{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:42:16Z","timestamp":1765622536841,"version":"3.48.0"},"reference-count":28,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:p>Maintenance treatment of duodenal ulcer (DU) with ranitidine 150 mg\/day was compared with placebo in a two year prospective multicentre randomised study. Three hundred and ninety nine patients were included (mean age: 44.7 years, M\/F ratio = 2.47\/1; 37.6% of smokers) in placebo (n = 202) and ranitidine (n = 197) groups. Efficacy was assessed by the length of time to the first ulcer pain attack (with or without endoscopic confirmation) or DU complication. One hundred and fourteen patients of 399 (28.6%) had incomplete follow up. Actuarial survival curves of patients without ulcer pain (26 and 53% at two years in placebo and ranitidine groups, respectively) were significantly different (p &lt; 0.0001). Endoscopies were performed depending on physicians' decision (mainly where there was severe pain or complication). Patients without relapses from endoscopy were more frequent in the ranitidine group (83%) than in the placebo group (47%, p &lt; 0.0001). A greater incidence of complications, mainly bleeding, was also seen in the placebo group (13 complications v two in the ranitidine group, p &lt; 0.002). No factor predicting DU relapse was identified. No important side effect was encountered. Ranitidine 150 mg\/day is effective and well tolerated in preventing ulcer pain attacks and DU complications for up to two years.<\/jats:p>","DOI":"10.1136\/gut.34.12.1662","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1662-1665","source":"Crossref","is-referenced-by-count":6,"title":["Two year maintenance treatment of duodenal ulcer disease with ranitidine 150 mg: a prospective multicentre randomised study. GEMUD (Groupe d'Etude de la Maladie Ulc\u00e9reuse Duod\u00e9nale)."],"prefix":"10.1136","volume":"34","author":[{"given":"P","family":"Ruszniewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Slama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pappo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,12,1]]},"reference":[{"key":"ref_1","first-page":"394","article-title":"Safety of ranitidine maintenance treatment of duodenal ulcer","volume":"19","author":"Boyd, E.J.S.; Wilson, J.A.; Wormsley, K.G.","year":"1984","unstructured":"Boyd EJS, Wilson JA, Wormsley KG. Safety of ranitidine maintenance treatment of duodenal ulcer. ScandJ3 Gastroenterol 1984; 19: 394-400."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2036.1988.tb00713.x","article-title":"Six years of continuous cimetidine treatment in peptic ulcer disease: efficacy and safety","volume":"2","author":"Bardhan, K.D.","year":"1988","unstructured":"Bardhan KD. Six years of continuous cimetidine treatment in peptic ulcer disease: efficacy and safety. Aliment Pharmacol Therap 1988; 2: 395-405.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_3","first-page":"79","article-title":"Nizatidine as maintenance therapy of duodenal ulcer disease in remission","volume":"136","author":"Cerrulli, M.A.; Cloud, M.L.; Offen, W.W.; Chernish, S.M.; Matsumoto, C.","year":"1987","unstructured":"Cerrulli MA, Cloud ML, Offen WW, Chernish SM, Matsumoto C. Nizatidine as maintenance therapy of duodenal ulcer disease in remission. ScandJ7 Gastroenterol 1987; 22 (suppl 136): 79-83."},{"key":"ref_4","first-page":"732","article-title":"et Groupe d'Etude de la Maladie Ulcereuse Duodenale (GEMUD). Traitement des poussees ou traitement preventif des recidives dans la maladie ulcereuse duodenale?","volume":"14","author":"Mignon, M.; Ruszniewski, P.; Pappo, M.; Alberola, B.; Georges, D.","year":"1990","unstructured":"Mignon M, Ruszniewski P, Pappo M, Alberola B, Georges D, et Groupe d'Etude de la Maladie Ulcereuse Duodenale (GEMUD). Traitement des poussees ou traitement preventif des recidives dans la maladie ulcereuse duodenale? Gastroenterol Clin Biol 1990; 14: 732-8.