{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:43:52Z","timestamp":1771872232881,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:p>Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on the 8th day of dosing with either ranitidine bismuth citrate 800 mg twice daily or ranitidine 300 mg twice daily (double blind, randomised, parallel groups). Fasting and postprandial plasma gastrin and plasma pepsinogen I and II concentrations were measured, and a 13C-urea breath test was performed before and on the 8th day of dosing. The 13C-urea breath tests were positive in 21 patients before dosing and remained positive in nine of nine of the ranitidine dosed patients, whereas only two of 12 patients treated with ranitidine bismuth citrate remained positive. The expected rise in meal stimulated plasma gastrin with ranitidine was seen in the 12 patients who received ranitidine but, despite suppression of H pylori urease activity in 10 of 12 patients taking ranitidine bismuth citrate, there was no attenuation of the meal stimulated gastrin rise. There was no significant difference in the mean derived (4 hour) plasma pepsinogen I and II concentrations after dosing with ranitidine or ranitidine bismuth citrate.<\/jats:p>","DOI":"10.1136\/gut.34.3.338","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"338-342","source":"Crossref","is-referenced-by-count":6,"title":["Effect of ranitidine bismuth citrate on postprandial plasma gastrin and pepsinogens."],"prefix":"10.1136","volume":"34","author":[{"given":"A G","family":"Fraser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y W","family":"Luk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sercombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Sawyerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Samloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E","family":"Pounder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,3,1]]},"reference":[{"key":"ref_1","first-page":"481","article-title":"The effect of GR122311X, a bismuth compound with H2-antagonist activity, on 24-hour intragastric acidity","volume":"5","author":"Prewett, E.J.; Nwokolo, C.U.; Hudson, M.; Sawyerr, A.M.; Fraser, A.; Pounder, R.E.","year":"1991","unstructured":"Prewett EJ, Nwokolo CU, Hudson M, Sawyerr AM, Fraser A, Pounder RE. The effect of GR122311X, a bismuth compound with H2-antagonist activity, on 24-hour intragastric acidity. AlimentPharmacol Ther 1991; 5: 481-90.","journal-title":"AlimentPharmacol Ther"},{"key":"ref_2","first-page":"1364","article-title":"Twenty-four hour intragastric acidity and plasma gastrin concentration in healthy volunteers taking nizatidine 150 mg, nizatidine 300 mg, ranitidine 300 mg, or placebo at 2215h","volume-title":"Gut","volume":"29","author":"Lanzon-Miller, S.; Pounder, R.E.; Chronos, N.A.F.; Raymond, F.; Hamilton, M.R.; Dalgleish, D.","year":"1988","unstructured":"Lanzon-Miller S, Pounder RE, Chronos NAF, Raymond F, Hamilton MR, Dalgleish D. Twenty-four hour intragastric acidity and plasma gastrin concentration in healthy volunteers taking nizatidine 150 mg, nizatidine 300 mg, ranitidine 300 mg, or placebo at 2215h. Gut 1988; 29: 1364-9."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0889-8553(21)00461-1","article-title":"Drug-induced changes of plasma gastrin concentration","volume":"19","author":"Pounder, R.E.; Smith, J.","year":"1990","unstructured":"Pounder RE, Smith J. Drug-induced changes of plasma gastrin concentration. Gastroenterol Clin North Am 1990; 19: 141-53.","journal-title":"Gastroenterol Clin North Am"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(89)80057-5","article-title":"Campylobacter pylori and peptic ulcer disease","volume":"96","author":"Graham, D.Y.","year":"1989","unstructured":"Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989; 96: 615-25.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/gut.31.5.522","article-title":"Inappropriate hypergastrinaemia in asvmptomatic healthy subjects with Campylobacterpylori","volume":"31","author":"Smith, J.T.L.; Pounder, R.E.; Nwokolo, C.U.; Lanzon-Miller, S.; Evans, D.G.; Graham, D.Y.","year":"1990","unstructured":"Smith JTL, Pounder RE, Nwokolo CU, Lanzon-Miller S, Evans DG, Graham DY, et al. Inappropriate hypergastrinaemia in asvmptomatic healthy subjects with Campylobacterpylori. 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Gut 1990; 31: 1237-41.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2036.1992.tb00549.x","article-title":"Comparison of one day dosing with three differents formulations of bismuth compounds","volume":"6","author":"Prewett, E.J.; Luk, Y.W.; Fraser, A.G.; Lam, W.M.; Pounder, R.E.","year":"1992","unstructured":"Prewett EJ, Luk YW, Fraser AG, Lam WM, Pounder RE. Comparison of one day dosing with three differents formulations of bismuth compounds. Aliment Pharmacol Ther 1992; 6: 97-102.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_19","first-page":"1217","article-title":"Bismuth pharmacokinetics in healthy male subjects after twice daily oral dosing for 10 days with ranitidine bismuth citrate, tripotassium dicitrato bismuthate (DeNoltab), or placebo","volume":"32","author":"Lacy, L.F.; Frazer, N.M.; Keene, O.N.; Smith, J.T.L.","year":"1991","unstructured":"Lacy LF, Frazer NM, Keene ON, Smith JTL. 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Aliment Pharmacol Ther 1989; 3: 2939.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_21","first-page":"1174","article-title":"Campylobacter pylonidis detected noninvasively by the \"C-urea breath test","volume":"i:","author":"Graham, D.Y.; Klein, P.D.; Evans, D.J.; Evans, D.G.; Alpert, L.C.; Opekun, A.R.","year":"1987","unstructured":"Graham DY, Klein PD, Evans DJ, Evans DG, Alpert LC, Opekun AR, et al. Campylobacter pylonidis detected noninvasively by the \"C-urea breath test. Lancet 1987; i: 1174-7.","journal-title":"Lancet"},{"key":"ref_22","first-page":"1245","article-title":"'Eradication' of Campylobacter pylori: are we being misled?","volume":"ii:","author":"Weil, J.; Bell, G.D.; Jones, P.H.; Grant, P.; Trowell, J.E.; Harvison, G.","year":"1988","unstructured":"Weil J, Bell GD, Jones PH, Grant P, Trowell JE, Harvison G. 'Eradication' of Campylobacter pylori: are we being misled? Lancet 1988 ii: 1245.","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/gut.32.1.21","article-title":"Effect of increasing Helicobacter pylon' ammonia production by urea infusion on plasma gastrin concentration","volume":"32","author":"Chittajallu, R.S.; Neithercut, W.D.; MacDonald, A.M.I.; McColl, K.E.L.","year":"1991","unstructured":"Chittajallu RS, Neithercut WD, MacDonald AMI, McColl KEL. Effect of increasing Helicobacter pylon' ammonia production by urea infusion on plasma gastrin concentration. 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Aliment Pharmacol Ther 1992; 6: 169-78.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_36","first-page":"339","article-title":"Plasma gastrin daytime intragastric pH and nocturnal acid output before and","volume":"26","author":"McColl, K.E.L.; Fullarton, G.M.; Chitlajallu, R.S.; El Nujumi, A.M.; MacDonald, A.M.I.; Dahill, S.W.","year":"1991","unstructured":"McColl KEL, Fullarton GM, Chitlajallu RS, El Nujumi AM, MacDonald AMI, Dahill SW, et al. Plasma gastrin daytime intragastric pH and nocturnal acid output before and at 1 and 7 months after eradication of Helicobacter pylorn in duodenal ulcer subjects. 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