{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:19:02Z","timestamp":1790252342492,"version":"4.1.0"},"reference-count":5,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:p>The hypothesis that non-secretors of ABO blood group antigens, a group shown to be more susceptible to certain bacterial infections, may be at greater risk of gastroduodenal disease because of increased susceptibility to Helicobacter pylori infection was investigated. Of 101 patients with symptoms of dyspepsia who were undergoing endoscopy, 32% were non-secretors (determined from Lewis blood group phenotype), 36% had endoscopically visible gastroduodenal disease (antral gastritis, gastric ulcer, erosive duodenitis, duodenal ulcer or some combination), and 58% had H pylori detected in antral biopsy specimens. Non-secretors and patients with H pylori infection were significantly more likely to have gastroduodenal disease (p = 0.02 and p = 0.002 respectively). There was, however, no significant association between secretor status and H pylori infection, logistic regression analysis confirming that these were independently associated with gastroduodenal disease. Overall, the relative risk of gastroduodenal disease for non-secretors compared with secretors was 1.9 (95% confidence intervals 1.2, 3.2). Non-secretion of ABO blood group antigens is not related to H pylori infection but is independently and significantly associated with endoscopic gastroduodenal disease. The mechanism of this remains to be explained.<\/jats:p>","DOI":"10.1136\/gut.34.3.351","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"351-353","source":"Crossref","is-referenced-by-count":42,"title":["Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease."],"prefix":"10.1136","volume":"34","author":[{"given":"W","family":"Dickey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R G","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K G","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1993,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/gut.6.3.270","article-title":"ABO blood group and secretor status in relation to clinical characteristics of peptic ulcers","volume":"6","author":"Langman, M.J.S.; Doll, R.","year":"1965","unstructured":"Langman MJS, Doll R. ABO blood group and secretor status in relation to clinical characteristics of peptic ulcers. Gut 1965; 6: 270-3.","journal-title":"Gut"},{"key":"ref_2","first-page":"815","article-title":"Effect of ABO blood group and secretor status on the frequency of Helicobacter pylori antibodies","volume":"25","author":"Hook-Nikeanne, J.; Sistonen, P.; Kosunen, T.U.","year":"1990","unstructured":"Hook-Nikeanne J, Sistonen P, Kosunen TU. Effect of ABO blood group and secretor status on the frequency of Helicobacter pylori antibodies. Scand]7 Gastroenterol 1990; 25: 815-8."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1017\/S0950268800048366","article-title":"ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers","volume":"106","author":"Mentis, A.; Blackwell, C.C.; Weir, D.M.; Spiladis, C.; Dailianas, A.; Skandalis, N.","year":"1991","unstructured":"Mentis A, Blackwell CC, Weir DM, Spiladis C, Dailianas A, Skandalis N. ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers. Epidemiol Infect 1991; 106: 221-9.","journal-title":"Epidemiol Infect"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gut.12.8.646","article-title":"ABO blood groups, secretor status, salivary protein, and serum and salivary immunoglobulin concentrations","volume":"12","author":"Waissbluth, J.G.; Langman, M.J.S.","year":"1971","unstructured":"Waissbluth JG, Langman MJS. ABO blood groups, secretor status, salivary protein, and serum and salivary immunoglobulin concentrations. Gut 1971; 12: 646-9.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1574-6968.1989.tb02420.x","article-title":"Blood groups, secretor status and susceptibility to bacterial meningitis","volume":"47","author":"Blackwell, C.C.; Jonsdottir, K.; Weir, D.M.; Hanson, M.F.; Cartwright, K.A.V.; Stewart, J.","year":"1989","unstructured":"Blackwell CC, Jonsdottir K, Weir DM, Hanson MF, Cartwright KAV, Stewart J, et al. Blood groups, secretor status and susceptibility to bacterial meningitis. FEMS Microbiol Immunol 1989; 47: 351-6.","journal-title":"FEMS Microbiol Immunol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.3.351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:12:53Z","timestamp":1765008773000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.3.351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1993,3,1]]},"published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1136\/gut.34.3.351"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.3.351","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}