{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:01:44Z","timestamp":1770566504725,"version":"3.49.0"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p>Colonisation with Helicobacter pylori may influence susceptibility to gastroduodenal injury and ulceration in patients taking non-steroidal anti-inflammatory drugs (NSAIDs). The aim of this study was to determine if Helicobacter pylori colonisation altered eicosanoid synthesis by gastric mucosa in these patients. Sixty five patients with long-standing NSAID intake and 23 control subjects underwent endoscopy. In vitro gastric antral biopsies were stimulated by vortex mixing and eicosanoid measurements determined by radioimmunoassay. Helicobacter pylori colonisation was determined by a CLO test (a gel based rapid urease test) and histological assessment. Median prostaglandin E2 synthesis by gastric mucosa was 61.0 (interquartile range: 19.2-73.1) pg\/mg in control subjects colonised with Helicobacter pylori compared with 46.5 (23.3-65.5) pg\/mg in Helicobacter pylori negative subjects. This was not significantly different. Treatment with NSAIDs was associated with a significant difference (p &lt; 0.001) in prostaglandin E2 (PGE2) synthesis between those colonised with Helicobacter pylori (37.5(22.0-77.3) pg\/mg) compared with patients not infected (12.6(7.0-19.3) pg\/mg). Values in patients taking NSAIDs who were colonised were not different from control subjects. Synthesis of PGE2 was strongly associated with type B (chronic active), but not type C (chemical) gastritis. Dyspeptic symptoms were more common in subject colonised with Helicobacter pylori (p &lt; 0.002) and were associated with higher PGE2 synthesis. In patients taking NSAIDs Helicobacter pylori colonisation removes rather then enhances depression of PGE2 synthesis associated with NSAIDs and may promote dyspepsia associated with ulcers and prevent superficial mucosal injury.<\/jats:p>","DOI":"10.1136\/gut.34.6.748","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"748-751","source":"Crossref","is-referenced-by-count":113,"title":["Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs."],"prefix":"10.1136","volume":"34","author":[{"given":"N","family":"Hudson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Balsitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Filipowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Hawkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199104113241507","article-title":"Helicobacter pylori and peptic ulcer disease","volume":"324","author":"Desforges, J.F.","year":"1991","unstructured":"Desforges JF. Helicobacter pylori and peptic ulcer disease [Editorial]. N EngJ Med 1991; 324: 1043-9.","journal-title":"N EngJ Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/bmj.300.6720.278","article-title":"Non steroidal anti-inflammatory drugs and peptic ulcers","volume":"300","author":"Hawkey, C.J.","year":"1990","unstructured":"Hawkey CJ. Non steroidal anti-inflammatory drugs and peptic ulcers. BMJ 1990; 300: 278-84.","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/rheumatology\/30.1.16","article-title":"Serological evidence of infection with Helicobacter pylorn may predict gastrointestinal intolerance to non steroidal antiinflammatory drug (NSAID) treatment in rheumatoid arthritis","volume":"30","author":"Jones, S.T.M.; Clague, R.B.; Eldridge, J.; Jones, D.M.","year":"1991","unstructured":"Jones STM, Clague RB, Eldridge J, Jones DM. Serological evidence of infection with Helicobacter pylorn may predict gastrointestinal intolerance to non steroidal antiinflammatory drug (NSAID) treatment in rheumatoid arthritis. BrJr Rheumatol 1991; 30: 16-20.","journal-title":"BrJr Rheumatol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/0016-5085(91)90665-8","article-title":"Long term non steroidal anti-imflammatory drug use and Helicobacter pylori infection","volume":"100","author":"Graham, D.Y.; Lidsky, M.D.; Cox, A.M.; Evans, D.J.; Evans, D.G.; Alpert, L.","year":"1991","unstructured":"Graham DY, Lidsky MD, Cox AM, Evans DJ, Evans DG, Alpert L, et al. Long term non steroidal anti-imflammatory drug use and Helicobacter pylori infection. 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Gastroenterology 1985; 89: 1162-88.