{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:36:26Z","timestamp":1766428586122,"version":"3.48.0"},"reference-count":45,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>Of 46 patients who had Nissen fundoplication for proved gastro-oesophageal reflux, 25 were available for follow up after a median of 20 years, 15 had died of unrelated causes, and six could not be traced. All 25 patients in the follow up study were personally interviewed: 21 consented to an endoscopy, 14 to 24 hour recording of oesophageal pH and manometry, and 15 to radionuclide transit test. Repeat fundoplication for recurrent reflux was performed in two cases during the study. Heartburn and regurgitation were significantly lessened (p &lt; 0.005), but the incidence of dysphagia was slightly increased. Endoscopy showed six of 21 fundic wraps to be defective. Erosive oesophagitis was seen in two patients, and Barrett's oesophagus (histologically confirmed) in one of them and six other patients. Total reflux time was abnormal in four of 14 patients. No patient with an intact fundic wrap seen on endoscopy, only two of seven with Barrett's oesophagus, and one of four with abnormal reflux had oesophagitis. Fundoplication in itself did not affect oesophageal motility or transit, provided that the wrap was intact. It is concluded that Nissen fundoplication gave a reasonably good longterm effect in chronic reflux disease, with the stage of the fundic wrap as the main determinant of outcome.<\/jats:p>","DOI":"10.1136\/gut.34.8.1015","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1015-1020","source":"Crossref","is-referenced-by-count":113,"title":["Fate of Nissen fundoplication after 20 years. A clinical, endoscopical, and functional analysis."],"prefix":"10.1136","volume":"34","author":[{"given":"M","family":"Luostarinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Isolauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Laitinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Koskinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Keyril\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Markkula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Uusitalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"key":"ref_1","first-page":"590","article-title":"Eine einfache Operation zur Beeinflussung de Refluxosophagitis","volume":"86","author":"Nissen, R.","year":"1956","unstructured":"Nissen R. Eine einfache Operation zur Beeinflussung de Refluxosophagitis. Schweiz Med Wochenschr 1956; 86: 590-2.","journal-title":"Schweiz Med Wochenschr"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0002-9610(83)90301-X","article-title":"Nissen fundoplication: results at 10 year follow-up","volume":"146","year":"1983","unstructured":"Negre JB, Markkula HT, Keyrilainen 0, Matikainen M. Nissen fundoplication: results at 10 year follow-up. Am J Surg 1983; 146: 635-8.","journal-title":"Am J Surg"},{"key":"ref_3","first-page":"1198","article-title":"Symptoms 10-20 years after fundoplication","volume-title":"Diseases of the esophagus","author":"Ch, Ackermann; L, Margareth; C, Muller; F, Harder","year":"1988","unstructured":"Ackermann Ch, Margareth L, Muller C, Harder F. Symptoms 10-20 years after fundoplication. In: Siewert JR, Holscher AH, eds. Diseases of the esophagus. Berlin, Heidelberg: Springer Verlag, 1988: 1198-202."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-198607000-00002","article-title":"Nissen fundoplication for gastroesophageal reflux disease","volume":"204","author":"DeMeester, T.R.; Bonavina, L.; Albertolucci, M.","year":"1986","unstructured":"DeMeester TR, Bonavina L, Albertolucci M. Nissen fundoplication for gastroesophageal reflux disease. Ann Surg 1986; 204: 9-20.","journal-title":"Ann Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1001\/archsurg.1985.01390300013002","article-title":"The floppy Nissen fundoplication","volume":"120","author":"Donahue, P.E.; Samuelson, S.; Nyhus, L.M.; Bombeck, T.","year":"1985","unstructured":"Donahue PE, Samuelson S, Nyhus LM, Bombeck T. The floppy Nissen fundoplication. Arch Surg 1985; 120: 663-8.","journal-title":"Arch Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/archsurg.1987.01400170054008","article-title":"Long-term follow-up for treatment of complicated