{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:13:02Z","timestamp":1773681182124,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>The potential involvement of neutrophils in the pathogenesis of indomethacin induced ulceration of the gastric antrum in the re-fed rat was studied. Indomethacin was associated with a time dependent increase in the extent and severity of ulceration, blood neutrophilia, neutrophil infiltration into the gastric antrum, and calcium ionophore induced immunoreactive leukotriene B4 (LTB4) release from the antrum ex vivo. Neutrophil infiltration into the antrum was detectable 1 hour after dosing with indomethacin, at which time damage was apparent microscopically but not macroscopically. Thus, cell infiltration may contribute to the development, if not the initiation, of ulceration. Consistent with this suggestion, oral dexamethasone (5 mg\/kg) significantly attenuated indomethacin induced ulceration, the associated neutrophil infiltration, and calcium ionophore induced immunoreactive leukotriene B4 release from the gastric antrum and whole blood ex vivo, although the blood neutrophilia was unaffected. These results suggest that indomethacin induced ulceration of the rat gastric antrum may have a dependence on neutrophil infiltration for its pathogenesis.<\/jats:p>","DOI":"10.1136\/gut.34.2.156","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"156-160","source":"Crossref","is-referenced-by-count":39,"title":["Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum?"],"prefix":"10.1136","volume":"34","author":[{"given":"M A","family":"Trevethick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N M","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Strong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I W","family":"Harman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,2,1]]},"reference":[{"key":"ref_1","first-page":"1017","article-title":"Prevention of gastroduodenal damage induced by non-steroidal antiinflammatory drugs: controlled trial of ranitidine. 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This activity is in marked contrast with the reported ability of higher doses of dexamethasone to induce gastrointestinal damage.'5 In other systems dexamethasone has been found to inhibit neutrophil accumulation in response to chemotactic stimuli.'\"'8 Interestingly, we found that dexamethasone inhibited A23187-induced immunoreactive leukotriene B4 synthesis by dependent process","volume":"259","author":"Wallace, J.L.; Keenan, C.M.; Granger, D.N.","year":"1990","unstructured":"Wallace JL, Keenan CM, Granger DN. Gastric ulceration by non-steroidal anti-inflammatory drugs is a neutrophilwith dexamethasone inhibited both ulceration (assessed by either macroor microscopic criteria), and the associated neutrophil infiltration, is consistent with this hypothesis. Other workers have also shown that corticosteroids will reduce gastrointestinal damage induced by ethanol or indomethacin in the rat. 12-14 Thus, neutrophil infiltration may contribute to the pathogenesis of gastrointestinal damage induced by a variety of agents, including indomethacin. This activity is in marked contrast with the reported ability of higher doses of dexamethasone to induce gastrointestinal damage.'5 In other systems dexamethasone has been found to inhibit neutrophil accumulation in response to chemotactic stimuli.'\"'8 Interestingly, we found that dexamethasone inhibited A23187-induced immunoreactive leukotriene B4 synthesis by dependent process. AmJ Physiol 1990; 259: G462-7.","journal-title":"AmJ Physiol"},{"key":"ref_5","first-page":"878","article-title":"A monoclonal antibody against the CD18 leucocyte adhesion molecule prevents indomethacin-induced gastric damage","volume-title":"the rabbit. 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Glucocorticoid-induced gastric mucosal damage: inhibition of leukotriene Prostaglandins 1987; 34: but not 31 1-23."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.2.156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:02:38Z","timestamp":1765076558000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.2.156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1993,2,1]]},"published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1136\/gut.34.2.156"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.2.156","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}