{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:24:15Z","timestamp":1765661055616,"version":"3.48.0"},"reference-count":31,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>To explore the role played by beta adrenoreceptor mediated pathways on human upper gut function a series of studies were conducted into the effects of beta adrenoreceptor agonists and antagonists on orocaecal and duodenocaecal transit and on antral and duodenal motor activity. Under control conditions orocaecal transit was consistent within individuals (mean coefficient of variation (18.0%) but varied widely between individuals (median transit 63 minutes, range 33-164). Prior administration of the non-selective beta adrenergic antagonist propranolol consistently hastened orocaecal transit (median transit 51:25-93, v control p &lt; 0.005). The selective beta-1 antagonist, atenolol, also hastened transit (median transit 50:35-93 minutes, v control p &lt; 0.01). The magnitude of an individual's response to beta blockade correlated closely with the orocaecal transit (Tau = 0.54, p &lt; 0.01). Duodenocaecal transit was also hastened by propranolol from control values of 66:45-107 minutes to 50:16-62 minutes, p &lt; 0.025). In contrast neither duodenal nor antral motility were consistently altered by beta blockade. The beta adrenoreceptor agonist, isoprenaline, delayed both orocaecal transient (97:55-178 minutes, v control p &lt; 0.005) and also duodenocaecal transit (160:45-215 minutes, v 73:40-133) (p &lt; 0.025). Isoprenaline also reduced antral motility by an effect which appeared to occur predominantly through a reduction in contraction amplitude (from a median amplitude of 27:5.39 mm Hg to 14:3-24 mm Hg, p &lt; 0.03) rather than an effect on the interval between contractions. No effect on either amplitude or frequency of duodenal motor activity was observed. A beta adrenoreceptor mediated pathway thus appears to exert a biologically relevant effect on gut function not only under conditions of sympathetic stimulation, but also at rest when a basal beta adrenergic tone appears to influence the speed of nutrient transit through the human upper gut.<\/jats:p>","DOI":"10.1136\/gut.33.8.1062","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1062-1070","source":"Crossref","is-referenced-by-count":32,"title":["Modulation of human upper intestinal nutrient transit by a beta adrenoreceptor mediated pathway."],"prefix":"10.1136","volume":"33","author":[{"given":"A S","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W R","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E R","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"ref_1","article-title":"Bodily changes in pain, hunger, fear and rage","author":"Cannon, W.B.","year":"1929","unstructured":"Cannon WB. Bodily changes in pain, hunger, fear and rage. New York: Appleton, 1929."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/214597a0","article-title":"Differentiation of receptor systems activated by sympathomimetic amines","volume":"214","author":"Lands, A.M.; Arnold, A.; AcAuliffJP","year":"1967","unstructured":"Lands AM, Arnold A, AcAuliffJP. Differentiation of receptor systems activated by sympathomimetic amines. Nature 1967; 214: 597-8.","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJM198312083092303","article-title":"Hypokalaemia from beta-2 receptor stimulation by circulating epinephrine","volume":"309","author":"Brown, M.J.; Brown, D.C.; Murphy, M.B.","year":"1983","unstructured":"Brown MJ, Brown DC, Murphy MB. Hypokalaemia from beta-2 receptor stimulation by circulating epinephrine. N EnglJ Med 1983; 309: 1414-9.","journal-title":"N EnglJ Med"},{"issue":"24","key":"ref_4","first-page":"99","article-title":"The movements and innervation of the small intestine","volume":"1899","author":"Bayliss, W.M.; Starling, E.H.","unstructured":"Bayliss WM, Starling EH. The movements and innervation of the small intestine. JPhysiol 1899; 24: 99-143.","journal-title":"JPhysiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0016-5085(84)90521-3","article-title":"Noradrenergic nerves in human small intestine distribution and ultrastructure","volume":"87","author":"Llewelyn-Smith, I.J.; Furness, J.B.; O'Brien, P.E.; Costa, M.","year":"1984","unstructured":"Llewelyn-Smith IJ, Furness JB, O'Brien PE, Costa M. Noradrenergic nerves in human small intestine distribution and ultrastructure. Gastroenterology 1984; 87: 513-29.