{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:36:02Z","timestamp":1772580962409,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>In the rat, hypergastrinaemia induced by drug treatment with omeprazole or potent H2-receptor antagonists leads to the development of gastric enterochromaffin-like cell carcinoids. In man, gastric carcinoids induced by hypergastrinaemia have been described only in patients with chronic atrophic gastritis type A and in patients with the multiple endocrine neoplasia syndrome type 1. This patient with Zollinger-Ellison syndrome without gastric mucosal atrophy and without evidence of the multiple endocrine neoplasia syndrome developed an argyrophil gastric carcinoid tumour. This observation indicates that hypergastrinaemia in the sporadic Zollinger-Ellison-syndrome may induce gastric carcinoids.<\/jats:p>","DOI":"10.1136\/gut.35.2.275","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"275-277","source":"Crossref","is-referenced-by-count":35,"title":["Argyrophil cell hyperplasia and a carcinoid tumour in the stomach of a patient with sporadic Zollinger-Ellison syndrome."],"prefix":"10.1136","volume":"35","author":[{"given":"G E","family":"Feurle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/00365529109093190","article-title":"Trophic effects of gastrin","volume":"180","author":"Hakanson, R.; Sundler, F.","year":"1991","unstructured":"Hakanson R, Sundler F. Trophic effects of gastrin. Scand J Gastroenterol 1991; 180 (suppl): 130-6.","journal-title":"Scand J Gastroenterol"},{"issue":"57","key":"ref_2","first-page":"641","article-title":"Proliferation of endocrine-like (enterochromaffine) cells in atrophic gastric mucosa","volume":"1969","author":"Rubin, W.","unstructured":"Rubin W. Proliferation of endocrine-like (enterochromaffine) cells in atrophic gastric mucosa. Gastroenterology 1969; 57: 641-8.","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"638","article-title":"Gastric endocrine cell hyperplasia and carcinoid tumours","volume-title":"pernicious anemia. Gastroenterology 1985; 88","author":"Borch, K.; Renvall, H.; Liedberg, G.","unstructured":"Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumours in pernicious anemia. Gastroenterology 1985; 88: 638-48."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0016-5085(90)91224-T","article-title":"Quantitative ultrastructure of endocrine cells of oxyntic mucosa in Zollinger-Ellison syndrome","volume":"99","author":"D'Adda, T.; Corleto, V.; Pilato, F.P.; Baggi, M.T.; Robutti, F.; Delle Fave, G.; Bordi, C.","year":"1990","unstructured":"D'Adda T, Corleto V, Pilato FP, Baggi MT, Robutti F, Delle Fave G, Bordi C. Quantitative ultrastructure of endocrine cells of oxyntic mucosa in Zollinger-Ellison syndrome. Gastroenterology 1990; 99: 17-26.","journal-title":"Gastroenterology"},{"key":"ref_5","first-page":"274","article-title":"Gastric endocrine cell proliferation","volume":"98","author":"Bordi, C.; Cocconi, G.; Togni, R.; Vezzadini, P.; Missale, G.","year":"1974","unstructured":"Bordi C, Cocconi G, Togni R, Vezzadini P, Missale G. Gastric endocrine cell proliferation. Arch Pathol 1974; 98: 274-8.","journal-title":"Arch Pathol"},{"key":"ref_6","first-page":"561","article-title":"Reversal by antrectomy of endocrine cell hyperplasia in the gastric body in pernicious anemia: a morphometric study","volume":"3","author":"Kern, S.E.; Yardley, J.H.; Lazenby, A.J.; Boitnott, J.K.; Yang, V.W.; Bayless, T.M.; Sitzmann, J.V.","year":"1990","unstructured":"Kern SE, Yardley JH, Lazenby AJ, Boitnott JK, Yang VW, Bayless TM, Sitzmann JV. Reversal by antrectomy of endocrine cell hyperplasia in the gastric body in pernicious anemia: a morphometric study. Modern Pathology 1990; 3: 561-6.","journal-title":"Modern Pathology"},{"key":"ref_7","first-page":"1","article-title":"Effect of gastrin receptor blockade on endocrine cells in rate during achlorhydria","volume":"103","author":"Eissele, R.; Patberg, H.; Koop, H.; Krack, W.; Lorenz, W.; McKnight, A.T.; Arnold, R.","year":"1992","unstructured":"Eissele R, Patberg H, Koop H, Krack W, Lorenz W, McKnight AT, Arnold R. Effect of gastrin receptor blockade on endocrine cells in rate during achlorhydria. Gastroenterology 1992; 103: 1-596-601.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"503","article-title":"Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia","volume":"14","author":"Solcia, E.; Capella, C.; Fiocca, R.; Rindi, G.; Rosai, J.","year":"1990","unstructured":"Solcia E, Capella C, Fiocca R, Rindi G, Rosai J. Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia. AmJ SurgPathol 1990; 14: 503-13.","journal-title":"AmJ SurgPathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000199378","article-title":"Gastric carcinoids and related endocrine growths","volume":"35","author":"Solcia, E.; Capella, C.; Sessa, F.; Rindi, G.; Cornaggia, M.; Riva, C.; Villani, L.","year":"1986","unstructured":"Solcia E, Capella C, Sessa F, Rindi G, Cornaggia M, Riva C, Villani L. Gastric carcinoids and related endocrine growths. Digestion 1986; 35: 3-22.","journal-title":"Digestion"},{"key":"ref_10","first-page":"53","article-title":"Toxicological studies on omeprazole","volume":"108","author":"Ekman, L.; Hansson, E.; Havu, N.; Carlsson, E.; Lundberg, G.","year":"1985","unstructured":"Ekman L, Hansson E, Havu N, Carlsson E, Lundberg G. Toxicological studies on omeprazole. ScandJ Gastroenterol 1985; 20 (suppl): 108, 53-69.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1476-5381.1985.tb11083.x","article-title":"Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an unsurmountable histamine H2 receptor blocking drug","volume":"85","author":"Brittain, R.T.; Jack, D.; Reeves, J.J.; Stables, R.","year":"1985","unstructured":"Brittain RT, Jack D, Reeves JJ, Stables R. Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an unsurmountable histamine H2 receptor blocking drug. BrJ Pharmacol 1985; 85: 843-7.","journal-title":"BrJ Pharmacol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1136\/gut.27.11.1338","article-title":"Changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade","volume":"27","author":"Poynter, D.; Selway, S.A.M.; Papworth, S.A.; Riches, SR","year":"1986","unstructured":"Poynter D, Selway SAM, Papworth SA, Riches SR. Changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade. Gut 1986; 27: 1338-46.","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0167-0115(89)90265-6","article-title":"Omeprazole and ranitidine, antisecretagogues with different modes of action, are equally effective in causing hyperplasia of enterochromaffin-like cells in rat stomach","volume":"25","author":"Ryberg, B.; Bishop, A.E.; Bloom, SR, Carlsson; E, Hakanson; R, Larsson; H, Mattsson; H, Polak; JM, Sundler; F.","year":"1989","unstructured":"Ryberg B, Bishop AE, Bloom SR, Carlsson E, Hakanson R, Larsson H, Mattsson H, Polak JM, Sundler F. Omeprazole and ranitidine, antisecretagogues with different modes of action, are equally effective in causing hyperplasia of enterochromaffin-like cells in rat stomach. Regul Pep 1989; 25: 235-46.","journal-title":"Regul Pep"},{"key":"ref_14","first-page":"723","article-title":"Proliferation of enterochromaffinlike cells in omeprazole-treated hypergastrinemic rats","volume":"96","author":"Tielemans, Y.; Hakanson, R.; Sundler, F.; Willems, G.","year":"1989","unstructured":"Tielemans Y, Hakanson R, Sundler F, Willems G; Proliferation of enterochromaffinlike cells in omeprazole-treated hypergastrinemic rats. Gastroenterology 1989; 96: 723-9.","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000199615","article-title":"Long-term omeprazole treatment in man: Effects on gastric endocrine cell populations","volume":"39","author":"Lamberts, R.; Creutzfeldt, W.; Stockmann, F.; Jacubaschke, U.; Maas, S.; Brunner, G.","year":"1988","unstructured":"Lamberts R, Creutzfeldt W, Stockmann F, Jacubaschke U, Maas S, Brunner G. Long-term omeprazole treatment in man: Effects on gastric endocrine cell populations. Digestion 1988; 39: 126-35.","journal-title":"Digestion"},{"key":"ref_16","first-page":"373","article-title":"Gastrinoma as a model for prolonged hypergastremia in the human","author":"Jensen, R.T.","year":"1993","unstructured":"Jensen RT. Gastrinoma as a model for prolonged hypergastremia in the human. In: Walsh JM ed. Gastrin. New York: Raven Press 1993: 373-93."