{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:26:51Z","timestamp":1772864811169,"version":"3.50.1"},"reference-count":27,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p>In a 15 year prospective study of endoscopic surveillance of columnar lined oesophagus, 102 patients with a mean follow up of 54 (12.5) months and total follow up of 462 years have been evaluated. Of all the sets of biopsies taken, 59 in 21 patients were found to exhibit dysplasia or carcinoma. Four male patients had carcinoma of the oesophagus, indicating a 30 times increased risk of development of adenocarcinoma in columnar lined oesophagus. The length of columnar lined oesophagus in subjects with dysplasia was significantly longer as compared with the whole group (p = 0.01) and when compared with the patients without dysplasia (p = 0.005). None of the patients with dysplasia had a columnar lined oesophagus of less than 8 cm. Length of columnar lined oesophagus therefore seems to be a significant risk factor in the development of dysplasia and subsequent carcinoma and intensive follow up of patients with columnar lined oesophagus greater than 8 cm in length is recommended.<\/jats:p>","DOI":"10.1136\/gut.33.9.1155","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1155-1158","source":"Crossref","is-referenced-by-count":221,"title":["Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma."],"prefix":"10.1136","volume":"33","author":[{"given":"S Y","family":"Iftikhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Steele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"ref_1","article-title":"The significance of dysplasia in terms of clinical management is still uncertain, however, as the rate of progression to malignancy is not clear. In 1976, an endoscopic surveillance programme for columnar lined oesophagus was established at Queen's Medical Centre, Nottingham. The aim of present study was to identify any significant risk factor for the adenocarcinoma arising in Barrett's oesophagus","unstructured":"The significance of dysplasia in terms of clinical management is still uncertain, however, as the rate of progression to malignancy is not clear. In 1976, an endoscopic surveillance programme for columnar lined oesophagus was established at Queen's Medical Centre, Nottingham. The aim of present study was to identify any significant risk factor for the adenocarcinoma arising in Barrett's oesophagus."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5223(19)39666-7","article-title":"Columnar lined lower oesophagus: an acquired lesion with malignant predisposition. Report of 140 cases of Barrett's oesophagus with 12 adenocarcinomas","volume":"70","author":"Naef, A.P.; Savary, M.; Ozzello, L.","year":"1975","unstructured":"Naef AP, Savary M, Ozzello L. Columnar lined lower oesophagus: an acquired lesion with malignant predisposition. Report of 140 cases of Barrett's oesophagus with 12 adenocarcinomas. J Thorac Cardiovasc Surg 1975; 70: 826-35.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_3","first-page":"187","article-title":"Barrett's esophagus: Its prevalence and association with adenocarcinoma in patients with symptoms of gastro-esophageal reflux","volume-title":"AmjSurg","volume":"149","author":"Sarr, M.G.; Hamilton, SR, Marrone; GC, Cameron; J.L.","year":"1985","unstructured":"Sarr MG, Hamilton SR, Marrone GC, Cameron JL. Barrett's esophagus: Its prevalence and association with adenocarcinoma in patients with symptoms of gastro-esophageal reflux. AmjSurg 1985; 149: 187-92."},{"key":"ref_4","first-page":"97","article-title":"Barrett's oesophagus: a clinical study of 52 patients","volume":"62","author":"Cooper, B.T.; Barbezat, G.O.","year":"1987","unstructured":"Cooper BT, Barbezat GO. Barrett's oesophagus: a clinical study of 52 patients. Q] Med 1987; 62: 97-108.","journal-title":"Q] Med"},{"key":"ref_5","first-page":"118","article-title":"Barrett's oesophagus - a prevalent occult complication of gastro-oesophageal reflux","volume":"92","author":"Winters, C.; Spurling, T.J.; Chobanian, S.J.; Curtis, D.J.; Esposito, R.L.; Hacker, J.F.","year":"1987","unstructured":"Winters C, Spurling TJ, Chobanian SJ, Curtis DJ, Esposito RL, Hacker JF, et al. Barrett's oesophagus - a prevalent occult complication of gastro-oesophageal reflux. Gastroenterology 1987; 92: 118-24.