{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:09:48Z","timestamp":1765656588989,"version":"3.48.0"},"reference-count":48,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms suggestive of ulcer recurrence developed. The 12 month crude relapse rates (that underestimate the probability of ulcer recurrence) showed that cisapride was superior to placebo (34% (11\/32) relapsed on cisapride v 68% (23\/34) on placebo, p = 0.007). This finding was confirmed using lifetable analysis, with a 35% reduction (95% confidence intervals 10-59%, p &lt; 0.05) in the proportion of ulcer relapses in patients who had received cisapride compared with those treated with placebo. These results are similar to those reported in maintenance trials of H2 receptor antagonists analysed by the same method. Drug related adverse clinical events were mainly trivial, but led to three patients on cisapride and one on placebo withdrawing from the trial.<\/jats:p>","DOI":"10.1136\/gut.34.8.1042","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1042-1046","source":"Crossref","is-referenced-by-count":7,"title":["Acid, motility, and ulcers: a comparison of cisapride with placebo in the prevention of duodenal ulcer relapse."],"prefix":"10.1136","volume":"34","author":[{"given":"D D","family":"Kerrigan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N W","family":"Read","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"issue":"2","key":"ref_1","first-page":"447","article-title":"Pathogenesis and pathophysiology of duodenal ulcer","volume-title":"Clinics in gastroenterology - Peptic ulcer disease","volume":"13","author":"Lam, S.K.","year":"1984","unstructured":"Lam SK. Pathogenesis and pathophysiology of duodenal ulcer. In: Isenberg JI, Johansson C, eds. Clinics in gastroenterology - Peptic ulcer disease. Vol 13. No 2. Philadelphia: Saunders, 1984: 447-72."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/0016-5085(91)90261-I","article-title":"Disturbed gastroduodenal motility in patients with active and healed duodenal ulceration","volume":"100","author":"Kerrigan, D.D.; Read, N.W.; Houghton, L.A.; Taylor, M.E.; Johnson, A.G.","year":"1991","unstructured":"Kerrigan DD, Read NW, Houghton LA, Taylor ME, Johnson AG. Disturbed gastroduodenal motility in patients with active and healed duodenal ulceration. Gastroenterology 1991; 100: 892-900.","journal-title":"Gastroenterology"},{"issue":"4","key":"ref_3","first-page":"100","article-title":"Trials with metoclopramide in duodenal ulceration","volume":"49","author":"Moshal, M.G.","year":"1973","unstructured":"Moshal MG. Trials with metoclopramide in duodenal ulceration. Postgrad MedJ 1973; 49 (suppl 4): 100-3.","journal-title":"Postgrad MedJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/bmj.2.5966.307","article-title":"Relief of duodenal ulcer symptoms by oral metiamide","volume":"2","author":"Pounder, R.E.; Williams, J.G.; Milton-Thompson, G.J.; Misiewicz, J.J.","year":"1975","unstructured":"Pounder RE, Williams JG, Milton-Thompson GJ, Misiewicz JJ. Relief of duodenal ulcer symptoms by oral metiamide. BMJ 1975; 2: 307-9.","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/BF01296370","article-title":"Effects of oral cisapride on interdigestive jejunal motor activity, psychomotor function and side-effect profile in healthy man","volume":"32","author":"Stacher, G.; Gaupmann, G.; Mittelbach, G.; Schneider, C.; Steinringer, H.; Langer, B.","year":"1987","unstructured":"Stacher G, Gaupmann G, Mittelbach G, Schneider C, Steinringer H, Langer B. Effects of oral cisapride on interdigestive jejunal motor activity, psychomotor function and side-effect profile in healthy man. Dig Dis Sci 1987; 32: 1223-30.","journal-title":"Dig Dis Sci"},{"key":"ref_6","first-page":"1512","article-title":"Cisapride stimulates propulsive motility patterns in human