{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:13Z","timestamp":1790744533844,"version":"4.1.0"},"reference-count":42,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>Dysmotility of the duodenum and proximal jejunum has been reported in patients with irritable bowel syndrome. This study extended these findings by recording fasting ambulatory motility from electronic strain gauge sensors sited in the jejunum and ileum of eight diarrhoea predominant irritable bowel syndrome patients and 12 healthy controls. During the day, periodicity of migrating motor complexes mean (SEM) did not differ between patients (92 (10) min) and controls (85 (7) min). At night, periodicity was shorter in both patients and controls, and the daytime dominance of phase II was replaced by phase I. In both groups, aboral progression of phase III fronts was associated with a slowing of propagation velocity and maximum contractile rate, but an increase in mean amplitude of contraction. Discrete clustered contractions were seen in seven patients and 10 controls occupying 14 and 16% of daytime phase II activity, respectively. Pain episodes were not associated with any specific motility patterns. Despite the lack of motility differences between the two groups, orocaecal transit time in the irritable bowel syndrome patients was shorter at 57 (9) min than in the controls, 82 (6) min (p &lt; 0.05). This ambulant study has failed to show any abnormalities of fasting small intestinal motility that might distinguish diarrhoea predominant irritable bowel syndrome patients from healthy controls.<\/jats:p>","DOI":"10.1136\/gut.35.2.203","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"203-210","source":"Crossref","is-referenced-by-count":70,"title":["Ambulatory small intestinal motility in 'diarrhoea' predominant irritable bowel syndrome."],"prefix":"10.1136","volume":"35","author":[{"given":"D A","family":"Gorard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G W","family":"Libby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Farthing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"ref_1","first-page":"19","article-title":"Disturbances in colonic motility","volume-title":"bowel syndrome","author":"NWIrtable, Read","year":"1991","unstructured":"Read NW. Disturbances in colonic motility. In: Read NW, ed. Irtable bowel syndrome. Oxford: Blackweli Scientific, 1991: 19-23."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0889-8553(21)00551-3","article-title":"Motility disorders in the irritable bowel syndrome","volume":"20","author":"Lind, C.D.","year":"1991","unstructured":"Lind CD. Motility disorders in the irritable bowel syndrome. GastroenteroliClin North Am 1991; 20: 279-95.","journal-title":"GastroenteroliClin North Am"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/bmj.284.6330.1670","article-title":"Functional abdominal pain: further evidence that the whole gut is affected","volume":"284","author":"Moriarty, K.J.; Dawson, A.M.","year":"1982","unstructured":"Moriarty KJ, Dawson AM. Functional abdominal pain: further evidence that the whole gut is affected. BMJ 1982; 284: 1670-2.","journal-title":"BMJ"},{"key":"ref_4","first-page":"405","article-title":"CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns","volume-title":"Gut","volume":"24","author":"Gann, P.A.","year":"1983","unstructured":"Gann PA, Read NW, Brown C, Hobson N, Holdsworth CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 1983; 24: 405-11."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI108740","article-title":"The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine","volume":"59","author":"Vantrappen, G.; Janssens, J.; Hellemans, J.; Ghoos, Y.","year":"1977","unstructured":"Vantrappen G, Janssens J, Hellemans J, Ghoos Y. The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. JClin Invest 1977; 59: 1158-66.","journal-title":"JClin Invest"},{"key":"ref_6","first-page":"500","article-title":"Normal patterns of human upper small bowel motor activity recorded by prolonged telemetry","volume-title":"Gut","volume":"21","author":"Thompson, D.G.; Wingate, D.L.; Archer, L.; Benson, M.J.; Green, W.J.; Hardy, R.J.","year":"1980","unstructured":"Thompson DG, Wingate DL, Archer L, Benson MJ, Green WJ, Hardy RJ. Normal patterns of human upper small bowel motor activity recorded by prolonged telemetry. Gut 1980; 21: 500-6."