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1113\/jphysiol.1977.sp011837","article-title":"The site and receptors responsible for the inhibition of sympathetic nerves of intestinal smooth muscle and its parasympathetic motor nerves","volume":"267","author":"Gillespie, J.S.; Khoyi, M.A.","year":"1977","unstructured":"Gillespie JS, Khoyi MA. The site and receptors responsible for the inhibition of sympathetic nerves of intestinal smooth muscle and its parasympathetic motor nerves. J Physiol 1977; 267: 767-89.","journal-title":"J Physiol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.2042-7158.1971.tb09893.x","article-title":"The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuro-effector transmission; the inhibition of acetylcholine release","volume":"23","author":"Vizi, E.S.; Knoll, J.","year":"1971","unstructured":"Vizi ES, Knoll J. The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuro-effector transmission; the inhibition of acetylcholine release. J Pharmnacol 1971; 23: 918-25.","journal-title":"J Pharmnacol"},{"key":"ref_8","article-title":"Isolated smooth muscle cells of the gut","volume-title":"Physiology of the gastrointestinal tract","author":"Makhlouf, G.M.","year":"1987","unstructured":"Makhlouf GM. Isolated smooth muscle cells of the gut. In: Johnson LR, ed. Physiology of the gastrointestinal tract. 2nd ed. New York: Raven Press, 1987.","edition":"2nd ed"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2125.1980.tb00509.x","article-title":"The effects of beta-adrenoreceptor agonists and antagonists on gastric emptying in man","volume":"10","author":"Rees, M.R.; Clark, R.A.; Holdsworth, C.D.; Barber, D.C.; Howlett, P.J.","year":"1980","unstructured":"Rees MR, Clark RA, Holdsworth CD, Barber DC, Howlett PJ. The effects of beta-adrenoreceptor agonists and antagonists on gastric emptying in man. Brj Clin Pharmacol 1980; 10: 551-4.","journal-title":"Brj Clin Pharmacol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1136\/gut.30.11.1530","article-title":"Perturbation of upper gastrointestinal transit and antro duodenal motility be experimentally applied stress: the role of beta-adrenoreceptor mediated pathways","volume":"30","author":"O'Brien, J.D.; Thompson, D.G.; Day, S.J.; Burnham, W.R.; Walker, E.","year":"1989","unstructured":"O'Brien JD, Thompson DG, Day SJ, Burnham WR, Walker E. Perturbation of upper gastrointestinal transit and antro duodenal motility be experimentally applied stress: the role of beta-adrenoreceptor mediated pathways. Gut 1989; 30: 1530-9.","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0016-5085(84)80070-0","article-title":"Effect of opiate and adrenergic blockers on the gut motor response to centrally acting stimuli","volume":"87","author":"Stangellini, V.; Malagelada, JR, Zinsmeister; AR, Go; VLW, Kao; P.C.","year":"1984","unstructured":"Stangellini V, Malagelada JR, Zinsmeister AR, Go VLW, Kao PC. Effect of opiate and adrenergic blockers on the gut motor response to centrally acting stimuli. Gastroenterology 1984; 87: 1104-13.","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.284.6325.1304","article-title":"Failure of ranitidine to interact with propranolol","volume":"284","author":"Hegarty, A.M.; Castleden, C.M.; Patel, L.","year":"1982","unstructured":"Hegarty AM, Castleden CM, Patel L. Failure of ranitidine to interact with propranolol. BMJ 1982; 284: 1304.","journal-title":"BMJ"},{"key":"ref_13","article-title":"Norepinephrine, epinephrine and the sympathomimetic amines","volume-title":"The pharmacological basis oftherapeutics","author":"Innes, I.R.; Nickerson, M.","year":"1975","unstructured":"Innes IR, Nickerson M. Norepinephrine, epinephrine and the sympathomimetic amines. In: Goodman LS, Gilman A, eds. The pharmacological basis oftherapeutics. 