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3109\/00365528909089269","article-title":"Efficacy and safety of long-term maintenance therapy of duodenal ulcers","volume":"24","author":"Penston, J.; Wormsley, K.G.","year":"1989","unstructured":"Penston J, Wormsley KG. Efficacy and safety of long-term maintenance therapy of duodenal ulcers. Scand J Gastrenterol 1989; 24: 1145-52.","journal-title":"Scand J Gastrenterol"},{"key":"ref_6","first-page":"3","article-title":"Review article: maintenance treatment with H2-receptor antagonists for peptic ulcer disease","volume":"6","author":"Penston, J.G.; Wormsley, K.G.","year":"1992","unstructured":"Penston JG, Wormsley KG. Review article: maintenance treatment with H2-receptor antagonists for peptic ulcer disease. AlimentPharmacol Therap 1992; 6: 3-29.","journal-title":"AlimentPharmacol Therap"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/00365528708991481","article-title":"Maintenance treatment with cimetidine in peptic ulcer disease for up to 4 years","volume":"22","author":"Walan, A.; Bianchi-Porro, G.; Hentschel, E.; Bardhan, K.D.; Delattre, M.","year":"1987","unstructured":"Walan A, Bianchi-Porro G, Hentschel E, Bardhan KD, Delattre M. Maintenance treatment with cimetidine in peptic ulcer disease for up to 4 years. ScandJ Gastroenterol 1987; 22: 397-405.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00004836-198706000-00013","article-title":"Prevention of duodenal ulcer occurrence. Double-blind comparison of ranitidine and cimetidine","volume":"9","author":"Bolin, T.D.; Davis, A.E.; Billington, B.","year":"1987","unstructured":"Bolin TD, Davis AE, Billington B. Prevention of duodenal ulcer occurrence. Double-blind comparison of ranitidine and cimetidine.J Clin Gastroenterol 1987; 9: 310-3.","journal-title":"J Clin Gastroenterol"},{"key":"ref_9","first-page":"58","article-title":"Prevention of relapse with various anticular drugs","volume-title":"ScandJ Gastroenterol","volume":"121","author":"Bresci, G.; Capria, A.; Federici, G.; Rindi, G.; Geloni, M.; Corsini, G.","year":"1986","unstructured":"Bresci G, Capria A, Federici G, Rindi G, Geloni M, Corsini G. Prevention of relapse with various anticular drugs. ScandJ Gastroenterol 1986; 21 (suppl 121): 58-61."},{"key":"ref_10","first-page":"253","article-title":"A comparison of nizatidine and ranitidine in the maintenance treatment of duodenal ulcer. A randomized, double-blind, multicentre, 2-year study","volume":"23","author":"F, Di Mario; G, Battaglia; A, Saggioro; P, Chiozzini; A, D.'Angelo; R, Marin","year":"1991","unstructured":"Di Mario F, Battaglia G, Saggioro A, Chiozzini P, D'Angelo A, Marin R, et al. A comparison of nizatidine and ranitidine in the maintenance treatment of duodenal ulcer. A randomized, double-blind, multicentre, 2-year study. ItalJ Gastroenterol 1991; 23: 253-6.","journal-title":"ItalJ Gastroenterol"},{"key":"ref_11","first-page":"65","article-title":"Randomized controlled study of ranitidine maintenance for patients with a recent severe duodenal ulcer hemorrhage","volume":"98","author":"Jensen, D.M.; You, S.; Jensen, M.E.; Kovacs, T.O.G.; Machicado, G.A.; Frankl, H.","year":"1990","unstructured":"Jensen DM, You S, Jensen ME, Kovacs TOG, Machicado GA, Frankl H, et al. Randomized controlled study of ranitidine maintenance for patients with a recent severe duodenal ulcer hemorrhage. Gastroenterology 1990; 98: A65.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"183","article-title":"Maintenance ranitidine treatment after haemorrhage from a duodenal ulcer. 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Gastroenterology 1990; 99: 27-35."