chronic reflux esophagitis","volume":"122","author":"Schirazi, S.S.; Schulze, K.; Soper, R.T.","year":"1987","unstructured":"Schirazi SS, Schulze K, Soper RT. Long-term follow-up for treatment of complicated chronic reflux esophagitis. Arch Surg 1987; 122: 548-52.","journal-title":"Arch Surg"},{"key":"ref_7","first-page":"782","article-title":"Comparison of crural repair and Nissen fundoplication in the treatment of esophageal hiatus hernia with peptic esophagitis","volume":"173","author":"Woodward, E.R.; Thomas, H.F.; McAlhany, J.C.","year":"1971","unstructured":"Woodward ER, Thomas HF, McAlhany JC. Comparison of crural repair and Nissen fundoplication in the treatment of esophageal hiatus hernia with peptic esophagitis. Ann Surg 1971; 173: 782-9."},{"key":"ref_8","first-page":"485","article-title":"Complications of surgery for gastroesophageal reflux","volume-title":"WorldJSurg","volume":"1","author":"Skinner, D.B.","year":"1977","unstructured":"Skinner DB. Complications of surgery for gastroesophageal reflux. WorldJSurg 1977; 1: 485-92."},{"key":"ref_9","first-page":"689","article-title":"Post-fundoplication symptoms. Do they restrict the success of Nissen fundoplication?","author":"Negre, J.B.","year":"1983","unstructured":"Negre JB. Post-fundoplication symptoms. Do they restrict the success of Nissen fundoplication? Ann Surg 1983; 198: 689-700.","journal-title":"Ann Surg"},{"key":"ref_10","first-page":"1","article-title":"Post Nissen syndrome","volume":"167","author":"Low, D.E.; Mercer, C.D.; James, E.C.; Hill, L.D.","year":"1988","unstructured":"Low DE, Mercer CD, James EC, Hill LD. Post Nissen syndrome. Surg Gynecol Obstet 1988; 167: 1-5.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1056\/NEJM199203193261202","article-title":"The Department of Veterans Affairs Gastroesophageal Reflux Disease Study Group. Comparison of medical and surgical therapy for complicated gastroesophageal reflux disease in veterans","volume":"326","author":"Spechler, S.J.","year":"1992","unstructured":"Spechler SJ. The Department of Veterans Affairs Gastroesophageal Reflux Disease Study Group. Comparison of medical and surgical therapy for complicated gastroesophageal reflux disease in veterans. N EngI J7 Med 1992; 326: 786-92.","journal-title":"N EngI J7 Med"},{"key":"ref_12","first-page":"1111","article-title":"Effects of fundoplication on the antireflux mechanism","volume-title":"BrJ7 Surg","volume":"74","author":"Johnsson, F.; Joelsson, B.; Gudmundsson, K.; Floren, C.-H.; Walther, B.","year":"1987","unstructured":"Johnsson F, Joelsson B, Gudmundsson K, Floren C-H, Walther B. Effects of fundoplication on the antireflux mechanism. BrJ7 Surg 1987; 74: 1111-4."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0002-9610(75)90174-9","article-title":"Evaluation of the Nissen antireflux procedure by esophageal manometry and twenty-four hour pH monitoring","volume":"129","author":"DeMeester, T.R.; Johnson, L.F.","year":"1975","unstructured":"DeMeester TR, Johnson LF. Evaluation of the Nissen antireflux procedure by esophageal manometry and twenty-four hour pH monitoring. AmJ Surg 1975; 129: 94-100.","journal-title":"AmJ Surg"},{"key":"ref_14","first-page":"115","article-title":"Prospective evaluation of the effects of Nissen fundoplication on gastroesophageal reflux","volume":"171","author":"Breumelhof, R.; Smout, A.J.P.M.; Schyns, M.W.R.J.; Bronzwaer, P.W.A.; Akkermanas, L.M.A.; Jansen, A.","year":"1990","unstructured":"Breumelhof R, Smout AJPM, Schyns MWRJ, Bronzwaer PWA, Akkermanas LMA, Jansen A. Prospective evaluation of the effects of Nissen fundoplication on gastroesophageal reflux. SurgGynecol Obstet 1990; 171: 115-9.","journal-title":"SurgGynecol Obstet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0003-4975(10)62292-8","article-title":"Reflux control by fundoplication: A clinical and manometric assessment of the Nissen operation","volume":"38","author":"Ellis, F.H.; Crozier, R.E.","year":"1984","unstructured":"Ellis FH, Crozier RE. Reflux control by fundoplication: A clinical and manometric assessment of the Nissen operation. Ann Thorac Surg 1984; 38: 387-91.","journal-title":"Ann Thorac Surg"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0016-5085(86)90570-6","article-title":"Esophageal motor