jejunum","volume":"33","author":"Coremans, G.; Janssens, J.; Vantrappen, G.; Chaussade, S.; Ceccatelli, P.","year":"1988","unstructured":"Coremans G, Janssens J, Vantrappen G, Chaussade S, Ceccatelli P. Cisapride stimulates propulsive motility patterns in human jejunum. DigDisSci 1988; 33: 1512-9.","journal-title":"DigDisSci"},{"key":"ref_7","first-page":"619","article-title":"Impaired transit of chyme in chronic intestinal pseudo-obstruction","volume-title":"Correction by cisapride. Gastroenterology 1986; 91","author":"Camilleri, M.; Brown, M.L.; Malagelada, JR","unstructured":"Camilleri M, Brown ML, Malagelada JR. Impaired transit of chyme in chronic intestinal pseudo-obstruction. Correction by cisapride. Gastroenterology 1986; 91: 619-26."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/gut.28.3.300","article-title":"Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis","volume":"28","author":"Corinaldesi, R.; Stanghellini, V.; Raiti, C.; Rea, E.; Salgemini, R.; Barbara, L.","year":"1987","unstructured":"Corinaldesi R, Stanghellini V, Raiti C, Rea E, Salgemini R, Barbara L. Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. Gut 1987; 28: 300-5.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0016-5085(87)90976-0","article-title":"Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa","volume":"92","author":"Stacher, G.; Bergmann, H.; Wiensnagrotzki, S.; Kiss, A.; Schneider, C.; Mittelbach, G.","year":"1987","unstructured":"Stacher G, Bergmann H, Wiensnagrotzki S, Kiss A, Schneider C, Mittelbach G, et al. Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa. Gastroenterology 1987; 92: 1000-6.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.0954-6820.1987.tb10681.x","article-title":"Effects of cisapride on gastroparesis in patients with insulin-dependant diabetes mellitus. A double-blind controlled trial","volume":"222","year":"1987","unstructured":"Havelund T, Oster-Jorgensen E, Eshoj 0, Larsen ML, Lauritsen K. Effects of cisapride on gastroparesis in patients with insulin-dependant diabetes mellitus. A double-blind controlled trial. Acta Med Scand 1987; 222: 339-43.","journal-title":"Acta Med Scand"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/BF01550963","article-title":"Effect of cisapride on gastric emptying in dyspeptic patients","volume":"33","author":"Urbain, J.-L.; Siegel, J.A.; Debie, N.C.; Pauwels, S.P.","year":"1988","unstructured":"Urbain J-L, Siegel JA, Debie NC, Pauwels SP. Effect of cisapride on gastric emptying in dyspeptic patients. Dig Dis Sci 1988; 33:779-83.","journal-title":"Dig Dis Sci"},{"key":"ref_12","first-page":"43","article-title":"Acute effect of the gastrokinetics cisapride and metoclopramide on the gastric emptying function in patients with the early satiety syndrome","volume":"17","author":"Ghigliani, M.; Iantorno, G.; Vazquez, S.; Varela, A.","year":"1987","unstructured":"Ghigliani M, Iantorno G, Vazquez S, Varela A. Acute effect of the gastrokinetics cisapride and metoclopramide on the gastric emptying function in patients with the early satiety syndrome. Acta Gastroenterol Latinoam 1987; 17: 43-50.","journal-title":"Acta Gastroenterol Latinoam"},{"key":"ref_13","first-page":"288","article-title":"Long-term oral cisapride improves interdigestive antroduodenal motility in dyspetic patients","volume":"31","author":"Testoni, P.A.; Bagnolo, F.; Fanti, L.; Passaretti, S.; Tittobello, A.","year":"1990","unstructured":"Testoni PA, Bagnolo F, Fanti L, Passaretti S, Tittobello A. Long-term oral cisapride improves interdigestive antroduodenal motility in dyspetic patients. Gut 1990; 31: 288-90.","journal-title":"Gut"},{"key":"ref_14","first-page":"138","article-title":"Bingham 5, Andrews PLR. Preliminary studies on the mechanism of action of cisapride","volume":"34","year":"1986","unstructured":"Bingham 5, Andrews PLR. Preliminary studies on the mechanism of action of cisapride. Digestion 1986; 34: 138.","journal-title":"Digestion"},{"key":"ref_15","first-page":"11","article-title":"Animal pharmacology of the gastrointestinal prokinetic, cisapride","volume-title":"in the treatment of gastrointestinal motility disorders: the role ofcisapride","author":"Schuurkes, J.A.J.; Van Neuten, J.M.","year":"1988","unstructured":"Schuurkes JAJ, Van Neuten JM. Animal pharmacology of the gastrointestinal prokinetic, cisapride. In: Johnson AG, Lux G, eds. Progress in the treatment of gastrointestinal motility disorders: the role ofcisapride. Amsterdam: Excerpta Medica, 1988: 11-8."