{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:40:24Z","timestamp":1765658424032,"version":"3.48.0"},"reference-count":31,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p>Adolescents with coeliac disease often fail to adhere to a strict gluten free diet. The effectiveness of intestinal permeability to sugars as a marker of slight dietary transgressions by such adolescents was assessed. Severe dietary transgressions were excluded from the study. Subjects were divided into two groups according to whether they committed slight dietary transgressions or adhered to a strict gluten free diet. A reference group of preadolescents with coeliac disease was also included in the study. Intestinal permeability and antigliadin antibody tests were performed on all patients. The diagnostic marker of intestinal permeability was excellent in the reference group. Neither the intestinal permeability test nor antigliadin antibody tests, however, succeeded in discriminating between the two groups of adolescents considered in this study. In conclusion the intestinal permeability test is not a valid marker for slight dietary transgression in such patients.<\/jats:p>","DOI":"10.1136\/gut.34.6.774","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"774-777","source":"Crossref","is-referenced-by-count":7,"title":["Is an intestinal permeability test a valid marker for slight dietary transgressions in adolescents with coeliac disease?"],"prefix":"10.1136","volume":"34","author":[{"given":"P","family":"Fern\u00e1ndez-Calle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Codoceo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Polanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"G\u00f3mez-Cerezo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Tenias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,6,1]]},"reference":[{"key":"ref_1","first-page":"151","article-title":"Enfermedad celiaca","volume":"1","author":"Polanco, I.","year":"1986","unstructured":"Polanco I. Enfermedad celiaca. In: Chantar C. Rhodes J, eds. Actualidades en Gastroenterologia, vol 1. Barcelona: JR Prous, 1986: 151-4."},{"key":"ref_2","first-page":"333","article-title":"Malignancy in coeliac disease-effect of a gluten free diet","volume":"30","author":"Holmes, G.K.T.; Prior, P.; Lane, M.R.; Pope, D.; Allan, R.N.","year":"1989","unstructured":"Holmes GKT, Prior P, Lane MR, Pope D, Allan RN. Malignancy in coeliac disease-effect of a gluten free diet. Cut 1989; 30: 333-8.","journal-title":"Cut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1056\/NEJM199112123252406","article-title":"Celiac sprue","volume":"325","author":"Trier, J.S.","year":"1991","unstructured":"Trier JS, Celiac sprue. NEnglJfMed 1991; 325: 1709-19.","journal-title":"NEnglJfMed"},{"key":"ref_4","first-page":"565","article-title":"Childhood coeliac disease: a long termn analysis","volume-title":"of relapses in 91 patients. J Pediatrn GastroenterolNutr","volume":"5","author":"Shmerling, D.H.; Franckx, J.","year":"1986","unstructured":"Shmerling DH, Franckx J. Childhood coeliac disease: a long termn analysis of relapses in 91 patients. J Pediatrn GastroenterolNutr 1986; 5: 565-9."},{"key":"ref_5","first-page":"551","article-title":"The teenage coeliac","volume":"26","author":"Kumar, P.S.; Harris, T.; Walker-Smith, J.","year":"1985","unstructured":"Kumar PS, Harris T, Walker-Smith J, et al. The teenage coeliac. Gut 1985; 26: A551.","journal-title":"Gut"},{"key":"ref_6","first-page":"286","article-title":"Coeliac disease and related disorders","volume":"31","author":"Mulder, C.J.J.; Tytgat, G.N.J.","year":"1987","unstructured":"Mulder CJJ, Tytgat GNJ. Coeliac disease and related disorders. NethJrMed 1987; 31: 286-99.","journal-title":"NethJrMed"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0016-5085(89)90060-7","article-title":"Mortality in coeliac disease","volume":"97","author":"Loga, R.F.A.; Rifkind, E.A.; Turner, I.D.","year":"1989","unstructured":"Loga RFA, Rifkind EA, Turner ID. Mortality in coeliac disease. Gastroenterology 1989; 97: 265-71.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"92","article-title":"Diagnosis of coeliac disease","volume":"19","author":"editorial","year":"1991","unstructured":"Diagnosis of coeliac disease [editorial]. Lancet 1991; 19: 92-3.","journal-title":"Lancet"},{"key":"ref_9","first-page":"320","article-title":"IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease","volume":"i:","author":"Savilahti, E.; Perkkio, M.; Kalimo, K.; Viander, M.; Varnio, E.; Reunala, T.","year":"1983","unstructured":"Savilahti E, Perkkio M, Kalimo K, Viander M, Varnio E, Reunala T. IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease. Lancet 1983; i: 320-2.","journal-title":"Lancet"},{"issue":"35","key":"ref_10","first-page":"157","article-title":"Gluten-sensitive