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0016-5085(84)90080-5","article-title":"ileocecal sphincter in healthy humans","volume":"87","year":"1984","unstructured":"Quigley EMM, Borody TJ, Phillips SF, Wienbeck M, Tucker RL, Haddad A. Motility of the terminal ileum and ileocecal sphincter in healthy humans. Gastroenterology 1984; 87: 857-66.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"386","article-title":"Human interdigestive motility: variations in patterns from","volume-title":"esophagus to colon. Gastroenterology 1986; 91","author":"Kellow, J.E.; Borody, T.J.; Phillips, S.F.; Tucker, R.L.; Haddad, A.C.","unstructured":"Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC. Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology 1986; 91: 386-95."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/00365521.1990.12067094","article-title":"Digital ambulatory monitoring of small-bowel motility","volume":"25","author":"Lindberg, G.; Iwarzon, M.; Stal, P.; Seensalu, R.","year":"1990","unstructured":"Lindberg G, Iwarzon M, Stal P, Seensalu R. Digital ambulatory monitoring of small-bowel motility. Scand J Gastroenterol 1990; 25: 216-24.","journal-title":"Scand J Gastroenterol"},{"key":"ref_10","first-page":"694700","article-title":"Variability of motility of the ileum and jejunum in healthy humans","volume":"82","author":"Kerlin, P.; Phillips, S.F.","year":"1982","unstructured":"Kerlin P, Phillips SF. Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology 1982; 82: 694700.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF01296429","article-title":"Variability of migrating motor complex in humans","volume":"37","author":"Dooley, C.P.; Di Lorenzo, C.; Valenzuela, J.E.","year":"1992","unstructured":"Dooley CP, Di Lorenzo C, Valenzuela JE. Variability of migrating motor complex in humans. Dig Dis Sci 1992; 37: 723-8.","journal-title":"Dig Dis Sci"},{"issue":"217","key":"ref_12","first-page":"1757","article-title":"A migrating electric complex of canine small intestine","volume":"1969","author":"Szurszewski, J.H.","unstructured":"Szurszewski JH. A migrating electric complex of canine small intestine. AmJ Physiol 1969; 217: 1757-63.","journal-title":"AmJ Physiol"},{"key":"ref_13","first-page":"641","article-title":"Backwards and forwards with the migrating complex","volume":"26","author":"Wingate, D.L.","year":"1981","unstructured":"Wingate DL. Backwards and forwards with the migrating complex. DigDisSci 1981; 26: 641-66.","journal-title":"DigDisSci"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/0016-5085(85)90589-X","article-title":"Cyclic motor activity; migrating motor complex","volume":"89","author":"Sarna, S.K.","year":"1985","unstructured":"Sarna SK. Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 1985; 89: 894-913.","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0140-6736(85)90525-2","article-title":"The irritable bowel syndrome: a paroxysmal motor disorder","volume":"ii:","author":"Kumar, D.; Wingate, D.L.","year":"1985","unstructured":"Kumar D, Wingate DL. The irritable bowel syndrome: a paroxysmal motor disorder. Lancet 1985; ii: 973-7.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/0016-5085(87)90620-2","article-title":"Altered small bowel motility in irritable bowel syndrome is correlated with symptoms","volume":"92","author":"Kellow, J.E.; Phillips, S.F.","year":"1987","unstructured":"Kellow JE, Phillips SF. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987; 92: 1885-93.","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/0016-5085(90)90335-X","article-title":"Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome","volume":"98","author":"Kellow, J.E.; Gill, R.C.; Wingate, D.L.","year":"1990","unstructured":"Kellow JE, Gill RC, Wingate DL. Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 1990; 98:1208-18.","journal-title":"Gastroenterology"},{"key":"ref_18","first-page":"168","article-title":"Enteric and central contributions to intestinal dysmotility in irritable bowel syndrome","volume":"37","author":"Kellow, J.E.; Eckersley, G.M.; Jones, M.","year":"1992","unstructured":"Kellow JE, Eckersley GM, Jones M. Enteric and central contributions to intestinal dysmotility in irritable bowel syndrome. DigDisSci 1992; 37: 168-74.","journal-title":"DigDisSci"},{"key":"ref_19","first-page":"69","article-title":"Intestinal motility in man. III. Mechanisms of constipation and diarrhoea with particular reference to the irritable colon syndrome","volume":"48","author":"Wangel, A.G.; Deller, D.J.","year":"1965","unstructured":"Wangel AG, Deller DJ. Intestinal motility in man. III. Mechanisms of constipation and diarrhoea with particular reference to the irritable colon syndrome. Gastroenterology 1965; 48: 69-84.","journal-title":"Gastroenterology"},{"key":"ref_20","first-page":"404","article-title":"Irritable bowel syndrome. Physiological and psychological differences between diarrhoea-predominant and constipationpredominant patients","volume":"25","author":"Whitehead, W.E.; Engel, B.T.; Schuster, M.M.","year":"1980","unstructured":"Whitehead WE, Engel BT, Schuster MM. Irritable bowel syndrome. Physiological and psychological differences between diarrhoea-predominant and constipationpredominant patients. Dig DisSci 1980; 25: 404-13.","journal-title":"Dig DisSci"},{"key":"ref_21","first-page":"45862","article-title":"Anorectal manometry in irritable bowel syndrome: differences between diarrhoea and constipation predominant subjects","volume":"31","author":"Prior, A.; Maxton, D.G.; Whorwell, P.J.","year":"1990","unstructured":"Prior A, Maxton DG, Whorwell PJ. Anorectal manometry in irritable bowel syndrome: differences between diarrhoea and constipation predominant subjects. Gut 1990; 31: 45862.","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bmj.2.6138.653","article-title":"Towards positive diagnosis of the irritable bowel","volume":"2","author":"Manning, A.P.; Thompson, W.G.; Heaton, K.W.; Morris, A.F.","year":"1978","unstructured":"Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. BMJ 1978; 2: 653-4.","journal-title":"BMJ"},{"key":"ref_23","first-page":"92","article-title":"Irritable bowel syndrome: guidelines","volume-title":"for the diagnosis. Gastroenterology International 1989; 2","author":"Thompson, W.G.; Dotevall, G.; Drossman, D.A.; Heaton, K.W.; Kruis, W.","unstructured":"Thompson WG, Dotevall G, Drossman DA, Heaton KW, Kruis W. Irritable bowel syndrome: guidelines for the diagnosis. Gastroenterology International 1989; 2: 92-5."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1445-5994.1983.tb02610.x","article-title":"Rapid intubation of the ileocolonic region of man","volume":"13","author":"Kerlin, P.; Tucker, R.; Phillips, S.F.","year":"1983","unstructured":"Kerlin P, Tucker R, Phillips SF. Rapid intubation of the ileocolonic region of man. Aust NZJ Med 1983; 13: 591-3.","journal-title":"Aust NZJ Med"},{"key":"ref_25","first-page":"1290","article-title":"Jejunal manometry patterns in health, partial intestinal obstruction","volume-title":"and pseudoobstruction. Gastroenterology 1983; 85","author":"Summers, R.W.; Anuras, S.; Green, J.","unstructured":"Summers RW, Anuras S, Green J. Jejunal manometry patterns in health, partial intestinal obstruction, and pseudoobstruction. Gastroenterology 1983; 85: 1290-300"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/0016-5085(86)90696-7","article-title":"Circadian variation in the propagation velocity of the migrating motor complex","volume":"91","author":"Kumar, D.; Wingate, D.; Ruckebusch, Y.","year":"1986","unstructured":"Kumar