},{"key":"ref_14","first-page":"113","article-title":"A randomized study ofmaintenance therapy with ranitidine to prevent the recurrence of duodenal ulcer","volume":"320","author":"GM, Van Deventer; JD, Elashoff; TJ, Reedy; D, Schneidman; JH, Walsh","year":"1989","unstructured":"Van Deventer GM, Elashoff JD, Reedy TJ, Schneidman D, Walsh JH. A randomized study ofmaintenance therapy with ranitidine to prevent the recurrence of duodenal ulcer. NEnglJMed 1989; 320: 113-9.","journal-title":"NEnglJMed"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/bmj.296.6627.971","article-title":"Long term management of duodenal ulcer in general practice: How best to use cimetidine?","volume":"2","author":"Wade, A.G.; Rowley-Jones, D.","year":"1988","unstructured":"Wade AG, Rowley-Jones D. Long term management of duodenal ulcer in general practice: How best to use cimetidine? BMJ 1988; 2%: 971-4.","journal-title":"BMJ"},{"key":"ref_16","article-title":"Two-year maintenance treatment of duodenal ulcer (DU) with ranitidine (R) 150 mg. A double-blind","volume-title":"multicentric randomized study. Gastroenterology 1991; 100: Al50","author":"Ruszniewski, P.; Mignon, M.; Slama, A.; Pappo, M.; Group, D.U.Study","unstructured":"Ruszniewski P, Mignon M, Slama A, Pappo M, DU Study Group. Two-year maintenance treatment of duodenal ulcer (DU) with ranitidine (R) 150 mg. A double-blind multicentric randomized study. Gastroenterology 1991; 100: Al50."},{"article-title":"What do duodenal ulcer patients known and think about their disease?","author":"Ruszniewski, P.; Amouretti, M.; Slama, A.; Mignon, M.; Florent, C.; Vallot, T.","key":"ref_17","unstructured":"Ruszniewski P, Amouretti M, Slama A, Mignon M, Florent C, Vallot T, et al. What do duodenal ulcer patients known and think about their disease? Gasiroenterology 1992; 102: Al55."},{"key":"ref_18","first-page":"626","article-title":"Silent peptic ulceration. Deadly silence or","volume-title":"golden silence? Gastroenterology 1989; %","author":"Pounder, R.","unstructured":"Pounder R. Silent peptic ulceration. Deadly silence or golden silence? Gastroenterology 1989; %: 626-31."},{"key":"ref_19","first-page":"1324","article-title":"Does maintenance therapy keep duodenal ulcer healed?","volume":"i:","author":"Boyd, E.J.S.; Johnston, D.A.; Penston, J.G.; Worsmiley, K.G.","year":"1988","unstructured":"Boyd EJS, Johnston DA, Penston JG, Worsmiley KG. Does maintenance therapy keep duodenal ulcer healed? Lancet 1988;i: 1324-7.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00004836-198712000-00007","article-title":"Comparison of ranitidine and cimetidine ulcer maintenance therapy","volume":"9","author":"Kurata, J.H.; Koch, G.G.; Nogawra, A.N.","year":"1987","unstructured":"Kurata JH, Koch GG, Nogawra AN. Comparison of ranitidine and cimetidine ulcer maintenance therapy. J Clin Gastroenterol 1987; 9: 644-50.","journal-title":"J Clin Gastroenterol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2036.1990.tb00473.x","article-title":"Maintenance therapy of duodenal ulcer with H2-receptor antagonists - a metaanalysis","volume":"4","author":"Palmer, R.H.; Frank, W.O.; Karlstadt, R.","year":"1990","unstructured":"Palmer RH, Frank WO, Karlstadt R. Maintenance therapy of duodenal ulcer with H2-receptor antagonists - a metaanalysis. Aliment Pharmacol Therap 1990; 4: 283-94.