enteropathy in childhood","volume":"1988","author":"Auricchio, S.; Greco, L.; Troncone, R.","unstructured":"Auricchio S, Greco L, Troncone R. Gluten-sensitive enteropathy in childhood. Pediatr Clin North Am 1988 35: 157-87.","journal-title":"Pediatr Clin North Am"},{"key":"ref_11","first-page":"1060","article-title":"Intestinal permeability assessed by the excretion ratios of two molecules: results in coeliac disease","volume":"i:","author":"Cobden, I.; Dickinson, R.J.; Rothwell, J.; Axon, A.T.R.","year":"1978","unstructured":"Cobden I, Dickinson RJ, Rothwell J, Axon ATR. Intestinal permeability assessed by the excretion ratios of two molecules: results in coeliac disease. BMJ 1978 i: 1060.","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1136\/gut.25.11.1241","article-title":"The cellobiose\/mannitol test complements biopsy histopathology in clinical investigation of the jejunum","volume":"25","author":"Strobel, S.; Brydon, W.G.; Fergusson, A.","year":"1984","unstructured":"Strobel S, Brydon WG, Fergusson A. The cellobiose\/mannitol test complements biopsy histopathology in clinical investigation of the jejunum. Gut 1984; 25: 1241-6.","journal-title":"Gut"},{"key":"ref_13","first-page":"1107","article-title":"Abnormal intestinal permeability to sugars in villous atrophy","volume":"ii:","author":"Menzies, I.S.; Laker, M.F.; Pounder, R.","year":"1989","unstructured":"Menzies IS, Laker MF, Pounder R, et al. Abnormal intestinal permeability to sugars in villous atrophy. Lancet 1989; ii: 1107-9.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/cs061039P","article-title":"Is small intestinal permeability increased or decreased in untreated coeliac disease?","volume":"61","author":"Okabam, S.O.; Clamp, J.; Cooper, B.T.","year":"1981","unstructured":"Okabam SO, Clamp J, Cooper BT. Is small intestinal permeability increased or decreased in untreated coeliac disease? Clin Sci 1981; 61: 39.","journal-title":"Clin Sci"},{"key":"ref_15","first-page":"20","article-title":"Intestinal permeability in children with Crohn's disease and coeliac disease","author":"Pearson, A.D.J.; Eastham, E.J.; Laker, M.F.; Craft, J.W.; Nelson, R.","year":"1982","unstructured":"Pearson ADJ, Eastham EJ, Laker MF, Craft JW, Nelson R. Intestinal permeability in children with Crohn's disease and coeliac disease. BMJ 1982; 285: 20-1.","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/gut.21.6.512","article-title":"Intestinal permeability and screening test for coeliac disease","volume":"21","author":"Cobden, I.; Rothwell, J.; Axon, A.T.R.","year":"1980","unstructured":"Cobden I, Rothwell J, Axon ATR. Intestinal permeability and screening test for coeliac disease. Gut 1980; 21: 512-8.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/gut.23.3.202","article-title":"Intestinal permeability in coeliac disease. The response to treatment and single-dose gluten challenge","volume":"23","author":"Hamilton, I.; Cobden, I.; Rothwell, J.; Axon, A.T.R.","year":"1982","unstructured":"Hamilton I, Cobden I, Rothwell J, Axon ATR. Intestinal permeability in coeliac disease. The response to treatment and single-dose gluten challenge. Gut 1982; 23: 202-10.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/cs063021Pa","article-title":"Changes in small intestinal permeability reflect the degree of mucosal abnormality in coeliac patients on a gluten free diet","volume":"63","author":"Cooper, B.T.; Ukabam, S.O.","year":"1982","unstructured":"Cooper BT, Ukabam SO. Changes in small intestinal permeability reflect the degree of mucosal abnormality in coeliac patients on a gluten free diet. Clin Sci 1982; 63: 21.","journal-title":"Clin Sci"},{"key":"ref_19","first-page":"461","article-title":"European Society for Pediatric Gastroenterology and Nutrition. Diagnostic criteria in coeliac disease","volume":"49","author":"Meewise, G.","year":"1970","unstructured":"Meewise G. European Society for Pediatric Gastroenterology and Nutrition. Diagnostic criteria in coeliac disease. Acta PediatrScand 1970; 49: 461-3.","journal-title":"Acta PediatrScand"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0021-9258(18)57092-7","article-title":"Rapid method for the determination of fat feces","volume":"177","author":"de Kamer JH, Van","year":"1949","unstructured":"Van de Kamer JH. Rapid method for the determination of fat feces. JBiol Chem 1949; 177: 347-55.","journal-title":"JBiol Chem"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry, O.H.; Rosenbrough, N.J.; Lewiss, F.A.; Randall, R.J.","year":"1951","unstructured":"Lowry OH, Rosenbrough NJ, Lewiss FA, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-75.","journal-title":"J Biol Chem"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/clinchem\/32.8.1542","article-title":"Liquid chromatographic method for estimating urinary sugars: applicability to studies of intestinal permeability","volume":"32","author":"Delhunty, T.; Hollander, D.","year":"1986","unstructured":"Delhunty T, Hollander D. Liquid chromatographic method for estimating urinary sugars: applicability to studies of intestinal permeability. Clin Chem 1986; 32: 1542-4.","journal-title":"Clin Chem"},{"key":"ref_23","article-title":"Base de datos bioestadisticospara un ordenadorpersonal","author":"Fernandez-Peris, E.; Molinero-Casares, L.M.; Sigma, Morey Aboal E.","year":"1986","unstructured":"Fernandez-Peris E, Molinero-Casares LM, Morey Aboal E. Sigma. Base de datos bioestadisticospara un ordenadorpersonal. Madrid: Horus Hardware, 1986."