{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:29:24Z","timestamp":1765661364677,"version":"3.48.0"},"reference-count":37,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>The distribution of carbohydrate antigens of the ABO, Lewis, and Kell systems was examined in biliary and colonic epithelial of 11 patients with primary sclerosing cholangitis (PSC) using a panel of 11 monoclonal antibodies. Controls consisted of 27 liver biopsy specimens (11 normal, six alcoholic liver disease, five extrahepatic obstruction, and five primary biliary cirrhosis) and 24 colonic biopsy specimens (six normal, four Crohn's disease, and 14 ulcerative colitis). There was inappropriate staining with anti-A (four of six, 66%) and anti-B (nine of 11, 81%) in biliary epithelium of PSC patients compared with normal and disease controls. Expression of Lewis antigens was increased in patients with cholestatic liver disease. Ninety one per cent of PSC patients showed a similar pattern of inappropriate staining by anti-A and anti-B antibodies in colonic epithelium compared with 33% of normal and 42% of inflammatory bowel disease controls. There is inappropriate expression of A and B carbohydrate antigens in biliary and colonic epithelium in PSC. Whether these oncofetal antigens are implicated in the pathogenesis of this condition is discussed.<\/jats:p>","DOI":"10.1136\/gut.34.7.977","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"977-983","source":"Crossref","is-referenced-by-count":10,"title":["Inappropriate expression of blood group antigens on biliary and colonic epithelia in primary sclerosing cholangitis."],"prefix":"10.1136","volume":"34","author":[{"given":"S","family":"Bloom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Heryet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,7,1]]},"reference":[{"year":"1992","key":"ref_1","unstructured":"November 1992"},{"key":"ref_2","first-page":"870","article-title":"Primary sclerosing cholangitis: a review of its clinical features, cholangiography and hepatic histology","volume-title":"Gut","volume":"21","author":"Chapman, R.W.G.; Arborgh, B.A.M.; Rhodes, J.M.; Summerfield, J.A.; Dick, R.; Scheuer, P.J.","year":"1980","unstructured":"Chapman RWG, Arborgh BAM, Rhodes JM, Summerfield JA, Dick R, Scheuer PJ, et al. Primary sclerosing cholangitis: a review of its clinical features, cholangiography and hepatic histology. Gut 1980; 21: 870-7."},{"issue":"2","key":"ref_3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0016-5085(80)90131-6","article-title":"Clinicopathologic features of the syndrome of primary sclerosing cholangitis","volume":"79","author":"Wiesner, R.H.; LaRusso, N.F.","year":"1980","unstructured":"Wiesner RH, LaRusso NF. Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology 1980; 79(2): 200-6.","journal-title":"Gastroenterology"},{"key":"ref_4","first-page":"38","article-title":"Association of primary sclerosing cholangitis with HLA-B8","volume-title":"Gut","volume":"24","author":"Chapman, R.W.; Varghese, Z.; Gaul, R.; Patel, G.; Kokinon, N.; Sherlock, S.","year":"1983","unstructured":"Chapman RW, Varghese Z, Gaul R, Patel G, Kokinon N, Sherlock S. Association of primary sclerosing cholangitis with HLA-B8. Gut 1983; 24: 38-41."},{"key":"ref_5","first-page":"187","article-title":"HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease","volume":"\"Forre\" # \"17:\"","author":"Schrumpf, E, Fausa 0","year":"1982","unstructured":"Schrumpf E, Fausa 0, Forre 0, Dobloug JH, Ritland S, Thorsby E. HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease. ScandjGastroenterol. 