},{"key":"ref_16","first-page":"354","article-title":"Chronic oral treatment with cisapride decrease high bile salt reflux rates","volume":"81","author":"Muller-Lissner, S.A.; Fraass, C.","year":"1986","unstructured":"Muller-Lissner SA, Fraass C. Chronic oral treatment with cisapride decrease high bile salt reflux rates. Am J Gastroenterol 1986; 81: 354-7.","journal-title":"Am J Gastroenterol"},{"key":"ref_17","first-page":"585","article-title":"Design and analysis of randomised clinical trials requiring prolonged observation of each patient","volume":"34","author":"Peto, R.; Pike, M.C.; Armitage, P.; Breslow, N.E.; Cox, D.R.; Howard, S.V.","year":"1976","unstructured":"Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, et al. Design and analysis of randomised clinical trials requiring prolonged observation of each patient. I. Introduction and design. Brj Cancer 1976; 34: 585-612.","journal-title":"I. Introduction and design. Brj Cancer"},{"key":"ref_18","first-page":"1","article-title":"Design and analysis of randomised clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto, R.; Pike, M.C.; Armitage, P.; Breslow, N.E.; Cox, D.R.; Howard, S.V.","year":"1977","unstructured":"Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, et al. Design and analysis of randomised clinical trials requiring prolonged observation of each patient. II. Analysis and examples. BrJr Cancer 1977; 35: 1-39.","journal-title":"II. Analysis and examples. BrJr Cancer"},{"key":"ref_19","first-page":"64","article-title":"Calculating confidence intervals for survival time analyses","volume-title":"Statistics with confidence - confidence intervals and statistical guidelines","author":"Machin, D.; Gardner, M.J.","year":"1989","unstructured":"Machin D, Gardner MJ. Calculating confidence intervals for survival time analyses. In: Gardner MJ, Altman DG, eds. Statistics with confidence - confidence intervals and statistical guidelines. London: British Medical Journal, 1989: 64-70."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJM198904273201704","article-title":"A randomised study of maintenance therapy with ranitidine to prevent the recurrence of duodenal ulcer","volume":"320","author":"GM, Van Deventer; JD, Elashoff; TJ, Reedy; JH, Schneidman D.Walsh","year":"1989","unstructured":"Van Deventer GM, Elashoff JD, Reedy TJ, Schneidman D Walsh JH. A randomised study of maintenance therapy with ranitidine to prevent the recurrence of duodenal ulcer. N Engl Med 1989; 320: 1113-9.","journal-title":"N Engl Med"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00004836-198712000-00007","article-title":"Comparison of ranitidine and cimetidine ulcer maintenance therapy","volume":"9","author":"Kurata, J.H.; Koch, G.G.; Nogawa, A.N.","year":"1987","unstructured":"Kurata JH, Koch GG, Nogawa AN. Comparison of ranitidine and cimetidine ulcer maintenance therapy. J Clin Gastroenterol 1987; 9: 644-50.","journal-title":"J Clin Gastroenterol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/00004836-198512000-00008","article-title":"Final report on the United States multicenter trial comparing ranitidine to cimetidine as maintenance therapy following healing of duodenal ulcer","volume":"7","author":"Silvis, S.E.","year":"1985","unstructured":"Silvis SE. Final report on the United States multicenter trial