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In contrast, the antral somatostatin concentration was significantly decreased in infected patients. Progastrin processing, determined by gel chromatography, seemed unaffected by H pylori infection. The results suggest that the finding of increased gastrin secretion from the antral G cells in H pylori infected patients may be a result of reduced inhibition of G-cell secretion by somatostatin.<\/jats:p>","DOI":"10.1136\/gut.35.5.615","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"615-618","source":"Crossref","is-referenced-by-count":53,"title":["Gastrin and somatostatin in Helicobacter pylori infected antral mucosa."],"prefix":"10.1136","volume":"35","author":[{"given":"L","family":"Odum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H D","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I B","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B F","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"ref_1","first-page":"11","article-title":"Campylobacter pylori and duodenal ulcers: the gastrin link","volume":"i:","author":"Levi, S.; Beardshall, K.; Haddad, G.; Playford, R.; Ghosh, P.; Calam, J.","year":"1989","unstructured":"Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lanzcet 1989; i: 11 67-8.","journal-title":"Lanzcet"},{"key":"ref_2","first-page":"394","article-title":"Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter","volume-title":"(Campylobacter) pylorn infection. Gastroenterology 1990; 85","author":"Graham, D.Y.; Opekun, A.; Lew, G.M.; Evans, D.J.; Klein, P.D.; Evans, D.G.","unstructured":"Graham DY, Opekun A, Lew GM, Evans DJ, Klein PD, Evans DG. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylorn infection. 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Scanid _7 Gastroenterol 1991; 26: 339-46."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/gut.33.5.601","article-title":"Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients","volume":"33","author":"Beardshall, K.; Moss, S.; Gill, J.; Levi, S.; Ghosh, P.; Playford, R.J.; Calam, J.","year":"1992","unstructured":"Beardshall K, Moss S, Gill J, Levi S, Ghosh P, Playford RJ, Calam J. Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. 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Effect of increasing Helicobacter pylorn ammonia production by urea infusion on plasma gastrin concentrations. Gut 1991; 32: 21-4.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1136\/gut.32.8.866","article-title":"Effect of inhibition of Helicobacter pylori urease activity by acetohydromamic acid on serum gastrin in duodenal ulcer subjects","volume":"32","author":"AM, El Nujumi; CA, Dorrian; RS, Chittajallu; WD, Neithercut; KEL, McColl","year":"1991","unstructured":"El Nujumi AM, Dorrian CA, Chittajallu RS, Neithercut WD, McColl KEL. Effect of inhibition of Helicobacter pylori urease activity by acetohydromamic acid on serum gastrin in duodenal ulcer subjects. 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Helicobacter pylori-related hypergastrinaemia is not due to elevated antral surface pH. Scandj7 Gastroeniterol 1992; 27: 218-22."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3109\/00365529209000154","article-title":"Effect of Helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer subjects","volume":"27","author":"Chittajallu, R.S.; Howie, C.A.; McColl, K.E.L.","year":"1992","unstructured":"Chittajallu RS, Howie CA, McColl KEL. Effect of Helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer subjects. 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Amsterdam: Elsevier Science Publishers BV, 1989: 405-7."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1042\/cs0760237","article-title":"Ascorbic acid: a factor conccntrated in human gastric juice","volume":"76","author":"Rathbone, B.J.; Johnson, A.W.; Wyatt, J.I.; Kelleher, J.; Heatlev, R.V.; Losowsky, M.S.","year":"1989","unstructured":"Rathbone BJ, Johnson AW, Wyatt JI, Kelleher J, Heatlev RV, Losowsky MS. Ascorbic acid: a factor conccntrated in human gastric juice. 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