1982; 17: 187-91.","journal-title":"ScandjGastroenterol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/BF01296138","article-title":"Lymphocyte subsets in primary sclerosing cholangitis","volume":"32","author":"Lindor, K.D.; Wiesner, R.H.; Katzmann, J.A.; LaRusso, N.F.; Beaver, S.J.","year":"1987","unstructured":"Lindor KD, Wiesner RH, Katzmann JA, LaRusso NF, Beaver SJ. Lymphocyte subsets in primary sclerosing cholangitis. Dig Dis Sci 1987; 32: 720-5.","journal-title":"Dig Dis Sci"},{"key":"ref_7","first-page":"844","article-title":"Enhanced autoreactivity of T lymphocytes in primary sclerosing cholangitis","volume":"7","author":"Lindor, K.D.; Wiesner, R.H.; LaRusso, N.F.; Homburger, H.A.","year":"1987","unstructured":"Lindor KD, Wiesner RH, LaRusso NF, Homburger HA. Enhanced autoreactivity of T lymphocytes in primary sclerosing cholangitis. Hepatology 1987; 7: 844-8.","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/gut.29.4.422","article-title":"Expression of HLA DR antigens on bile duct epithelium in primary sclerosing cholangitis","volume":"29","author":"Chapman, R.W.; Kelly, P.M.A.; Heryet, A.; Jewell, D.P.; Fleming, K.A.","year":"1988","unstructured":"Chapman RW, Kelly PMA, Heryet A, Jewell DP, Fleming KA. Expression of HLA DR antigens on bile duct epithelium in primary sclerosing cholangitis. Gut 1988; 29: 422-7.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/hep.1840050321","article-title":"Immunologic analysis of mononuclear cells in liver tissues and blood of patients with primary sclerosing cholangitis","volume":"5","author":"Whiteside, T.L.; Lasky, S.; Si, L.; Van Thiel, D.H.","year":"1985","unstructured":"Whiteside TL, Lasky S, Si L, Van Thiel DH. Immunologic analysis of mononuclear cells in liver tissues and blood of patients with primary sclerosing cholangitis. Hepatology 1985; 5: 468-74.","journal-title":"Hepatology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/hep.1840030203","article-title":"Elevated circulating immune complexes in primary sclerosing cholangitis","volume":"3","author":"HC, Jr, Bodenheimer; NF, LaRusso; WR, Thayer; C, Charland; Pj, Staples; J, Ludwig","year":"1983","unstructured":"Bodenheimer HC Jr, LaRusso NF, Thayer WR, Charland C, Staples Pj, Ludwig J. Elevated circulating immune complexes in primary sclerosing cholangitis. Hepatology 1983; 3: 150-4.","journal-title":"Hepatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0016-5085(85)80149-9","article-title":"Abnormal clearance of immune complexes from the circulation of patients with primary sclerosing cholangitis","volume":"88","author":"Minuk, G.Y.; Angus, M.; Brickman, C.M.; Lawley, T.J.; Frank, M.M.; Hoofnagle, J.A.","year":"1985","unstructured":"Minuk GY, Angus M, Brickman CM, Lawley TJ, Frank MM, Hoofnagle JA, et al. Abnormal clearance of immune complexes from the circulation of patients with primary sclerosing cholangitis. Gastroenterology 1985; 88: 166-70.","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/00365528209182243","article-title":"The in vivo metabolism of C3 in hepatobiliary disease associated with ulcerative colitis","volume":"17","author":"Brinch, L.; Teisberg, P.; Schrumpf, E.; Akesson, I.","year":"1982","unstructured":"Brinch L, Teisberg P, Schrumpf E, Akesson I. The in vivo metabolism of C3 in hepatobiliary disease associated with ulcerative colitis. ScandJf Gastroenterology 1982; 17: 523-7.","journal-title":"ScandJf Gastroenterology"},{"key":"ref_13","first-page":"8691","article-title":"Sherlock 5, Jewell DP. Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis","volume":"27","author":"Chapman, R.W.; Cottone, M.; Selby, W.S.; Shepherd, H.A.","year":"1986","unstructured":"Chapman RW, Cottone M, Selby WS, Shepherd HA, Sherlock 5, Jewell DP. Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis. Gut 1986; 27: 8691.","journal-title":"Gut"},{"key":"ref_14","first-page":"1494","article-title":"Antineutrophil nuclear antibody in inflammatory bowel disease and primary sclerosing cholangitis","volume":"29","author":"Snook, J.; Chapman, R.W.; Fleming, K.; Jewell, D.P.","year":"1988","unstructured":"Snook J, Chapman RW, Fleming K, Jewell DP. Antineutrophil nuclear antibody in inflammatory bowel disease and primary sclerosing cholangitis. Gut 1988; 29: A1494.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJM198404053101407","article-title":"Current concepts: primary sclerosing cholangitis","volume":"310","author":"NF, La Russo; RH, Wiesner; J, Ludwig; RL, MacCarty","year":"1984","unstructured":"La Russo NF, Wiesner RH, Ludwig J, MacCarty RL. Current concepts: primary sclerosing cholangitis. N Engi J Med 1984; 310: 899-903.","journal-title":"N Engi J Med"},{"key":"ref_16","first-page":"394","article-title":"Monoclonal localisation of Lewis antigens in fixed tissue","author":"Ernst, C.; Atkinson, B.; Wysocka, M.; Blaszczyk, M.; Herlyn, M.; Sears, H.","year":"1984","unstructured":"Ernst C, Atkinson B, Wysocka M, Blaszczyk M, Herlyn M, Sears H, et al. Monoclonal localisation of Lewis antigens in fixed tissue. Lab Invest 1984; 50 (4): 394-400.","journal-title":"Lab Invest"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jnci\/78.1.19","article-title":"Neoexpression of ABH and Lewis blood group antigens in human hepatocellular carcinomas","volume":"78","author":"Okada, Y.; Arima, T.; Togawa, K.; Nagashima, H.; Jinno, K.; Moriwaki, S.","year":"1987","unstructured":"Okada Y, Arima T, Togawa K, Nagashima H, Jinno K, Moriwaki S, et al. Neoexpression of ABH and Lewis blood group antigens in human hepatocellular carcinomas. JNCI 1987; 78: 19-28.","journal-title":"JNCI"},{"key":"ref_18","article-title":"Cancer associated alterations in blood group expression","volume-title":"ulcerative colitis. Gastroenterology 1988; 94","author":"Itzkowitz, S.H.; Yuan, M.; Hanauer, S.; Goldenberg, A.; Kim, Y.S.","unstructured":"Itzkowitz SH, Yuan M, Hanauer S, Goldenberg A, Kim YS. Cancer associated alterations in blood group expression in ulcerative colitis. Gastroenterology 1988; 94 (5): A202."},{"key":"ref_19","first-page":"63","article-title":"Distribution in the normal liver","volume":"6","year":"1988","unstructured":"Distribution in the normal liver. J Hepatol 1988; 6: 63-70.","journal-title":"J Hepatol"},{"key":"ref_20","first-page":"330","article-title":"Blood group antigens in the intrahepatic biliary tree. II Type 1 chain N-acetyllactosamine-related carbohydrate antigens in the proliferated bile ductules","volume":"8","author":"Jinno, K.; Moriwaki, S.; Govindarajan, S.; Okada, Y.; Tsuji, T.","year":"1989","unstructured":"Jinno K, Moriwaki S, Govindarajan S, Okada Y, Tsuji T. Blood group antigens in the intrahepatic biliary tree. II Type 1 chain N-acetyllactosamine-related carbohydrate antigens in the proliferated bile ductules.JHepatol 1989; 8: 330-7.","journal-title":"JHepatol"},{"key":"ref_21","first-page":"193","article-title":"Primary sclerosing cholangitis. Contemnp Issues in Surgical","volume":"8","author":"Ludwig, J.; LaRusso, N.F.; Wiesner, R.H.","year":"1986","unstructured":"Ludwig J, LaRusso NF, Wiesner RH. Primary sclerosing cholangitis. Contemnp Issues in Surgical Pathology 1986; 8: 193-213.","journal-title":"Pathology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/hep.1840090214","article-title":"Biochemical aspects of a-L-fucosidase in hepatocellular carcinoma","volume":"9","author":"Leray, G.; Deugnier, Y.; Jouanolle, A.; Lehry, D.; Bretagne, J.; Campion, J.","year":"1989","unstructured":"Leray G, Deugnier Y, Jouanolle A, Lehry D, Bretagne J, Campion J, et al. Biochemical aspects of a-L-fucosidase in hepatocellular carcinoma. Hepatology 1989; 9: 249-52.","journal-title":"Hepatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hep.1840140318","article-title":"Movement