{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:26:29Z","timestamp":1764019589895,"version":"3.44.0"},"reference-count":36,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>Bacterial translocation occurs in ascitic cirrhotic rats, but its association with ascites infection is unknown. The aim of this study was to assess the relation between bacterial translocation and ascites infection in cirrhotic rats. Male Sprague-Dawley rats were induced to cirrhosis with intragastric CCl4. Ascitic fluid, portal and peripheral blood, mesenteric lymph nodes, liver and spleen samples were cultured before death in those cirrhotic rats with less (group A) or more (group B) than 250 polymorphonuclear neutrophils\/mm3 in ascitic fluid, as well as in healthy control rats. Histological examination of jejunum, ileum, and caecum was also performed. Bacterial translocation occurred in 45% of ascitic rats (without differences between groups A and B), but in 0% controls (p = 0.01). Bacterial translocation was associated with positive ascitic fluid culture in 60% of the cases. In all of them the same bacterial species was isolated in both mesenteric lymph node and ascitic fluid. Submucosal caecal oedema (100%), ileal lymphangiectasia (41%), and caecal inflammatory infiltrate (41%) occurred in ascitic rats, the last being associated with ascitic fluid positive culture (p = 0.04). These results suggests that bacterial translocation occurs frequently in ascitic cirrhotic rats, and may play a permissive, but not unique, part in a number of ascites infections. Whether histological changes seen in cirrhotic ascitic rats favour bacterial translocation remains to be elucidated.<\/jats:p>","DOI":"10.1136\/gut.35.11.1648","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1648-1652","source":"Crossref","is-referenced-by-count":102,"title":["Bacterial translocation in cirrhotic rats. Its role in the development of spontaneous bacterial peritonitis."],"prefix":"10.1136","volume":"35","author":[{"given":"J M","family":"Llovet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bartol\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Planas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Cabr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Ojanguren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Arnal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Gassull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0011-5029(85)90002-1","article-title":"Spontaneous bacterial peritonitis","volume":"31","author":"Hoefs, J.C.; Runyon, B.A.","year":"1985","unstructured":"Hoefs JC, Runyon BA. Spontaneous bacterial peritonitis. Disc Mon 1985; 31: 1-48.","journal-title":"Disc Mon"},{"key":"ref_2","first-page":"388","article-title":"Short-term prognosis of cirrhotics with spontaneous bacterial peritonitis: multivariate study","volume":"88","author":"Llovet, J.M.; Planas, R.; Morillas, R.; Quer, J.C.; Cabre, E.; Boix, J.","year":"1993","unstructured":"Llovet JM, Planas R, Morillas R, Quer JC, Cabre E, Boix J, et al. Short-term prognosis of cirrhotics with spontaneous bacterial peritonitis: multivariate study. Am J Gastroenterol 1993; 88: 388-92.","journal-title":"Am J Gastroenterol"},{"key":"ref_3","first-page":"257","article-title":"Spontaneous bacterial peritonitis. Gastroenterol Clin North","volume":"21","author":"Garcia-Tsao, G.","year":"1992","unstructured":"Garcia-Tsao G. Spontaneous bacterial peritonitis. 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Infect Immun 1983; 39: 1252-9.","journal-title":"Infect Immun"},{"key":"ref_26","first-page":"1722","article-title":"Bacterial translocation in portal-hypertensive rat: studies in basal conditions and on exposure","volume-title":"to haemorrhagic shock. Gastroenterology 1993; 104","author":"Sorell, W.T.; Quigley, E.M.; Jin, G.; Johnson, T.J.; Rikkers, L.F.","unstructured":"Sorell WT, Quigley EM, Jin G, Johnson TJ, Rikkers LF. Bacterial translocation in portal-hypertensive rat: studies in basal conditions and on exposure to haemorrhagic shock. Gastroenterology 1993; 104: 1722-6."},{"key":"ref_27","first-page":"40","article-title":"Bacterial translocation in portally hypertensive rats","volume":"16","author":"Duda, P.; Vauthey, J.N.; Ph, Gertsch; Wheatley, A.M.","year":"1992","unstructured":"Duda P, Vauthey JN, Gertsch Ph, Wheatley AM. Bacterial translocation in portally hypertensive rats. 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