{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:33:10Z","timestamp":1761561190166,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>A female patient with a three year history of Crohn's disease of the colon developed myasthenia gravis. Despite diversion of the faecal stream by an ileostomy, and total colectomy, the patient had continuing problems with perineal and perianal abscesses and fistulas. Her myasthenia gravis became unresponsive to anti-cholinergics so a thymectomy was performed. The perineal and perianal disease improved subsequently. This case supports the theory that functional disturbances of the thymus may have a role in the pathogenesis of inflammatory bowel disease.<\/jats:p>","DOI":"10.1136\/gut.35.2.278","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"278-279","source":"Crossref","is-referenced-by-count":21,"title":["Crohn's disease and myasthenia gravis: a possible role for thymectomy."],"prefix":"10.1136","volume":"35","author":[{"given":"I A","family":"Finnie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Shields","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A I","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"ref_1","first-page":"112","article-title":"Myasthenia gravis coexistent with Crohn's disease","volume":"13","author":"Martin, R.W.; Shah, A.","year":"1991","unstructured":"Martin RW, Shah A. 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Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques. Gut 1984; 25: 32-40.","journal-title":"Gut"},{"key":"ref_13","first-page":"415","article-title":"The immunological basis of inflammatory bowel disease","volume-title":"I Clin Immunol","volume":"6","author":"Stroker, W.; James, S.P.","year":"1986","unstructured":"Stroker W, James SP. The immunological basis of inflammatory bowel disease. I Clin Immunol 1986; 6: 415-32."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S0016-5085(88)80094-5","article-title":"Remission ofCrohn's disease after human immunodeficiency virus infection","volume":"95","author":"James, S.P.","year":"1989","unstructured":"James SP. Remission ofCrohn's disease after human immunodeficiency virus infection. 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