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Report of the working group of the European Society of Paediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of coeliac disease","volume":"65","author":"Walker-Smith, J.A.; Guandalini, S.; Schmitz, J.; Shermerling, D.H.; Visakorpi, J.K.","year":"1990","unstructured":"Walker-Smith JA, Guandalini S, Schmitz J, Shermerling DH, Visakorpi JK. Report of the working group of the European Society of Paediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 1990; 65: 909-11.","journal-title":"Arch Dis Child"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/gut.30.4.476","article-title":"Cellobiose\/mannitol sugar test - a sensitive tubeless test for coeliac disease: results on 1010 unselected patients","volume":"30","author":"Juby, L.D.; Rothwell, J.; Axon, A.T.R.","year":"1989","unstructured":"Juby LD, Rothwell J, Axon ATR. Cellobiose\/mannitol sugar test - a sensitive tubeless test for coeliac disease: results on 1010 unselected patients. Gut 1989; 30: 476-80.","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00005176-199004000-00002","article-title":"Intestinal permeability tests: are they clinically useful?","volume":"10","author":"Lifschitz, C.H.; Shulman, R.J.","year":"1990","unstructured":"Lifschitz CH, Shulman RJ. Intestinal permeability tests: are they clinically useful? J Pediatr Gastroenterol Nutr 1990; 10: 283-7.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref_27","first-page":"7985","article-title":"Lacntlose\/mannitol test: an ideal screen for celiac disease","volume":"96","author":"Juby, L.D.; Rothweli, J.; Axon, A.T.R.","year":"1989","unstructured":"Juby LD, Rothweli J, Axon ATR. Lacntlose\/mannitol test: an ideal screen for celiac disease. Gastroenterolog 1989; 96: 7985.","journal-title":"Gastroenterolog"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00005176-198803000-00032","article-title":"Intestinal permeability to Lactulose\/L-rhamnose in children with celiac disease and other gastrointestinal disorders","volume":"7","author":"Stenhammar, L.; Stomberg, S.","year":"1988","unstructured":"Stenhammar L, Stomberg S. Intestinal permeability to Lactulose\/L-rhamnose in children with celiac disease and other gastrointestinal disorders. J Pediatr Gastroenterol Nutr 1988; 7:304-6.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref_29","first-page":"468","article-title":"Intestinal sugar permeability: relationship to diarrheal disease and small bowel morphology","volume":"4","author":"Ford, R.P.K.; Menzies, I.S.; Phillips, A.D.; Walker-Smith, J.A.; Turner, M.W.","year":"1985","unstructured":"Ford RPK, Menzies IS, Phillips AD, Walker-Smith JA, Turner MW. Intestinal sugar permeability: relationship to diarrheal disease and small bowel morphology. J Pediatr Gastroenterol Nutr 1985; 4: 468-74.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1136\/adc.63.9.1054","article-title":"Urinary mannitol: lactulose excretion ratios and jejunal mucosal structure","volume":"63","author":"Nathavitharana, K.A.; Lloyd, D.R.; Brown, G.A.; McNeish, A.S.","year":"1988","unstructured":"Nathavitharana KA, Lloyd DR, Brown GA, McNeish AS. Urinary mannitol: lactulose excretion ratios and jejunal mucosal structure. Arch Dis Child 1988; 63: 1054-9.","journal-title":"Arch Dis Child"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1136\/adc.64.11.1604","article-title":"Postpubertal gluten challenge in coeliac disease","volume":"64","year":"1989","unstructured":"Maki M, Lahdeaho ML, Hiillstrom 0, Viander M, Visakorpi JK. Postpubertal gluten challenge in coeliac disease. Arch Dis Child 1989; 64:1604-7.","journal-title":"Arch Dis Child"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.6.774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:39:08Z","timestamp":1765658348000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.6.774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1993,6,1]]},"published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1136\/gut.34.6.774"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.6.774","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}