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/bjs.1800750813","article-title":"Value of endoscopic surveillance in the detection of neoplastic changes in Barrett's oesophagus","volume":"75","author":"Robertson, C.S.; Mayberry, J.F.; Nicholson, D.A.; James, P.D.; Atkinson, M.","year":"1988","unstructured":"Robertson CS, Mayberry JF, Nicholson DA, James PD, Atkinson M. Value of endoscopic surveillance in the detection of neoplastic changes in Barrett's oesophagus. Brj Surg 1988; 75: 760-3.","journal-title":"Brj Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1056\/NEJM198510033131404","article-title":"The incidence of adenocarcinoma in a columnar lined Barrett's oesophagus","volume":"313","author":"Cameron, A.J.; Ott, B.J.; Payne, W.S.","year":"1985","unstructured":"Cameron AJ, Ott BJ, Payne WS. The incidence of adenocarcinoma in a columnar lined Barrett's oesophagus. N Engl J Med 1985; 313: 857-9.","journal-title":"N Engl J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"902","DOI":"10.7326\/0003-4819-106-6-902","article-title":"Endoscopic surveillance for patients with Barrett's oesophagus: does cancer risk justify the practice?","volume":"106","author":"Spechler, S.J.","year":"1987","unstructured":"Spechler SJ. Endoscopic surveillance for patients with Barrett's oesophagus: does cancer risk justify the practice? Ann Intern Med 1987; 106: 902-4.","journal-title":"Ann Intern Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","article-title":"Adenocarcinoma and Barrett's oesophagus: an over-rated risk","volume":"87","author":"Spechler, S.J.; Robbins, A.H.; Rubins, H.A.; Vincent, M.E.; Heeren, T.; Doos, W.G.","year":"1984","unstructured":"Spechler SJ, Robbins AH, Rubins HA, Vincent ME, Heeren T, Doos WG, et al. Adenocarcinoma and Barrett's oesophagus: an over-rated risk. Gastroenterology 1984; 87: 927-33.","journal-title":"Gastroenterology"},{"key":"ref_10","first-page":"220","article-title":"Barrett's oesophagus: what's new and what to do","volume":"84","author":"Spechler, S.J.","year":"1989","unstructured":"Spechler SJ. Barrett's oesophagus: what's new and what to do. Am] Gastroenterol 1989; 84: 220-3.","journal-title":"Am] Gastroenterol"},{"key":"ref_11","first-page":"53","article-title":"Barrett's oesophagus. Correlation between mucin histochemistry, flow cytometry and histologic diagnosis for predicting increased cancer risk","volume":"131","author":"Haggit, R.C.; Reid, B.J.; Rabinovitch, P.S.; Rubin, C.E.","year":"1988","unstructured":"Haggit RC, Reid BJ, Rabinovitch PS, Rubin CE. Barrett's oesophagus. Correlation between mucin histochemistry, flow cytometry and histologic diagnosis for predicting increased cancer risk. Am] Pathol 1988; 131: 53-61.","journal-title":"Am] Pathol"},{"key":"ref_12","first-page":"1567","article-title":"Progression - regression","volume-title":"of Barrett's oesophagus. Gastroenterology 1985; 88","author":"Sampliner, R.E.; Kogan, F.J.; Morgan, T.R.; Tripp, M.","unstructured":"Sampliner RE, Kogan FJ, Morgan TR, Tripp M. Progression - regression of Barrett's oesophagus. Gastroenterology 1985; 88: A1567."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0046-8177(88)80344-7","article-title":"Observer variation in the diagnosis of dysplasia in Barrett's oesophagus","volume":"19","author":"Reid, B.J.; Haggit, R.C.; Rubin, C.E.; Roth, G.; Surawicz, C.M.; Van Belle, G.","year":"1988","unstructured":"Reid BJ, Haggit RC, Rubin CE, Roth G, Surawicz CM, Van Belle G, et al. Observer variation in the diagnosis of dysplasia in Barrett's oesophagus. Hum Pathol 1988; 19: 166-78.","journal-title":"Hum Pathol"},{"key":"ref_14","first-page":"845","article-title":"Dysplasia in Barrett's oesophagus. A clinicopathologic study of six patients","volume":"9","author":"Lee, R.G.","year":"1985","unstructured":"Lee RG. Dysplasia in Barrett's oesophagus. A clinicopathologic study of six patients. Am ] Surg Pathol 1985; 9: 845-52.","journal-title":"Am"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJM197608262950904","article-title":"The histological spectrum of Barrett's ocsophagus","volume":"295","author":"Paull, A.; Trier, J.; Dalton, M.; Camp, R.; Loeb, P.; Goval, R.","year":"1976","unstructured":"Paull A, Trier J, Dalton M, Camp R, Loeb P, Goval R. The histological spectrum of Barrett's ocsophagus. N Engli7 Med 1976; 295: 476-80.","journal-title":"N Engli7 Med"},{"key":"ref_16","article-title":"Intestinal metaplasia subtypes and cancer risk","author":"Fillipe, M.I.; Jass, JR","year":"1986","unstructured":"Fillipe MI, Jass JR. Intestinal metaplasia subtypes and cancer risk. In: Fillipe MI, Jass JR, eds. Gastric carcinoma. Edinburgh: Churchill Livingstone, 1986."},{"key":"ref_17","first-page":"931","article-title":"Dysplasia in inflammatory bowel disease. Standardised classification with pro)visional clinical applications","volume-title":"Hum Pathol","volume":"14","author":"true","year":"1983","unstructured":"Riddell RH, (Goldman H, Ransohoff DF, Appleman HI), Fenoglio CM, Haggitt RC, et al. Dysplasia in inflammatory bowel disease. Standardised classification with pro)visional clinical applications. Hum Pathol 1983; 14: 931-68."