{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:36:37Z","timestamp":1792287397765,"version":"4.4.0"},"reference-count":13,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:p>Colorectal strictures, either benign or malignant, are not uncommon in ulcerative colitis. Fifty nine of 1156 ulcerative colitis patients (5%) admitted to this hospital between 1959 and 1983 developed 70 separate colorectal strictures. Seventeen of the 70 strictures (24%) proved to be malignant and the other 53 benign. Nine patients developed more than one stricture. Three principal features distinguished the 17 malignant from the 53 benign strictures in this series: (1) appearance late in the course of ulcerative colitis (61% probability of malignancy in strictures that develop after 20 years of disease v 0% probability in those occurring before 10 years); (2) location proximal to the splenic flexure (86% probability of malignancy v 47% in sigmoid, 10% in rectum, and 0% in splenic flexure and descending colon); and (3) symptomatic large bowel obstruction (100% probability of malignancy v only 14% in the absence of obstruction or constipation). Moreover, cancer associated with strictures tends to be more advanced (76% stage D, 24% A and B) than that which does not produce strictures (18% stage D, 59% A and B).<\/jats:p>","DOI":"10.1136\/gut.33.7.938","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"938-941","source":"Crossref","is-referenced-by-count":196,"title":["Benign and malignant colorectal strictures in ulcerative colitis."],"prefix":"10.1136","volume":"33","author":[{"given":"V","family":"Gumaste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D B","family":"Sachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Greenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/00000658-195406000-00015","article-title":"The prognostic significance of direct extension of carcinoma of the colon and rectum","volume":"139","author":"Astler, V.A.; Coller, F.A.","year":"1954","unstructured":"Astler VA, Coller FA. The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 1954; 139: 846-52.","journal-title":"Ann Surg"},{"key":"ref_2","first-page":"737","article-title":"Adjuvant therapy of colon cancer - results of a prospectively randomized trial. NEnglJ3Med","volume":"310","author":"Group, Gastrointestinal Tumor Study","year":"1984","unstructured":"Gastrointestinal Tumor Study Group. Adjuvant therapy of colon cancer - results of a prospectively randomized trial. NEnglJ3Med 1984; 310: 737-43."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/bmj.1.5501.1442","article-title":"Local complications of ulcerative colitis: Stricture, pseudopolyposis and carcinoma of the colon and rectum","volume":"1","author":"deDombal FT; J, Watts; G, Watkinson; JC, Goligher","year":"1966","unstructured":"deDombal FT, Watts J, Watkinson G, Goligher JC. 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Gastroenterology 1958; 34: 381-407.","journal-title":"Gastroenterology"},{"issue":"40","key":"ref_8","first-page":"290","article-title":"Pathology of ulcerative colitis","volume":"1961","author":"Lumb, G.","unstructured":"Lumb G. Pathology of ulcerative colitis. Gastroenterology 1961; 40:290-8.","journal-title":"Gastroenterology"},{"issue":"281","key":"ref_9","first-page":"290","article-title":"The nature of benign strictures in ulcerative colitis","volume":"1969","author":"Goulston, S.J.M.; McGovern, V.J.","unstructured":"Goulston SJM, McGovern VJ. The nature of benign strictures in ulcerative colitis. N EnglJ Med 1969; 281: 290-5.","journal-title":"N EnglJ Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1148\/57.1.1","article-title":"Reversibility in ulcerative colitis","volume":"57","author":"Kirsner, J.B.; Palmer, W.L.; Klotz, A.P.","year":"1951","unstructured":"Kirsner JB, Palmer WL, Klotz AP. Reversibility in ulcerative colitis. Radiology 1951; 57: 1-14.","journal-title":"Radiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/bmj.3.5979.360","article-title":"Colonscopy in the management of colonic strictures","volume":"3","author":"Hunt, R.H.; Teague, R.H.; Swarbrick, E.T.; Williams, C.B.","year":"1975","unstructured":"Hunt RH, Teague RH, Swarbrick ET, Williams CB. Colonscopy in the management of colonic strictures. BMJ 1975; 3: 360-1.","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.7.5.427","article-title":"Risk of malignant change in ulcerative colitis","volume":"7","author":"Hinton, J.M.","year":"1966","unstructured":"Hinton JM. Risk of malignant change in ulcerative colitis. Gut 1966; 7:426-32.","journal-title":"Gut"},{"key":"ref_13","first-page":"290","article-title":"Cancer in universal and left-sided ulcerative colitis: Clinical and pathological features","volume":"46","author":"Greenstein, A.J.; Sachar, D.B.; Pucillo, Geller; S.A.","year":"1979","unstructured":"Greenstein AJ, Sachar DB, Pucillo, Geller SA. Cancer in universal and left-sided ulcerative colitis: Clinical and pathological features. MtSinaiJ7Med 1979; 46: 290-8."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.7.938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:13:13Z","timestamp":1763752393000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.7.938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1992,7,1]]},"published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1136\/gut.33.7.938"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.7.938","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}