{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:42:19Z","timestamp":1765622539426,"version":"3.48.0"},"reference-count":35,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>Helicobacter pylori status, gastric histology, and 24 hour acidity were studied in 35 gastritis patients, 21 duodenal ulcer patients, and 14 subjects with normal gastric mucosa. H pylori was identified in 21 of 35 patients with chronic active gastritis and in 19 of 21 duodenal ulcer patients, but in none of those with normal gastric mucosa. Mean scores of activity of gastritis were similar in H pylori positive gastritis and duodenal ulcer patients, but were significantly lower in H pylori negative gastritis patients (2.1 (0.8) and 2.3 (0.9) v 1.4 (0.7); p &lt; 0.01, respectively). Median 24 hour hydrogen ion activity (interquartile range) was 21 (8.9-38.0) mmol\/l in normal subjects and 23 (11.2-49.0) mmol\/l, 19 (7.1-33.1) mmol\/l, 44 (25.1-63.1) mmol\/l, and 36 (31.6-39.8) mmol\/l respectively in gastritis and duodenal ulcer patients with and without H pylori infection. During all predefined time periods, intragastric acidity was significantly higher in patients with H pylori positive duodenal ulcers compared with gastritis patients and normal subjects. However, there was no significant difference in intragastric acidity between the H pylori positive and negative gastritis patients. These results suggest that most of the subjects with chronic H pylori infection have normal gastric acidity.<\/jats:p>","DOI":"10.1136\/gut.33.8.1024","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1024-1028","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Helicobacter pylori infection on 24 hour intragastric acidity in patients with gastritis and duodenal ulcer."],"prefix":"10.1136","volume":"33","author":[{"given":"S","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Gladziwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Varrentrapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/gut.31.8.940","article-title":"Helicobacter pylori: bridging the credibility gap","volume":"31","author":"McKinlay, A.W.; Upadhyay, R.; Gemmell, C.G.; Russel, R.I.","year":"1990","unstructured":"McKinlay AW, Upadhyay R, Gemmell CG, Russel RI. 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Gastroenterology"},{"key":"ref_17","first-page":"974","article-title":"Iatrogenic Campylobacter pyloni infection is a cause of epidemic achlorhydria","volume":"83","author":"Graham, D.Y.; Smith, J.L.; Alpert, L.C.; Yoshimura, H.H.","year":"1988","unstructured":"Graham DY, Smith JL, Alpert LC, Yoshimura HH. Iatrogenic Campylobacter pyloni infection is a cause of epidemic achlorhydria. Am] Gastroenterol 1988; 83: 974-80.","journal-title":"Am] Gastroenterol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1001\/archinte.1988.00380050153022","article-title":"Gastritis and Campylobacter pylori in healthy, asymptomatic volunteers","volume":"148","author":"Barthel, J.S.; Westblom, T.U.; Havey, A.D.; Gonzalez, F.; Everett, E.D.","year":"1988","unstructured":"Barthel JS, Westblom TU, Havey AD, Gonzalez F, Everett ED. Gastritis and Campylobacter pylori in healthy, asymptomatic volunteers. Arch Intern Med 1988; 148: 1149-51.","journal-title":"Arch Intern Med"},{"key":"ref_19","first-page":"92","article-title":"Does Helicobacter pylori infection affect gastric acid secretion?","volume":"98","author":"Mullin, G.E.; Kalloo, A.N.","year":"1990","unstructured":"Mullin GE, Kalloo AN. Does Helicobacter pylori infection affect gastric acid secretion? [Abstract]. Gastroenterology 1990; 98: A92.","journal-title":"Gastroenterology"},{"key":"ref_20","first-page":"407","article-title":"Epidemiologie und Therapie der Campylobacter-pyloriInfektion","author":"Wagner, S.; Freise, J.; Bar, W.; Fritsch, S.; Schmidt, F.W.","year":"1989","unstructured":"Wagner S, Freise J, Bar W, Fritsch S, Schmidt FW. Epidemiologie und Therapie der Campylobacter-pyloriInfektion. Dtsch Med Wochenschr 1989; 114; 407-13.","journal-title":"Dtsch Med Wochenschr"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/gut.33.2.179","article-title":"Bismuth subsalicylate in the treatment of H2-blocker resistant duodenal ulcers: role of Helicobacter pylori","volume":"33","author":"Wagner, S.; Gebel, M.; Haruma, K.; Bar, W.; Lange, P.; Freise, J.","year":"1992","unstructured":"Wagner S, Gebel M, Haruma K, Bar W, Lange P, Freise J, et al. Bismuth subsalicylate in the treatment of H2-blocker resistant duodenal ulcers: role of Helicobacter pylori. Gut 1992; 33: 179-83.","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/gut.32.10.1104","article-title":"Circadian pattern of intragastric acidity in duodenal ulcer patients: a study of variations in relation to ulcer activity","volume":"32","author":"Wagner, S.; Gladziwa, U.; Gebel, M.; Schtiler, A.; Freise, J.; Schmidt, F.W.","year":"1991","unstructured":"Wagner S, Gladziwa U, Gebel M, Schtiler A, Freise J, Schmidt FW. Circadian pattern of intragastric acidity in duodenal ulcer patients: a study of variations in relation to ulcer activity. Gut 1991; 32: 1104-9.","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0016-5085(86)91106-6","article-title":"Total 24-hour gastric secretion in patients with duodenal ulcer. 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Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest 1987; 79: 582-7.","journal-title":"J Clin Invest"},{"key":"ref_25","first-page":"225","article-title":"Twenty-four hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer or pernicious anemia","volume":"1","author":"Lanzon-Miller, S.; Pounder, R.E.; Hamilton, M.R.; Ball, S.; Chronos, N.A.F.; Raymond, F.","year":"1987","unstructured":"Lanzon-Miller S, Pounder RE, Hamilton MR, Ball S, Chronos NAF, Raymond F, et al. Twenty-four hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer or pernicious anemia. 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