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/gut.28.3.294","article-title":"Effect of bedtime ranitidine on overnight gastric acid output and intragastric pH: dose\/response study and comparison with cimetidine","volume":"28","author":"Chambers, J.B.; Pryce, D.; Bland, J.M.; Northfield, T.C.","year":"1987","unstructured":"Chambers JB, Pryce D, Bland JM, Northfield TC. Effect of bedtime ranitidine on overnight gastric acid output and intragastric pH: dose\/response study and comparison with cimetidine. Gut 1987; 28: 294-9.","journal-title":"Gut"},{"key":"ref_23","first-page":"122","article-title":"Intragastric acidity during duodenal ulcer maintenance treatment with H2-blockers","volume":"1","author":"Santana, I.A.; Pounder, R.E.; Orchard, K.; Wood, E.C.; Chronos, N.; Neame, R.","year":"1986","unstructured":"Santana IA, Pounder RE, Orchard K, Wood EC, Chronos N, Neame R. Intragastric acidity during duodenal ulcer maintenance treatment with H2-blockers. J Clin Nutr Gastroenterol 1986; 1: 122-6.","journal-title":"J Clin Nutr Gastroenterol"},{"key":"ref_24","first-page":"629","article-title":"Nine years of maintenance treatment with ranitidine for patients with duodenal ulcer disease","volume":"6","author":"Penston, J.G.; Wormsley, K.G.","year":"1992","unstructured":"Penston JG, Wormsley KG. Nine years of maintenance treatment with ranitidine for patients with duodenal ulcer disease. AlimentPharmacol Therap 1992; 6: 629-45.","journal-title":"AlimentPharmacol Therap"},{"key":"ref_25","first-page":"27","article-title":"Ruder: a two-year prospective study of risk factors for recurrent duodenal ulceration","volume-title":"(DU) in 1899 patients. Gastroenterology 1991","volume":"100","author":"Armstrong, D.; Blum, A.L.; Arnold, R.; Classen, M.; Goebell, H.; Fischer, M.; Group, Ruder Study","unstructured":"Armstrong D, Blum AL, Arnold R, Classen M, Goebell H, Fischer M, Ruder Study Group. Ruder: a two-year prospective study of risk factors for recurrent duodenal ulceration (DU) in 1899 patients. Gastroenterology 1991; 100: A27."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00004836-198612000-00006","article-title":"Comparison of ranitidine and sucralfate in the long-term treatment of duodenal ulcer","volume":"8","author":"Masoero, G.; Rocchia, F.; Rossanino, A.; Marchetto, M.; Benitti, V.; De La Pierre, M.","year":"1986","unstructured":"Masoero G, Rocchia F, Rossanino A, Marchetto M, Benitti V, De La Pierre M. Comparison of ranitidine and sucralfate in the long-term treatment of duodenal ulcer. J Clin Gastroenterol 1986; 8: 624-7.","journal-title":"J Clin Gastroenterol"},{"key":"ref_27","first-page":"842","article-title":"Groupe d'Etude de la Maladie Ulcereuse Duodenale (GEMUD). Analyse economique du traitement d'entretien de la maladie ulcereuse duodenale par la ranitidine 150 mg","volume":"16","author":"Ruszniewski, P.; Levy, E.; et, Mignon M.","year":"1992","unstructured":"Ruszniewski P, Levy E, Mignon M et Groupe d'Etude de la Maladie Ulcereuse Duodenale (GEMUD). Analyse economique du traitement d'entretien de la maladie ulcereuse duodenale par la ranitidine 150 mg. Gastroenterol Clin Biol 1992; 16: 842-7.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_28","first-page":"29","article-title":"Pharmacoeconomic benefits of ranitidine maintenance therapy. A retrospective analysis of a clinical trial","volume":"6","author":"GM, Van Deventer; JT, Osterhaus","year":"1992","unstructured":"Van Deventer GM, Osterhaus JT. Pharmacoeconomic benefits of ranitidine maintenance therapy. A retrospective analysis of a clinical trial. Y Clin Res Pharmacoepidemiol 1992; 6: 29-37.","journal-title":"Y Clin Res Pharmacoepidemiol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.12.1662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:40:41Z","timestamp":1765622441000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.12.1662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,12]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1993,12,1]]},"published-print":{"date-parts":[[1993,12]]}},"alternative-id":["10.1136\/gut.34.12.1662"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.12.1662","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1993,12]]}}}