. Prevention of gastroduodenal injury induced by chronic nonsteroidal anti-inflammatory drug therapy. Gastroenterology 1989; %: 675-81."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1001\/archinte.1989.00390090105021","article-title":"Economic effects of prophylactic use of misoprostol to prevent gastric ulcer in patients taking nonsteroidal anti-inflammatory drugs","volume":"149","author":"Hillman, A.L.; Bloom, B.S.","year":"1989","unstructured":"Hillman AL, Bloom BS. Economic effects of prophylactic use of misoprostol to prevent gastric ulcer in patients taking nonsteroidal anti-inflammatory drugs. Arch Intern Med 1989; 149: 2061-5.","journal-title":"Arch Intern Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.7326\/0003-4819-114-4-307","article-title":"Nonsteroidal anti-inflammatory drugs and peptic ulcer disease","volume":"114","author":"Soll, A.H.; Weinstein, W.M.; Kurata, J.; McCarty, D.","year":"1991","unstructured":"Soll AH, Weinstein WM, Kurata J, McCarty D. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med 1991; 114: 307-19.","journal-title":"Ann Intern Med"},{"key":"ref_9","first-page":"145","article-title":"NSAID-induced gastropathy: a neutrophil-dependent process","volume":"98","author":"Wallace, J.L.; Keenan, C.M.; Granger, D.N.","year":"1990","unstructured":"Wallace JL, Keenan CM, Granger DN. NSAID-induced gastropathy: a neutrophil-dependent process. Gastroenterology 1990; 98: A145.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1056\/NEJM198007173030305","article-title":"Endoscopic evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa","volume":"303","author":"Lanza, F.L.; Royer, G.L.; Nelson, R.S.","year":"1980","unstructured":"Lanza FL, Royer GL, Nelson RS. Endoscopic evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa. NEnglJ Med 1980; 303: 136-8.","journal-title":"NEnglJ Med"},{"key":"ref_11","first-page":"1","article-title":"The Sydney system: a new classification of gastritis. Working party reports of the 9th World Congress of Gastroenterology","author":"Misiewicz, J.J.; Tytgat, G.; Goodwin, C.S.; Price, A.; Sipponen, P.; Strickland, R.","year":"1989","unstructured":"Misiewicz JJ, Tytgat G, Goodwin CS, Price A, Sipponen P, Strickland R. The Sydney system: a new classification of gastritis. Working party reports of the 9th World Congress of Gastroenterology. Melbourne: Blackwell Scientific, 1989: 1-10."},{"key":"ref_12","article-title":"Chemical gastritis and Helicobacter (H) pylori in patients receiving nonsteroidal anti inflammatory drugs (NSAID) - correlation with peptic ulceration","volume-title":"Gastroenterology 1991; 100: A 1108","author":"Taha, A.S.; Lee, F.D.; Sturrock, R.D.; Russell, R.I.","unstructured":"Taha AS, Lee FD, Sturrock RD, Russell RI. Chemical gastritis and Helicobacter (H) pylori in patients receiving nonsteroidal anti inflammatory drugs (NSAID) - correlation with peptic ulceration. Gastroenterology 1991; 100: A 1108."},{"key":"ref_13","article-title":"Follow up of Campylobacter pylori gastric infection after treatment of gastroduodenal ulcers with sucralfate of H2 antagonists","volume-title":"pathology and Campylobacter pylon","author":"JD, De Korvin; F, Vicari; V, Chambre; B, Foliguet; D, Wahl; J, Laurent","unstructured":"De Korvin JD, Vicari F, Chambre V, Foliguet B, Wahl D, Laurent J, et al. Follow up of Campylobacter pylori gastric infection after treatment of gastroduodenal ulcers with sucralfate of H2 antagonists. In: Megraud F, Lamouliatte H, eds. Gastroduodenal pathology and Campylobacter pylon'. Bordeaux: 1988: 178."