{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:26Z","timestamp":1790744546864,"version":"4.1.0"},"reference-count":37,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>This study aimed to compare fasting and postprandial gastrointestinal motor patterns in patients with ulcer and non-ulcer dyspepsia. Forty five subjects were studied: 10 with uncomplicated gastric ulcer, eight with uncomplicated duodenal ulcer, 18 with chronic idiopathic dyspepsia, and nine healthy asymptomatic controls. Gastrointestinal fasting and postprandial motor patterns were recorded using a low compliance perfusion technique. The interdigestive antral cumulative motility index, computed for 30 minutes before the appearance of duodenal activity fronts, and the number of activity fronts with an antral component were significantly less in patients with ulcers and those with non-ulcer dyspepsia compared with asymptomatic controls. The patient groups also had a reduced antral motor response to a solid-liquid test meal compared with healthy controls. Intestinal motor abnormalities (bursts of non-propagated phasic pressure activity and discrete clustered contractions) were recorded in a minority of patients, all with associated irritable bowel symptoms. In conclusion, antral hypomotility is a frequent but nonspecific motor abnormality in dyspepsia; abnormal motor patterns of the small bowel are less frequent and seem to be confined to patients with concomitant irritable bowel syndrome.<\/jats:p>","DOI":"10.1136\/gut.33.2.184","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"184-190","source":"Crossref","is-referenced-by-count":152,"title":["Fasting and postprandial gastrointestinal motility in ulcer and non-ulcer dyspepsia."],"prefix":"10.1136","volume":"33","author":[{"given":"V","family":"Stanghellini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ghidini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Maccarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G F","family":"Paparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Corinaldesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Barbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"ref_1","first-page":"1272","article-title":"Definition and investigation of dyspepsia. Consensus of an international ad hoc Working Party","volume":"34","author":"Barbara, L.; Camilleri, M.; Corinaldesi, R.","year":"1989","unstructured":"Barbara L, Camilleri M, Corinaldesi R, et al. Definition and investigation of dyspepsia. Consensus of an international ad hoc Working Party. Dig Dis Sci 1989; 34: 1272-6. In keeping with this concept, Garret etalobserved improvement in gastric hypomotility in three","journal-title":"Dig Dis Sci; keeping with this concept, Garret etalobserved improvement in gastric hypomotility in three"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.7326\/0003-4819-108-6-865","article-title":"Non-ulcer dyspepsia: potential causes and pathophysiology","volume":"108","author":"Talley, N.J.; Phillips, S.F.","year":"1988","unstructured":"Talley NJ, Phillips SF. Non-ulcer dyspepsia: potential causes and pathophysiology. Ann Intern Med 1988; 108: 865-79.","journal-title":"Ann Intern Med"},{"key":"ref_3","first-page":"780","article-title":"Antral motility in patients after healing of the ulcer crater and resolution of the symptoms.3 The relation patients with gastric ulcer","volume":"10","author":"Garrett, J.M.; Summerskill, W.H.J.; Code, C.F.","year":"1966","unstructured":"Garrett JM, Summerskill WHJ, Code CF. Antral motility in patients after healing of the ulcer crater and resolution of the symptoms.3 The relation patients with gastric ulcer. AmJ7 Dig Dis 1966; 10: 780-9.","journal-title":"AmJ7 Dig Dis"},{"key":"ref_4","first-page":"16","article-title":"Abnormalities of interdigestive motility complex and increased duodenobetween gastrointestinal motor disorders and dyspeptic symptoms is far from established. Severe gastroparesis is sometimes asymptomatic36 and, as previously shown7l9 and confirmed gastric reflux in gastric ulcer patients","volume":"30","author":"Miranda, M.; DeFilippi, C.; Valenzuela, J.E.","year":"1985","unstructured":"Miranda M, DeFilippi C, Valenzuela JE. Abnormalities of interdigestive motility complex and increased duodenobetween gastrointestinal motor disorders and dyspeptic symptoms is far from established. Severe