abnormalities in gastroesophageal reflux and the effects of fundoplication","volume":"91","author":"Gill, R.C.; Bowes, K.L.; Murphy, P.D.; Kingma, Y.J.","year":"1986","unstructured":"Gill RC, Bowes KL, Murphy PD, Kingma YJ. Esophageal motor abnormalities in gastroesophageal reflux and the effects of fundoplication. Gastroenterology: 1986; 91: 364-9.","journal-title":"Gastroenterology"},{"key":"ref_17","first-page":"1095","article-title":"Surgery improves defective oesophageal peristalsis in patients with gastro-oesophageal reflux","volume-title":"BrJ7Surg","volume":"78","author":"Ortiz, A.O.; Martinez de Hero, L.F.; Parrilla, P.P.; Aguayo, J.L.; Garcia, J.A.; Morales, G.C.","year":"1991","unstructured":"Ortiz AO, Martinez de Hero LF, Parrilla PP, Aguayo JL, Garcia JA, Morales GC. Surgery improves defective oesophageal peristalsis in patients with gastro-oesophageal reflux. BrJ7Surg 1991; 78: 1095-7."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0016-5085(58)80023-2","article-title":"A clinical test for esophagitis","volume":"34","author":"Bernstein, L.M.; Baker, L.A.","year":"1958","unstructured":"Bernstein LM, Baker LA. A clinical test for esophagitis. Gastroenterology 1958; 34: 760-81","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF01565907","article-title":"Fundoplication for treatment of gastroesophageal reflux in hiatus hernia","volume":"1","author":"Rossetti, M.; Hell, K.","year":"1977","unstructured":"Rossetti M, Hell K. Fundoplication for treatment of gastroesophageal reflux in hiatus hernia. World Y Surg 1977; 1: 439-44.","journal-title":"World Y Surg"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archsurg.1959.04320060077010","article-title":"Balanced operations for esophagitis associated with oesophageal hiatal hernia","volume":"78","author":"Berman, J.K.; Berman, E.J.","year":"1959","unstructured":"Berman JK, Berman EJ. Balanced operations for esophagitis associated with oesophageal hiatal hernia. Arch Surg 1959; 78: 889-96.","journal-title":"Arch Surg"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(48)90722-3","article-title":"Measured radical gastrectomy. Review of 505 operations for peptic ulcer","volume":"i:","author":"Visick, A.H.","year":"1948","unstructured":"Visick AH. Measured radical gastrectomy. Review of 505 operations for peptic ulcer. Lancet 1948; i: 505-10.","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00000658-197610000-00009","article-title":"Patterns of gastroesophageal reflux in health and disease","volume":"184","author":"DeMeester, T.R.; Johnson, L.F.; Joseph, G.J.; Toscano, M.S.; Hall, A.W.; Skinner, D.B.","year":"1976","unstructured":"DeMeester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.","journal-title":"Ann Surg"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0039-6109(16)40834-0","article-title":"The evaluation of objective measurements ofgastroesophageal reflux and their contribution to patient management","volume":"56","author":"DeMeester, T.R.; Johnson, L.F.","year":"1976","unstructured":"DeMeester TR, Johnson LF. The evaluation of objective measurements ofgastroesophageal reflux and their contribution to patient management. Surg Clin North Am 1976; 56: 39-53.","journal-title":"Surg Clin North Am"},{"key":"ref_24","first-page":"21","article-title":"Functional evaluation of interposed colon in esophagus","volume":"153","author":"Isolauri, J.; Reinikainen, P.; Markkula, H.","year":"1987","unstructured":"Isolauri J, Reinikainen P, Markkula H. Functional evaluation of interposed colon in esophagus. Acta ChirScand 1987; 153: 21-4.","journal-title":"Acta ChirScand"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0022-5223(19)36213-0","article-title":"Radionuclide transit in patients with colon interposition","volume":"94","author":"Isolauri, J.; Koskinen, M.O.; Markkula, H.","year":"1987","unstructured":"Isolauri J, Koskinen MO, Markkula H. Radionuclide transit in patients with colon interposition. Y Thorac Cardiovasc Surg 1987; 94: 521-5.","journal-title":"Y Thorac Cardiovasc Surg"},{"key":"ref_26","article-title":"Der oesophagus, lehrbuch und endoskopischer atlas","author":"Savary, M.; Miller, G.","year":"1977","unstructured":"Savary M, Miller G. Der oesophagus, lehrbuch und endoskopischer atlas. Solothurn: Gassmann, 1977."