comparing ranitidine to cimetidine as maintenance therapy following healing of duodenal ulcer. J Clin Gastroenterol 1985; 7: 482-7.","journal-title":"J Clin Gastroenterol"},{"key":"ref_23","first-page":"659","article-title":"Ranitidine and cimetidine in prevention of duodenal ulcer relapse","volume":"ii:","author":"Gough, K.R.; Bardhan, K.D.; Crowe, J.P.; Korman, M.G.; Lee, F.I.; Reed, P.I.","year":"1984","unstructured":"Gough KR, Bardhan KD, Crowe JP, Korman MG, Lee FI, Reed PI, et al. Ranitidine and cimetidine in prevention of duodenal ulcer relapse. Lancet 1984; ii: 659-62.","journal-title":"Lancet"},{"key":"ref_24","first-page":"1061","article-title":"Predictors of duodenal ulcer","volume-title":"healing and relapse. Gastroenterology 1981; 81","author":"Sonnenberg, A.; Schuurkes, S.A.; Vogel, E.; Schmid, P.; Gonvers, J.J.; Peter, P.","unstructured":"Sonnenberg A, Schuurkes SA, Vogel E, Schmid P, Gonvers JJ, Peter P, et al. Predictors of duodenal ulcer healing and relapse. Gastroenterology 1981; 81: 1061-7."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJM198409133111101","article-title":"Cimetidine, cigarette smoking and recurrence of duodenal ulcer","volume":"311","author":"Sontag, S.; Graham, D.Y.; Belsito, A.; Weiss, J.; Farley, A.; Grunt, R.","year":"1984","unstructured":"Sontag S, Graham DY, Belsito A, Weiss J, Farley A, Grunt R, et al. Cimetidine, cigarette smoking and recurrence of duodenal ulcer. N EnglJr Med 1984; 311: 689-93.","journal-title":"N EnglJr Med"},{"key":"ref_26","first-page":"58","article-title":"Prevention of relapse with various antiulcer drugs","volume-title":"ScandJ Gastroenterol","volume":"121","author":"Bresci, G.; Capria, A.; Federici, G.; Rindi, G.; Geloni, M.; Corsini, G.","year":"1986","unstructured":"Bresci G, Capria A, Federici G, Rindi G, Geloni M, Corsini G. Prevention of relapse with various antiulcer drugs. ScandJ Gastroenterol 1986; 21 (suppl 121): 58-62."},{"issue":"62","key":"ref_27","first-page":"347","article-title":"Low dose maintenance treatment with cimetidine in duodenal ulcer: intermediate-term results","volume":"1986","author":"Bardhan, K.D.; Hinchliffe, R.F.C.; Bose, K.","unstructured":"Bardhan KD, Hinchliffe RFC, Bose K. Low dose maintenance treatment with cimetidine in duodenal ulcer: intermediate-term results. Postgrad MedJ7 1986; 62: 347-51.","journal-title":"Postgrad MedJ7"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/00365521.1984.12005741","article-title":"Safety of ranitidine maintenance treatment of duodenal ulcer","volume":"19","author":"Boyd, E.J.S.; Wilson, J.A.; Wormsley, K.G.","year":"1984","unstructured":"Boyd EJS, Wilson JA, Wormsley KG. Safety of ranitidine maintenance treatment of duodenal ulcer. Scand J Gastroenterol 1984; 19: 394-400.","journal-title":"Scand J Gastroenterol"},{"key":"ref_29","first-page":"149","article-title":"Comparison of maintenance treatment versus intermittent treatment with ranitidine in preventing duodenal ulcers","volume":"98","author":"Witzel, L.; Ansari, A.; Blum, A.L.; Merki, H.","year":"1990","unstructured":"Witzel L, Ansari A, Blum AL, Merki H. Comparison of maintenance treatment versus intermittent treatment with ranitidine in preventing duodenal ulcers. Gastroenterol 1990; 98: A149.","journal-title":"Gastroenterol"},{"key":"ref_30","first-page":"341","article-title":"Maintenance therapy with ranitidine following healing of acute duodenal ulcer","volume":"38","author":"Kozarek, R.; Berenson, M.; Berkowitz, J.; Bright-Asare, P.; DeLuca, V.; Font, R.","year":"1985","unstructured":"Kozarek R, Berenson M, Berkowitz J, Bright-Asare P, DeLuca V, Font R, et al. Maintenance therapy with ranitidine following healing of acute duodenal ulcer. Curr TherapRes 1985; 38: 341-51.","journal-title":"Curr TherapRes"},{"key":"ref_31","first-page":"1242","article-title":"H2-receptor antagonists and duodenal ulcer recurrence: analysis of efficacy and commentary on safety, costs and patient selection","volume":"82","author":"Freston, J.W.","year":"1987","unstructured":"Freston JW. H2-receptor antagonists and duodenal ulcer recurrence: analysis of efficacy and commentary on safety, costs and patient selection. Am J Gastroenterol 1987; 82: 1242-9.","journal-title":"Am J Gastroenterol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(78)91200-X","article-title":"Maintenance treatment of recurrent peptic ulcer by cimetidine","volume":"i:","author":"Bodemar, G.; Walan, A.","year":"1978","unstructured":"Bodemar G, Walan A. Maintenance treatment of recurrent peptic ulcer by cimetidine. Lancet 1978; i: 403-7.","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/00365528609003094","article-title":"Results of shortand long-term cimetidine treatment in patients with juxtapyloric ulcers, with special reference to gastric acid and pepsin secretion","volume":"21","author":"Strom, M.; Berstad, A.; Bodemar, G.; Walan, A.","year":"1986","unstructured":"Strom M, Berstad A, Bodemar G, Walan A. Results of shortand long-term cimetidine treatment in patients with juxtapyloric ulcers, with special reference to gastric acid and pepsin secretion. ScandJ Gastroenterol 1986; 21: 521-30.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/gut.24.5.418","article-title":"Ranitidine in the prevention of gastric and duodenal ulcer relapse","volume":"24","author":"Alstead, E.M.; Ryan, F.P.; Holdsworth, C.D.; Ashton, M.G.; Moore, M.","year":"1983","unstructured":"Alstead EM, Ryan FP, Holdsworth CD, Ashton MG, Moore M. Ranitidine in the prevention of gastric and duodenal ulcer relapse. Gut 1983; 24: 418-20.","journal-title":"Gut"},{"issue":"5","key":"ref_35","first-page":"33","article-title":"Results of the United States ranitidine maintenance trials","volume":"77","author":"Silvis, S.E.","year":"1984","unstructured":"Silvis SE. Results of the United States ranitidine maintenance trials. AmJ Med 1984; 77 (suppl 5B): 33-8.","journal-title":"AmJ Med"},{"issue":"4","key":"ref_36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0002-9343(86)90597-8","article-title":"Maintenance therapy of duodenal ulcer with famotidine. A multicenter United States study","volume":"81","author":"Texter, E.C.; Navab, F.; Mantell, G.; Berman, R.","year":"1986","unstructured":"Texter EC, Navab F, Mantell G, Berman R. Maintenance therapy of duodenal ulcer with famotidine. A multicenter United States study. AmJ Med 1986; 81 (suppl 4B): 25-32.","journal-title":"AmJ Med"},{"key":"ref_37","first-page":"1324","article-title":"Does maintenance therapy keep duodenal ulcers healed?","volume":"i:","author":"Boyd, E.J.S.; Penston, J.G.; Johnson, D.A.; Wormsley, K.G.","year":"1988","unstructured":"Boyd EJS, Penston JG, Johnson DA, Wormsley KG. Does maintenance therapy keep duodenal ulcers healed? Lancet 1988;i: 1324-7.","journal-title":"Lancet"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/00365521.1984.12005812","article-title":"The fate of asymptomatic recurrences of duodenal ulcer","volume":"19","author":"Boyd, E.J.S.; Wilson, J.A.; Wormsley, K.G.","year":"1984","unstructured":"Boyd EJS, Wilson JA, Wormsley KG. The fate of asymptomatic recurrences of duodenal ulcer. Scand J Gastroenterol 1984; 19: 808-12.","journal-title":"Scand J Gastroenterol"},{"issue":"177","key":"ref_39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/00365529009094496","article-title":"Mainternance treatment versus no treatment in patients with duodenal ulcer disease","volume":"25","author":"Penston, J.G.","year":"1990","unstructured":"Penston JG. Mainternance treatment versus no treatment in patients with duodenal ulcer disease. Scandj Gastroenterol 1990; 25 (suppl 177): 42-5 1.","journal-title":"Scandj Gastroenterol"},{"issue":"129","key":"ref_40","first-page":"325","article-title":"Factors influencing the treatment of perforated duodenal ulcer","volume":"1969","author":"Mark, J.B.D.","unstructured":"Mark JBD. Factors influencing the treatment of perforated duodenal ulcer. Surg Gynecol Obstet 1969; 129: 325-30.