{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:40:44Z","timestamp":1784194844288,"version":"3.55.0"},"reference-count":30,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Cryptosporidium had chronic diarrhoea. Most cases (63%) of chronic diarrhoea occurred in the first two years of life. A mild to moderate enteropathy was present in all nine children undergoing a small intestinal biopsy and seven showed the presence of Cryptosporidium adhering to villous epithelium. All patients eventually recovered spontaneously. Cryptosporidium is a cause of chronic diarrhoea and a proximal small intestinal mucosal enteropathy in children without immune deficiency. Screening for the parasite should be part of the investigative procedures in children with chronic diarrhoea.<\/jats:p>","DOI":"10.1136\/gut.33.8.1057","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1057-1061","source":"Crossref","is-referenced-by-count":58,"title":["Cryptosporidium, chronic diarrhoea and the proximal small intestinal mucosa."],"prefix":"10.1136","volume":"33","author":[{"given":"A D","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Walker-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"ref_1","article-title":"In order to further study the relationship with chronic diarrhoea we have reviewed patients presenting at Queen Elizabeth Hospital for Children with cryptosporidiosis since 1983 when routine screening of the stools was introduced","unstructured":"In order to further study the relationship with chronic diarrhoea we have reviewed patients presenting at Queen Elizabeth Hospital for Children with cryptosporidiosis since 1983 when routine screening of the stools was introduced."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0950268800054480","article-title":"Epidemiological aspects of human cryptosporidiosis","volume":"104","author":"Casemore, D.P.","year":"1990","unstructured":"Casemore DP. 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BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00005176-198401000-00028","article-title":"Intestinal and pulmonary cryptosporidiosis in an infant with severe combined immunodeficiency","volume":"3","author":"Kocoshis, S.A.; Cibull, M.L.; Davis, T.E.; Hinton, J.T.; Seip, M.; Banwell, J.G.","year":"1984","unstructured":"Kocoshis SA, Cibull ML, Davis TE, Hinton JT, Seip M, Banwell JG. Intestinal and pulmonary cryptosporidiosis in an infant with severe combined immunodeficiency. J Pediatr Gastroenterol Nutr 1984; 3: 149-57.","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.8.1057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:07:52Z","timestamp":1765634872000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.8.1057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1992,8,1]]},"published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1136\/gut.33.8.1057"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.8.1057","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8]]}}}