},{"key":"ref_27","first-page":"163","article-title":"Histological consequences of gastroesophageal","volume-title":"reflux in man. Gastroenterology 1970","volume":"58","author":"Ismail-Beigi, F.; Horton, P.F.; CE, II, Pope","unstructured":"Ismail-Beigi F, Horton PF, Pope CE II. Histological consequences of gastroesophageal reflux in man. Gastroenterology 1970; 58: 163-74."},{"key":"ref_28","first-page":"325","article-title":"Twenty-four-hour pH monitoring of the distal esophagus","volume":"62","author":"Johnson, L.F.; DeMeester, T.R.","year":"1974","unstructured":"Johnson LF, DeMeester TR. Twenty-four-hour pH monitoring of the distal esophagus. Am J Gastroenterol 1974; 62: 325-32.","journal-title":"Am J Gastroenterol"},{"key":"ref_29","first-page":"130","article-title":"The nutcracker esophagus and other primary esophageal motility disorders","volume-title":"motility testing","author":"Castell, D.O.","year":"1987","unstructured":"Castell DO. The nutcracker esophagus and other primary esophageal motility disorders. In: Castell DO, Richter JE, Dalton CB, eds. Esophageal motility testing. New York: Elsevier, 1987: 130-42."},{"key":"ref_30","first-page":"61","article-title":"Measurements and interpretations","volume-title":"motility testing","author":"Dalton, C.B.","year":"1987","unstructured":"Dalton CB. Measurements and interpretations. In: Castell DO, Richter JE, Dalton CB, eds. Esophageal motility testing. New York: Elsevier, 1987: 61-78."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02071541","article-title":"Fundoplication: How to do it? Periesophageal wrapping as a therapeutic principal in gastroesophageal reflux","volume":"16","author":"Siewart, JR, Feussner; H, Walker; S.J.","year":"1992","unstructured":"Siewart JR, Feussner H, Walker SJ. Fundoplication: How to do it? Periesophageal wrapping as a therapeutic principal in gastroesophageal reflux. Worldj Surg 1992; 16: 326-34.","journal-title":"Worldj Surg"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0039-6109(16)41097-2","article-title":"Postoperative alkaline reflux gastritis","volume":"56","author":"Cooperman, A.M.","year":"1976","unstructured":"Cooperman AM. Postoperative alkaline reflux gastritis. Surg Clin North Am 1976; 56: 1445.","journal-title":"Surg Clin North Am"},{"key":"ref_33","first-page":"359","article-title":"Surgical management after failed antireflux operations","volume":"16","author":"Skinner, D.B.","year":"1992","unstructured":"Skinner DB. Surgical management after failed antireflux operations. WorldJSurg 1992; 16: 359-63.","journal-title":"WorldJSurg"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-5223(19)41954-5","article-title":"Long-term results of the Mark IV operation for hiatal hernia and analyses of recurrences and their treatment","volume":"63","author":"Orringer, M.; Skinner, D.; Belsey, R.","year":"1972","unstructured":"Orringer M, Skinner D, Belsey R. Long-term results of the Mark IV operation for hiatal hernia and analyses of recurrences and their treatment. J Thorac Cardiovasc Surg 1972; 63:25.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00000658-198912000-00005","article-title":"A long-term randomized prospective trial of the Nissen procedure versus a modified Toupet technique","volume":"210","author":"Thor, K.; Silander, T.","year":"1989","unstructured":"Thor K, Silander T. A long-term randomized prospective trial of the Nissen procedure versus a modified Toupet technique. Ann Surg 1989; 210: 719-24.","journal-title":"Ann Surg"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/bjs.1800770526","article-title":"Recurrent reflux and wrap disruption after Nissen fundoplication: detection, incidence and timing","volume":"77","author":"O'Hanrahan, T.; Marples, M.; Bancewicz, J.","year":"1990","unstructured":"O'Hanrahan T, Marples M, Bancewicz J. Recurrent reflux and wrap disruption after Nissen fundoplication: detection, incidence and timing. BrJ Surg 1990; 77: 545-7.","journal-title":"BrJ Surg"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3109\/00365528709011148","article-title":"Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease","volume":"22","author":"Johnsson, F.; Joelsson, B.; Gudmundsson, K.; Greiff, L.","year":"1987","unstructured":"Johnsson F, Joelsson B, Gudmundsson K, Greiff L. Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease. ScandJ Gastroenterol 1987; 22: 714-8.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00000658-199304000-00004","article-title":"Nissen fundoplication for reflux esophagitis: long-term clinical and endoscopic results in 109 of 127 consecutive cases","volume":"217","author":"Luostarinen, M.","year":"1993","unstructured":"Luostarinen M. Nissen fundoplication for reflux esophagitis: long-term clinical and endoscopic results in 109 of 127 consecutive cases. Ann Surg 1993; 217: 329-37.","journal-title":"Ann Surg"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/bjs.1800780816","article-title":"The modified AFP score: an attempt to make the results of anti-reflux surgery comparable","volume":"78","author":"Feussner, H.; Petri, A.; Walker, S.; Bollschweiler, E.; Siewert, JR","year":"1991","unstructured":"Feussner H, Petri A, Walker S, Bollschweiler E, Siewert JR. The modified AFP score: an attempt to make the results of anti-reflux surgery comparable. Br J Surg 1991; 78: 942-6.","journal-title":"Br J Surg"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-0028-1098335","article-title":"Barrett-esophagus following total gastrectomy","volume":"2","author":"Meyer, W.; Vollmar, F.; Bar, W.","year":"1979","unstructured":"Meyer W, Vollmar F, Bar W. Barrett-esophagus following total gastrectomy. Endoscopy 1979; 2: 121-6.","journal-title":"Endoscopy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/00000658-199010000-00015","article-title":"Surgical therapy in Barrett's esophagus","volume":"212","author":"DeMeester, T.R.; Attwood, S.E.A.; Smyrk, T.C.; Therkildsen, D.H.; Hinder, R.A.","year":"1990","unstructured":"DeMeester TR, Attwood SEA, Smyrk TC, Therkildsen DH, Hinder RA. Surgical therapy in Barrett's esophagus. Ann Surg 1990; 212: 528-42.","journal-title":"Ann Surg"},{"key":"ref_42","first-page":"733","article-title":"Barrett's esophagus, current assessment and future perspectives","volume":"19","author":"Polepalle, S.C.; McCallum, R.W.","year":"1990","unstructured":"Polepalle SC, McCallum RW. Barrett's esophagus, current assessment and future perspectives. Gastroenterol Clin North Am 1990; 19: 733-44.","journal-title":"Gastroenterol Clin North Am"},{"issue":"166","key":"ref_43","first-page":"88","article-title":"Use of omeprazole in the management of reflux esophagitis resistant to H2-receptor antagonists","volume":"24","author":"Klinkenberg-Knol, E.C.; Jansen, J.B.M.J.; Lamers, C.B.H.W.; Nelis, F.; Snel, P.; Meuwissen, S.G.M.","year":"1989","unstructured":"Klinkenberg-Knol EC, Jansen JBMJ, Lamers CBHW, Nelis F, Snel P, Meuwissen SGM. Use of omeprazole in the management of reflux esophagitis resistant to H2-receptor antagonists. Scand J Gastroenterol 1989; 24: (suppl 166): 88-93.","journal-title":"Scand J Gastroenterol"},{"key":"ref_44","first-page":"73","article-title":"Esophageal peristaltic dysfunction","volume-title":"peptic esophagitis. Gastroenterology 1988; 94","author":"Kahrilas, P.J.; Dodds, W.J.; Hogan, W.J.; Kern, M.; Arndorfer, R.C.; Reece, A.","unstructured":"Kahrilas PJ, Dodds WJ, Hogan WJ, Kern M, Arndorfer RC, Reece A. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology 1988; 94: 73-80."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0003-4975(89)90374-3","article-title":"Esophageal function in patients with refluxinduced strictures and its relevance to surgical treatment","volume":"47","author":"Zaninotto, G.; De Meester, T.R.; Bremner, C.G.; Smyrk, T.C.; Shih-Chuan, Cheng","year":"1989","unstructured":"Zaninotto G, De Meester TR, Bremner CG, Smyrk TC, Cheng Shih-Chuan. Esophageal function in patients with refluxinduced strictures and its relevance to surgical treatment. Ann Thorac Surg 1989; 47: 362-70.","journal-title":"Ann Thorac Surg"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.8.1015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:32:29Z","timestamp":1765621949000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.8.1015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1993,8,1]]},"published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1136\/gut.34.8.1015"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.8.1015","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}