{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:34:53Z","timestamp":1763750093187,"version":"3.45.0"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:p>Short term sclerotherapy (by injection(s) around the bleeding point) is used for immediate control of massive haemorrhage from oesophagogastric varices. The usefulness of longterm sclerotherapy once short term sclerotherapy has been successfully carried out was assessed. Two treatment groups were studied: 50 patients were treated by 'combined' (short term followed by longterm) sclerotherapy; 56 patients were treated by short term sclerotherapy only. Patients included in the second group were treated by short term sclerotherapy only if a variceal rebleeding was present. The overall cumulative proportion of patients rebleeding was not significantly different in either group. Combined sclerotherapy patients, however, experienced less episodes of variceal haemorrhage and the source of haemorrhage was different (p &lt; 0.002). Combined sclerotherapy was more efficient in preventing bleeding from oesophageal bleeding points but not those arising from a junctional source (p &lt; 0.05). A greater incidence of oesophageal rebleeding was found in those patients whose first source of bleeding was oesophageal (p &lt; 0.05). No significant difference was detected in survival expectancy between either group. In conclusion, after short term sclerotherapy is carried out successfully, those patients with bleeding from variceal bleeding points located on oesophageal mucosa should benefit most from a longterm sclerotherapy programme.<\/jats:p>","DOI":"10.1136\/gut.35.5.687","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"687-691","source":"Crossref","is-referenced-by-count":8,"title":["Combined (short-term plus longterm) sclerotherapy v short-term only sclerotherapy: a randomised prospective trial."],"prefix":"10.1136","volume":"35","author":[{"given":"M","family":"Moret\u00f3","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zaballa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ojembarrena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Seti\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"ref_1","first-page":"323","article-title":"A prospective controlled trial of sclerotherapy in the long term management of patients after esophageal variceal bleeding","volume":"148","author":"Terblanche, J.; Northover, J.M.A.; Bornman, P.; Kahn, D.; Silber, W.; Barbezat, G.O.","year":"1979","unstructured":"Terblanche J, Northover JMA, Bornman P, Kahn D, Silber W, Barbezat GO, et al. A prospective controlled trial of sclerotherapy in the long term management of patients after esophageal variceal bleeding. Surg Gynecol Obstet 1979; 148: 323-33.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_2","first-page":"552","article-title":"Prospective controlled trial of injection sclerotherapy in patients with cirrhosis and recent variceal haemorrhage","volume":"ii:","author":"Clark, A.W.; Macdougall, B.R.D.; Westaby, D.; Mitchell, K.J.; Silk, D.B.A.; Strunin, L.","year":"1980","unstructured":"Clark AW, Macdougall BRD, Westaby D, Mitchell KJ, Silk DBA, Strunin L, et al. Prospective controlled trial of injection sclerotherapy in patients with cirrhosis and recent variceal haemorrhage. Lancet 1980; ii: 552-4.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/bjs.1800690206","article-title":"Tamponade and injection sclerotherapy in the management of bleeding oesophageal varices","volume":"69","author":"Barsoum, M.S.; Fl, Bolous; El-Rooby, A.A.; Rizk-Allah, M.A.; Ibrahim, A.S.","year":"1982","unstructured":"Barsoum MS, Bolous Fl, El-Rooby AA, Rizk-Allah MA, Ibrahim AS. Tamponade and injection sclerotherapy in the management of bleeding oesophageal varices. Br J Surg 1982; 69: 76-8.","journal-title":"Br J Surg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0016-5107(86)71916-0","article-title":"A comparison of immediate versus delayed injection sclerosis of bleeding esophageal varices","volume":"32","author":"Prindiville, T.; Trudeau, W.","year":"1986","unstructured":"Prindiville T, Trudeau W. A comparison of immediate versus delayed injection sclerosis of bleeding esophageal varices. Gastrointest Endosc 1986; 32: 