5th ed. New York: Macmillan, 1975.","edition":"5th ed"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/gut.28.8.960","article-title":"The action of centrally mediated autonomic stimulation on human upper gastrointestinal transit: a comparative study of two stimuli","volume":"28","author":"O'Brien, J.D.; Thompson, D.G.; Burnham, W.R.; Holly, J.; Walker, E.","year":"1987","unstructured":"O'Brien JD, Thompson DG, Burnham WR, Holly J, Walker E. The action of centrally mediated autonomic stimulation on human upper gastrointestinal transit: a comparative study of two stimuli. Gut 1987; 28: 960-9.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1136\/gut.26.12.1349","article-title":"Extra intestinal influences on exhaled breath hydrogen measurements during the investigation of gastrointestinal disease","volume":"26","author":"Thompson, D.G.; Binfield, P.; De Belder, A.; O'Brien, J.; Warren, S.; Wilson, M.","year":"1985","unstructured":"Thompson DG, Binfield P, De Belder A, O'Brien J, Warren S, Wilson M. Extra intestinal influences on exhaled breath hydrogen measurements during the investigation of gastrointestinal disease. Gut 1985; 26: 1349-52.","journal-title":"Gut"},{"key":"ref_16","first-page":"1076","article-title":"Influence of isoproterenol and propranolol on human intestinal","volume-title":"transport in vivo. Gastroenterology 1981; 81","author":"Morris, A.L.; Turnberg, L.A.","unstructured":"Morris AL, Turnberg LA. Influence of isoproterenol and propranolol on human intestinal transport in vivo. Gastroenterology 1981; 81: 1076-9."},{"key":"ref_17","article-title":"Statistical methods in medical research","author":"Armitage, P.; Berry, G.","year":"1987","unstructured":"Armitage P, Berry G. Statistical methods in medical research. 2nd ed. London: Blackwell, 1987.","edition":"2nd ed"},{"key":"ref_18","article-title":"Non parametric statistics for the behavioural sciences","author":"Siegal, S.; Castellan, N.J.","year":"1988","unstructured":"Siegal S, Castellan NJ. Non parametric statistics for the behavioural sciences. 2nd ed. New York: McGraw Hill, 1988.","edition":"2nd ed"},{"key":"ref_19","article-title":"An introduction to medical statistics","author":"Bland, M.","year":"1987","unstructured":"Bland M. An introduction to medical statistics. Oxford: Oxford University Press, 1987."},{"key":"ref_20","first-page":"586","article-title":"A study of the adrenotopic receptors","volume":"153","author":"Ahlquist, R.P.","year":"1948","unstructured":"Ahlquist RP. A study of the adrenotopic receptors. J Physiol 1948; 153: 586-600.","journal-title":"J Physiol"},{"key":"ref_21","first-page":"146","article-title":"Adrenergic receptive mechanism of canine ileum","volume":"127","author":"Ahlquist, R.P.; Levy, B.","year":"1959","unstructured":"Ahlquist RP, Levy B. Adrenergic receptive mechanism of canine ileum.J Pharmacol Exp Ther 1959; 127: 146-9.","journal-title":"J Pharmacol Exp Ther"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/277032a0","article-title":"Mechanism of beta adrenergic relaxation of smooth muscle","volume":"277","author":"Scheid, C.R.; Honeyman, T.W.; Fay, F.S.","year":"1979","unstructured":"Scheid CR, Honeyman TW, Fay FS. Mechanism of beta adrenergic relaxation of smooth muscle. Nature 1979; 277: 32-6.","journal-title":"Nature"},{"key":"ref_23","article-title":"The enteric nervous system","author":"Furness, J.B.; Costa, M.","year":"1987","unstructured":"Furness JB, Costa M. The enteric nervous system. London: Churchill Livingstone, 1987."