{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:12:25Z","timestamp":1769238745190,"version":"3.49.0"},"reference-count":41,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:p>The exact relation between gastro-oesophageal reflux and asthma remains poorly understood. To determine whether gastro-oesophageal reflux in asthmatics results in oesophagitis, endoscopy and oesophageal biopsy were performed on 186 consecutive adult asthmatics. The presence or absence of reflux symptoms was not used as a selection criterion for asthmatics. Endoscopy was performed by two endoscopists using predefined criteria. All asthmatics had discrete wheezing and either a previous diagnosis of asthma or documented reversible airways obstruction of at least 20%. The oesophageal mucosa was graded as normal if no erosions or ulcerations were present in the tubular oesophagus; as oesophagitis if a mucosal break with exudate (erosions and\/or ulcerations) was present; and as Barrett's if specialised (intestinal) columnar epithelium was present. A hiatal hernia was diagnosed if greater than or equal to 2 cm of gastric mucosa appeared above the diaphragm during endoscopy. Thirty nine per cent of the patients with asthma had oesophagitis or Barrett's oesophagus, or both. There was no difference in the oesophageal mucosal status between asthmatics who required and those who did not require bronchodilators. Fifty eight per cent of asthmatics had a hiatal hernia. It is concluded that oesophagitis is common and independent of the use of bronchodilator therapy in asthmatics.<\/jats:p>","DOI":"10.1136\/gut.33.7.872","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"872-876","source":"Crossref","is-referenced-by-count":137,"title":["Prevalence of oesophagitis in asthmatics."],"prefix":"10.1136","volume":"33","author":[{"given":"S J","family":"Sontag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T G","family":"Schnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T Q","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Chejfec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Greenlee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U J","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Brand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1001\/jama.1976.03270240022017","article-title":"Intrinsic asthma in adults, association with gastroesophageal reflux","volume":"236","author":"Mays, E.E.","year":"1976","unstructured":"Mays EE. 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Chest 1976; 69: 512-5.","journal-title":"Chest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1378\/chest.76.6.618","article-title":"Respiratory symptoms and esophageal reflux","volume":"76","author":"Orringer, M.B.","year":"1979","unstructured":"Orringer MB. Respiratory symptoms and esophageal reflux. Chest 1979; 76: 618-9.","journal-title":"Chest"},{"key":"ref_13","first-page":"613","article-title":"Sontag 5, O'Connell","volume":"99","author":"T, Nemchausky B.; R, Serlovsky","year":"1990","unstructured":"Sontag 5, O'Connell 5, Khandelwal 5, Miller T, Nemchausky B, Serlovsky R, et al. Most asthmatics have GER with or without bronchodilator therapy. 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Gastroesophageal reflux and hiatal hernia: complications and therapy.J Thorac Cardiovasc Surg 1967; 53: 21-32.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_30","first-page":"238","article-title":"The effect of theophylline on the lower esophageal sphincter pressure","volume":"45","author":"Stein, M.R.; Towner, T.G.; Weber, R.W.; Mansfield, L.E.; Jacobson, K.W.; McDonnell, J.T.","year":"1980","unstructured":"Stein MR, Towner TG, Weber RW, Mansfield LE, Jacobson KW, McDonnell JT, et al. The effect of theophylline on the lower esophageal sphincter pressure. Ann Allergy 1980; 45: 238-9."