{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:21:17Z","timestamp":1772752877112,"version":"3.50.1"},"reference-count":14,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>The incidence and characteristics of reservoir inflammation after restorative proctocolectomy for ulcerative colitis were studied in a series of 179 patients. The median follow up time was 27 months (range 6-80). Pouchitis occurred in 36 patients (20%) and nine of these (5%) developed a chronic, persisting pouchitis. There were no pouch failures as a result of pouchitis and no significant adverse effect on longterm functional outcome. The overall cumulative risk to develop pouchitis four years after surgery was 23%. The risk of pouchitis is unpredictable on clinical grounds except that there were significantly less patients with left sided colitis in the group who subsequently developed pouchitis. Morphological and histochemical studies showed a greater degree of colonic metaplasia in the pouch mucosa in patients with pouchitis and patients with a chronic pouchitis had the highest degree of changes. The results support the view that pouchitis is a novel manifestation of inflammatory bowel disease in ileal mucosa that has changed slowly to a colon like mucosa.<\/jats:p>","DOI":"10.1136\/gut.35.2.243","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"243-246","source":"Crossref","is-referenced-by-count":90,"title":["Pouchitis--recurrence of the inflammatory bowel disease?"],"prefix":"10.1136","volume":"35","author":[{"given":"P","family":"Luukkonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tanskanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kahri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF01648551","article-title":"The clinical and functional outcome after restorative proctocolectomy. A prospective study in 100 patients","volume":"4","author":"Oresland, T.; Fasth, S.; Nordgren, S.; Hulten, L.","year":"1989","unstructured":"Oresland T, Fasth S, Nordgren S, Hulten L. The clinical and functional outcome after restorative proctocolectomy. A prospective study in 100 patients. IntJ Colorect Dis 1989; 4: 50-6.","journal-title":"IntJ Colorect Dis"},{"key":"ref_2","first-page":"622","article-title":"Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis","volume":"211","author":"Lohmuller, J.L.; Pemberton, J.H.; Dozois, R.R.; Ilstrup, D.; van Heerden, J.","year":"1990","unstructured":"Lohmuller JL, Pemberton JH, Dozois RR, Ilstrup D, van Heerden J. Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis. Ann Surg 1990; 211: 622-9."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/BF02050351","article-title":"Pouchitis - is it a wastebasket diagnosis","volume":"34","author":"Rauh, S.M.; DJ, Jr, Schoetz; Roberts, P.L.; Murray, J.J.; Coller, J.A.; Veidenheimer, M.C.","year":"1991","unstructured":"Rauh SM, Schoetz DJ Jr, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC. Pouchitis - is it a wastebasket diagnosis. Dis Colon Rectum 1991; 34: 685-9.","journal-title":"Dis Colon Rectum"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/archsurg.1992.01420070036009","article-title":"Ileal pouch-anal anastomosis. Patterns of failure","volume":"127","author":"Gemlo, B.T.; Wong, W.D.; Rothenberger, D.A.; Goldberg, S.M.","year":"1992","unstructured":"Gemlo BT, Wong WD, Rothenberger DA, Goldberg SM. Ileal pouch-anal anastomosis. Patterns of failure. Arch Surg 1992; 127: 784-7.","journal-title":"Arch Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF01660720","volume":"3","author":"Tytgat, G.N.J.; Deventer, S.J.H.","year":"1988","unstructured":"Tytgat GNJ, Deventer SJH. Pouchitis. Intr Colorect Dis 1988; 3:226-8.","journal-title":"Pouchitis. Intr Colorect Dis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/BF02554850","article-title":"Fecal bacteriology and reservoir ileitis in patients operated on for ulcerative colitis","volume":"31","author":"Luukkonen, P.; Valtonen, V.; Sivonen, A.; Sipponen, P.; Jarvinen, H.","year":"1988","unstructured":"Luukkonen P, Valtonen V, Sivonen A, Sipponen P, Jarvinen H. Fecal bacteriology and reservoir ileitis in patients operated on for ulcerative colitis. Dis Colon Rectum 1988; 31: 