{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:55:36Z","timestamp":1790517336592,"version":"4.1.0"},"reference-count":27,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p>This study examined the hypothesis that 5HT3 mechanisms mediate the postprandial gastrocolonic response in humans. Fasting and postprandial colonic tone and motility were studied in 12 healthy volunteers and the effects of a selective 5HT3 antagonist, ondansetron assessed in a double blind, randomised, placebo controlled fashion. A manometry barostat assembly was positioned in the transverse or descending colon to quantitate contractile activity fasting, after drug infusion and postprandially after a 1000 kcal meal. Fasting colonic tone and motility indices were similar in the placebo and ondansetron groups; ondansetron did not affect fasting motility. The placebo group showed a significant reduction in barostat balloon volume (signifying increased tone) from 232 ml (median, interquartile range (IQR) 179-261) during fasting to 181 ml (median, IQR 128-208) (postprandially) (p = 0.02). In contrast, the ondansetron group did not have a tonic colonic response (median 248 ml (IQR 199-300) fasting to median, 226 ml (IQR 185-290) postprandially) after the meal. Phasic volume events measured by the barostat increased postprandially in both groups. Postprandial motor activity measured by manometry increased significantly in the placebo group, but not in the ondansetron group. In conclusion, a 5HT3 mechanism participates in the physiological contractile responses in the human transverse and descending colon after ingestion of a high energy meal.<\/jats:p>","DOI":"10.1136\/gut.35.4.536","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"536-541","source":"Crossref","is-referenced-by-count":110,"title":["Serotonergic mediation of postprandial colonic tonic and phasic responses in humans."],"prefix":"10.1136","volume":"35","author":[{"given":"M R","family":"von der Ohe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R B","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Camilleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"issue":"6","key":"ref_1","first-page":"251","article-title":"The movements of the intestines studied by means of the Rontgen rays","volume":"1902","author":"Cannon, W.B.","unstructured":"Cannon WB. 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Gut 1966; 7: 468-73.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0016-5085(78)90835-1","article-title":"Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity","volume":"75","author":"WJ, Jr, Snape; SA, Matarazzo; S, Cohen","year":"1978","unstructured":"Snape WJ Jr, Matarazzo SA, Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology 1978; 75: 373-8.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJM197804202981604","article-title":"Colonic myoelectrical activity in irritable bowel syndrome","volume":"298","author":"Sullivan, M.A.; Cohen, S.; WJ, Jr, Snape","year":"1978","unstructured":"Sullivan MA, Cohen S, Snape WJ Jr. Colonic myoelectrical activity in irritable bowel syndrome. 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Right and left colonic transit after eating assessed by a dual isotopic technique in healthy humans. Gastroenterology 1992; 103: 80-5."},{"key":"ref_10","first-page":"118","article-title":"Colonic motor response to eating: a manometric investigation in proximal and distal portions of the viscus in man","volume":"84","author":"Bassotti, G.; Betti, C.; Imbimbo, B.P.; Pelli, M.A.; Morelli, A.","year":"1989","unstructured":"Bassotti G, Betti C, Imbimbo BP, Pelli MA, Morelli A. Colonic motor response to eating: a manometric investigation in proximal and distal portions of the viscus in man. AmJ Gastroenterol 1989; 84: 118-22.","journal-title":"AmJ Gastroenterol"},{"key":"ref_11","first-page":"1899","article-title":"Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome","volume":"102","author":"Niederau, C.; Faber, S.; Karaus, M.","year":"1992","unstructured":"Niederau C, Faber S, Karaus M. Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome. Gastroenterology 1992; 102: 1899-905.","journal-title":"Gastroenterology"},{"issue":"40","key":"ref_12","first-page":"1","article-title":"Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome","volume":"1961","author":"Chaudhary, N.A.; Truelove, S.C.","unstructured":"Chaudhary NA, Truelove SC. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. I. Resting patterns ofmotility. Gastroenterology 1961; 40: 1-17.","journal-title":"I. Resting patterns ofmotility. Gastroenterology"},{"key":"ref_13","first-page":"505","article-title":"Measurement of tone in canine colon","volume":"260","author":"Neri, M.; Phillips, S.F.; Fich, A.","year":"1991","unstructured":"Neri M, Phillips SF, Fich A. 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The gastrointestinal prokinetic benzamide derivatives are agonists at the nonclassical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons. Naunyn Schmiedebergs Arch Pharmacol 1989; 340: 403-10.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0922-4106(90)90190-9","article-title":"The concept of selectivity in 5-HT receptor research","volume":"188","author":"I, Van Winigaarden; MThM, Tulp; W, Soudiin","year":"1990","unstructured":"Van Winigaarden I, Tulp MThM, Soudiin W. The concept of selectivity in 5-HT receptor research. EurJ7 Pharmacol 1990; 188: 301-12.","journal-title":"EurJ7 Pharmacol"},{"key":"ref_25","first-page":"579","article-title":"Postprandial function of human ascending colon: a biphasic response involving 5HT3 mechanism","volume":"104","author":"Scolapio, J.S.; von der Ohe, M.; Hanson, R.B.; Camilleri, M.","year":"1993","unstructured":"Scolapio JS, von der Ohe M, Hanson RB, Camilleri M. Postprandial function of human ascending colon: a biphasic response involving 5HT3 mechanism. Gastroenterology 1993; 104: A579.","journal-title":"Gastroenterology"},{"key":"ref_26","first-page":"139","article-title":"Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonist. Alim Pharmacol Ther","volume":"4","author":"Gore, S.; Gilmore, I.T.; Haigh, C.G.; Brownless, S.M.; Stockdale, H.; Al, Morris","year":"1990","unstructured":"Gore S, Gilmore IT, Haigh CG, Brownless SM, Stockdale H, Morris Al. Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonist. Alim Pharmacol Ther 1990; 4: 139-44."},{"key":"ref_27","first-page":"732","article-title":"Selective 5-HT3 receptor antagonist, Ondansetron, as treatment for diarrhea-predominant IBS. A pilot study","volume-title":"Mayo Clin Proc 1992","volume":"67","author":"Steadman, C.J.; Talley, N.J.; Phillips, S.F.; Zinsmeister, A.R.","unstructured":"Steadman CJ, Talley NJ, Phillips SF, Zinsmeister AR. Selective 5-HT3 receptor antagonist, Ondansetron, as treatment for diarrhea-predominant IBS. A pilot study. Mayo Clin Proc 1992; 67: 732-8."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.4.536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:32:38Z","timestamp":1763749958000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.4.536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1994,4,1]]},"published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1136\/gut.35.4.536"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.4.536","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}