{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:08:48Z","timestamp":1770822528420,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>The expression of nerve growth factor receptor in colon from 20 patients with Hirshsprung's disease and 10 controls was studied immunohistochemically. The myenteric and submucous plexuses in the ganglionic bowel and hypertrophic nerve trunks in the aganglionic bowel displayed strong expression of nerve growth factor receptor. The most important finding was the identical localisation of nerve growth factor receptor immunoreactivity on the perineurium of both hypertrophic nerve trunks in Hirshsprung's diseases, and of normal extrinsic nerves, seen as a thick ring surrounding the nerve trunks. This suggests that the hypertrophic nerve trunks are of extrinsic origin and that nerve growth factor receptor plays a role in their development and maintenance.<\/jats:p>","DOI":"10.1136\/gut.35.11.1605","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1605-1607","source":"Crossref","is-referenced-by-count":24,"title":["Nerve growth factor receptor immunostaining suggests an extrinsic origin for hypertrophic nerves in Hirschsprung's disease."],"prefix":"10.1136","volume":"35","author":[{"given":"H","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"O'Briain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/0896-6273(89)90040-8","article-title":"Trophic factors and neuronal survival","volume":"2","author":"Barde, Y.A.","year":"1989","unstructured":"Barde YA. 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Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): distribution, morphology, and colocalization with cholinergic enzymes.JyComp Neurol 1988; 277: 465-86.","journal-title":"JyComp Neurol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ana.410300613","article-title":"Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates","volume":"30","author":"Koliatsos, V.E.; Clatterbuck, R.E.; Nauta, H.W.; Knusel, B.; Burton, L.E.; Hefti, F.F.","year":"1991","unstructured":"Koliatsos VE, Clatterbuck RE, Nauta HW, Knusel B, Burton LE, Hefti FF, et al. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. 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J7 Pediatr Surg 1987; 22: 246-5 1."},{"key":"ref_8","first-page":"823","article-title":"Histologic and embryologic studies on the innervation of the pelvic viscera in patients with Hirshsprung's disease","volume":"155","author":"Okamoto, E.; Satani, M.; Kuwata, K.","year":"1982","unstructured":"Okamoto E, Satani M, Kuwata K. Histologic and embryologic studies on the innervation of the pelvic viscera in patients with Hirshsprung's disease. Surg Gynecol Obstet 1982; 155: 823-8.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1365-2559.1987.tb01845.x","article-title":"An immunohistochemical study of the enteric neural plexi in Hirshsprung's disease","volume":"11","author":"Mackenzie, J.M.; Dixon, M.F.","year":"1987","unstructured":"Mackenzie JM, Dixon MF. An immunohistochemical study of the enteric neural plexi in Hirshsprung's disease. Histopathology 1987; 11: 1055-66.","journal-title":"Histopathology"},{"key":"ref_10","first-page":"886","article-title":"An immunohistochemical study of neurofilament and microtubule-associated tau protein in the enteric innervation in Hirshsprung's disease","volume":"28","author":"Deguchi, E.; Iwai, N.; Goto, Y.; Yanagihara, J.; Fushiki, S.","year":"1993","unstructured":"Deguchi E, Iwai N, Goto Y, Yanagihara J, Fushiki S. An immunohistochemical study of neurofilament and microtubule-associated tau protein in the enteric innervation in Hirshsprung's disease. _7 Pediatr Surg 1993; 28: 886-90."},{"key":"ref_11","first-page":"457","article-title":"course and endings of abnormal enteric nerve fibres in Hirshsprung's disease defined by whole mount immunohistochemistry..7 Pediatr Surg","volume":"25","author":"Tam, P.K.H.; Origin, Boyd G.P.","year":"1990","unstructured":"Tam PKH, Boyd GP. Origin, course and endings of abnormal enteric nerve fibres in Hirshsprung's disease defined by whole mount immunohistochemistry..7 Pediatr Surg 1990; 25: 457-61."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.11.1605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T21:55:46Z","timestamp":1757282146000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.11.1605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1994,11,1]]},"published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1136\/gut.35.11.1605"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.11.1605","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}