{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:55:22Z","timestamp":1770324922973,"version":"3.49.0"},"reference-count":42,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>There is little information about the organisation of antroduodenal contractions or pyloric motility in patients with gastroparesis. The mechanisms responsible for the acceleration of gastric emptying by cisapride in patients with gastroparesis are also poorly understood. Simultaneous manometric and scintigraphic recordings were performed in 12 patients with gastroparesis and nine healthy volunteers before and after cisapride administration. Antropyloroduodenal pressures were recorded with a sleeve\/side hole manometric assembly and gastric emptying with a scintigraphic method. Thirty minutes after the solid component of the test meal had begun to empty from the stomach all subjects received 5 mg cisapride intravenously over 10 minutes and recordings continued for a further 60 minutes. In the 30 minutes before cisapride there was no significant difference in the number of antral pressure waves (median 20 v 33, NS), basal pyloric pressure, or the number of isolated pyloric pressure waves between patients and volunteers, but the number of antral waves of extent &gt; or = 6 cm (median 1 v 5, p &lt; 0.05) was less in the patients, as was gastric emptying (8% v 20%, p &lt; 0.05). In the patients, there was no change in the number of antral waves after cisapride, but there was an increase in the number of antral waves &gt; or = 6 cm in extent (median 7 v 1, p &lt; 0.05) and in the rate of gastric emptying (26% v 8%, p &lt; 0.01). In the healthy subjects, cisapride increased gastric emptying (31% v 20%, p &lt; 0.05), but reduced the number of antral waves (10 v 33, p &lt; 0.05). Cisapride had no significant effect on the number of antral waves of extent more than or equal to 6 cm (11 v 5, NS). The number of isolated pyloric pressure waves decreased after cisapride (4 v 11, p &lt; 0.05). There was a relationship between gastric emptying and the number of antral pressure waves of extent more than or equal to 6 cm in both the patients (r=0.38, p&lt;0.05) and healthy subjects (r=0.05, p&lt;0.01). There was no significant relationship between gastric emptying and the number of antral waves. It is concluded that disturbance of the relationship between antral, pyloric, and duodenal pressure waves is a major abnormality of postprandial gastric motor function in patients with gastroparesis. The stimulation of antral pressure waves of extent more than or equal to 6 cm may contribute to the acceleration of gastric emptying produced by cisapride in patients with gastroparesis and in normal subjects.<\/jats:p>","DOI":"10.1136\/gut.35.2.172","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"172-178","source":"Crossref","is-referenced-by-count":86,"title":["Postprandial antropyloroduodenal motility and gastric emptying in gastroparesis--effects of cisapride."],"prefix":"10.1136","volume":"35","author":[{"given":"R J","family":"Fraser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A F","family":"Maddox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"ref_1","first-page":"371","article-title":"Disordered gastric emptying: mechanical basis, assessment and treatment","volume-title":"Balliere's Clinical Gastroenterology 1991; 5","author":"Horowitz, M.; Dent, J.","unstructured":"Horowitz M, Dent J. Disordered gastric emptying: mechanical basis, assessment and treatment. Balliere's Clinical Gastroenterology 1991; 5: 371-407."},{"key":"ref_2","first-page":"613","article-title":"Motility of the stomach and gastroduodenal function","volume-title":"Physiology of the gastrointestinal tract","volume":"1","author":"Meyer, J.H.","year":"1987","unstructured":"Meyer JH. Motility of the stomach and gastroduodenal function. In: Johnson LR, ed. Physiology of the gastrointestinal tract. 2nd Ed, Vol 1. New York: Raven Press, 1987: 613-30.","edition":"2nd Ed"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gut.30.1.54","article-title":"Postprandial antral hypomotility in patients with idiopathic nausea and vomiting","volume":"30","author":"Kerlin, P.","year":"1989","unstructured":"Kerlin P. Postprandial antral hypomotility in patients with idiopathic nausea and vomiting. 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A comparison with metoclopramide and placebo","volume":"92","author":"Feldman, M.; Smith, H.J.","year":"1987","unstructured":"Feldman M, Smith HJ. Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo. Gastroenterology 1987; 92: 171-4.","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/0016-5085(87)90622-6","article-title":"Effect of cispride on gastric and esophageal emptying in insulin-dependent diabetes mellitus","volume":"92","author":"Horowitz, M.; Maddox, A.; Harding, P.E.; Maddern, G.J.; Chatterton, B.E.; Shearman, D.J.C.","year":"1987","unstructured":"Horowitz M, Maddox A, Harding PE, Maddern GJ, Chatterton BE, Shearman DJC. Effect of cispride on gastric and esophageal emptying in insulin-dependent diabetes mellitus. 