D, Wingate D, Ruckebusch Y. Circadian variation in the propagation velocity of the migrating motor complex. Gastroenterology 1986; 91: 926-30.","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0016-5085(66)80069-0","article-title":"The small intestinal basic electrical rhythm (slow wave) frequency gradient in normal men and in patients with a variety of diseases","volume":"50","author":"Christensen, J.; Schedl, H.P.; Clifton, J.A.","year":"1966","unstructured":"Christensen J, Schedl HP, Clifton JA. The small intestinal basic electrical rhythm (slow wave) frequency gradient in normal men and in patients with a variety of diseases. Gastroenterology 1966; 50: 309-15.","journal-title":"Gastroenterology"},{"key":"ref_28","first-page":"54","article-title":"Diurnal variation in human jejunal fasting motor activity","volume":"305","author":"Ritchie, H.D.; Thompson, D.G.; Wingate, D.L.","year":"1980","unstructured":"Ritchie HD, Thompson DG, Wingate DL. Diurnal variation in human jejunal fasting motor activity. J Physiol 1980; 305: 54-SP.","journal-title":"J Physiol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.23.5.404","article-title":"Sustained mental stress alters human jejunal motor activity","volume":"23","author":"McRae, S.; Younger, K.; Thompson, D.G.; Wingate, D.L.","year":"1982","unstructured":"McRae S, Younger K, Thompson DG, Wingate DL. Sustained mental stress alters human jejunal motor activity. Gut 1982; 23: 404-9.","journal-title":"Gut"},{"key":"ref_30","first-page":"1890","article-title":"Effects of different types of stress and of 'prokinetic' drugs on the control of the fasting motor","volume-title":"complex in humans. Gastroenterology 1986; 90","author":"Valori, R.M.; Kumar, D.; Wingate, D.L.","unstructured":"Valori RM, Kumar D, Wingate DL. Effects of different types of stress and of 'prokinetic' drugs on the control of the fasting motor complex in humans. Gastroenterology 1986; 90: 1890-900."},{"issue":"42","key":"ref_31","first-page":"455","article-title":"Intraluminal small intestinal pressures in normal patients and in patients with functional gastrointestinal disorders","volume":"1962","author":"Horowitz, L.; Farrar, J.T.","unstructured":"Horowitz L, Farrar JT. Intraluminal small intestinal pressures in normal patients and in patients with functional gastrointestinal disorders. Gastroenterology 1962; 42: 455-64.","journal-title":"Gastroenterology"},{"issue":"10","key":"ref_32","first-page":"19","article-title":"Observations on the mechanism of abdominal pain","volume":"1969","author":"Holdstock, D.J.; Misiewicz, J.J.; Waller, S.L.","unstructured":"Holdstock DJ, Misiewicz JJ, Waller SL. Observations on the mechanism of abdominal pain. Gut 1969; 10: 19-31.","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/gut.25.4.375","article-title":"Jejunal motility in patients with functional abdominal pain","volume":"25","author":"Kingham, J.G.C.; Bown, R.; Colson, R.; Clark, M.L.","year":"1984","unstructured":"Kingham JGC, Bown R, Colson R, Clark ML. Jejunal motility in patients with functional abdominal pain. Gut 1984; 25: 375-80.","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/0016-5085(91)90400-F","article-title":"Enhanced perception of physiological intestinal motility in the irritable bowel syndrome","volume":"101","author":"Kellow, J.E.; Eckersley, G.M.; Jones, M.P.","year":"1991","unstructured":"Kellow JE, Eckersley GM, Jones MP. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991; 101: 1621-7.","journal-title":"Gastroenterology"},{"key":"ref_35","first-page":"123","article-title":"The role of short-term multilumen duodenojejunal manometry in patients with intestinal motor dysfunction","volume":"12","author":"Soffer, E.E.; Bruck, R.; Bar-Meir, S.","year":"1988","unstructured":"Soffer EE, Bruck R, Bar-Meir S. The role of short-term multilumen duodenojejunal manometry in patients with intestinal motor dysfunction. Gastroenterol Clin Biol 1988; 12: 123-5.