{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:12:20Z","timestamp":1772809940343,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>In a healthy population pepsinogen A and pepsinogen C increase with advancing age. As pepsinogen A and C are raised in chronic superficial gastritis which is caused by H pylori infection, we investigated whether H pylori is responsible for the age related increase of pepsinogen A and C. In H pylori positive blood transfusion donors serum pepsinogen A (mean (SD) 73 (35) micrograms\/ml v 52 (19) micrograms\/ml, p much less than 0.01) and C (mean (SD) 24 (13) micrograms\/ml v 10 (7) micrograms\/ml, p much less than 0.01) concentrations were significantly higher than in H pylori negative blood transfusion donors, while the serum pepsinogen A:C ratio mean (SD) 3.5 (1.4) v 6.2 (3.4), p much less than 0.01) was significantly decreased because of a relative greater increase in serum pepsinogen C in H pylori positive blood transfusion donors. Analysis of variance showed that pepsinogen A and C concentrations differed significantly in the different age groups (p much less than 0.01) when we considered all blood transfusion donors and H pylori positive blood transfusion donors, the mean pepsinogen levels being highest in the older age categories. In H pylori negative blood transfusion donors no such age related difference in pepsinogen A and C could be shown. In H pylori positive blood transfusion donors a weak positive but significant correlation between pepsinogen A and C and age could be shown (r = 0.30; p = 0.01 and r = 0.31; p = 0.01 respectively). In H pylori negative blood transfusion donors no correlation between serum pepsinogens and age was found. We conclude that the age related increase in serum pepsinogen A and C described in healthy control populations is caused by an increasing prevalence of H pylori infection. Serum pepsinogen A and C concentrations in patients should therefore be related to the presence or absence of H pylori infection.<\/jats:p>","DOI":"10.1136\/gut.33.4.452","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"452-455","source":"Crossref","is-referenced-by-count":25,"title":["Influence of age and Helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors."],"prefix":"10.1136","volume":"33","author":[{"given":"R A","family":"Veenendaal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Biemond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"van Duijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kreuning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0016-5085(19)33596-6","article-title":"Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence","volume":"61","author":"Samloff, I.M.","year":"1971","unstructured":"Samloff IM. Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence. Gastroenterology 1971; 61: 185-8.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0016-5085(19)33138-5","article-title":"Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence","volume":"65","author":"Samloff, I.M.; Liebman, W.M.","year":"1973","unstructured":"Samloff IM, Liebman WM. Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence. Gastroenterology 1973; 65: 36-42.","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0016-5085(82)90176-7","article-title":"Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology","volume":"83","author":"Samloff, I.M.; Varis, K.; Ihamaki, T.; Siurala, M.; Rotter, J.I.","year":"1982","unstructured":"Samloff IM, Varis K, Ihamaki T, Siurala M, Rotter JI. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. Gastroenterology 1982; 83: 204-9.","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3109\/00365528909089228","article-title":"The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis","volume":"24","author":"Borch, K.; Axelsson, C.K.; Halgreen, H.; Damkjaer Nielsen, M.; Ledin, T.","year":"1989","unstructured":"Borch K, Axelsson CK, Halgreen H, Damkjaer Nielsen M, Ledin T, et al. The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. Scand J Gastroenterol 1989; 24: 870-6.","journal-title":"Scand J Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0009-8981(82)90034-1","article-title":"Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders","volume":"126","author":"Ichinose, M.; Miki, K.; Furihata, C.; Kageyama, T.; Niwa, H.; Oka, H.","year":"1982","unstructured":"Ichinose M, Miki K, Furihata C, Kageyama T, Niwa H, Oka H, et al. Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders. Clin Chim Acta 1982; 126: 183-91.","journal-title":"Clin Chim Acta"},{"key":"ref_6","first-page":"19","article-title":"Radioimmunoassay of human pepsinogen A and pepsinogen C","volume":"27","author":"Biemond, I.; Jansen, J.B.M.J.; Crobach, L.F.S.J.; Kreuning, J.; Lamers, C.B.H.W.","year":"1989","unstructured":"Biemond I, Jansen JBMJ, Crobach LFSJ, Kreuning J, Lamers CBHW. Radioimmunoassay of human pepsinogen A and pepsinogen C. J Clin Chem Clin Biochem 1989; 27: 19-25.","journal-title":"J Clin Chem Clin Biochem"},{"key":"ref_7","article-title":"Enzyme linked immunosorbent assay of serum pepsinogen A and C in normal controls and patients with superficial or atrofic gastritis","author":"Pals, G.; Westerveld, B.D.; Pronk, J.C.; Frants, R.R.; Defize, J.; Kostense, P.J.","year":"1986","unstructured":"Pals G, Westerveld BD, Pronk JC, Frants RR, Defize J, Kostense PJ, et al. Enzyme linked immunosorbent assay of serum pepsinogen A and C in normal controls and patients with superficial or atrofic gastritis. [Thesis]. 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Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels. Cancer 1987; 59: 952-8.","journal-title":"Cancer"},{"key":"ref_13","first-page":"690","article-title":"Amoxycillin plus Tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels","volume":"i:","year":"1989","unstructured":"Oderda G, Vaira 0, Holton J, Ainley C, Altare F, Ansaldi N. Amoxycillin plus Tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels. 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Digestion 1989; 44: 131-41.","journal-title":"Digestion"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0016-5085(19)32639-3","article-title":"Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer","volume":"69","author":"Samloff, I.M.; Liebman, W.M.; Panitch, N.M.","year":"1975","unstructured":"Samloff IM, Liebman WM, Panitch NM. Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology 1975; 69: 83-90.","journal-title":"Gastroenterology"},{"key":"ref_16","first-page":"1125","article-title":"Radioimmunoassay of group","volume-title":"II pepsinogens in serum. Gastroenterology 1977; 71","author":"Samloff, I.M.","unstructured":"Samloff IM. Radioimmunoassay of group II pepsinogens in serum. Gastroenterology 1977; 71: A1125."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/00365528209182048","article-title":"Renal excretion and the effect of posture on serum group I pepsinogens","volume":"17","author":"Waldum, H.L.; Jarde, R.; Gunnes, P.","year":"1982","unstructured":"Waldum HL, Jarde R, Gunnes P. Renal excretion and the effect of posture on serum group I pepsinogens. Scand J Gastroenterol 1982; 17: 253-5.","journal-title":"Scand J Gastroenterol"},{"key":"ref_18","first-page":"33","article-title":"Campylobacter pyloridis-associated chronic active antral gastritis: a prospective study of its prevalence and the effects","volume-title":"of antibacterial and antiulcer treatment. Gastroenterology 1988; 94","author":"Rauws, E.A.J.; Langenberg, W.; Houthoff, H.J.; Zanen, H.C.; Tytgat, G.N.J.","unstructured":"Rauws EAJ, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GNJ. Campylobacter pyloridis-associated chronic active antral gastritis: a prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology 1988; 94: 33-40."},{"key":"ref_19","first-page":"13","article-title":"Serum pepsinogen A and C levels before and after treatment of Helicobacter pylori infection. Autumn meeting of the Dutch Society of Gastroenterology","volume":"38","author":"Veenendaal, R.A.; Biemond, I.; Pefia, A.S.; Kreuning, J.; Lamers, C.B.H.W.","year":"1991","unstructured":"Veenendaal RA, Biemond I, Pefia AS, Kreuning J, Lamers CBHW. Serum pepsinogen A and C levels before and after treatment of Helicobacter pylori infection. Autumn meeting of the Dutch Society of Gastroenterology. NethJI Med 1991; 38: A13-4.","journal-title":"NethJI Med"},{"issue":"1","key":"ref_20","series-title":"Proceedings of the third workshop of the European Helicobacter pylori study group. Rev Esp Enferm Dig","first-page":"168","article-title":"Serum pepsinogens: sensitive indicators of gastritis activity","volume":"78","author":"Hengels, K.J.; Jablonowski, K.; Schumacher, B.; Porschen, R.; Cooreman, M.; Barchard, F.","year":"1990","unstructured":"Hengels KJ, Jablonowski K, Schumacher B, Porschen R, Cooreman M, Barchard F, et al. Serum pepsinogens: sensitive indicators of gastritis activity. In: Vilardell F, Hernandez, Guio C, eds. Proceedings of the third workshop of the European Helicobacter pylori study group. 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