{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:20:09Z","timestamp":1764998409912,"version":"3.46.0"},"reference-count":38,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>The staining of HLA class II antigens, the presence of cells positive for interleukin-2 receptors, the proportion of crypt cells in mitosis in the jejunal biopsy specimens, and the dose of coeliac disease marker HLA-DQ genes were studied in 75 healthy family members of coeliac disease patients. Eleven had silent coeliac disease; in the rest the morphology of the jejunum was normal. In the specimens from family members, staining of epithelial cells with HLA-DP and -DR antibodies was more widely distributed and stronger than in those from 19 controls. Interleukin-2 receptor+ cells were seen in the epithelium of all eight specimens from subjects with silent coeliac disease, and also in 24 morphologically normal specimens from family members, but not in the 19 control specimens. The proportion of crypt cells in mitosis was increased only in the specimens from the subjects with silent coeliac disease. The staining intensity of the epithelial cells with HLA-DP and -DR antibodies, the presence of interleukin-2 receptor+ cells and the percentage of crypt cells in mitosis were significantly associated with the number of coeliac disease marker DQB genes. Many family members of patients with coeliac disease have signs of inflammation even in morphologically normal jejunum; these inflammatory changes together with coeliac disease marker DQ genes may point to latent disease in these subjects.<\/jats:p>","DOI":"10.1136\/gut.35.1.55","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"55-60","source":"Crossref","is-referenced-by-count":32,"title":["Immunohistochemical changes in the jejunum in first degree relatives of patients with coeliac disease and the coeliac disease marker DQ genes. HLA class II antigen expression, interleukin-2 receptor positive cells and dividing crypt cells."],"prefix":"10.1136","volume":"35","author":[{"given":"K","family":"Holm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Savilahti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Koskimies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Lipsanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"M\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0198-8859(88)90062-6","article-title":"An HLA-DQ alpha allele identified at DNA and protein level is strongly associated with coeliac disease","volume":"23","author":"Roep, B.O.; Bontrop, R.E.; Pena, A.S.; van Eggermond, M.C.J.A.; van Rood, J.J.; Giphart, M.J.","year":"1988","unstructured":"Roep BO, Bontrop RE, Pena AS, van Eggermond MCJA, van Rood JJ, Giphart MJ. An HLA-DQ alpha allele identified at DNA and protein level is strongly associated with coeliac disease. Human Immunol 1988; 23: 271-9.","journal-title":"Human Immunol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.169.1.345","article-title":"Evidence for a primary association of celiac disease to a particular HLA-DQ alpha\/beta heterodimer","volume":"169","author":"Sollid, L.M.; Markussen, G.; Ek, J.; Gjerde, H.; Vartdal, F.; Thorsby, E.","year":"1989","unstructured":"Sollid LM, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha\/beta heterodimer. J Exp Med 1989; 169: 345-50.","journal-title":"J Exp Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","article-title":"Gluten, major histocompatibility complex, and the small intestine - A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue)","volume":"102","author":"Marsh, M.N.","year":"1992","unstructured":"Marsh MN. Gluten, major histocompatibility complex, and the small intestine - A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology 1992; 102: 330-54.","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0016-5085(74)80034-X","article-title":"Latent celiac sprue","volume":"66","author":"Weinstein, W.M.","year":"1974","unstructured":"Weinstein WM. Latent celiac sprue. Gastroenterology 1974; 66: 489-93.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3109\/00365528708991895","article-title":"Effects of additional dietary gluten on the small-intestinal mucosa of volunteers and of patients with dermatitis herpetiformis","volume":"22","author":"Ferguson, A.; Blackwell, J.N.; RStC, Barnetson","year":"1987","unstructured":"Ferguson A, Blackwell JN, Barnetson RStC. Effects of additional dietary gluten on the small-intestinal mucosa of volunteers and of patients with dermatitis herpetiformis. ScandJ Gastroenterol 1987; 22: 543-9.