{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:14:09Z","timestamp":1772748849188,"version":"3.50.1"},"reference-count":38,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel disease and correlated it with the disease activity in 95 patients with inflammatory bowel disease (ulcerative colitis (n = 52), Crohn's disease (n = 43)) determined by the simple index of Harvey and Bradshaw. Fifty patients were in complete clinical remission and 45 patients had active disease. Microalbuminuria was detected in all patients with inflammatory bowel disease (147 (17) v 18 (2) microgram\/min, inflammatory bowel disease v controls mean (SEM), p &lt; 0.007). Patients with active inflammatory bowel disease had higher concentrations of microalbuminuria compared with patients in remission (206 (19) v 65 (8) microgram\/min, mean (SEM), p &lt; 0.0001). Eight patients with active inflammatory bowel disease who were sequentially followed up with measurements of microalbuminuria had significantly lower values, when the disease was inactive (active inflammatory bowel disease 192 (44) v inactive inflammatory bowel disease 64 (14) microgram\/min, p &lt; 0.03). There was a significant correlation with the simple index of Harvey and Bradshaw (r = 0.818, p &lt; 0.0001). Microalbuminuria values were significantly lower in inflammatory bowel disease patients in remission, maintained with olsalazine compared with those patients maintained with mesalazine and salazopyrine, but no significant difference was seen in values of microalbuminuria in active inflammatory bowel disease patients receiving different salicylates. This study also measured serum amyloid-A as an indicator of the acute phase response in the same patients. Serum amyloid-A was significantly increased in active disease compared with inactive disease (151 (43) v 33 (7) or controls 11 (2) micrograms\/ml, p &lt; 0.05). In conclusion microalbuminuria is present in abnormal amounts in all patients with active inflammatory bowel disease, and values fall when the disease is quiescent. Microalbuminuria is probably a consequence of an acute phase response and provides a simple, rapid, and inexpensive test, which has the potential to monitor inflammatory bowel disease activity and response to treatment.<\/jats:p>","DOI":"10.1136\/gut.35.11.1599","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1599-1604","source":"Crossref","is-referenced-by-count":48,"title":["Microalbuminuria in inflammatory bowel disease."],"prefix":"10.1136","volume":"35","author":[{"given":"N","family":"Mahmud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Stinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Mantle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P W","family":"Keeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Feely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G","family":"Weir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJM198402093100605","article-title":"Microalbuminuria predicts clinical proteinuria and increased mortality in maturity onset diabetes","volume":"310","author":"Mogensen, C.E.","year":"1984","unstructured":"Mogensen CE. 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J Clin Gastroenterol 1986; 6: 65 1-4.","journal-title":"J Clin Gastroenterol"},{"key":"ref_17","first-page":"1121","article-title":"Clinical activity assessment in inflammatory bowel disease","volume":"90","author":"Singleton, J.W.I.X.","year":"1987","unstructured":"Singleton JWIX. Clinical activity assessment in inflammatory bowel disease. Dig Dis Sci 1987; 32: 42-5S. 18 Saverymuttu SH, Camerilli M, Rees H, Lavender JP, Hodgson HJF, Chadwick VS. Indium-li11 granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. Gastroenterology 1986; 90: 1121-8.","journal-title":"Dig Dis Sci; 32: 42-5S. 18 Saverymuttu SH"},{"key":"ref_18","first-page":"388","article-title":"Location and activity of ulcerative colitis and Crohn's colitis by indium-i","volume-title":"11l leucocyte scan. 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Gut 1990; 31: 1365-70.","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0140-6736(92)90999-J","article-title":"Stool TNF as a marker of intestinal inflammation","volume":"339","author":"Braegger, C.P.; Nicholls, S.; Murch, S.H.; Stephens, S.; MacDonald, I.T.","year":"1992","unstructured":"Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald IT. Stool TNF as a marker of intestinal inflammation. Lancet 1992; 339: 89-91.","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/gut.30.6.835","article-title":"Enhanced production of interleukin-1 by the mononuclear cells isolated from the mucosa with active ulcerative colitis and Crohn's disease","volume":"30","author":"Mahida, Y.R.; Wu, K.; Jewell, D.P.","year":"1989","unstructured":"Mahida YR, Wu K, Jewell DP. 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FEBS Lett 1988; 232: 347-50.","journal-title":"FEBS Lett"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1084\/jem.162.3.930","article-title":"Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin-1 (IL-1) and purified human IL-1","volume":"162","author":"Ramadori, G.; Sipe, J.D.; Mizel, S.B.; Dinarello, C.A.; Colten, H.R.","year":"1985","unstructured":"Ramadori G, Sipe JD, Mizel SB, Dinarello CA, Colten HR. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin-1 (IL-1) and purified human IL-1. J Exp Med 1985; 162: 930-42.","journal-title":"J Exp Med"},{"key":"ref_35","first-page":"659","article-title":"Endotoxin, interleukin-I (IL-1) and tumor necrosis factor (TNF) cause neutrophil-dependent microvascular leakage in postcapillary venules","volume":"140","author":"Yi, E.S.; Ulich, T.R.","year":"1992","unstructured":"Yi ES, Ulich TR. 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Lab Invest 1982; 47: 177-84.","journal-title":"Lab Invest"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0140-6736(93)90485-Y","article-title":"Disruption of sulphated glycosaminoglycans in intestinal inflammation","volume":"341","year":"1993","unstructured":"Murch SH, MacDonald 1T, Walter-Smith JA, Levin M, Lionetti, P, Klein NJ. Disruption of sulphated glycosaminoglycans in intestinal inflammation. Lancet 1993; 341: 711-4.","journal-title":"Lancet"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1242\/jcs.102.4.821","article-title":"Alteration in glycoaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils","volume":"102","author":"Klein, N.J.; Shennan, G.I.; Heyderman, R.S.; Levin, M.","year":"1992","unstructured":"Klein NJ, Shennan GI, Heyderman RS, Levin M. 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