},{"issue":"253","key":"ref_24","first-page":"378","article-title":"Distribution of betaadrenoreceptors associated with cAMP-generating system in cat colon","volume":"1987","author":"Taniyama, K.; Kuno, T.; Tanak, C.","unstructured":"Taniyama K, Kuno T, Tanak C. Distribution of betaadrenoreceptors associated with cAMP-generating system in cat colon. AmJ Physiol 1987: 253: G378-82.","journal-title":"AmJ Physiol"},{"key":"ref_25","first-page":"125","article-title":"Evidence that blockade of adrenergic receptors causes overflow of noropinephrine in cats colon after nerve stimulation","volume":"157","author":"Boullin, D.J.; Costa, E.; Brodie, B.B.","year":"1967","unstructured":"Boullin DJ, Costa E, Brodie BB. Evidence that blockade of adrenergic receptors causes overflow of noropinephrine in cats colon after nerve stimulation. J Pharmacol Exp Ther 1967; 157: 125-34.","journal-title":"J Pharmacol Exp Ther"},{"key":"ref_26","first-page":"289","article-title":"Extrinsic control of digestive tract motility","volume-title":"Physiology of the gastrointestinal tract","author":"Roman, C.; Gonelli, J.","year":"1981","unstructured":"Roman C, Gonelli J. Extrinsic control of digestive tract motility. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press, 1981: 289-333."},{"key":"ref_27","first-page":"1","article-title":"The Vagal control of jejunal and ileal motility and blood flow","volume":"257","author":"Kewenter, J.","year":"1965","unstructured":"Kewenter J. The Vagal control of jejunal and ileal motility and blood flow. Acta Physiol Scand 1965; 257 (suppl): 1-68.","journal-title":"Acta Physiol Scand"},{"key":"ref_28","first-page":"546","article-title":"Direct measurement of distention induced oesophageal clearance forces in normal volunteers","volume-title":"and in reflux oesophagitis. [Abstract] Gastroenterology 1989; 96","author":"Williams, D.; Thompson, D.G.; Marple, M.; O\"Hanrahan, T.; Bancewicz, J.","unstructured":"Williams D, Thompson DG, Marple M, O\"Hanrahan T, Bancewicz J. Direct measurement of distention induced oesophageal clearance forces in normal volunteers and in reflux oesophagitis. [Abstract] Gastroenterology 1989; 96: A546."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(86)90513-3","article-title":"Differentiation between myenteric plexus and longitudinal muscle of the rat jejunum as the site of action of putative enteric neurotransmitters","volume":"131","author":"Fox, D.; Herman, J.; Bass, P.","year":"1986","unstructured":"Fox D, Herman J, Bass P. Differentiation between myenteric plexus and longitudinal muscle of the rat jejunum as the site of action of putative enteric neurotransmitters. Eur J Pharmacol 1986; 131: 39-47.","journal-title":"Eur J Pharmacol"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0016-5085(84)80056-6","article-title":"Isoproterenol induces activity fronts in fed dogs through somatostatin release","volume":"87","author":"Summers, R.W.; Flatt, A.; Yandu, R.J.; Yamada, T.","year":"1984","unstructured":"Summers RW, Flatt A, Yandu RJ, Yamada T. Isoproterenol induces activity fronts in fed dogs through somatostatin release. Gastroentrology 1984; 87: 999-1003.","journal-title":"Gastroentrology"},{"key":"ref_31","first-page":"988","article-title":"Adrenergic control of pancreatic enzyme secretion in rats","volume":"34","author":"Varga, G.; Papp, M.; Vizi, S.E.","year":"1989","unstructured":"Varga G, Papp M, Vizi SE. Adrenergic control of pancreatic enzyme secretion in rats. Dig Dis Sci 1989; 34: 988.","journal-title":"Dig Dis Sci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.8.1062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:19:46Z","timestamp":1765660786000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.8.1062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1992,8,1]]},"published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1136\/gut.33.8.1062"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.8.1062","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1992,8]]}}}