{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:46:06Z","timestamp":1768815966861,"version":"3.49.0"},"reference-count":21,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:p>Thirty two patients with Helicobacter pylori positive duodenal ulcers resistant to treatment were randomly assigned to 4 weeks' treatment with sucralphate 4 g\/day or colloidal bismuth subcitrate 480 mg\/day plus amoxycillin from days 1 to 7 and tinidazole from days 8 to 14. After 4 weeks, patients with unhealed ulcers were crossed over to the other form of treatment for a further 4 week period. Patients with healed ulcers were followed up for 1 year without maintenance therapy with clinical and endoscopic investigations 3, 6, and 12 months after healing. Complete healing rates at 4 weeks were 88% (15 of 17) in the colloidal bismuth subcitrate plus antibiotics group and 40% (six of 15) in the sucralphate group (p &lt; 0.05). After cross over, overall healing rates were 88% (22 of 25) and 47% (eight of 17), respectively (p &lt; 0.05). H pylori eradication occurred in 83% of patients treated with the triple therapy. Cumulative relapse rates at 12 months were 12% (two of 17) in patients in whom H pylori had been eradicated and 100% (10 of 10) in those with persistent infection after short term therapy (p &lt; 0.05). These results show that a colloidal bismuth subcitrate plus antibiotics regimen is highly effective in the short term treatment of resistant duodenal ulcers and that H pylori eradication can change the natural tendency to early recurrence of these ulcers.<\/jats:p>","DOI":"10.1136\/gut.34.4.466","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"466-469","source":"Crossref","is-referenced-by-count":34,"title":["Short and long term outcome of Helicobacter pylori positive resistant duodenal ulcers treated with colloidal bismuth subcitrate plus antibiotics or sucralfate alone."],"prefix":"10.1136","volume":"34","author":[{"given":"G","family":"Bianchi Porro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Parente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lazzaroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"issue":"153","key":"ref_1","first-page":"81","article-title":"Duodenal ulcers resistant to H2- blockers: an emerging therapeutic problem","volume":"23","author":"G, Bianchi Porro; F, Parente","year":"1988","unstructured":"Bianchi Porro G, Parente F. Duodenal ulcers resistant to H2- blockers: an emerging therapeutic problem. ScandJf Gastroenterol 1988; 23 (suppl 153): 81-8.","journal-title":"ScandJf Gastroenterol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/gut.28.7.907","article-title":"Tripotassium dicitrato bismuthate (TDB) versus two different doses of cimetidine in the treatment of resistant duodenal ulcers","volume":"28","author":"G, Bianchi Porro; F, Parente; M, Lazzaroni","year":"1987","unstructured":"Bianchi Porro G, Parente F, Lazzaroni M. Tripotassium dicitrato bismuthate (TDB) versus two different doses of cimetidine in the treatment of resistant duodenal ulcers. Gut 1987; 28: 907-11.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2036.1987.tb00603.x","article-title":"Omeprazole in peptic ulcers resistant to histamine H2- receptor antagonists","volume":"1","author":"Tytgat, G.N.J.; Lamers, C.B.; Hameeteman, W.; Jansen, J.M.; Wilson, J.A.","year":"1987","unstructured":"Tytgat GNJ, Lamers CB, Hameeteman W, Jansen JM, Wilson JA. Omeprazole in peptic ulcers resistant to histamine H2- receptor antagonists. Aliment Pharmacol Therap 1987; 1: 31-8.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000199610","article-title":"Therapy with omeprazole in patients with peptic ulcerations resistant to extended high-dose ranitidine treatment","volume":"39","author":"Brunner, G.; Creutzfeldt, W.; Harke, V.; Lamberts, R.","year":"1988","unstructured":"Brunner G, Creutzfeldt W, Harke V, Lamberts R. Therapy with omeprazole in patients with peptic ulcerations resistant to extended high-dose ranitidine treatment. Digestion 1988; 39: 80-90.","journal-title":"Digestion"},{"key":"ref_5","first-page":"712","article-title":"Treatment of ultra refractory duodenal ulcer with omeprazole","volume":"29","author":"Bardhan, K.D.; Dhande, D.; Hinchliffe, R.F.C.; Morris, P.; Thompson, M.; Carrol, N.J.H.","year":"1988","unstructured":"Bardhan KD, Dhande D, Hinchliffe RFC, Morris P, Thompson M, Carrol NJH, et al. Treatment of ultra refractory duodenal ulcer with omeprazole. Gut 1988; 29: A712.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2036.1990.tb00476.x","article-title":"Omeprazole in the treatment of peptic ulcers resistant to H2-receptor antagonists","volume":"4","author":"Guerreiro, A.S.; Neves, B.D.; Quina, M.G.","year":"1990","unstructured":"Guerreiro AS, Neves BD, Quina MG. Omeprazole in the treatment of peptic ulcers resistant to H2-receptor antagonists. Aliment Pharmacol Therap 1990; 4: 309-13.","journal-title":"Aliment Pharmacol Therap"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/gut.32.4.435","article-title":"Treatment of refractory peptic ulcer with omeprazole or continued H2-receptor antagonists: a controlled clinical trial","volume":"32","author":"Bardhan, K.D.; Naesdal, J.; Bianchi Porro, G.; Petrillo, M.; Lazzaroni, M.; Hinchcliffe, R.F.C.","year":"1991","unstructured":"Bardhan KD, Naesdal J, Bianchi Porro G, Petrillo M, Lazzaroni M, Hinchcliffe RFC, et al. Treatment of refractory peptic ulcer with omeprazole or continued H2-receptor antagonists: a controlled clinical trial. Gut 1991; 32: 435-8.","journal-title":"Gut"},{"key":"ref_8","first-page":"155","article-title":"Ofloxacin in der therapie 'resistenter' ulcera duodeni. 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Gut 1984; 25: 711-7.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.4.466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:32:25Z","timestamp":1764995545000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.4.466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1993,4,1]]},"published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1136\/gut.34.4.466"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.4.466","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}