},{"key":"ref_18","first-page":"554","article-title":"Barrett's oesophagus: comparison of benign and malignant cases","author":"Skinner, D.B.; Walther, B.C.; Riddell, R.H.; Schmidt, H.; lascone C; Demeester, T.R.","year":"1983","unstructured":"Skinner DB, Walther BC, Riddell RH, Schmidt H, lascone C, Demeester TR. Barrett's oesophagus: comparison of benign and malignant cases. Ann Surg 1983; 198: 554-66.","journal-title":"Ann Surg"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1056\/NEJM198608073150605","article-title":"Barrett's oesophagus","volume":"315","author":"Spechler, S.J.; Goval, R.K.","year":"1986","unstructured":"Spechler SJ, Goval RK. Barrett's oesophagus. N Engl JMed 1986; 315: 362-71.","journal-title":"N Engl JMed"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/ajcp\/87.3.301","article-title":"The relationship between columnar epithelial dysplasia and invasive adenocarcinoma arising in Barrett's oesophagus","volume":"87","author":"Hamilton, SR, Smith; R.R.L.","year":"1987","unstructured":"Hamilton SR, Smith RRL. The relationship between columnar epithelial dysplasia and invasive adenocarcinoma arising in Barrett's oesophagus. Amj Clin Pathol 1987; 87: 301-12.","journal-title":"Amj Clin Pathol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/gut.27.9.1062","article-title":"Histological and histochemical changes in the columnar lined (Barrett's) oesophagus","volume":"27","author":"Rothery, G.A.; Patterson, J.E.; Stoddard, C.J.; Day, D.W.","year":"1986","unstructured":"Rothery GA, Patterson JE, Stoddard CJ, Day DW. Histological and histochemical changes in the columnar lined (Barrett's) oesophagus. Gut 1986; 27: 1062-8.","journal-title":"Gut"},{"key":"ref_22","article-title":"The epidemiologv of chronic digestive disease","author":"Langman, M.J.","year":"1986","unstructured":"Langman MJ. The epidemiologv of chronic digestive disease. Chicago: Year Book Medical Publishers, 1986."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0046-8177(83)80045-8","article-title":"Barrett's metaplasia and adenocarcinoma of the oesophagus and gastrooesophageal junction","volume":"14","author":"Thompson, J.J.; Zinsser, K.R.; Enterline, H.T.","year":"1983","unstructured":"Thompson JJ, Zinsser KR, Enterline HT. Barrett's metaplasia and adenocarcinoma of the oesophagus and gastrooesophageal junction. Hum Pathol 1983; 14: 42-61.","journal-title":"Hum Pathol"},{"key":"ref_24","first-page":"1","article-title":"Correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma","volume":"93","author":"Reid, B.J.; Haggit, R.C.; Rubin, C.E.; Rabinovitch, P.S.","year":"1987","unstructured":"Reid BJ, Haggit RC, Rubin CE, Rabinovitch PS. Correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma. Gastroenterology 1987; 93: 1-11.","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0016-5085(88)90613-0","article-title":"Endoscopic biopsy can detect high grade dysplasia or early adenocarcinoma in Barrett's oesophagus without grossly recognisable neoplastic lesions","volume":"94","author":"Reid, B.J.; Weinstein, W.M.; Lewin, K.J.; Haggit, R.C.; Van Deventer, G.; Den Besten, L.","year":"1988","unstructured":"Reid BJ, Weinstein WM, Lewin KJ, Haggit RC, Van Deventer G, Den Besten L, et al. Endoscopic biopsy can detect high grade dysplasia or early adenocarcinoma in Barrett's oesophagus without grossly recognisable neoplastic lesions. Gastroenterology 1988; 94: 81-90.","journal-title":"Gastroenterology"},{"key":"ref_26","first-page":"1552","article-title":"Criteria for dysplasia in Barrett's oesophagus: a co-operative consensus study","volume":"88","author":"Reid, B.J.; Haggit, R.C.; Rubin, C.E.; Roth, G.; Surawicz, C.M.; Van Belle, G.","year":"1985","unstructured":"Reid BJ, Haggit RC, Rubin CE, Roth G, Surawicz CM, Van Belle G, et al. Criteria for dysplasia in Barrett's oesophagus: a co-operative consensus study. Gastroenterologv 1985; 88: 1552.","journal-title":"Gastroenterologv"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/gut.30.1.14","article-title":"Adenocarcinoma in Barrett's oesophagus: an overated risk","volume":"30","author":"AH, Van Der Veen; J, Dees; JD, Blankensteijn; M, Van Blankestein","year":"1989","unstructured":"Van Der Veen AH, Dees J, Blankensteijn JD, Van Blankestein M. Adenocarcinoma in Barrett's oesophagus: an overated risk. Gut 1989; 30: 14-8.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.9.1155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:26:01Z","timestamp":1765610761000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.9.1155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1992,9,1]]},"published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1136\/gut.33.9.1155"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.9.1155","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}