},{"key":"ref_31","first-page":"1501","article-title":"Gastro-oesophageal reflux and night-time asthma","volume":"i:","author":"true","year":"1985","unstructured":"Bengtsson U, Sandberg N, Bake B, Lowhagen 0, Svedmyr N, Mansson I, et al. Gastro-oesophageal reflux and night-time asthma. Lancet 1985; i: 1501-2.","journal-title":"Lancet"},{"key":"ref_32","first-page":"645","article-title":"Gastroesophageal reflux and chronic respiratory disease. Clinical commentary","volume":"129","author":"Allen, C.J.; Newhouse, M.T.","year":"1984","unstructured":"Allen CJ, Newhouse MT. Gastroesophageal reflux and chronic respiratory disease. Clinical commentary. Am Rev Respir Dis 1984; 129: 645-7.","journal-title":"Am Rev Respir Dis"},{"key":"ref_33","first-page":"207","article-title":"Gastroesophageal reflux in steroid dependent youths","volume":"63","author":"Shapiro, G.G.; Christie, D.L.","year":"1979","unstructured":"Shapiro GG, Christie DL. Gastroesophageal reflux in steroid dependent youths. Pediatrics 1979; 63: 207-12.","journal-title":"Pediatrics"},{"key":"ref_34","first-page":"1063","article-title":"Effect of an orall beta 2-adrenergic agonist on lower esophageall sphincter pressure in normals and in patients with achalasia","volume":"27","author":"DiMarino, A.J.; Cohen, S.","year":"1982","unstructured":"DiMarino AJ, Cohen S. Effect of an orall beta 2-adrenergic agonist on lower esophageall sphincter pressure in normals and in patients with achalasia. DigDisSci 1982; 27: 1063-6.","journal-title":"DigDisSci"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF02239282","article-title":"Inhibitory beta adrenergic receptors in the human distal esophagus","volume":"15","author":"Zfass, A.M.; Prince, R.; Allen, F.N.; Farrar, T.","year":"1970","unstructured":"Zfass AM, Prince R, Allen FN, Farrar T. Inhibitory beta adrenergic receptors in the human distal esophagus. Dig Dis 1970; 15: 303-10.","journal-title":"Dig Dis"},{"key":"ref_36","first-page":"253","article-title":"Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy. JAllergy Clin Immunol","volume":"73","author":"Berquist, W.E.; Rachelefsky, G.S.; Rowshan, N.; Siegel, S.; Katz, R.; Welch, M.","year":"1984","unstructured":"Berquist WE, Rachelefsky GS, Rowshan N, Siegel S, Katz R, Welch M. Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy.JAllergy Clin Immunol 1984; 73: 253-8."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/0091-6749(88)90886-X","article-title":"Effect of theophylline on gastroesophageal reflux in patients with asthma","volume":"81","author":"Hubert, D.; Gaudric, M.; Guerre, J.; Lockhart, A.; Marsac, J.","year":"1988","unstructured":"Hubert D, Gaudric M, Guerre J, Lockhart A, Marsac J. Effect of theophylline on gastroesophageal reflux in patients with asthma. J Allergy Clin Immunol 1988; 81: 1168-74.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_38","first-page":"337","article-title":"On blind men, elephants, spectrums, and controversies: lessons from rheumatic fever revisited. J7 Chronic","volume":"39","author":"Feinstein, A.R.","year":"1986","unstructured":"Feinstein AR. On blind men, elephants, spectrums, and controversies: lessons from rheumatic fever revisited. J7 Chronic Dis 1986; 39: 337-42.","journal-title":"Dis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0895-4356(88)90017-0","article-title":"Disease based spectrum bias in referred samples and the relationship between Type A behavior and arteriosclerosis","volume":"41","author":"Miller, T.Q.; Turner, C.W.; Tinsdale, R.S.; Posavac, E.J.","year":"1988","unstructured":"Miller TQ, Turner CW, Tinsdale RS, Posavac EJ. Disease based spectrum bias in referred samples and the relationship between Type A behavior and arteriosclerosis. J Clin Epidemiol 1988; 41: 1139-49.","journal-title":"J Clin Epidemiol"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1001\/jama.1982.03330190031026","article-title":"The limited spectrum of patients studied in exercise test research: analyzing the tip of the iceberg","volume":"248","author":"Philbrick, J.T.; Horowitz, R.I.; Feinstein, A.R.; Langou, R.A.; Chandler, J.P.","year":"1982","unstructured":"Philbrick JT, Horowitz RI, Feinstein AR, Langou RA, Chandler JP. The limited spectrum of patients studied in exercise test research: analyzing the tip of the iceberg. JAMA 1982; 248: 2467-70.","journal-title":"JAMA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1056\/NEJM197810262991705","article-title":"Problems of spectrum and bias in evaluating the efficacy of diagnostic tests","volume":"299","author":"Ransohoff, D.F.; Feinstein, A.R.","year":"1978","unstructured":"Ransohoff DF, Feinstein AR. 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