{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:03:26Z","timestamp":1773421406275,"version":"3.50.1"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>Stimulation of localised pyloric contractions may be an important mechanism in the slowing of gastric emptying by cholecystokinin infusion. The effect of cholecystokinin octapeptide on fasting pyloric motility was investigated in 14 healthy volunteers. Antral, pyloric, and duodenal pressure responses to normal saline and graded injections of cholecystokinin octapeptide (5, 10, and 20 ng\/kg) were measured. Injections were given double blind and in randomised order. All doses of cholecystokinin octapeptide initially stimulated (p &lt; 0.05 cf saline) phasic pressure waves localised to the pylorus--the median number of pyloric pressure waves in the 5 minutes after injection being 0, 3.5, 6, and 7 for the saline and the 5, 10, 20 ng\/kg cholecystokinin octapeptide injections respectively. The phasic pyloric motor response to 20 ng\/kg cholecystokinin octapeptide injection was greater than that to 5 ng\/kg (p &lt; 0.05). Basal pyloric pressure increased after 20 ng\/kg (1.0 v 0.2 mm Hg, p &lt; 0.05 cf saline). Antral and duodenal pressure waves were suppressed initially by all doses of cholecystokinin (p &lt; 0.05 cf saline). Subsequently, 20 of the 42 cholecystokinin octapeptide, injections but none of the saline injections, were followed by antropyloric pressure waves. Atropine, 15 micrograms\/kg iv as a bolus, and then 4 micrograms\/kg\/hour iv as an infusion, had no effect on the stimulation of localised phasic pyloric pressure waves by cholecystokinin octapeptide 10 ng\/kg. It is concluded that stimulation of pyloric contractions and suppression of antral and proximal duodenal motility may contribute to the slowing of gastric emptying produced by cholecystokinin.<\/jats:p>","DOI":"10.1136\/gut.34.1.33","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"33-37","source":"Crossref","is-referenced-by-count":58,"title":["Cholecystokinin octapeptide stimulates phasic and tonic pyloric motility in healthy humans."],"prefix":"10.1136","volume":"34","author":[{"given":"R","family":"Fraser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Fone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1172\/JCI112401","article-title":"Regulation of gastric emptying in humans by cholecystokinin","volume":"77","author":"Liddle, R.A.; Morita, E.T.; Conrad, C.K.; Williams, J.A.","year":"1986","unstructured":"Liddle RA, Morita ET, Conrad CK, Williams JA. Regulation of gastric emptying in humans by cholecystokinin. ] Clin Invest 1986; 77: 992-6.","journal-title":"Clin Invest"},{"key":"ref_2","first-page":"173","article-title":"Cholecystokinin is a physiologic hormonal mediator of fat-induced inhibition of gastric emptying. Eur CGlin Invest","volume":"18","author":"Kleibeuker, J.H.; Beekhuis, H.; Jansen, J.B.M.J.; Piers, D.A.; Lamers, C.B.H.W.","year":"1988","unstructured":"Kleibeuker JH, Beekhuis H, Jansen JBMJ, Piers DA, Lamers CBHW. Cholecystokinin is a physiologic hormonal mediator of fat-induced inhibition of gastric emptying. Eur CGlin Invest 1988; 18: 173-7."},{"key":"ref_3","first-page":"12","article-title":"Role of cholecystokinin in regulation of gastrointestinal motor functions","volume":"i:","author":"Meyer, B.M.; Beglinger, C.; Jansen, J.B.M.J.; Rovati, L.C.; Werth, B.A.; Hilderbrand, P.","year":"1989","unstructured":"Meyer BM, Beglinger C, Jansen JBMJ, Rovati LC, Werth BA, Hilderbrand P, et al. 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Effects of a novel cholecystokinin (CCK) antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. ] Clin Invest 1989; 84: 1220-5.","journal-title":"Clin Invest"},{"key":"ref_5","first-page":"437","article-title":"Dent","volume-title":"mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion","volume":"4","author":"Heddle, R.; Collins, P.J.","year":"1989","unstructured":"Heddle R, Collins PJ, Dent J, Horowitz M, Read NW, Chatterton B, et al. Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. ] Gastroenterol Hepatol 1989; 4: 437-47."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/gut.33.4.466","article-title":"Relationship of pyloric motility to transpyloric flow in healthy subjects","volume":"33","author":"Tougas, G.; Anvari, M.; Richards, D.; Dent, J.; Somers, S.; Stevenson, G.W.","year":"1992","unstructured":"Tougas G, Anvari M, Richards D, Dent J, Somers S, Stevenson GW. Relationship of pyloric motility to transpyloric flow in healthy subjects. Gut 1992; 33: 466-71.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1152\/ajplegacy.1972.222.2.428","article-title":"Effect of octapeptide of cholecystokinin on canine pyloric pressure","volume":"222","author":"Isenberg, J.I.; Csendes, A.","year":"1972","unstructured":"Isenberg JI, Csendes A. Effect of octapeptide of cholecystokinin on canine pyloric pressure. Am]7 Physiol 1972; 222: 428-31.","journal-title":"Am]7 Physiol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0016-5085(76)80358-7","article-title":"Effect of intestinal hormones and peptides on intragastric pressure in dogs","volume":"71","author":"Valenzuela, J.","year":"1976","unstructured":"Valenzuela J. Effect of intestinal hormones and peptides on intragastric pressure in dogs. 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Paillieres G,lin1 Gastroenterol 1991; 5: 371-407."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.1.33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:55:46Z","timestamp":1765076146000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.1.33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1993,1,1]]},"published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1136\/gut.34.1.33"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.1.33","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}