},{"key":"ref_14","article-title":"The efficacy of furazolidone and metronidazole in the treatment of chronic gastritis associated with Campylobacter pylori","volume-title":"pathology and Campylobacter pylori","author":"Shu-dong, X.; Wen-Zong, L.; De-Huang, X.; Shao-Ji, J.; Rui-Nian, W.; Zhen-Hua, Z.","unstructured":"Shu-dong X, Wen-Zong L, De-Huang X, Shao-Ji J, Rui-Nian W, Zhen-Hua Z. The efficacy of furazolidone and metronidazole in the treatment of chronic gastritis associated with Campylobacter pylori. In: Megraud F, Lamouliatte H, eds. Gastroduodenal pathology and Campylobacter pylori. Bordeaux: 1988: 181."},{"key":"ref_15","first-page":"28","article-title":"Le diagnostic de l'infection gastrique a helicobacter pylori. Quelles methodes choisir en routine","volume":"14","author":"JD, De Korvin; JL, Jacob; MC, Conroy; A, Duprez; JC, Burdin; J, Schmitt","year":"1990","unstructured":"De Korvin JD, Jacob JL, Conroy MC, Duprez A, Burdin JC, Schmitt J. Le diagnostic de l'infection gastrique a helicobacter pylori. Quelles methodes choisir en routine. Gastroenterol Clin Biol 1990; 14: A28.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1136\/gut.31.2.139","article-title":"Tightly spiral shaped bacteria in the human stomach: another cause of active gastritis?","volume":"31","author":"Morris, A.; Ali, M.R.; Thomsen, L.; Hollis, B.","year":"1990","unstructured":"Morris A, Ali MR, Thomsen L, Hollis B. Tightly spiral shaped bacteria in the human stomach: another cause of active gastritis? Gut 1990; 31: 139-43.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/0016-5085(91)90665-8","article-title":"Long-term non-steroidal antiinflammatory drug use and Helicobacter pylori infection","volume":"100","author":"Graham, D.Y.; Lidsky, M.D.; Cox, A.M.; Evans, D.J.; Evans, D.G.; Alpert, L.","year":"1991","unstructured":"Graham DY, Lidsky MD, Cox AM, Evans DJ, Evans DG, Alpert L, et al. Long-term non-steroidal antiinflammatory drug use and Helicobacter pylori infection. Gastroenterology 1991; 100:1653-7.","journal-title":"Gastroenterology"},{"key":"ref_18","first-page":"599","article-title":"The presence of Campylobacter pylori in nonsteroidal antiinflammatory drug associated gastritis","volume":"16","author":"Iglehart, I.W.; Edlow, D.W.; Mills, L.; Morrison, S.A.; Hochberg, M.C.","year":"1989","unstructured":"Iglehart IW, Edlow DW, Mills L, Morrison SA, Hochberg MC. The presence of Campylobacter pylori in nonsteroidal antiinflammatory drug associated gastritis. J Rheumatol 1989; 16: 599-603.","journal-title":"J Rheumatol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/rheumatology\/27.2.113","article-title":"Campylobacter pylon' associated gastritis in patients with rheumatoid arthritis taking non steroidal anti-inflammatory drugs","volume":"27","author":"Upadhyay, R.; Howatson, A.; McKinlay, A.; Danesh, B.J.Z.; Sturrock, R.D.; Russell, R.I.","year":"1988","unstructured":"Upadhyay R, Howatson A, McKinlay A, Danesh BJZ, Sturrock RD, Russell RI. Campylobacter pylon' associated gastritis in patients with rheumatoid arthritis taking non steroidal anti-inflammatory drugs. BrJt Rhumatol 1988; 27: 113-6.","journal-title":"BrJt Rhumatol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/rheumatology\/27.2.110","article-title":"Nonsteroidal anti-inflammatory druginduced dyspepsia is campylobacterpyloridis implicated?","volume":"27","author":"Doube, A.; Morris, A.","year":"1988","unstructured":"Doube A, Morris A. Nonsteroidal anti-inflammatory druginduced dyspepsia is campylobacterpyloridis implicated? BrJ Rheumatol 1988; 27: 110-2.","journal-title":"BrJ Rheumatol"},{"issue":"1","key":"ref_21","article-title":"Chemical gastritis and Helicobacter pylori in patients receiving nonsteroidal anti-inflammatory drugs (NSAID). Correlation with peptic ulceration","volume-title":"Gastroenterology 1991; 100: A","volume":"17","author":"Taha, A.S.; FD, Lee; Sturrock, R.D.; Russell, R.I.","unstructured":"Taha AS, Lee.FD, Sturrock RD, Russell RI. Chemical gastritis and Helicobacter pylori in patients receiving nonsteroidal anti-inflammatory drugs (NSAID). Correlation with peptic ulceration. Gastroenterology 1991; 100: A 17 1."},{"key":"ref_22","first-page":"25","article-title":"Gold - a new potential drug for the treatment of Helicobacter pylori infection","volume":"98","author":"Braga, L.L.; Sarosiek, J.; Marshall, B.; McCallum, R.W.; Barrett, L.; Guerrant, R.","year":"1990","unstructured":"Braga LL, Sarosiek J, Marshall B, McCallum RW, Barrett L, Guerrant R. Gold - a new potential drug for the treatment of Helicobacter pylori infection. Gastroenterology 1990; 98: A25.","journal-title":"Gastroenterology"},{"key":"ref_23","first-page":"76","article-title":"Gold and the seroprevalence of Helicobacter pylori in rheumatoid arthritis patients","volume":"100","author":"Gubbins, G.P.; Schubert, T.T.; Attanasio, F.; Lubetsky, M.; Perez-Perez, G.I.; Mj, Blaser","year":"1991","unstructured":"Gubbins GP, Schubert TT, Attanasio F, Lubetsky M, Perez-Perez GI, Blaser Mj. Gold and the seroprevalence of Helicobacter pylori in rheumatoid arthritis patients. Gastroenterology 1991; 100: A76.","journal-title":"Gastroenterology"},{"key":"ref_24","first-page":"950","article-title":"Hemorragies digestives par ulcerations gastro-duodenales secondaires aux gastrotoxiques","volume":"15","author":"Raoul, J.L.; Emery, P.; Bretagne, J.F.; Chaperon, J.; Bansard, J.Y.; Siproudhis, L.","year":"1991","unstructured":"Raoul JL, Emery P, Bretagne JF, Chaperon J, Bansard JY, Siproudhis L, et al. Hemorragies digestives par ulcerations gastro-duodenales secondaires aux gastrotoxiques. Castroenterol Clin Biol 1991; 15: 950-5.","journal-title":"Castroenterol Clin Biol"},{"key":"ref_25","first-page":"86","article-title":"Elevation of gastric mucosal leukotriene B4 levels in patients on longstanding NSAID therapy","volume":"100","author":"Hudson, N.; Everitt, S.; Edwards, T.; Filopowicz, B.; Hawkey, C.J.","year":"1991","unstructured":"Hudson N, Everitt S, Edwards T, Filopowicz B, Hawkey CJ. Elevation of gastric mucosal leukotriene B4 levels in patients on longstanding NSAID therapy. Gastroenterology 1991; 100: A86.","journal-title":"Gastroenterology"},{"key":"ref_26","first-page":"133","article-title":"The effect of Helicobacter pylori (HP) \"toxin\" on human gastric mucosa and its interaction with indomethacin","volume":"98","author":"Taha, A.S.; Kelly, R.W.; Gemmell, C.G.; Lee, F.D.; Russell, R.I.","year":"1990","unstructured":"Taha AS, Kelly RW, Gemmell CG, Lee FD, Russell RI. The effect of Helicobacter pylori (HP) \"toxin\" on human gastric mucosa and its interaction with indomethacin. Castroenterology 1990; 98: A133.","journal-title":"Castroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.12.1608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:55:56Z","timestamp":1765644956000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.12.1608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1992,12,1]]},"published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1136\/gut.33.12.1608"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.12.1608","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}