of IgM antibody from blood to bile in rats","volume":"14","author":"Hansen, P.C.G.; Jackson, G.D.F.","year":"1991","unstructured":"Hansen PCG, Jackson GDF. Movement of IgM antibody from blood to bile in rats. Hepatology 1991; 14: 518-22.","journal-title":"Hepatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1172\/JCI107792","article-title":"Measurement of circulating desialylated glycoproteins and corellation with hepatocellular damage","volume":"54","author":"Marshall, J.S.; Green, A.M.; Pensky, J.; Williams, S.; Zinn, A.; Carlson, D.M.","year":"1974","unstructured":"Marshall JS, Green AM, Pensky J, Williams S, Zinn A, Carlson DM. Measurement of circulating desialylated glycoproteins and corellation with hepatocellular damage. J Clin Inv 1974; 54: 555-62.","journal-title":"J Clin Inv"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1084\/jem.119.4.503","article-title":"The histological distribution of blood substances in man disclosed by immunofluorescence","volume":"119","author":"Szulman, A.E.","year":"1964","unstructured":"Szulman AE. The histological distribution of blood substances in man disclosed by immunofluorescence. J Exp Med 1964; 119: 503-15.","journal-title":"J Exp Med"},{"key":"ref_26","first-page":"16171","article-title":"X and related antigens","volume":"51","author":"Oriol, R.; Le Pendu, J.; of ABO, Mollicone R.Genetics; H, Lewis","year":"1986","unstructured":"Oriol R, Le Pendu J, Mollicone R. Genetics of ABO, H, Lewis, X and related antigens. Vox Sanguis 1986; 51: 16171.","journal-title":"Vox Sanguis"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0338-4535(87)80120-4","article-title":"Inhibition on haemagglutination with synsorbs and salivas of anti-B and anti-AB monoclonal antibodies","author":"Mollicone, R.; Gane, P.; Rouger, P.; Oriol, R.","year":"1987","unstructured":"Mollicone R, Gane P, Rouger P, Oriol R. Inhibition on haemagglutination with synsorbs and salivas of anti-B and anti-AB monoclonal antibodies. Revue Franfaise de Transfusion et Immuno-Henatologie 1987; XXX (5): 579-87.","journal-title":"Revue Franfaise de Transfusion et Immuno-Henatologie"},{"key":"ref_28","first-page":"435","article-title":"Inhibition of haemagglutination with synsorbs and salivas of anti-A monoclonal antibodies","author":"Gane, P.; Mollicone, R.; Rouger, P.; Oriol, R.","year":"1987","unstructured":"Gane P, Mollicone R, Rouger P, Oriol R. Inhibition of haemagglutination with synsorbs and salivas of anti-A monoclonal antibodies. Revue Franfaise de Transfusion et Immuno-Henatologie 1987; XXX (5): 435-442.","journal-title":"Revue Franfaise de Transfusion et Immuno-Henatologie"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/gut.32.3.287","article-title":"Regulation of the oncodevelopmental expression of type 1 chain ABH and Lewis b blood group antigens in human colon by alpha 2-L fucosylation","volume":"32","author":"Orntoft, T.F.; Greenwell, P.; Clausen, H.; Watkins, W.M.","year":"1991","unstructured":"Orntoft TF, Greenwell P, Clausen H, Watkins WM. Regulation of the oncodevelopmental expression of type 1 chain ABH and Lewis b blood group antigens in human colon by alpha 2-L fucosylation. Gut 1991; 32: 287-93.","journal-title":"Gut"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0016-5085(84)80055-4","article-title":"Glycoprotein composition of colonic mucosa - specific alterations in ulcerative colitis","volume":"87","author":"Podolsky, D.K.; Isselbacher, K.J.","year":"1984","unstructured":"Podolsky DK, Isselbacher KJ. Glycoprotein composition of colonic mucosa - specific alterations in ulcerative colitis. Gastroenterology 1984; 87: 991-8.","journal-title":"Gastroenterology"},{"key":"ref_31","first-page":"578","article-title":"Carcinoma-type