{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T03:25:47Z","timestamp":1778383547336,"version":"3.51.4"},"reference-count":26,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p>The alpha-glucosidase inhibitors acarbose and miglitol have been successfully used to control postprandial hyperglycaemia in diabetics. They probably work by slowing carbohydrate digestion and absorption, but their effect on mouth to caecum transit time has not been studied. The effect acarbose (100 mg), miglitol (100 mg), and placebo on mouth to caecum transit time (380 kcal breakfast with 20 g of lactulose) was investigated in 18 normal volunteers using breath hydrogen analysis. Both miglitol and acarbose significantly increased breath hydrogen excretion (F2,34 = 6.31, p = 0.005) and shortened the mouth to caecum transit time (F2,34 = 3.49, p = 0.04) after breakfast compared with placebo. There was a significant negative correlation between breath hydrogen excretion and mouth to caecum transit time suggesting that with shorter transit times significantly more carbohydrates were spilled into the colon. These results indicate that alpha-glucosidase inhibitors accelerate mouth to caecum transit time by inducing carbohydrate malabsorption.<\/jats:p>","DOI":"10.1136\/gut.33.9.1246","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1246-1248","source":"Crossref","is-referenced-by-count":19,"title":["Effects of alpha-glucosidase inhibitors on mouth to caecum transit time in humans."],"prefix":"10.1136","volume":"33","author":[{"given":"S D","family":"Ladas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Frydas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Raptis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/bmj.1.6158.220","article-title":"Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor","volume":"1","author":"Walton, R.J.; Sherif, I.T.; Noy, G.A.; Alberti, K.G.M.M.","year":"1979","unstructured":"Walton RJ, Sherif IT, Noy GA, Alberti KGMM. 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EurJ7 Clin Invest","volume":"18","author":"Dimitriadis, G.; Hatziagelaki, E.; Ladas, S.; Linos, A.; Hillebrand, I.; Raptis, S.","year":"1988","unstructured":"Dimitriadis G, Hatziagelaki E, Ladas S, Linos A, Hillebrand I, Raptis S. Effects of prolonged administration on two new at-glucosidase inhibitors on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus. EurJ7 Clin Invest 1988; 18: 33-8."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/BF00483562","article-title":"Glucosidase inhibition: a new approach to the treatment of diabetes, obesity and hyperlipoproteinaemia","volume":"64","author":"Puls, W.; Keup, V.; HP, Krause; Thomas, G.; Hoffmeister, F.","year":"1977","unstructured":"Puls W, Keup V, Krause. HP, Thomas G, Hoffmeister F. Glucosidase inhibition: a new approach to the treatment of diabetes, obesity and hyperlipoproteinaemia. 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Am J Clin Nutr 1978; 31: S 169-74.","journal-title":"Am J Clin Nutr"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.33.9.1246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:45:47Z","timestamp":1757274347000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.33.9.1246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1992,9,1]]},"published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1136\/gut.33.9.1246"],"URL":"https:\/\/doi.org\/10.1136\/gut.33.9.1246","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}