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0140-6736(81)92860-9","article-title":"Gluten-induced mucosal changes in subjects without overt small-bowel disease","volume":"i:","author":"Doherty, M.; Barry, R.E.","year":"1981","unstructured":"Doherty M, Barry RE. Gluten-induced mucosal changes in subjects without overt small-bowel disease. Lancet 1981; i: 517-20.","journal-title":"Lancet"},{"key":"ref_7","first-page":"1137","article-title":"Normal small bowel biopsy followed by coeliac disease","volume":"65","year":"1990","unstructured":"Maki M, Holm K, Koskimies S, Hallstrom 0, Visakorpi J. Normal small bowel biopsy followed by coeliac disease. Arch DisChild 1990; 65: 1137-41.","journal-title":"Arch DisChild"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1136\/gut.27.12.1464","article-title":"Gluten challenge in children with dermatitis herpetiformis: A clinical, morphological and immunohistological study","volume":"27","author":"Kosnai, I.; Karpati, S.; Savilahti, E.; Verkasalo, M.; Bucsky, P.; Torok, E.","year":"1986","unstructured":"Kosnai I, Karpati S, Savilahti E, Verkasalo M, Bucsky P, Torok E. Gluten challenge in children with dermatitis herpetiformis: A clinical, morphological and immunohistological study. Gut 1986; 27: 1464-70.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/0140-6736(90)93029-O","article-title":"Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease","volume":"335","author":"O'Mahony, S.; Vestey, J.P.; Ferguson, A.","year":"1990","unstructured":"O'Mahony S, Vestey JP, Ferguson A. Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. Lancet 1990; 335: 1487-90.","journal-title":"Lancet"},{"key":"ref_10","first-page":"125","article-title":"Studies of intestinal lymphoid tissue. XV. Histopathologic features suggestive of cell-mediated reactivity in jejunal mucosae of patients with dermatitis herpetiformis","volume":"416","author":"Marsh, M.N.","year":"1989","unstructured":"Marsh MN. Studies of intestinal lymphoid tissue. XV. Histopathologic features suggestive of cell-mediated reactivity in jejunal mucosae of patients with dermatitis herpetiformis. Virchows Arch [A] 1989; 416: 125-32.","journal-title":"Virchows Arch [A]"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/gut.31.1.32","article-title":"Studies of intestinal lymphoid tissue. XIV-HLA status, mucosal morphology, permeability and epithelial lymphocyte populations in first degree relatives of patients with coeliac disease","volume":"31","author":"Marsh, M.N.; Bjarnason, I.; Shaw, J.; Ellis, A.; Baker, R.; Peters, T.J.","year":"1990","unstructured":"Marsh MN, Bjarnason I, Shaw J, Ellis A, Baker R, Peters TJ. Studies of intestinal lymphoid tissue. XIV-HLA status, mucosal morphology, permeability and epithelial lymphocyte populations in first degree relatives of patients with coeliac disease. Gut 1990; 31: 32-6.","journal-title":"Gut"},{"key":"ref_12","first-page":"35","article-title":"Correlation of HLA-DR alleles to jejunal mucosal morphology in healthy first-degree relatives of coeliac disease patients","volume":"5","author":"Holm, K.","year":"1993","unstructured":"Holm K. Correlation of HLA-DR alleles to jejunal mucosal morphology in healthy first-degree relatives of coeliac disease patients. EurJ3 Gastroenterol Hepatol 1993; 5: 35-9."},{"key":"ref_13","first-page":"1500","article-title":"Dose effect of DQA and DQB genes on the density of intraepithelial gamma\/delta T cell receptor bearing lymphocytes in healthy first-degree relatives of coeliac disease patients","volume":"339","author":"Holm, K.; Maki, M.; Savilahti, E.; Lipsanen, V.; Laippala, P.; Koskimies, S.","year":"1992","unstructured":"Holm K, Maki M, Savilahti E, Lipsanen V, Laippala P, Koskimies S. Dose effect of DQA and DQB genes on the density of intraepithelial gamma\/delta T cell receptor bearing lymphocytes in healthy first-degree relatives of coeliac disease patients. Lancet 1992; 339: 1500-3.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gut.32.11.1412","article-title":"Increase of gamma\/ delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease","volume":"32","author":"Maki, M.; Holm, K.; Collin, P.; Savilahti, E.","year":"1991","unstructured":"Maki M, Holm K, Collin P, Savilahti E. Increase of gamma\/ delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut 1991; 32: 1412-4.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/0140-6736(91)92234-S","article-title":"Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease","volume":"338","author":"true","year":"1991","unstructured":"Maki M, Holm K, Lipsanen V, Hallstrom 0, Viander M, Collin P, et al. Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet 1991; 338: 1350-3.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gut.30.3.339","article-title":"Changes in intraepithaliel lymphocyte subpopulations in coeliac disease and enteropathy associated T cell Iymphoma (malignant histiocytosis of the intestine)","volume":"30","author":"Spencer, J.; MacDonald, T.T.; Diss, T.C.; Walker-Smith, J.A.; Ciclitira, P.J.; Isaacson, P.G.","year":"1989","unstructured":"Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG. Changes in intraepithaliel lymphocyte subpopulations in coeliac disease and enteropathy associated T cell Iymphoma (malignant histiocytosis of the intestine). Gut 1989; 30: 339-46.