{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:45:58Z","timestamp":1764996358203,"version":"3.46.0"},"reference-count":25,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>Fifty nine patients with Helicobacter pylori positive duodenal ulcers that failed to heal after a six week course of treatment with H2 blockers were randomly assigned to one of the following three regimens: (i) bismuth subsalicylate, 600 mg three times daily (n = 19), (ii) ranitidine, 300 mg at night (n = 20), (iii) bismuth subsalicylate plus ranitidine (n = 20). Cumulative ulcer healing rates after four and eight weeks respectively were as follows: bismuth subsalicylate 74% (14\/19) and 95% (18\/19), ranitidine 40% (8\/20) and 65% (13\/20), bismuth subsalicylate plus ranitidine 80% (16\/20) and 95% (19\/20). Bismuth subsalicylate treatment was better than ranitidine at both four and at eight weeks (p less than 0.05). The clearance rates for H pylori after four weeks were: bismuth subsubsalicylate 58%, ranitidine 0%, bismuth subsalicylate plus ranitidine 55%. After stopping bismuth therapy bacterial recrudescence frequently occurred. After bismuth treatment 86% (19\/22) of ulcers had healed if H pylori had been cleared, whereas only 65% (11\/17) had healed if H pylori persisted (NS). This study shows that bismuth subsalicylate is more effective in the treatment of resistant duodenal ulcers than standard dose ranitidine. It may be that suppression of H pylori by bismuth subsalicylate promotes ulcer healing.<\/jats:p>","DOI":"10.1136\/gut.33.2.179","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"179-183","source":"Crossref","is-referenced-by-count":25,"title":["Bismuth subsalicylate in the treatment of H2 blocker resistant duodenal ulcers: role of Helicobacter pylori."],"prefix":"10.1136","volume":"33","author":[{"given":"S","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"B\u00e4r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Freise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Gladziwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F W","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/bmj.289.6452.1095","article-title":"Duodenal ulcers which do not heal rapidly","volume":"289","author":"Wormsley, K.G.","year":"1984","unstructured":"Wormsley KG. Duodenal ulcers which do not heal rapidly. BMJ 1984; 289: 1095.","journal-title":"BMJ"},{"key":"ref_2","first-page":"85","article-title":"H2blocker-resistant duodenal ulceration","volume":"2","author":"Domschke, W.; Lam, S.K.; Pounder, R.E.; Andersen, D.","year":"1989","unstructured":"Domschke W, Lam SK, Pounder RE, Andersen D. H2blocker-resistant duodenal ulceration. Gastroenterol International 1989; 2: 85-91.","journal-title":"Gastroenterol International"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1136\/gut.25.11.1211","article-title":"The effect of no treatment, cimetidine 1 g\/d, cimetidine 2 g\/d and cimetidine combined with atropine on nocturnal gastric secretion in cimetidine non-responders","volume":"25","author":"Gledhill, T.; Buck, M.; Hunt, R.H.","year":"1984","unstructured":"Gledhill T, Buck M, Hunt RH. 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