gastroparesis is sometimes asymptomatic36 and, as previously shown7l9 and confirmed gastric reflux in gastric ulcer patients. Dig Dis Sci 1985; 30: 16-21.","journal-title":"Dig Dis Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0016-5085(80)90589-2","article-title":"Dyspepsia, antral motor dysfunction, and gastric stasis of solids","volume":"78","author":"Rees, W.D.; Miller, L.J.; Malagelada, JR","year":"1980","unstructured":"Rees WD, Miller LJ, Malagelada JR. Dyspepsia, antral motor dysfunction, and gastric stasis of solids. Gastroenterology 1980; 78: 360-5.","journal-title":"Gastroenterology"},{"key":"ref_6","first-page":"18","article-title":"Prokinetic effects of in the present study, dyspeptic symptoms are not invariably accompanied by detectable motor cisapride on normal and reduced antroduodenal motility and reflexes","volume":"36","author":"Reboa, G.; Arnulfo, G.; DiSomma, C.","year":"1984","unstructured":"Reboa G, Arnulfo G, DiSomma C. Prokinetic effects of in the present study, dyspeptic symptoms are not invariably accompanied by detectable motor cisapride on normal and reduced antroduodenal motility and reflexes. Curr Ther Res 1984; 36: 18-23.","journal-title":"Curr Ther Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0016-5085(85)80083-4","article-title":"Manometric evaluation of disorders in the distal antrum and proximal small bowel. Approximately 40% of our dyspeptic functional upper gut symptoms","volume":"88","author":"Malagelada, JR, Stangehellini; V.","year":"1985","unstructured":"Malagelada JR, Stangehellini V. Manometric evaluation of disorders in the distal antrum and proximal small bowel. Approximately 40% of our dyspeptic functional upper gut symptoms. Gastroenterology 1985; 88: 1223-31.","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/BF01296514","article-title":"patients showed normal motor responses to feeding and no statistical correlation was found Gastric and autonomic responses to stress in functional dyspepsia","volume":"31","author":"Camilleri, M.; Malagelada, JR, Kao; PC, Zinsmeister; A.R.","year":"1986","unstructured":"Camilleri M, Malagelada JR, Kao PC, Zinsmeister AR. patients showed normal motor responses to feeding and no statistical correlation was found Gastric and autonomic responses to stress in functional dyspepsia. Dig Dis Sci 1986; 31: 1169-77.","journal-title":"Dig Dis Sci"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gut.30.1.54","article-title":"Postprandial antral hypomotility in patients with between symptom scores and the postprandial antral contractile responses to feeding. Psychoidiopathic nausea and vomiting","volume":"30","author":"Kerlin, P.","year":"1989","unstructured":"Kerlin P. Postprandial antral hypomotility in patients with between symptom scores and the postprandial antral contractile responses to feeding. Psychoidiopathic nausea and vomiting. Gut 1989; 30: 54-9.","journal-title":"Gut"},{"key":"ref_10","first-page":"393","article-title":"Motility of the stomach and gastroduodenal manometry,7 but no attempt was made to investigate this aspect in our patients. junction","volume-title":"Physiology of the gastrointestinal tract","author":"Kelly, K.A.","year":"1981","unstructured":"Kelly KA. Motility of the stomach and gastroduodenal manometry,7 but no attempt was made to investigate this aspect in our patients. junction. In: Johnsons LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press, 1981; 393-410."},{"key":"ref_11","first-page":"726","article-title":"Duodenogastric In this study, sporadic motor abnormalities only were observed in the proximal small bowel, reflux in humans: its relationship to fasting antroduodenal motility and gastric, pancreatic, and biliary secretion","volume":"81","author":"Keane, F.B.; DiMagno, E.P.; Malagelada, JR","year":"1981","unstructured":"Keane FB, DiMagno EP, Malagelada JR. Duodenogastric In this study, sporadic motor abnormalities only were observed in the proximal small bowel, reflux in humans: its relationship to fasting antroduodenal motility and gastric, pancreatic, and biliary secretion. Gastroenterology 1981; 81: 726-31. and all the intestinal activity fronts seemed normal for propagation and configuration.","journal-title":"Gastroenterology; intestinal activity fronts seemed normal for propagation and configuration"},{"key":"ref_12","first-page":"241","article-title":"Increased reflux of bile into the stomach in patients with gastric ulcer","volume":"57","author":"Rhodes, J.; Barnardo, D.E.; Phillips, S.F.; Rovelstad, R.A.; Hofman, A.F.","year":"1966","unstructured":"Rhodes J, Barnardo DE, Phillips SF, Rovelstad RA, Hofman AF. Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology 1966; 57: 241-52. Interestingly, the intestinal motor abnormalities (repetitive clustered contractions in two patients","journal-title":"Gastroenterology"},{"key":"ref_13","first-page":"94","article-title":"Relationship between impaired gastric emptying and abnormal gastrointestinal motility","volume-title":"Gastroenterology 1986; 91; and a non-propagated burst of contractions in one patient) were recorded in 13% of the subjects","author":"Camilleri, M.; Brown, M.L.; MalageladaJR","unstructured":"Camilleri M, Brown ML, MalageladaJR. Relationship between impaired gastric emptying and abnormal gastrointestinal motility. Gastroenterology 1986; 91: 94-9. and a non-propagated burst of contractions in one patient) were recorded in 13% of the subjects"},{"key":"ref_14","first-page":"4","article-title":"Non-ulcer dyspepsia: a candidate motility disorder","volume":"3","author":"0, Nyren","year":"1988","unstructured":"Nyren 0. Non-ulcer dyspepsia: a candidate motility disorder. Motility 1988; 3: 4-10.","journal-title":"Motility"},{"key":"ref_15","first-page":"989","article-title":"Summerskill complaining of symptoms compatible with the diagnosis of irritable bowel syndrome, but in none of those complaining of dyspeptic symptoms only. Similar results have recently been","volume":"73","author":"Malagelada, JR, Longstreth; GF, Deering; T.B.","year":"1977","unstructured":"Malagelada JR, Longstreth GF, Deering TB, Summerskill complaining of symptoms compatible with the diagnosis of irritable bowel syndrome, but in none of those complaining of dyspeptic symptoms only. Similar results have recently been WH, Go VL. Gastric secretion and emptying after ordinary meals in duodenal ulcer. Gastroenterology 1977; 73: 989-94.","journal-title":"Gastroenterology; Gastric secretion and emptying after ordinary meals in duodenal ulcer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bmj.2.6138.653","article-title":"Towards positive diagnosis of the irritable bowel","volume":"2","author":"Manning, A.P.; Thompson, W.G.; Heaton, K.W.; Morris, A.F.","year":"1978","unstructured":"Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. BMJ 1978; 2: 653-4.","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1136\/gut.24.9.790","article-title":"Gastric manometric abnormalities in patients with dyspeptic symptoms after habits and diffuse abdominal bloating. A larger percentage of abnormal intestinal motor patterns fundoplication","volume":"24","author":"Stanghellini, V.; Malagelada, JR","year":"1983","unstructured":"Stanghellini V, Malagelada JR. Gastric manometric abnormalities in patients with dyspeptic symptoms after habits and diffuse abdominal bloating. A larger percentage of abnormal intestinal motor patterns fundoplication. Gut 1983; 24: 790-7.","journal-title":"Gut"},{"key":"ref_18","first-page":"147","article-title":"Dose-related effects of synthetic human was found in the Mayo Clinic series (30%),7 in which subjects with symptoms of irritable bowel syndrome and associated metabolic and neurogenic diseases were also included. Episodes of clustered contractions were found in over 90% of the irritable bowel syndrome patients evaluated B-endorphin and naloxone on fed gastrointestinal motility","volume":"251","author":"Camilleri, M.; Malagelada, JR, Stanghellini; V, Zinsmeister; AR, Kao; PC, Choh; H.L.","year":"1986","unstructured":"Camilleri M, Malagelada JR, Stanghellini V, Zinsmeister AR, Kao PC, Choh HL. Dose-related effects of synthetic human was found in the Mayo Clinic series (30%),7 in which subjects with symptoms of irritable bowel syndrome and associated metabolic and neurogenic diseases were also included. Episodes of clustered contractions were found in over 90% of the irritable bowel syndrome patients evaluated B-endorphin and naloxone on fed gastrointestinal motility. AmJ Physiol 1986; 251: G147-54.","journal-title":"AmJ Physiol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/BF01297215","article-title":"Rapid gastric emptying in duodenal ulcer patients","volume":"27","author":"Lam, S.K.; Inseberg, J.I.; Grossman, M.I.; Lane, W.H.; Hogan, D.L.","year":"1982","unstructured":"Lam SK, Inseberg JI, Grossman MI, Lane WH, Hogan DL. Rapid gastric emptying in duodenal ulcer patients. Dig Dis Sci 1982; 27: 598-604.","journal-title":"Dig Dis Sci"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/gut.28.1.5","article-title":"Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings","volume":"28","author":"Stanghellini V. Camilleri M, Malagelada JR","year":"1987","unstructured":"Stanghellini V. Camilleri M, Malagelada JR. Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings. Gut 1987; 28: 5-12.","journal-title":"Gut"},{"key":"ref_21","first-page":"1290","article-title":"Anuras 5, Green J. Jejunal manometry patterns in two recent studies.373X In both studies, intestinal motility was recorded for long periods","volume-title":"health, partial intestinal obstruction and pseudoobstruction. Gastroenterology 1983; 85","author":"Summers, R.W.","unstructured":"Summers RW, Anuras 5, Green J. Jejunal manometry patterns in two recent studies.373X In both studies, intestinal motility was recorded for long periods in health, partial intestinal obstruction and pseudoobstruction. Gastroenterology 1983; 85: 1290-300."},{"key":"ref_22","first-page":"1919","article-title":"Pyloric dysfunction in of time and clustered contractions accounted for 12","volume":"90","author":"Mearin, F.; Camilleri, M.; Malagelada, JR","year":"1986","unstructured":"Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in of time and clustered contractions accounted for 12 (1 1)% 36 to 34 (7)%38 Of the total duration of diabetics with recurrent nausea and vomiting. Gastroenterology 1986; 90: 1919-25.","journal-title":"Gastroenterology; 1)% 36 to 34 (7)%38 Of the total duration of diabetics with recurrent nausea and vomiting"},{"key":"ref_23","first-page":"286","article-title":"Gastric motor phase II activity. Shorter recording times, such as those of the present study, can underestimate abnormalities in diabetic and postvagotomy gastroparesis: effect","volume-title":"of metoclopramide and bethanecol. Gastroenterology 1980","volume":"78","author":"Malagelada, JR, Rees; WD, Mazzotta U1; Go, V.L.","unstructured":"Malagelada JR, Rees WD, Mazzotta U1, Go VL. Gastric motor phase II activity. Shorter recording times, such as those of the present study, can underestimate abnormalities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and bethanecol. Gastroenterology 1980; 78: 286-93."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0016-5085(82)80192-3","article-title":"Interdigestive motor activity in patients with systemic sclerosis","volume":"83","author":"Rees, W.D.; Leigh, R.J.; Christofides, N.D.; Bloom, SR, Turnberg; L.A.","year":"1982","unstructured":"Rees WD, Leigh RJ, Christofides ND, Bloom SR, Turnberg LA. Interdigestive motor activity in patients with systemic sclerosis. Gastroenterology 1982; 83: 575-80.","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/0016-5085(85)90010-1","article-title":"Gastrointestinal motility disturbances in patients with orthostatic hypotension","volume":"88","author":"Camilleri, M.; Malagelada, JR, Stanghellini; V, Fealey; RD, Sheps; S.G.","year":"1985","unstructured":"Camilleri M, Malagelada JR, Stanghellini V, Fealey RD, Sheps SG. Gastrointestinal motility disturbances in patients with orthostatic hypotension. Gastroenterolog 1985; 88: 1852-9.","journal-title":"Gastroenterolog"},{"key":"ref_26","first-page":"958","article-title":"Gastric electromechanical and neurohormonal function","volume-title":"anorexia nervosa. Gastroenterology","volume":"93","author":"Abell, T.L.; Malagelada, JR, Lucas; A.R.","year":"1987","unstructured":"Abell TL, Malagelada JR, Lucas AR, et al. Gastric electromechanical and neurohormonal function in anorexia nervosa. Gastroenterology 1987; 93: 958-65."