864-7.","journal-title":"Dis Colon Rectum"},{"key":"ref_7","first-page":"817","article-title":"Ileal ecology after pouch-anal anastomosis or ileostomy: a study of mucosal morphology, fecal bacteriology, fecal volatile fatty acids","volume-title":"and their interrelationship. Gastroenterology 1989; %","author":"Nasmyth, D.G.; Godwin, P.G.R.; Dixon, M.F.; Williams, N.S.; Johnston, D.","unstructured":"Nasmyth DG, Godwin PGR, Dixon MF, Williams NS, Johnston D. Ileal ecology after pouch-anal anastomosis or ileostomy: a study of mucosal morphology, fecal bacteriology, fecal volatile fatty acids, and their interrelationship. Gastroenterology 1989; %: 817-24."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF01648445","article-title":"An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal reservoir","volume":"1","author":"Moskowitz, R.L.; Shepherd, N.A.; Nicholls, R.J.","year":"1986","unstructured":"Moskowitz RL, Shepherd NA, Nicholls RJ. An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal reservoir. IntJ7 Colorect Dis 1986; 1: 167-74.","journal-title":"IntJ7 Colorect Dis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/jcp.40.6.601","article-title":"Restorative proctocolectomy with ileal reservoir: pathological and histochemical study of mucosal biopsy specimens","volume":"40","author":"Shepherd, N.A.; Jass, JR, Duval; I, Moskowitz; RL, Nicholls; RJ, Morson; B.C.","year":"1987","unstructured":"Shepherd NA, Jass JR, Duval I, Moskowitz RL, Nicholls RJ, Morson BC. Restorative proctocolectomy with ileal reservoir: pathological and histochemical study of mucosal biopsy specimens. J Clin Pathol 1987; 40: 601-7.","journal-title":"J Clin Pathol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/gut.32.1.61","article-title":"Mucosal characteristics of pelvic ileal pouches","volume":"32","author":"HJ, De Silva; PR, Millard; M, Kettlewell; NJ, Mortensen; C, Prince; DP, Jewell","year":"1991","unstructured":"De Silva HJ, Millard PR, Kettlewell M, Mortensen NJ, Prince C, Jewell DP. Mucosal characteristics of pelvic ileal pouches. Gut 1991; 32: 61-5.","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1136\/gut.32.10.1166","article-title":"Effects of the faecal stream and stasis on the ileal pouch mucosa","volume":"32","author":"HJ, De Silva; PR, Millard; N, Soper; M, Kettlewell; N, Mortensen; DP, Jewell","year":"1991","unstructured":"De Silva HJ, Millard PR, Soper N, Kettlewell M, Mortensen N, Jewell DP. Effects of the faecal stream and stasis on the ileal pouch mucosa. Gut 1991; 32: 1166-9.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF01644986","article-title":"Symposium - pouchitis","volume":"4","author":"Nicholls, R.J.","year":"1989","unstructured":"Nicholls RJ. Symposium - pouchitis. IntJ Colorect Dis 1989; 4:205-29.","journal-title":"IntJ Colorect Dis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/gut.22.6.462","article-title":"Restorative proctocolectomy with ileal reservoir: a pathophysiological assessment","volume":"22","author":"Nicholls, R.J.; Belliveau, P.; Neill, M.; Wilks, M.; Tabaqchali, S.","year":"1981","unstructured":"Nicholls RJ, Belliveau P, Neill M, Wilks M, Tabaqchali S. Restorative proctocolectomy with ileal reservoir: a pathophysiological assessment. Gut 1981; 22: 462-8.","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/BF02555768","article-title":"Outcome of 'indeterminate' colitis following ileal pouch-anal anastomosis","volume":"32","author":"Pezim, M.E.; Pemberton, J.H.; RW, Jr, Beart; Wolff, B.G.; Dozois, R.R.","year":"1989","unstructured":"Pezim ME, Pemberton JH, Beart RW Jr, Wolff BG, Dozois RR. Outcome of 'indeterminate' colitis following ileal pouch-anal anastomosis. Dis Colon Rectum 1989; 32: 653-8.","journal-title":"Dis Colon Rectum"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.2.243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:55:31Z","timestamp":1765626931000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.2.243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1994,2,1]]},"published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1136\/gut.35.2.243"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.2.243","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}