{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:29:02Z","timestamp":1765009742371,"version":"3.46.0"},"reference-count":5,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:p>A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. The past history of 540 patients with motor neurone disease in this period was compared with that of 1370 patients with multiple sclerosis (neurological controls) and over 240,000 control patients with a variety of other conditions. Among those with motor neurone disease, five had been previously admitted to hospital with peptic ulcer in comparison with an expected number of 7.4 (morbidity ratio 0.68, 95% confidence interval: 0.2 to 1.6). The corresponding figures for those with multiple sclerosis were 12 and 9.7 respectively (morbidity ratio 1.24, 95% confidence interval: 0.6 to 2.2). This study provides some evidence against the possibility that cimetidine (and ranitidine) are related to motor neurone disease.<\/jats:p>","DOI":"10.1136\/gut.34.12.1660","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1660-1661","source":"Crossref","is-referenced-by-count":4,"title":["Peptic ulcer, cimetidine, and motor neurone disease--a record linkage study."],"prefix":"10.1136","volume":"34","author":[{"given":"M P","family":"Vessey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Goldacre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Seagroatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Yeates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1136\/bmj.285.6351.1311","article-title":"Cimetidine use and gastric cancer: a preliminary report from a postmarketing surveillance study","volume":"285","author":"Colin-Jones, D.G.; Langman, M.J.S.; Lawson, D.H.; Vessey, M.P.","year":"1982","unstructured":"Colin-Jones DG, Langman MJS, Lawson DH, Vessey MP. Cimetidine use and gastric cancer: a preliminary report from a postmarketing surveillance study. BMJ 1982; 285: 1311-3.","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1136\/gut.33.9.1280","article-title":"Postmarketing surveillance of the safety of cimetidine: 10 year mortality report","volume":"33","author":"Colin-Jones, D.G.; Langman, M.J.S.; Lawson, D.H.; Logan, R.F.A.; Paterson, K.R.; Vessey, M.P.","year":"1992","unstructured":"Colin-Jones DG, Langman MJS, Lawson DH, Logan RFA, Paterson KR, Vessey MP. Postmarketing surveillance of the safety of cimetidine: 10 year mortality report. Gut 1992; 33: 1280-4.","journal-title":"Gut"},{"key":"ref_3","first-page":"39","article-title":"Methods and technology of record linkage: some practical considerations","volume-title":"Textbook of medical record linkage","author":"Gill, L.E.; Baldwin, J.A.","year":"1987","unstructured":"Gill LE, Baldwin JA. Methods and technology of record linkage: some practical considerations. In: Baldwin JA, Acheson ED, Graham WJ, eds. Textbook of medical record linkage. Oxford: Oxford University Press, 1987: 39-54."},{"key":"ref_4","first-page":"107","article-title":"Geigy Scientific Tables","author":"KDocumenta, Geigy (UK) Ltd. Diem","year":"1968","unstructured":"Geigy (UK) Ltd. Diem K, ed. Documenta Geigy Scientific Tables. 6th Ed. Macclesfield: Geigy (UK) Ltd, 1968: 107-8.","edition":"6th Ed"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000110267","article-title":"Risk factors in motor neuron disease: a case-control study","volume":"10","author":"Chio, A.; Meineri, P.; Tribolo, A.; Schiffer, D.","year":"1991","unstructured":"Chio A, Meineri P, Tribolo A, Schiffer D. Risk factors in motor neuron disease: a case-control study. Neuroepidemiology 1991; 10: 174-84.","journal-title":"Neuroepidemiology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.12.1660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:24:16Z","timestamp":1765009456000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.12.1660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,12]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1993,12,1]]},"published-print":{"date-parts":[[1993,12]]}},"alternative-id":["10.1136\/gut.34.12.1660"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.12.1660","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1993,12]]}}}