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3109\/00365528509089284","article-title":"Symptoms in patients with peptic ulcer and haematemesis and\/or melaena related to the use of non steroidal anti-inflammatory drugs","volume":"20","author":"Mellum, H.; Stave, R.; Myren, J.; Osnes, M.; Hanssen, L.E.; Mosvols, J.; Hibnes, K.","year":"1985","unstructured":"Mellum H, Stave R, Myren J, Osnes M, Hanssen LE, Mosvols J, Hibnes K. Symptoms in patients with peptic ulcer and haematemesis and\/or melaena related to the use of non steroidal anti-inflammatory drugs. Scand J Gastroenterol 1985; 20: 1246-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","first-page":"47","article-title":"Gastric mucosal prostaglandin synthesis in the presence of Campylobacter pylon in patients with gastric ulcers and non-ulcer dyspepsia","volume":"85","author":"Taha, A.S.; Boothman, P.; Holland, P.; McKinlay, A.; Upadhyay, R.; Kelly, R.W.","year":"1990","unstructured":"Taha AS, Boothman P, Holland P, McKinlay A, Upadhyay R, Kelly RW, et al. Gastric mucosal prostaglandin synthesis in the presence of Campylobacter pylon in patients with gastric ulcers and non-ulcer dyspepsia. AmJ Gastroentero 1990; 85: 47-50.","journal-title":"AmJ Gastroentero"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF01298870","article-title":"Gastroduodenal mucosal prostaglandin generation in patients with Helicobacter pylon before and after treatment with Bismuth Subsalicylate","volume":"36","author":"Avunduk, C.; Suliman, M.; Gang, G.; Polakowski, N.; Eastwood, G.L.","year":"1991","unstructured":"Avunduk C, Suliman M, Gang G, Polakowski N, Eastwood GL. Gastroduodenal mucosal prostaglandin generation in patients with Helicobacter pylon before and after treatment with Bismuth Subsalicylate. Dig Dis Sci 1991; 36: 431-4.","journal-title":"Dig Dis Sci"},{"key":"ref_10","first-page":"212","article-title":"Campylobacter pylori and acid secretion","volume":"ii:","author":"Goren, A.; Fotherby, K.J.; Shorthosue, M.; Wright, D.G.D.; Hunter, J.O.","year":"1989","unstructured":"Goren A, Fotherby KJ, Shorthosue M, Wright DGD, Hunter JO. Campylobacter pylori and acid secretion [Letter]. Lancet 1989; ii: 212.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.1711540203","article-title":"Chronic gastritis: a pathogenetic approach","volume":"154","author":"Wyatt, J.I.; Dixon, M.F.","year":"1988","unstructured":"Wyatt JI, Dixon MF. Chronic gastritis: a pathogenetic approach. J Pathol 1988; 154: 113-24.","journal-title":"J Pathol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1136\/gut.27.12.1484","article-title":"Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer","volume":"27","author":"Hawkey, C.J.","year":"1986","unstructured":"Hawkey CJ. Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer. Gut 1986; 27: 1484-92.","journal-title":"Gut"},{"key":"ref_13","first-page":"513","article-title":"Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-Lipoxygenase inhibitor BW A4C","volume-title":"Gut","volume":"33","author":"Hawthorne, B.A.; Boughton-Smith, N.K.; Whittle, B.J.R.; Hawkey, C.J.","year":"1992","unstructured":"Hawthorne BA, Boughton-Smith NK, Whittle BJR, Hawkey CJ. Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-Lipoxygenase inhibitor BW A4C. Gut 1992; 33: 513-7."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"616","DOI":"10.7326\/0003-4819-104-5-616","article-title":"Active smoking depresses prostaglandin synthesis in human gastric mucosa","volume":"104","author":"Quimby, G.F.; Bonnice, C.A.; Burstein, S.E.; Eastwood, G.L.","year":"1986","unstructured":"Quimby GF, Bonnice CA, Burstein SE, Eastwood GL. 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Adv Prostaglandin Thromboxane Leukotriene Res 1991; 21B: 777-9.","journal-title":"Adv Prostaglandin Thromboxane Leukotriene Res"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"636","DOI":"10.7326\/0003-4819-116-8-636","article-title":"Factors influencing gastroduodenal mucosal prostaglandin concentrations: roles of smoking and ageing","volume":"116","author":"Cryer, C.; Lee, E.; Feldman, M.","year":"1992","unstructured":"Cryer C, Lee E, Feldman M. Factors influencing gastroduodenal mucosal prostaglandin concentrations: roles of smoking and ageing. Ann Intern Med 1992; 116: 