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_36","first-page":"20","article-title":"Antroduodenal manometry. Usefulness and limitations as an outpatient study","volume":"37","author":"Quigley, E.M.M.; Donovan, J.P.; Lane, M.J.; Gallagher, T.F.","year":"1992","unstructured":"Quigley EMM, Donovan JP, Lane MJ, Gallagher TF. Antroduodenal manometry. Usefulness and limitations as an outpatient study. DigDisSci 1992; 37: 20-8.","journal-title":"DigDisSci"},{"key":"ref_37","first-page":"10","article-title":"Intestinal manometry - technical advances, clinical limitations","volume":"37","author":"Quigley, E.M.M.","year":"1992","unstructured":"Quigley EMM. Intestinal manometry - technical advances, clinical limitations. DigDisSci 1992; 37: 10-3.","journal-title":"DigDisSci"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/00365529209011167","article-title":"Effects of acute psychological stress on smallintestinal motility in health and the irritable bowel syndrome","volume":"27","author":"Kellow, J.E.; Langeluddecke, P.M.; Eckersley, G.M.; Jones, M.P.; Tennant, C.C.","year":"1992","unstructured":"Kellow JE, Langeluddecke PM, Eckersley GM, Jones MP, Tennant CC. Effects of acute psychological stress on smallintestinal motility in health and the irritable bowel syndrome. ScandJ Gastroenterol 1992; 27: 53-8.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1136\/gut.22.10.836","article-title":"Electrochemical detector for breath hydrogen determination: measurement of small bowel transit time in normal subjects and patients with the irritable bowel syndrome","volume":"22","author":"Corbett, C.L.; Thomas, S.; Read, N.W.; Hobson, N.; Bergman, I.; Holdsworth, C.D.","year":"1981","unstructured":"Corbett CL, Thomas S, Read NW, Hobson N, Bergman I, Holdsworth CD. Electrochemical detector for breath hydrogen determination: measurement of small bowel transit time in normal subjects and patients with the irritable bowel syndrome. Gut 1981; 22: 836-40.","journal-title":"Gut"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/gut.32.10.1127","article-title":"Role of fasting gastrointestinal motility in the variability of gastrointestinal transit time assessed by hydrogen breath test","volume":"32","author":"C, Di Lorenzo; CP, Dooley; JE, Valenzuela","year":"1991","unstructured":"Di Lorenzo C, Dooley CP, Valenzuela JE. Role of fasting gastrointestinal motility in the variability of gastrointestinal transit time assessed by hydrogen breath test. Gut 1991; 32: 1127-30.","journal-title":"Gut"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/BF01317038","article-title":"Failure to demonstrate altered gastric emptying in irritable bowel syndrome","volume":"28","author":"Acharya, U.; Waite, N.; Howlett, P.; Tanner, A.R.; Smith, C.L.","year":"1983","unstructured":"Acharya U, Waite N, Howlett P, Tanner AR, Smith CL. Failure to demonstrate altered gastric emptying in irritable bowel syndrome. Dig Dis Sci 1983; 28: 889-92.","journal-title":"Dig Dis Sci"},{"key":"ref_42","first-page":"1287","article-title":"Gastric emptying rate and small bowel transit time in patients with irritable bowel syndrome determined by '\"Tc-labelled pellets and scintigraphy","volume":"31","author":"Nielsen, O.H.; Gj0rup, T.; Christensen, F.N.","year":"1986","unstructured":"Nielsen OH, Gj0rup T, Christensen FN. Gastric emptying rate and small bowel transit time in patients with irritable bowel syndrome determined by '\"Tc-labelled pellets and scintigraphy. DigDisSci 1986; 31: 1287-91.","journal-title":"DigDisSci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.2.203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:23:23Z","timestamp":1757309003000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.2.203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1994,2,1]]},"published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1136\/gut.35.2.203"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.2.203","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}