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/eji.1830140404","article-title":"HLA-DC antigen can serve as recognition elements for human cytotoxic T lymphocytes","volume":"14","author":"Spits, H.; Borst, J.; Giphart, M.; Coligan, J.; Terhorst, C.; De Vries, J.E.","year":"1984","unstructured":"Spits H, Borst J, Giphart M, Coligan J, Terhorst C, De Vries JE. HLA-DC antigen can serve as recognition elements for human cytotoxic T lymphocytes. Eur J Immunol 1984; 14: 299-304.","journal-title":"Eur J Immunol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.133.4.1710","article-title":"Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki67","volume":"133","author":"Gerdes, J.; Lemke, H.; Baisch, H.; Wacker, H.-H.; Schwab, U.; Stein, H.","year":"1984","unstructured":"Gerdes J, Lemke H, Baisch H, Wacker H-H, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki67.J Immunol 1984; 133: 1710-5.","journal-title":"J Immunol"},{"key":"ref_19","article-title":"Immunology of HLA. II. Immunogenetics and histocompatibility","author":"Dupont, B.","year":"1989","unstructured":"Dupont B. Immunology of HLA. II. Immunogenetics and histocompatibility. New York: Springer, 1989."},{"key":"ref_20","first-page":"9","article-title":"HLA and coeliac disease, a Finnish family study","volume-title":"disease. 40 years gluten-free","author":"Koskimies, S.; Lipsanen, V.; Maki, M.; Visakorpi, J.","year":"1991","unstructured":"Koskimies S, Lipsanen V, Maki M, Visakorpi J. HLA and coeliac disease, a Finnish family study. In: Mearin ML, Mulder CJJ, eds. Coeliac disease. 40 years gluten-free. Dordrecht\/Boston\/London: Kluwer Academic, 1991: 9-13."},{"key":"ref_21","first-page":"233","article-title":"Relations between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coeliac disease or dermatits herpetiformis. Clin Exp Immunol","volume":"44","author":"Scott, H.; Brandtzaeg, P.; Solheim, B.G.; Thorsby, E.","year":"1981","unstructured":"Scott H, Brandtzaeg P, Solheim BG, Thorsby E. Relations between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coeliac disease or dermatits herpetiformis. Clin Exp Immunol 1981; 44: 233-8."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0016-5085(86)80018-X","article-title":"Increased HLA-DR expression by enterocytes in children with celiac disease","volume":"91","author":"Arnaud-Battandier, F.; Cerf-Bensussan, N.; Amsellem, R.; Schmitz, J.","year":"1986","unstructured":"Arnaud-Battandier F, Cerf-Bensussan N, Amsellem R, Schmitz J. Increased HLA-DR expression by enterocytes in children with celiac disease. Gastroenterology 1986; 91: 1206-12.","journal-title":"Gastroenterology"},{"key":"ref_23","first-page":"386","article-title":"DP and DQ expression in the small intestine of patients with coeliac disease","volume":"70","author":"Marley, N.J.; Macartney, J.C.; HLA-DR, Ciclitira P.J.","year":"1987","unstructured":"Marley NJ, Macartney JC, Ciclitira PJ. HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease. Clin Exp Immunol 1987; 70: 386-93.","journal-title":"Clin Exp Immunol"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/353134a0","article-title":"MHC class-II structure occupancy and surface expression determined by postendoplasmic reticulum antigen binding","volume":"353","author":"Germain, R.N.; Hendrix, L.R.","year":"1991","unstructured":"Germain RN, Hendrix LR. MHC class-II structure occupancy and surface expression determined by postendoplasmic reticulum antigen binding. Nature 1991; 353: 134-9.","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.4049\/jimmunol.130.6.2615","article-title":"Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies","volume":"130","author":"Cerf-Bensussan, N.; Schneeberger, E.E.; Bhan, A.K.","year":"1983","unstructured":"Cerf-Bensussan N, Schneeberger EE, Bhan AK. Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. J Immunol 1983; 130: 2615-22.","journal-title":"J Immunol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/gut.27.2.153","article-title":"Expression of HLA-DR antigens on epithelium associated with lymphoid tissue in the human gastrointestinal trace","volume":"27","author":"Spencer, J.; Finn, T.; Isaacson, P.G.","year":"1986","unstructured":"Spencer J, Finn T, Isaacson PG. Expression of HLA-DR antigens on epithelium associated with lymphoid tissue in the human gastrointestinal trace. Gut 1986; 27: 153-7.","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1203\/00006450-199012000-00005","article-title":"Intestinal gamma\/delta receptor-bearing T lymphocytes in celiac disease and inflammatory bowel diseases in children. Constant increase in celiac disease","volume":"28","author":"Savilahti, E.; Arato, A.; Verkasalo, M.","year":"1990","unstructured":"Savilahti E, Arato A, Verkasalo M. Intestinal gamma\/delta receptor-bearing T lymphocytes in celiac disease and inflammatory bowel diseases in children. Constant increase in celiac disease. Pediatr Res 1990; 28: 579-81.","journal-title":"Pediatr Res"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1399-0039.1988.tb02076.x","article-title":"Differential expression of HLA-DR gene products in the normal and coeliac small bowel","volume":"29","author":"Kelly, J.; Weir, D.G.; Feighery, C.","year":"1988","unstructured":"Kelly J, Weir DG, Feighery C. Differential expression of HLA-DR gene products in the normal and coeliac small bowel. Tissue Antigens 1988; 29: 151-60.","journal-title":"Tissue Antigens"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0016-5085(91)90575-6","article-title":"Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease","volume":"100","author":"Mayer, L.; Eisenhardt, D.; Salomon, P.; Bauer, W.; Plous, R.; Piccinini, L.","year":"1991","unstructured":"Mayer L, Eisenhardt D, Salomon P, Bauer W, Plous R, Piccinini L. Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease. Gastroenterology 1991; 100: 3-12.","journal-title":"Gastroenterology"},{"key":"ref_30","first-page":"605","article-title":"Expression of HLA-DQ antigens in the small-intestinal mucosa of patients with coeliac disease. ScandJ'","volume":"26","author":"Schweizer, J.J.; Mearin, M.L.; Pena, A.S.; Offerhaus, G.J.A.; Dreef, E.J.; Roep, B.O.","year":"1991","unstructured":"Schweizer JJ, Mearin ML, Pena AS, Offerhaus GJA, Dreef EJ, Roep BO, et al. Expression of HLA-DQ antigens in the small-intestinal mucosa of patients with coeliac disease. ScandJ' Gastroenterol 1991; 26: 605-10.","journal-title":"Gastroenterol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0167-5699(91)90124-C","article-title":"What is the basis for HLA-DQ associations with autoimmune disease","volume":"12","author":"Altmann, D.M.; Sansom, D.; Marsh, S.G.E.","year":"1991","unstructured":"Altmann DM, Sansom D, Marsh SGE. What is the basis for HLA-DQ associations with autoimmune disease. Immunol Today 1991; 12: 267-70.","journal-title":"Immunol Today"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/gut.14.9.701","article-title":"Cell kinetics in flat (avillous) mucosa of the human small intestine","volume":"14","author":"Wright, N.; Watson, A.; Morley, A.; Appleton, D.; Marks, J.","year":"1973","unstructured":"Wright N, Watson A, Morley A, Appleton D, Marks J. Cell kinetics in flat (avillous) mucosa of the human small intestine. Gut 1973; 14: 701-10.","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/gut.32.1.61","article-title":"Mucosal characteristics of pelvic ileal pouches","volume":"32","author":"HJ, De Silva; PR, Millard; M, Kettlewell; NJ, Mortensen; C, Prince; DP, Jewell","year":"1991","unstructured":"De Silva HJ, Millard PR, Kettlewell M, Mortensen NJ, Prince C, Jewell DP. Mucosal characteristics of pelvic ileal pouches. Gut 1991; 32: 61-5.","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0167-5699(88)91267-4","article-title":"Specificity and function of T cells bearing gammadelta receptors","volume":"9","author":"CA, Jr, Janeway; B, Jones; A, Hayday","year":"1988","unstructured":"Janeway CA Jr, Jones B, Hayday A. Specificity and function of T cells bearing gammadelta receptors. Immunol Today 1988; 9: 73-6.","journal-title":"Immunol Today"},{"issue":"2","key":"ref_35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000200400","article-title":"Role of in vivo activated T cells in the mechanisms of villous atrophy in humans: study of allograft rejection","volume":"46","author":"true","year":"1990","unstructured":"Cerf-Bensussan N, Brousse N, Jarry A, Goulet 0, Revillon Y, Ricour C, et al. Role of in vivo activated T cells in the mechanisms of villous atrophy in humans: study of allograft rejection. Digestion 1990; 46 (suppl 2): 297-301.","journal-title":"Digestion"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1084\/jem.167.4.1341","article-title":"Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine","volume":"167","author":"MacDonald, T.T.; Spencer, J.","year":"1988","unstructured":"MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 1988; 167: 1341-50.","journal-title":"J Exp Med"},{"key":"ref_37","first-page":"177","article-title":"Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel. Clin Exp Immunol","volume":"68","author":"Kelly, J.; O'Farrelly, C.; O'Mahony, C.; Weir, D.G.; Feighery, C.","year":"1987","unstructured":"Kelly J, O'Farrelly C, O'Mahony C, Weir DG, Feighery C. Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel. Clin Exp Immunol 1987; 68: 177-88."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/0016-5085(89)90379-X","article-title":"Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli","volume":"97","author":"Ebert, E.C.","year":"1989","unstructured":"Ebert EC. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 1989; 97: 1372-81.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.1.55","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:17:06Z","timestamp":1764998226000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.1.55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1994,1,1]]},"published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1136\/gut.35.1.55"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.1.55","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}