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/BF01296443","article-title":"Interrelationships among gastric mucosal morphology, secretion, and motility in peptic ulcer disease","volume":"31","author":"Moore, S.C.; Malagelada, JR, Shorter; RG, Zinsmeister; A.R.","year":"1986","unstructured":"Moore SC, Malagelada JR, Shorter RG, Zinsmeister AR. Interrelationships among gastric mucosal morphology, secretion, and motility in peptic ulcer disease. Dig Dis Sci 1986; 31: 673-84.","journal-title":"Dig Dis Sci"},{"key":"ref_28","first-page":"1444","article-title":"Read NW, Johnson AG. Disordered motility in duodenal ulcer disease","volume":"30","author":"Kerrigan, D.D.; Houghton, L.A.; Taylor, M.E.","year":"1989","unstructured":"Kerrigan DD, Houghton LA, Taylor ME, Read NW, Johnson AG. Disordered motility in duodenal ulcer disease. Gut 1989; 30: A1444.","journal-title":"Gut"},{"key":"ref_29","first-page":"34952","article-title":"Duodenal motility pattern in duodenal ulcer disease","volume":"13","author":"Borgstrom, S.; Arborelius, M.","year":"1978","unstructured":"Borgstrom S, Arborelius M. Duodenal motility pattern in duodenal ulcer disease. Scandj Gastroenterol 1978; 13: 34952.","journal-title":"Scandj Gastroenterol"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01536060","article-title":"Gastric acid secretion and gastric emptying of liquids in 99 male duodenal ulcer patients","volume":"34","author":"Corinaldesi, R.; Stanghellini, V.; Paparo, G.F.; Paternico, A.; Rusticali, A.G.; Barbara, L.","year":"1989","unstructured":"Corinaldesi R, Stanghellini V, Paparo GF, Paternico A, Rusticali AG, Barbara L. Gastric acid secretion and gastric emptying of liquids in 99 male duodenal ulcer patients. Dig Dis Sci 1989; 34: 251-6.","journal-title":"Dig Dis Sci"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF01338528","article-title":"Dysfunctions of the stomach with gastric ulceration","volume":"25","author":"Miller, L.J.; Malagelada, JR, Longstreth; GF, Go; V.L.","year":"1980","unstructured":"Miller LJ, Malagelada JR, Longstreth GF, Go VL. Dysfunctions of the stomach with gastric ulceration. Dig Dis Sci 1980; 25:857-64.","journal-title":"Dig Dis Sci"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2982.1989.tb00150.x","article-title":"Myoelectrical activity of the stomach in gastric ulcer patients: an electrogastrographic study","volume":"1","author":"Geldof, H.; Van Der Schee, E.J.; Smout, A.J.P.M.; Van De Merwe, J.P.; Van Blankenstein, M.; Grashuis, J.L.","year":"1989","unstructured":"Geldof H, Van Der Schee EJ, Smout AJPM, Van De Merwe JP, Van Blankenstein M, Grashuis JL. Myoelectrical activity of the stomach in gastric ulcer patients: an electrogastrographic study. J Gastrointest Mot 1989; 1: 122-30.","journal-title":"J Gastrointest Mot"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00004836-198908000-00014","article-title":"Effect of age on human gastric and small bowel motility","volume":"11","author":"Fich, A.; Camiiieri, M.; Phillips, S.F.","year":"1989","unstructured":"Fich A, Camiiieri M, Phillips SF. Effect of age on human gastric and small bowel motility. J Clin Gastroenterol 1989; 11:416-20.","journal-title":"J Clin Gastroenterol"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0016-5085(84)80019-0","article-title":"Gastric emptying in patients with diabetes mellitus","volume":"86","author":"Loo, F.D.; Palmer, D.W.; Kalbfleisch, Soergel K.H.; JH, Wood; C.M.","year":"1984","unstructured":"Loo FD, Palmer DW, Soergel KH. Kalbfleisch JH, Wood CM, Gastric emptying in patients with diabetes mellitus. Gastroenterology 1984; 86: 485-94.","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/0016-5085(87)90620-2","article-title":"Altered small bowel motility in irritable bowel syndrome is correlated with symptoms","volume":"92","author":"Kellow, J.E.; Phillips, S.F.","year":"1987","unstructured":"Kellow JE, Phillips SF. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987; 92: 1885-93.","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/0016-5085(90)90335-X","article-title":"Prolonged ambulant recordings ofsmall bowel motility demonstrate abnormalities in the irritable bowel syndrome","volume":"98","author":"Kellow, J.E.; Gill, R.C.; Wingate, D.L.","year":"1990","unstructured":"Kellow JE, Gill RC, Wingate DL. 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Lancet 1985; ii: 973-7.","journal-title":"Lancet"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.2.184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:53:22Z","timestamp":1765608802000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.2.184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1992,2,1]]},"published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1136\/gut.33.2.184"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.2.184","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}