636-40.","journal-title":"Ann Intern Med"},{"key":"ref_17","first-page":"255","article-title":"like substances in gastric mucosa of normal subjects and of patients with various gastric diseases","volume":"52","author":"Schegel, W.; Wenk, W.; Dollinger, H.C.; of prostaglandin A, Raptis S.Concentrations; E; F.","year":"1977","unstructured":"Schegel W, Wenk W, Dollinger HC, Raptis S. Concentrations of prostaglandin A, E, and F like substances in gastric mucosa of normal subjects and of patients with various gastric diseases. Clinical Science Molecular Medicine 1977; 52:255.","journal-title":"Clinical Science Molecular Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0016-5085(82)90014-2","article-title":"Gastric mucosal prostaglandion E2 levels in patients with gastric ulcer disease and carcinoma","volume":"82","author":"Wright, J.P.; Young, G.O.; Klaff, L.J.; Weerss, L.A.; Price, S.K.; Marks, I.N.","year":"1982","unstructured":"Wright JP, Young GO, Klaff LJ, Weerss LA, Price SK, Marks IN. Gastric mucosal prostaglandion E2 levels in patients with gastric ulcer disease and carcinoma. Gastroenterology 1982; 82: 263-7.","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/gut.26.3.237","article-title":"Duodenal mucosal synthesis of prostaglandins in duodenal ulcer disease","volume":"26","author":"Hillier, K.; Smith, C.L.; Jewel, R.; Arthur, M.J.P.; Ross, G.","year":"1985","unstructured":"Hillier K, Smith CL, Jewel R, Arthur MJP, Ross G. Duodenal mucosal synthesis of prostaglandins in duodenal ulcer disease. Gut 1985; 26: 237-40.","journal-title":"Gut"},{"key":"ref_20","first-page":"94854","article-title":"Evidence that adaptive cytoprotection is not mediated by prostaglandins","volume":"94","author":"Hawkey, C.J.; Kemp, R.T.; Walt, R.P.; Bhaskar, N.K.; Davies, J.; Filipowicz, B.","year":"1988","unstructured":"Hawkey CJ, Kemp RT, Walt RP, Bhaskar NK, Davies J, Filipowicz B. Evidence that adaptive cytoprotection is not mediated by prostaglandins. Gastroenterology 1988; 94: 94854.","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2036.1990.tb00471.x","article-title":"The interaction between Helicobacter pylori culture infiltrate and indomethacin: effects on the integrity of human gastric mucosa and its prostaglandin E2 production in vitro","volume":"4","author":"Taha, A.S.; Kelly, R.W.; Gemmell, C.G.; Lee, F.D.; Russell, R.I.","year":"1990","unstructured":"Taha AS, Kelly RW, Gemmell CG, Lee FD, Russell RI. The interaction between Helicobacter pylori culture infiltrate and indomethacin: effects on the integrity of human gastric mucosa and its prostaglandin E2 production in vitro. Aliments in Pharmacology and Theraputics 1990; 4: 265-73.","journal-title":"Aliments in Pharmacology and Theraputics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(86)92927-2","article-title":"Non steroidal antiinflammatory drugs and bleeding peptic ulcer","volume":"i:","author":"Somerville, K.; Faulkner, G.; Langman, M.J.S.","year":"1986","unstructured":"Somerville K, Faulkner G, Langman MJS. Non steroidal antiinflammatory drugs and bleeding peptic ulcer. Lancet 1986; i:462-4.","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/bmj.297.6652.833","article-title":"Non steroidal anti-inflammatory drugs and pain free peptic ulceration in the elderly","volume":"297","author":"Skander, M.P.; Ryan, F.P.","year":"1988","unstructured":"Skander MP, Ryan FP. Non steroidal anti-inflammatory drugs and pain free peptic ulceration in the elderly. BMJ 1988; 297: 833-4.","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0016-5085(91)90044-L","article-title":"NSAID-induced gastroduodenal injury: what's the score?","volume":"101","author":"Laine, L.","year":"1991","unstructured":"Laine L. NSAID-induced gastroduodenal injury: what's the score? Gastroenterology 1991; 101: 555-7.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.6.748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:47:26Z","timestamp":1765640846000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.6.748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1993,6,1]]},"published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1136\/gut.34.6.748"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.6.748","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}