{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:27:49Z","timestamp":1765607269081,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>Alcoholic hepatitis is characterised histologically by an intense inflammatory cell infiltrate made up predominantly of neutrophils but including other cell types, particularly lymphocytes. Leukocyte cytotoxicity requires cell adhesion, which is mediated via receptors on the leukocyte surface including leukocyte function associated antigen-1 (LFA-1) which binds to the ligand intercellular adhesion molecule-1 (ICAM-1) on the target cell. The distribution of ICAM-1 and LFA-1 expression in liver biopsy specimens from patients with alcoholic liver disease was examined to ascertain whether this pathway of leukocyte adhesion is involved in the tissue damage of alcoholic hepatitis. Specimens were stained for ICAM-1 and LFA-1 by a three step immunoalkaline-phosphatase method using monoclonal antibodies against ICAM-1 and LFA-1. LFA-1 staining on portal tract inflammatory cells and parenchymal inflammatory cells and ICAM-1 staining on liver components were examined. ICAM-1 expression on hepatocytes was significantly greater in alcoholic hepatitis compared with fatty liver (p less than 0.001) and normal controls (p less than 0.01). ICAM-1 expression correlated with the histological degree of hepatocellular damage (tau = 0.79; p = 0.0005) and parenchymal inflammation (tau = 0.65; p less than 0.001, and with LFA-1 expression on parenchymal leukocytes (tau = 0.63; p = 0.01). The ICAM-1\/LFA-1 pathway may therefore be involved in leukocyte mediated tissue damage during alcoholic hepatitis.<\/jats:p>","DOI":"10.1136\/gut.33.2.268","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"268-271","source":"Crossref","is-referenced-by-count":42,"title":["Is the intercellular adhesion molecule-1\/leukocyte function associated antigen 1 pathway of leukocyte adhesion involved in the tissue damage of alcoholic hepatitis?"],"prefix":"10.1136","volume":"33","author":[{"given":"P","family":"Burra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S G","family":"Hubscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Elias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"ref_1","first-page":"245","article-title":"Springer tumour necrosis factor (TNF) production by TA. Induction by IL 1 and interferon gamma:tissue distrimonocytes\" and interleukin-I release'6 are bution, biochemistry and function of a natural adherence molecule (ICAM-1). J7 Immunol","volume":"137","author":"Dustin, M.L.; Rothlein, R.; Bhan, A.K.; Dinarello, C.A.","year":"1986","unstructured":"Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer tumour necrosis factor (TNF) production by TA. Induction by IL 1 and interferon gamma:tissue distrimonocytes\" and interleukin-I release'6 are bution, biochemistry and function of a natural adherence molecule (ICAM-1).J7 Immunol 1986; 137: 245-54."},{"key":"ref_2","first-page":"1893","article-title":"Overlapping patterns of activation of stimulus for TNF production.'7 18 The release of human endothelial cells by interleukin 1, tumour necrosis TNF and other proinflammatory cytokines in factor and immune interferon","volume":"137","author":"Pober, J.S.; Gimbrone, M.A.; Lapierre, L.A.; Mendrick, D.L.; Fiers, W.; Rothlein, R.","year":"1986","unstructured":"Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, et al. Overlapping patterns of activation of stimulus for TNF production.'7 18 The release of human endothelial cells by interleukin 1, tumour necrosis TNF and other proinflammatory cytokines in factor and immune interferon. J I?nmunol 1986; 137: 1893-6.","journal-title":"J I?nmunol"},{"key":"ref_3","article-title":"Leucocyte adhesion to cells in response to either endotoxinaemia or alcoholic immune and inflammatory responses","author":"Patarroyo, M.; Makgoba, M.W.","year":"1989","unstructured":"Patarroyo M, Makgoba MW. Leucocyte adhesion to cells in response to either endotoxinaemia or alcoholic immune and inflammatory responses. Lancet 1989; ii: 1139-","journal-title":"Lancet"},{"issue":"1","key":"ref_4","first-page":"1","article-title":"Review by an International group. Alcoholic liver disease: increased expression of adhesion molecules in morphological manifestations","volume":"707","year":"1981","unstructured":"Review by an International group. Alcoholic liver disease: increased expression of adhesion molecules in morphological manifestations. Lancet 1981; i: 707-1 1. alcoholic hepatitis. 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CD8 T cells, which have been cholangitis","volume":"14","author":"Adams, D.H.; Hubscher, S.G.; Shaw, J.; Johnson, G.D.; Babbs, C.; Rothlein, R.","year":"1991","unstructured":"Adams DH, Hubscher SG, Shaw J, Johnson GD, Babbs C, Rothlein R, et al. Increased expression of ICAM-1 on bile ducts in primary biliary cirrhosis and primary sclerosing sing ICAM-1. CD8 T cells, which have been cholangitis. Hepatology 1991; 14: 426-31.","journal-title":"Hepatology"},{"key":"ref_7","first-page":"382","article-title":"Alcoholic implicated in the hepatocyte damage of alcoholic hepatitis. Cell-mediated immunological response to alcohepatitis,'9 also adhere via the ICAM-1\/LFA-1 pathway and could therefore also interact with holic hyalin","volume":"70","author":"Zetterman, R.K.; Luisada-Opper, A.; Leevy, C.M.","year":"1976","unstructured":"Zetterman RK, Luisada-Opper A, Leevy CM. Alcoholic implicated in the hepatocyte damage of alcoholic hepatitis. 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Gastroenterology 1977; 73: 1368-73. tially important therapeutic implications. Corticosteroids have been shown to diminish ICAM-","journal-title":"Gastroenterology; tially important therapeutic implications. Corticosteroids have been shown to diminish ICAM"},{"article-title":"Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatologv 1989; 9: 349-51. 1 expression during rejection of liver allografts9 and it is therefore possible that a similar mech-","author":"McClain, C.J.; Cohen, D.A.","key":"ref_10","unstructured":"McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatologv 1989; 9: 349-51. 1 expression during rejection of liver allografts9 and it is therefore possible that a similar mech-"},{"article-title":"Serum interleukin-I (IL-1) activity in alcoholic hepatitis. Life Sci 1986; 39: 1479-85. anism might explain the improved survival of patients with severe alcoholic hepatitis when","author":"McClain, C.J.; Cohen, D.A.; Dinarello, C.A.","key":"ref_11","unstructured":"McClain CJ, Cohen DA, Dinarello CA, et al. Serum interleukin-I (IL-1) activity in alcoholic hepatitis. Life Sci 1986; 39: 1479-85. anism might explain the improved survival of patients with severe alcoholic hepatitis when"},{"key":"ref_12","first-page":"234","article-title":"Tumor necrosis factor and interleukin-l: cytolines with multiple overlapping biological activities","volume":"56","author":"Le, J.; Vilcek, J.","year":"1987","unstructured":"Le J, Vilcek J. Tumor necrosis factor and interleukin-l: cytolines with multiple overlapping biological activities. Lab Invest 1987; 56: 234-48.","journal-title":"Lab Invest"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.2.268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:25:02Z","timestamp":1765607102000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.2.268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1992,2,1]]},"published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1136\/gut.33.2.268"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.2.268","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}