mucus abnormalities in ulcerative colitis and Crohn's disease demonstrated by altered lectin binding","volume":"26","author":"Rhodes, J.M.; Black, R.; Patel, P.; Savage, A.","year":"1985","unstructured":"Rhodes JM, Black R, Patel P, Savage A. Carcinoma-type mucus abnormalities in ulcerative colitis and Crohn's disease demonstrated by altered lectin binding. Gut 1985; 26: A578.","journal-title":"Gut"},{"key":"ref_32","first-page":"1364","article-title":"Abnormal goblet cell glycoconjugates in rectal biopsies associated with an increased risk ofneoplasia in patients with ulcerative colitis: early results of a prospective study","volume-title":"Gut","volume":"25","author":"Boland, C.R.; Lance, P.; Levin, B.; Riddell, R.H.; Kim, Y.S.","year":"1984","unstructured":"Boland CR, Lance P, Levin B, Riddell RH, Kim YS. Abnormal goblet cell glycoconjugates in rectal biopsies associated with an increased risk ofneoplasia in patients with ulcerative colitis: early results of a prospective study. Gut 1984; 25: 1364-71."},{"key":"ref_33","article-title":"The embryonic liver","author":"AM, Du Bois","year":"1963","unstructured":"Du Bois AM. The embryonic liver. In: Rouiller CH, ed. The Liver. Vol 1. Academic Press, New York: 1963; 1-16."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.111.6.785","article-title":"The histological distribution ot blood group substances A and B in man","volume":"111","author":"Szulman, A.E.","year":"1960","unstructured":"Szulman AE. The histological distribution ot blood group substances A and B in man. J Exp Med 1960; 111: 785-80.","journal-title":"J Exp Med"},{"key":"ref_35","first-page":"1","article-title":"The hepatocellular expression of a carbohydrate antigen 'sialyl Lewis X' in chronic hepatitis. A nove histological marker for active hepatic necroinflammation","author":"Okada, Y.; Usumoto, R.; Muguruma, M.; Shimoe, T.; Sunayama, T.; Yamada, G.","year":"1990","unstructured":"Okada Y, Usumoto R, Muguruma M, Shimoe T, Sunayama T, Yamada G, et al. The hepatocellular expression of a carbohydrate antigen 'sialyl Lewis X' in chronic hepatitis. A nove histological marker for active hepatic necroinflammation.J Hepatol 1990; 10 (1): 1-7.","journal-title":"J Hepatol"},{"key":"ref_36","first-page":"527985","article-title":"Characterisation of Sialosylated Lewis X as a new tumour associated antigen","volume":"44","author":"Fukushima, K.; Hirota, M.; Terasaki, P.; Wakisaka, A.; Togashi, H.; Chia, D.","year":"1984","unstructured":"Fukushima K, Hirota M, Terasaki P, Wakisaka A, Togashi H, Chia D, et al. Characterisation of Sialosylated Lewis X as a new tumour associated antigen. CancerRes 1984; 44: 527985.","journal-title":"CancerRes"},{"key":"ref_37","article-title":"The presence of circulating antibodies in patients with sclerosing cholangitis against an epitope on Mr 40 000 protein shared by colon and bile","volume-title":"duct epithelial cells. Gastroenterology 1989; %: A590","author":"Das, K.M.; Jeffers, L.; Squillante, L.; Hyder, S.; Reddy, R.; Schiffe, H.","unstructured":"Das KM, Jeffers L, Squillante L, Hyder S, Reddy R, Schiffe H, et al. The presence of circulating antibodies in patients with sclerosing cholangitis against an epitope on Mr 40 000 protein shared by colon and bile duct epithelial cells. Gastroenterology 1989; %: A590."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.7.977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:25:12Z","timestamp":1765661112000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.7.977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1993,7,1]]},"published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1136\/gut.34.7.977"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.7.977","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}