385-8.","journal-title":"Gastrointest Endosc"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh, R.N.H.; Murray-Lyon, I.M.; Dawson, J.L.; Pietroni, M.C.; Williams, R.","year":"1973","unstructured":"Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. BrJ Surg 1973; 60: 646-9.","journal-title":"BrJ Surg"},{"key":"ref_6","first-page":"121","article-title":"Tables of the number of patients required in clinical trials using the logrank test","volume":"1","author":"Freedman, L.S.","year":"1982","unstructured":"Freedman LS. Tables of the number of patients required in clinical trials using the logrank test. StatMed 1982; 1: 121-9.","journal-title":"StatMed"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archinte.1985.00360040141030","article-title":"When was a negative clinical trial big enough? How many patients you needed depends on what you found","volume":"145","author":"Detsky, A.S.; Sackett, D.L.","year":"1985","unstructured":"Detsky AS, Sackett DL. When was a negative clinical trial big enough? How many patients you needed depends on what you found. Arch Intern Med 1985; 145: 709-12.","journal-title":"Arch Intern Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7326\/0003-4819-105-3-429","article-title":"Confidence intervals for reporting results of clinical trials","volume":"105","author":"Simon, R.","year":"1986","unstructured":"Simon R. Confidence intervals for reporting results of clinical trials. Ann Intern Med 1986; 105: 429-35.","journal-title":"Ann Intern Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observations of each patient","volume":"35","author":"Peto, R.; Pike, M.C.; Armitage, P.; Breslow, N.E.; Cox, D.R.; Howard, S.W.","year":"1977","unstructured":"Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SW, et al. Design and analysis of randomized clinical trials requiring prolonged observations of each patient. Br J Cancer 1977; 35: 1-39.","journal-title":"Br J Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0016-5085(87)90453-7","article-title":"Normal venous circulation of the gastroesophageal junction. A route to understanding varices","volume":"93","author":"Vianna, A.; Hayes, P.C.; Moscoso, G.; Driver, M.; Portmann, B.; Westaby, D.","year":"1987","unstructured":"Vianna A, Hayes PC, Moscoso G, Driver M, Portmann B, Westaby D, et al. Normal venous circulation of the gastroesophageal junction. A route to understanding varices. Gastroenterology 1987; 93: 876-89.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0016-5085(89)90078-4","article-title":"Development of large spleno-adreno-renal shunt after endoscopic sclerotherapy","volume":"97","author":"Dilawari, J.B.; Raju, G.S.; Chawla, Y.K.","year":"1989","unstructured":"Dilawari JB, Raju GS, Chawla YK. Development of large spleno-adreno-renal shunt after endoscopic sclerotherapy. Gastroenterology 1989; 97: 421-6.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"1558","article-title":"Natural history of congestive gastropathy","volume-title":"cirrhosis. Gastroenterology 1990","volume":"99","author":"D'Amico, G.; Montalbano, L.; Traina, M.; Pisa, R.; Menozzi, M.; Spano, M.","unstructured":"D'Amico G, Montalbano L, Traina M, Pisa R, Menozzi M, Spano M, et al. Natural history of congestive gastropathy in cirrhosis. Gastroenterology 1990; 99: 1558-64."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/0016-5085(92)90188-5","article-title":"Factors influencing development of portal hypertensive gastropathy in patients with portal hypertension","volume":"102","author":"Sarin, S.K.; Sreenivas, Lahoti; D, Saraya; A.","year":"1992","unstructured":"Sarin SK, Sreenivas, Lahoti D, Saraya A. Factors influencing development of portal hypertensive gastropathy in patients with portal hypertension. Gastroenterology 1992; 102: 994-9.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.5.687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:30:44Z","timestamp":1763749844000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.5.687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1994,5,1]]},"published-print":{"date-parts":[[1994,5]]}},"alternative-id":["10.1136\/gut.35.5.687"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.5.687","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}