{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:47:48Z","timestamp":1768549668318,"version":"3.49.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>Helicobacter pylori (H pylori) eradication heals chronic active type B gastritis and dramatically changes the natural history of duodenal ulcer disease. There are few data concerning the role of anti-H pylori treatment in gastric ulcer disease. A total of 83 patients presenting with H pylori positive active gastric ulcer disease were treated with omeprazole and antibiotics (amoxicillin, ciprofloxacin, roxithromycin) in seven different clinical protocols, each of which included the attempt to eradicate H pylori infection and to evaluate the post-therapeutic course of ulcer disease. The overall proportion of H pylori eradication was 67.9% (53 of 78 patients available for follow up). Best results were obtained with two week treatment regimens comprising omeprazole 20 mg twice daily and amoxicillin 500 mg four times a day or 1000 mg twice daily (eradication &gt; 80%). Eradication of H pylori speeds up ulcer healing, with a six week healing rate of 84.9% compared with 60% in patients with persistent H pylori infection (p = 0.0148). In a subgroup of 11 patients with refractory ulcers, H pylori eradication (n = 10) was associated with ulcer healing on continued acid suppression in nine cases. One male patient with chronic antral ulcer did not respond to treatment within the next six months (H pylori and ulcer persistence), and in one female patient a resistant body ulcer was identified as gastric lymphoma. Fifty patients with healed ulcers were followed up for one year. Patients with (n = 32) and without (n = 18) bacterial eradication had similar demographic and clinical characteristics. H pylori eradication was associated with a statistically significant reduction of ulcer recurrences (3.1 v 55.6%, p&lt;0.001). This study concludes that H pylori eradication considerably changes the natural history of H pylori associated gastric ulcer disease. In addition, H pylori eradication speeds up ulcers healing and is associated with healing of previously refractory ulcers. Thus, treatment aimed at bacterial eradication should be considered in all patients with gastric ulcers severe enough to contemplate further treatment options.<\/jats:p>","DOI":"10.1136\/gut.35.1.19","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"19-22","source":"Crossref","is-referenced-by-count":119,"title":["Evidence for the essential role of Helicobacter pylori in gastric ulcer disease."],"prefix":"10.1136","volume":"35","author":[{"given":"J","family":"Labenz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"B\u00f6rsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"ref_1","first-page":"697","article-title":"High dose omeprazole treatment combined with amoxicillin eradicates Helicobacter pylori","volume":"4","author":"Bayerdorffer, E.; Mannes, G.A.; Sommer, A.; Hochter, W.; Weingart, J.; Hatz, R.","year":"1992","unstructured":"Bayerdorffer E, Mannes GA, Sommer A, Hochter W, Weingart J, Hatz R, et al. High dose omeprazole treatment combined with amoxicillin eradicates Helicobacter pylori. EurJ Gastroenterol Hepatol 1992; 4: 697-702.","journal-title":"EurJ Gastroenterol Hepatol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-116-9-705","article-title":"Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer","volume":"116","author":"Graham, D.Y.; Lew, G.M.; Klein, P.D.; Evans, D.G.; Evans, D.J.; Saeed, Z.A.","year":"1992","unstructured":"Graham DY, Lew GM, Klein PD, Evans DG, Evans DJ, Saeed ZA, et al. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. Ann Intern Med 1992; 116: 705-8.","journal-title":"Ann Intern Med"},{"key":"ref_3","first-page":"1437","article-title":"Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori","volume":"ii:","author":"Marshall, B.J.; Goodwin, C.S.; Warren, JR, Murray; R, Blincow; D, Blackbourn; S.J.","year":"1988","unstructured":"Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow D, Blackbourn SJ, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 1988; ii: 1437-42.