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Gastroenterology 1987; 92: 1000-7.","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/gut.28.3.300","article-title":"Effect of chronic administration of cisapride on gastric emptying of a.solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis","volume":"28","author":"Corinaldesi, R.; Stanghellini, V.; Raiti, C.; Rea, E.; Salgemini, A.; Barbara, L.","year":"1987","unstructured":"Corinaldesi R, Stanghellini V, Raiti C, Rea E, Salgemini A, Barbara L. Effect of chronic administration of cisapride on gastric emptying of a.solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. Gut 1987; 28: 300-5.","journal-title":"Gut"},{"key":"ref_21","first-page":"440","article-title":"Myoelectric and motor responses of the antropyloroduodenal region to intraduodenal lipid in the conscious dog-effect of cisapride","volume":"100","author":"Edelbroek, M.; Schuurkes, J.J.; de Ridder, W.; Horowitz, M.; Dent, J.; Fone, D.; Akkermans, L.M.A.","year":"1991","unstructured":"Edelbroek M, Schuurkes JJ, de Ridder W, Horowitz M, Dent J, Fone D, Akkermans LMA. Myoelectric and motor responses of the antropyloroduodenal region to intraduodenal lipid in the conscious dog-effect of cisapride. Gastroenterology 1991; 100: A440.","journal-title":"Gastroenterology"},{"key":"ref_22","first-page":"103","article-title":"Gastroduodenal coordination","volume-title":"gastroduodenal motility","author":"Schuurkes, J.A.J.; van Nueten, J.M.","year":"1984","unstructured":"Schuurkes JAJ, van Nueten JM. Gastroduodenal coordination. In: Akkermans LMA, Johnson AG, Read NW, eds. 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Gut 1988; 29: 1349-57.","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1440-1746.1989.tb01741.x","article-title":"Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion","volume":"4","author":"Heddle, R.; Collins, P.J.; Dent, J.; Horowitz, M.; Read, N.W.; Chatterton, B.; Houghton, L.A.","year":"1989","unstructured":"Heddle R, Collins PJ, Dent J, Horowitz M, Read NW, Chatterton B, Houghton LA. Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. Journal ofGastroenterology and Hepatology 1989; 4: 437-47.","journal-title":"Journal ofGastroenterology and Hepatology"},{"key":"ref_27","first-page":"1285","article-title":"Relationship of the motor activity of the antrum, pylorus and duodenum to gastric emptying of a","volume-title":"solid-liquid mixed meal. 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Gastroenterology 1976; 70: 190-6."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/BF00400569","article-title":"Hyperglycaemia slows gastric emptying in Type 1 diabetes mellitus","volume":"33","author":"Fraser, R.; Horowitz, M.; Maddox, A.; Chatterton, B.; Harding, P.; Dent, J.","year":"1990","unstructured":"Fraser R, Horowitz M, Maddox A, Chatterton B, Harding P, Dent J. Hyperglycaemia slows gastric emptying in Type 1 diabetes mellitus. Diabetologia 1990; 33: 675-80.","journal-title":"Diabetologia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/gut.32.5.475","article-title":"Hyperglycaemia stimulates pyloric motility in normal subjects","volume":"32","author":"Fraser, R.; Horowitz, M.; Dent, J.","year":"1991","unstructured":"Fraser R, Horowitz M, Dent J. Hyperglycaemia stimulates pyloric motility in normal subjects. Gut 1991; 32: 475-8.","journal-title":"Gut"},{"key":"ref_36","first-page":"195","article-title":"Dual effects of cisapride on gastric emptying and antropyloroduodenal motility","author":"Fraser, R.; Horowitz, M.; Maddox, A.; Dent, J.","year":"1993","unstructured":"Fraser R, Horowitz M, Maddox A, Dent J. Dual effects of cisapride on gastric emptying and antropyloroduodenal motility. AmJ3 Physiol 1993; 264 (27): G195-201."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/BF01536374","article-title":"Cisapride stimulates antral motility and decreases biliary reflux in patients with severe dyspepsia","volume":"34","author":"Rezende-Filho, J.; Di Lorenzo, C.; Dooley, C.P.; Valenzuela, J.E.","year":"1989","unstructured":"Rezende-Filho J, Di Lorenzo C, Dooley CP, Valenzuela JE. Cisapride stimulates antral motility and decreases biliary reflux in patients with severe dyspepsia. 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EurJ Clin Pharmacol 1986; 30: 205-8.","journal-title":"EurJ Clin Pharmacol"},{"key":"ref_40","first-page":"159","article-title":"Motility enhancing effects of cisapride and 5-hydroxytryptamine mediated via other than 5-HTI, 5HT2, 5HT3, and 5HT4 receptors","volume":"2","author":"Schuurkes, J.A.J.; De Ridder, W.J.E.","year":"1991","unstructured":"Schuurkes JAJ, De Ridder WJE. Motility enhancing effects of cisapride and 5-hydroxytryptamine mediated via other than 5-HTI, 5HT2, 5HT3, and 5HT4 receptors. J Gastrointestinal Motility 1991; 2: A159.","journal-title":"J Gastrointestinal Motility"},{"key":"ref_41","first-page":"1098","article-title":"Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors","volume":"258","author":"Taniyama, K.; Nakayama, S.; Takeda, K.; Matsuyama, S.; Shirakawa, J.; Sano, I.; Tanaka, C.","year":"1991","unstructured":"Taniyama K, Nakayama S, Takeda K, Matsuyama S, Shirakawa J, Sano I, Tanaka C. Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J Pharmnacol Exp Ther 1991; 258: 1098-105.","journal-title":"J Pharmnacol Exp Ther"},{"key":"ref_42","first-page":"1257","article-title":"Effects of cisapride on cholinergic neurotransmission and propulsive motility","volume-title":"the guinea pig ileum. Gastroenterology 1989; 96","author":"Tonini, M.; Galligan, J.J.; North, R.A.","unstructured":"Tonini M, Galligan JJ, North RA. Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum. Gastroenterology 1989; 96: 1257-64."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.2.172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T18:09:30Z","timestamp":1757268570000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.2.172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1994,2,1]]},"published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1136\/gut.35.2.172"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.2.172","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}