{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:29:50Z","timestamp":1773296990861,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>Benign intracranial hypertension (BIH, pseudotumour cerebri) is a rare condition with unknown aetiology although hormonal influences have been implicated. It occurs spontaneously, particularly in young obese women, and is associated with several drug treatments including corticosteroids. Two young adult women are described in whom headache and papilloedema in association with raised intracranial pressure occurred during prednisolone treatment for inflammatory bowel disease. This provides further evidence of the risk of BIH during corticosteroid treatment and has not been described before in adults with this condition. Advice is given to gastroenterologists to use corticosteroids with caution in adults, particularly young, fertile female patients. The treatment of a severe relapse of colitis in a patient who has had one episode of steroid related BIH remains a dilemma.<\/jats:p>","DOI":"10.1136\/gut.35.3.423","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"423-425","source":"Crossref","is-referenced-by-count":36,"title":["Benign intracranial hypertension during prednisolone treatment for inflammatory bowel disease."],"prefix":"10.1136","volume":"35","author":[{"given":"M","family":"Newton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B T","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1212\/WNL.31.7.877","article-title":"Pathogenesis of pseudotumour cerebri syndromes","volume":"31","author":"Donaldson, J.O.","year":"1981","unstructured":"Donaldson JO. Pathogenesis of pseudotumour cerebri syndromes. Neurology 1981; 31: 877-80.","journal-title":"Neurology"},{"key":"ref_2","first-page":"81","article-title":"Cerebrospinal fluid oestrone in pseudotumour cerebri: a change in cerebral steroid hormone metabolism?","volume":"14","author":"Toscano, V.; Sancesario, G.; Bianchi, P.; Cicasrdi, C.; Casilli, D.; Giacomini, P.","year":"1991","unstructured":"Toscano V, Sancesario G, Bianchi P, Cicasrdi C, Casilli D, Giacomini P. Cerebrospinal fluid oestrone in pseudotumour cerebri: a change in cerebral steroid hormone metabolism? JrEndocrinolInvest 1991; 14: 81-6.","journal-title":"JrEndocrinolInvest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/jnnp.45.8.734","article-title":"Cerebrospinal fluid oestrone in pseudotumour cerebri","volume":"45","author":"Donaldson, J.O.; Horak, E.","year":"1982","unstructured":"Donaldson JO, Horak E. Cerebrospinal fluid oestrone in pseudotumour cerebri. J Neurol Neurosurg Psychiatry 1982; 45: 734-6.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00005792-197505000-00002","article-title":"Benign intracranial hypertension","volume":"54","author":"Weisberg, L.A.","year":"1975","unstructured":"Weisberg LA. Benign intracranial hypertension. Medicine (Baltimore) 1975; 54: 197-207.","journal-title":"Medicine (Baltimore)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00006254-198506000-00001","article-title":"Pseudotumour cerebri in pregnancy. Case report and review of the literature","volume":"40","author":"Peterson, C.M.; Kelly, J.V.","year":"1985","unstructured":"Peterson CM, Kelly JV. Pseudotumour cerebri in pregnancy. Case report and review of the literature. Obstet Gynecol Surv 1985; 40: 323-9.","journal-title":"Obstet Gynecol Surv"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1227\/00006123-198308000-00017","article-title":"Cushing's disease in childhood: benign intracranial hypertension after transsphenoidal adenomectomy: case report","volume":"13","author":"Weissman, M.N.; Page, L.K.; Bejar, R.L.","year":"1983","unstructured":"Weissman MN, Page LK, Bejar RL. Cushing's disease in childhood: benign intracranial hypertension after transsphenoidal adenomectomy: case report. Neurosurgery 1983; 13: 195-8.","journal-title":"Neurosurgery"},{"issue":"5","key":"ref_7","first-page":"15","article-title":"Benign intracranial hypertension during etretinate therapy for mycosis fungoides","volume":"13","author":"Viraben, R.; Mathieu, C.; Fontan, B.","year":"1985","unstructured":"Viraben R, Mathieu C, Fontan B. Benign intracranial hypertension during etretinate therapy for mycosis fungoides. JAm Acad Dermatol 1985; 13: 5 15-7.","journal-title":"JAm Acad Dermatol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/bmj.3.5722.554","article-title":"Benign intracranial hypertension following corticosteroid withdrawl in childhood","volume":"3","author":"Neville, B.G.R.; Wilson, J.","year":"1970","unstructured":"Neville BGR, Wilson J. Benign intracranial hypertension following corticosteroid withdrawl in childhood. BMJ 1970; 3: 554-6.","journal-title":"BMJ"},{"key":"ref_9","first-page":"701","article-title":"Raised intracranial pressure associated with Triamcinolone","volume":"i:","author":"Laurance, B.M.; Matthews, W.B.; Shephard, R.H.","year":"1960","unstructured":"Laurance BM, Matthews WB, Shephard RH. Raised intracranial pressure associated with Triamcinolone. Lancet 1960; i: 701.