},{"key":"ref_17","first-page":"127","article-title":"Contribution of the antrum and duodenum to circulating forms of gastrin in the dog","volume":"7","author":"Feurle, G.E.; Menzel, J.; Klempa, I.","year":"1983","unstructured":"Feurle GE, Menzel J, Klempa I. Contribution of the antrum and duodenum to circulating forms of gastrin in the dog. RegulPept 1983; 7: 127-35.","journal-title":"RegulPept"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/jcem-67-2-353","article-title":"Two-site assay of intact parathyroid homone in the investigation of primary hyperparathyroidism and other disorders of calcium metabolism compared with a midregion assay","volume":"67","author":"Blind, E.; Schmidt-Gayk, H.; Flentje, Schlarla S.; D, Fischer; S, Gohring; U, Hitzler; W.","year":"1988","unstructured":"Blind E, Schmidt-Gayk H, Schlarla S. Flentje D, Fischer S, Gohring U, Hitzler W. Two-site assay of intact parathyroid homone in the investigation of primary hyperparathyroidism and other disorders of calcium metabolism compared with a midregion assay. Jf Clin Endocrin Metab 1988; 67: 353-60.","journal-title":"Jf Clin Endocrin Metab"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2265.1992.tb02324.x","article-title":"Circulating levels of midregional parathyroid hormone-related protein in hypercalcaemia of malignancy","volume":"37","author":"Blind, E.; Raue, F.; Gotzmann, J.; Schmidt-Gayk, H.; Kohl, B.; Ziegler, R.","year":"1992","unstructured":"Blind E, Raue F, Gotzmann J, Schmidt-Gayk H, Kohl B, Ziegler R. Circulating levels of midregional parathyroid hormone-related protein in hypercalcaemia of malignancy. Clin Endocrinol 1992; 37: 290-7.","journal-title":"Clin Endocrinol"},{"key":"ref_20","first-page":"271","article-title":"The argyrophil reaction in islet cells of adult human pancreas studied with a new silver nitrate procedure","volume":"73","author":"Grimelius, L.","year":"1968","unstructured":"Grimelius L. The argyrophil reaction in islet cells of adult human pancreas studied with a new silver nitrate procedure. Acta Soc Med Upsal 1968; 73: 271-4.","journal-title":"Acta Soc Med Upsal"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000199786","article-title":"Histopathological classification of nonantral gastric endocrine growths in man","volume":"41","author":"Solcia, E.; Bordi, C.; Creutzfeldt, W.; Dayal, Y.; Dayan, A.D.; Falkmer, S.; Grimelius, L.; Havu, N.","year":"1988","unstructured":"Solcia E, Bordi C, Creutzfeldt W, Dayal Y, Dayan AD, Falkmer S, Grimelius L, Havu N. Histopathological classification of nonantral gastric endocrine growths in man. Digestion 1988; 41: 185-200.","journal-title":"Digestion"},{"key":"ref_22","first-page":"335","article-title":"The endocrine system of the gut in health and disease","volume":"20","author":"Solcia, E.; Capella, C.; Buffa, R.; Rindi, G.; Fiocca, R.; Tenti, P.","year":"1988","unstructured":"Solcia E, Capella C, Buffa R, Rindi G, Fiocca R, Tenti P. The endocrine system of the gut in health and disease. Ital J Gastroenterol 1988; 20: 335-43.","journal-title":"Ital J Gastroenterol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198607033150101","article-title":"Cushing'\u00a7 syndrome patients with the Zollinger-Ellison Syndrome","volume":"315","author":"Maton, P.N.; Gardner, J.D.; Jensen, R.T.","year":"1986","unstructured":"Maton PN, Gardner JD, Jensen RT. Cushing'\u00a7 syndrome patients with the Zollinger-Ellison Syndrome. N EnglJ Med 1986; 315: 1-5.","journal-title":"N EnglJ Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/gut.33.10.1303","article-title":"Trophic effect of gastrin on the enterochromaffine-like cells of the rat stomach: establishment of a dose response relationship","volume":"33","author":"Brenna, E.; Waldum, H.L.","year":"1992","unstructured":"Brenna E, Waldum HL. Trophic effect of gastrin on the enterochromaffine-like cells of the rat stomach: establishment of a dose response relationship. Gut 1992; 33: 1303-6.","journal-title":"Gut"},{"key":"ref_25","first-page":"153","article-title":"Argyrophil cell hyperplasia and carcinoid tumours in oxyntic mucosa of the stomach. Dependence on duration of pernicious anaemia","volume-title":"Europ journal of Gastroenterology and Hepatology 1991; 3","author":"Sjoblom, S.M.; Sipponen, P.; Karonen, S.L.; Jarvinen, H.J.","unstructured":"Sjoblom SM, Sipponen P, Karonen SL, Jarvinen HJ. Argyrophil cell hyperplasia and carcinoid tumours in oxyntic mucosa of the stomach. Dependence on duration of pernicious anaemia. Europ journal of Gastroenterology and Hepatology 1991; 3: 153-7."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.2.275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:40:08Z","timestamp":1765622408000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.2.275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1994,2,1]]},"published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1136\/gut.35.2.275"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.2.275","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}