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(90)91301-P","article-title":"Cure of duodenal ulcer associated with eradication of Helicobacter pylori","volume":"ii:","author":"Rauws, E.A.J.; Tytgat, G.N.J.","year":"1990","unstructured":"Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 1990; ii: 1233-5.","journal-title":"Lancet"},{"key":"ref_5","first-page":"36","article-title":"Helicobacter pylori: causal agent in peptic ulcer disease? Working Party Report. World Congress of Gastroenterology: 26th-31st","author":"Tytgat, G.N.J.; Axon, A.T.R.; Dixon, M.F.; Graham, D.Y.; Lee, A.; Marshall, B.J.","year":"1990","unstructured":"Tytgat GNJ, Axon ATR, Dixon MF, Graham DY, Lee A, Marshall BJ. Helicobacter pylori: causal agent in peptic ulcer disease? Working Party Report. World Congress of Gastroenterology: 26th-31st August 1990, Sydney, Australia. Oxford: Blackwell Scientific, 1990: 36-45."},{"key":"ref_6","first-page":"391","article-title":"Nachweis von Helicobacter pylori","volume":"132","author":"Borsch, G.; Labenz, J.; Rehner, M.; Ruhl, G.H.; Gyenes, E.","year":"1990","unstructured":"Borsch G, Labenz J, Rehner M, Ruhl GH, Gyenes E. Nachweis von Helicobacter pylori. Munch Med Wschr 1990; 132: 391-4.","journal-title":"Munch Med Wschr"},{"key":"ref_7","first-page":"461","article-title":"Diagnosis of Helicobacter pyloni colonization of gastric mucosa. A prospective comparative study of direct tests and validity of a new urease test","volume":"86","author":"Labenz, J.; Gyenes, E.; Ruhl, G.H.; Peitz, U.; Borsch, G.","year":"1991","unstructured":"Labenz J, Gyenes E, Ruhl GH, Peitz U, Borsch G. Diagnosis of Helicobacter pyloni colonization of gastric mucosa. A prospective comparative study of direct tests and validity of a new urease test. Med Klin 1991; 86: 461-4.","journal-title":"Med Klin"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.1711540203","article-title":"Chronic gastritis - a pathogenetic approach","volume":"154","author":"Wyatt, J.I.; Dixon, M.F.","year":"1988","unstructured":"Wyatt JI, Dixon MF. Chronic gastritis - a pathogenetic approach. J Pathol 1988; 154: 113-24.","journal-title":"J Pathol"},{"key":"ref_9","first-page":"33","article-title":"Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effect of antibacterial","volume-title":"and antiulcer treatment. Gastroenterology 1988; 94","author":"Rauws, E.A.J.; Langenberg, W.; Houthoff, H.J.; Zanen, H.C.; Tytgat, G.N.J.","unstructured":"Rauws EAJ, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GNJ. Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effect of antibacterial and antiulcer treatment. Gastroenterology 1988; 94: 33-40."},{"issue":"10","key":"ref_10","first-page":"30","article-title":"Antibacterial treatment of gastric ulcers. German gastric ulcer study","volume":"161","author":"Bayerdorffer, E.; Mannes, G.A.; Hochter, W.; Weingart, J.; Sommer, A.; Klann, H.","year":"1992","unstructured":"Bayerdorffer E, Mannes GA, Hochter W, Weingart J, Sommer A, Klann H, et al. Antibacterial treatment of gastric ulcers. German gastric ulcer study. IrJ7 Med Sci 1992; 161 (suppl 10): 30.","journal-title":"IrJ7 Med Sci"},{"key":"ref_11","first-page":"166","article-title":"Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing","volume":"115","author":"Graham, D.Y.; Lew, G.M.; Evans, D.G.; Evans, D.J.; Klein, P.D.","year":"1991","unstructured":"Graham DY, Lew GM, Evans DG, Evans DJ, Klein PD. Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing. 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Am 7 Gastroenterol 1992; 87: 1271.","journal-title":"Am 7 Gastroenterol"},{"key":"ref_14","article-title":"Amoxicillin plus omeprazole versus triple therapy for eradication of Helicobacter pylori in duodenal ulcer disease","author":"Labenz, J.; Gyenes, E.; Ruhl, G.H.; Borsch, G.","unstructured":"Labenz J, Gyenes E, Ruhl GH, Borsch G. Amoxicillin plus omeprazole versus triple therapy for eradication of Helicobacter pylori in duodenal ulcer disease. Gut (In press)."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0140-6736(92)90502-T","article-title":"Clarithromycin and omeprazole for Helicobacter pylori","volume":"340","author":"Logan, R.P.H.; Gummett, P.A.; Hegarty, B.T.; Walker, M.M.; Baron, J.H.; Misiewicz, J.J.","year":"1992","unstructured":"Logan RPH, Gummett PA, Hegarty BT, Walker MM, Baron JH, Misiewicz JJ. Clarithromycin and omeprazole for Helicobacter pylori. 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