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0140-6736(60)92682-9","article-title":"Raised intracranial pressure associated with steroid therapy","volume":"ii:","author":"Warin, R.P.; Evan, C.D.","year":"1960","unstructured":"Warin RP, Evan CD. Raised intracranial pressure associated with steroid therapy. Lancet 1960; ii: 42.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0140-6736(59)91983-X","article-title":"Triamcinolone and intracranial hypertension: a side-effect?","volume":"i:","author":"Valentine, G.H.","year":"1959","unstructured":"Valentine GH. Triamcinolone and intracranial hypertension: a side-effect? Lancet 1959; i: 892.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2169\/internalmedicine1962.29.566","article-title":"A case of pseudotumour cerebri following glucocorticoid therapy in which warfarin prevented recurrence","volume":"29","author":"Sakamaki, Y.; Nakamura, R.; Uchida, M.; Saito, T.; Okajima, S.","year":"1990","unstructured":"Sakamaki Y, Nakamura R, Uchida M, Saito T, Okajima S. A case of pseudotumour cerebri following glucocorticoid therapy in which warfarin prevented recurrence. JpnJI Med 1990; 29: 566-70.","journal-title":"JpnJI Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/bmj.2.6035.564","article-title":"Benign intracranial hypertension after withdrawal of topical steroids in an infant","volume":"2","author":"Roussounis, S.H.","year":"1976","unstructured":"Roussounis SH. Benign intracranial hypertension after withdrawal of topical steroids in an infant. BMJ 1976; 2: 564.","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/bmj.1.6112.550-a","article-title":"Benign intracranial hypertension in a child with eczema treated with topical steroids","volume":"1","author":"Hosking, G.P.; Elliston, H.","year":"1978","unstructured":"Hosking GP, Elliston H. Benign intracranial hypertension in a child with eczema treated with topical steroids. BMJ 1978; 1: 550-1.","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0404.1988.tb05888.x","article-title":"Clinical course and prognosis of pseudotumour cerebri. A prospective study of 24 patients","volume":"77","author":"P, Soelberg Sorenson; B, Krogsaa; F, Gjerris","year":"1988","unstructured":"Soelberg Sorenson P, Krogsaa B, Gjerris F. Clinical course and prognosis of pseudotumour cerebri. A prospective study of 24 patients. Acta Neurol Scand 1988; 77: 164-72.","journal-title":"Acta Neurol Scand"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0090-3019(81)90010-0","article-title":"The treatment of benign intracranial hypertension: a review of 134 cases","volume":"16","author":"Johnston, I.; Paterson, A.; Besser, M.","year":"1981","unstructured":"Johnston I, Paterson A, Besser M. The treatment of benign intracranial hypertension: a review of 134 cases. Surg Neurol 1981; 16: 218-24.","journal-title":"Surg Neurol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/archinte.1974.00320170084007","article-title":"Pseudotumour cerebri treated by rice\/reduction diet","volume":"133","author":"Newborg, B.","year":"1974","unstructured":"Newborg B. Pseudotumour cerebri treated by rice\/reduction diet. Arch Intern Med 1974; 133: 802-7.","journal-title":"Arch Intern Med"},{"key":"ref_18","first-page":"313","article-title":"'Benign' intracranial hypertension. A survey of the clinical and radiological features, and long term prognosis","volume":"97","author":"Boddie, H.G.; Banna, M.; Bradley, W.G.","year":"1974","unstructured":"Boddie HG, Banna M, Bradley WG. 'Benign' intracranial hypertension. A survey of the clinical and radiological features, and long term prognosis. Brain 1974; 97: 313-26.","journal-title":"Brain"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.3.423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:26:54Z","timestamp":1765603614000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.3.423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1994,3,1]]},"published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1136\/gut.35.3.423"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.3.423","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}