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_41","first-page":"382","article-title":"The natural history of the perforated duodenal ulcer treated by suture plication","volume":"183","author":"Griffin, G.E.; Organ, C.H.","year":"1976","unstructured":"Griffin GE, Organ CH. The natural history of the perforated duodenal ulcer treated by suture plication. Ann Surg 1976; 183: 382-5."},{"key":"ref_42","first-page":"749","article-title":"Natural history of perforated duodenal ulcers treated by suture plication","volume":"ii:","author":"Drury, J.K.; McKay, A.J.; Hutchinson, J.S.F.; Joffe, S.N.","year":"1978","unstructured":"Drury JK, McKay AJ, Hutchinson JSF, Joffe SN. Natural history of perforated duodenal ulcers treated by suture plication. Lancet 1978; ii: 749-50.","journal-title":"Lancet"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/00365528708991869","article-title":"Asymptomatic peptic ulcer disease","volume":"22","author":"Jorde, R.; Burhol, P.G.","year":"1987","unstructured":"Jorde R, Burhol PG. Asymptomatic peptic ulcer disease. ScandJ Gastroentrol 1987; 22: 129-34.","journal-title":"ScandJ Gastroentrol"},{"key":"ref_44","first-page":"27","article-title":"Are hemorrhagic gastro-duodenal ulcers frequently asymptomatic or associated with pain?","volume":"100","author":"Aucouturier, J.P.; Renard, P.; Carteret, E.; Minault, S.; Zeitoun, P.","year":"1991","unstructured":"Aucouturier JP, Renard P, Carteret E, Minault S, Zeitoun P. Are hemorrhagic gastro-duodenal ulcers frequently asymptomatic or associated with pain? Gastroenterology 1991; 100: A27","journal-title":"Gastroenterology"},{"key":"ref_45","first-page":"1689","article-title":"The effect of cisapride on intraduodenal","volume-title":"pH in man. Gastroenterology 1987; 92","author":"Weiser, H.F.; Schippers, E.; Seebauer, L.","unstructured":"Weiser HF, Schippers E, Seebauer L. The effect of cisapride on intraduodenal pH in man. Gastroenterology 1987; 92: 1689."},{"key":"ref_46","first-page":"482","article-title":"Contractile activity of the sphincter of Oddi and duodenum is inhibited by cisapride in the Australian brush-tailed possum","volume-title":"vitro. Gastroenterology 1990","volume":"98","author":"Baker, R.A.; Saccone, G.T.P.; Toouli, J.","unstructured":"Baker RA, Saccone GTP, Toouli J. Contractile activity of the sphincter of Oddi and duodenum is inhibited by cisapride in the Australian brush-tailed possum in vitro. Gastroenterology 1990; 98: A482."},{"key":"ref_47","first-page":"27","article-title":"Does Helicobacter pylori gastritis change gastric emptying of a solid meal?","volume":"98","author":"Caldwell, S.H.; Marshall, B.J.; Hoffman, SR, Valenzuela; G, McCallum; R.W.","year":"1990","unstructured":"Caldwell SH, Marshall BJ, Hoffman SR, Valenzuela G, McCallum RW. Does Helicobacter pylori gastritis change gastric emptying of a solid meal? Gastroenterology 1990; 98: A27.","journal-title":"Gastroenterology"},{"issue":"67","key":"ref_48","first-page":"96","article-title":"Ueber penetrierende magen - und jejunalgeschwure","volume":"1910","author":"Schwarz, C.","unstructured":"Schwarz C. Ueber penetrierende magen - und jejunalgeschwure. BeitrKlin Chir 1910; 67: 96-128.","journal-title":"BeitrKlin Chir"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.34.8.1042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:06:22Z","timestamp":1765656382000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.34.8.1042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1993,8,1]]},"published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1136\/gut.34.8.1042"],"URL":"https:\/\/doi.org\/10.1136\/gut.34.8.1042","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}