{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T02:28:47Z","timestamp":1766888927727,"version":"3.46.0"},"reference-count":24,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:p>The effect of zinc supplementation on intestinal permeability changes and protein loss was studied in 32 children aged between 1 and 12 years during bouts of acute shigellosis and after recovery. An intestinal permeability test and then a 48 hour balance study were performed on all patients. They were then blindly assigned to receive vitamin B syrup either with or without zinc acetate (15 mg\/kg per day) for a month. All patients received a five day course of nalidixic acid. The balance study was repeated during convalescence and follow up, but a permeability test was done only at follow up after one month. Intestinal permeability, expressed as a urinary lactulose:mannitol excretion ratio, improved significantly (p = 0.001) along with a significant increase (p = 0.005) in mannitol excretion in the zinc supplemented children, suggesting a resolution of small bowel mucosal damage. The latter was associated with a higher coefficient of nitrogen absorption (p = 0.03), suggesting a possible role of zinc in the treatment of shigellosis. Enteric protein loss, as assessed by faecal alpha 1 antitrypsin clearance, was not influenced by zinc supplementation.<\/jats:p>","DOI":"10.1136\/gut.35.12.1707","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1707-1711","source":"Crossref","is-referenced-by-count":84,"title":["Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation."],"prefix":"10.1136","volume":"35","author":[{"given":"A N","family":"Alam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Sarker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Wahed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Khatun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Rahaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4615-9284-6_10","article-title":"Direct nutrient loss and diarrhoea","volume-title":"malnutrition interactions, mechanisms, and interventions","author":"Rahaman, M.M.; Wahed, M.A.","year":"1983","unstructured":"Rahaman MM, Wahed MA. Direct nutrient loss and diarrhoea. In: Chen LC, Scrimshaw NS, eds. Diarrhea and malnutrition interactions, mechanisms, and interventions. New York: Plenum, 1983: 155-60."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/infdis\/150.6.899","article-title":"Distribution and spread of colonic lesions in shigellosis: a colonoscopic study","volume":"150","author":"Speelman, P.; Kabir, I.; Islam, M.","year":"1984","unstructured":"Speelman P, Kabir I, Islam M. Distribution and spread of colonic lesions in shigellosis: a colonoscopic study. 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Evidence for a developmentally regulated glycolipid receptor for shigella toxin involved in the fluid secretory response of rabbit small intestine","volume":"157","author":"Mobassaleh, M.; Donohue-Rolfe, A.; Jacewicz, M.; Grand, R.J.; Keusch, G.T.","year":"1988","unstructured":"Mobassaleh M, Donohue-Rolfe A, Jacewicz M, Grand RJ, Keusch GT. Pathogenesis of shigella diarrhea. XIII. Evidence for a developmentally regulated glycolipid receptor for shigella toxin involved in the fluid secretory response of rabbit small intestine. J Infect Dis 1988; 157: 1023-31.","journal-title":"J Infect Dis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/infdis\/154.5.817","article-title":"Colonic dysfunction during shigellosis","volume":"154","author":"Butler, T.; Speelman, P.; Kabir, I.; Banwell, J.","year":"1986","unstructured":"Butler T, Speelman P, Kabir I, Banwell J. Colonic dysfunction during shigellosis. 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