{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:36:39Z","timestamp":1765629399297,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>Mucosa of healed gastric ulcers displays histological abnormalities that are possibly the basis of ulcer recurrence. The influence of antacid and omeprazole treatment was studied on the quality of ulcer healing. Sixty four rats with gastric cryoulcers were treated daily either with placebo, antacid, omeprazole, or antacid plus omeprazole. Ulcer size was measured three times per week with a novel video endoscopic method. Prostaglandin generation (day 6), cell proliferation (day 8 and 15), height and cell composition of ulcer margin (day 8), and mucosal scar (day 15) were quantitatively assessed. Antacid, omeprazole, and antacid plus omeprazole significantly accelerated ulcer healing predominantly during days 3-8. Compared with placebo, the height of ulcer margin and mucosal ulcer scar was significantly increased in antacid (+7 and +9% respectively) and significantly decreased in omeprazole (-33 and -22% respectively) and antacid plus omeprazole (-26 and -18% respectively) treated rats. The number of bromodeoxyuridine labelled cells (+42%, day 8), epithelial cell mass (+42%, day 15), and the ratios of epithelial cells\/connective tissue (+73%, day 15) and epithelial cells\/gland lumen (+100%, day 15) were significantly increased in antacid treated rats. In conclusion, both antacid and omeprazole accelerate ulcer healing but antacid provides a better quality of healing. This advantage is lost by cotreatment with omeprazole.<\/jats:p>","DOI":"10.1136\/gut.35.7.896","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"896-904","source":"Crossref","is-referenced-by-count":17,"title":["Antacid provides better restoration of glandular structures within the gastric ulcer scar than omeprazole."],"prefix":"10.1136","volume":"35","author":[{"given":"A","family":"Schmassmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tarnawski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H A","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Flogerzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Halter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3109\/00365528209181120","article-title":"Controlled clinical trial of duodenal ulcer healing with antacid tablets","volume":"17","author":"Berstad, A.; Rydning, A.; Aadland, E.; Kolstad, B.; Frislid, K.L.; Aaseth, J.","year":"1982","unstructured":"Berstad A, Rydning A, Aadland E, Kolstad B, Frislid KL, Aaseth J. Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scand J Gastroenterol 1982; 17: 953-9. E2","journal-title":"Scand J Gastroenterol"},{"key":"ref_2","first-page":"1199","article-title":"Controlled therapeutic trial to determine the optimum dose of antacids in duodenal ulcer","volume":"24","author":"Kumar, N.; Vij, J.C.; Karol, A.; Anand, B.S.","year":"1984","unstructured":"Kumar N, Vij JC, Karol A, Anand BS. Controlled therapeutic trial to determine the optimum dose of antacids in duodenal ulcer. Gut 1984; 24: 1199-202.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJM198504113121505","article-title":"Effect of omeprazole and cimetidine on duodenal ulcer: a double-blind comparative trial","volume":"312","author":"Lauritsen, K.; Rune, S.J.; Bytzer, P.; Kelbaek, H.; Jensen, K.G.; Rask-Madsen, J.","year":"1985","unstructured":"Lauritsen K, Rune SJ, Bytzer P, Kelbaek H, Jensen KG, Rask-Madsen J, et al. Effect of omeprazole and cimetidine on duodenal ulcer: a double-blind comparative trial. N EnglJMed 1985; 312: 958-61.","journal-title":"N EnglJMed"},{"issue":"1","key":"ref_4","first-page":"139","article-title":"'Healed' experimental gastric Fceilgo lusr\/econ1wn~ 0e: ctC~ievlelutli~assrueco(m~Apo)sia~tnidonespoiftahmeulciwaoilslaclelllusl3\/eglrnansedcalgruomneunda(sB)1q5w.eerTehtesirganetiifoioscaoneftlelypiitnnheclrieaalsend ulcers remain histologically and ultrastructurally abnormal","volume":"12","author":"Tarnawski, A.; Hollander, D.; Krause, W.J.; Dabros, W.; Stachura, J.; Gergely, H.","year":"1990","unstructured":"Tarnawski A, Hollander D, Krause WJ, Dabros W, Stachura J, Gergely H. 'Healed' experimental gastric Fceilgo lusr\/econ1wn~0e:ctC~ievlelutli~assrueco(m~Apo)sia~tnidonespoiftahmeulciwaoilslaclelllusl3\/eglrnansedcalgruomneunda(sB)1q5w.eerTehtesirganetiifoioscaoneftlelypiitnnheclrieaalsend ulcers remain histologically and ultrastructurally abnormal. J Clin Gastroenterol 1990; 12 (suppl 1): 139-47.","journal-title":"J Clin Gastroenterol"},{"article-title":"Morphologic studies on the margin of gastric corpus wounds in the rat. Jf Submicrosc Cytol 1983; 15: 627-43. omeprazole treatment is predominantly due to accelerated migration of cells over the granula-","author":"Helander, H.E.","key":"ref_5","unstructured":"Helander HE. Morphologic studies on the margin of gastric corpus wounds in the rat. Jf Submicrosc Cytol 1983; 15: 627-43. omeprazole treatment is predominantly due to accelerated migration of cells over the granula-"},{"key":"ref_6","article-title":"'Healed' duodenal ulcers are","volume-title":"histologically ill. Gastroenterology 1985; 88: 1390","author":"Fullman, H.; Van Deventer, G.; Schneidman, D.; Walsh, J.; Elashoff, J.; Weinstein, W.","unstructured":"Fullman H, Van Deventer G, Schneidman D, Walsh J, Elashoff J, Weinstein W. 'Healed' duodenal ulcers are histologically ill. Gastroenterology 1985; 88: 1390."},{"key":"ref_7","first-page":"585","article-title":"The course of recurrent ulcer","volume":"61","author":"Litman, A.; Hanscom, D.H.","year":"1971","unstructured":"Litman A, Hanscom DH. The course of recurrent ulcer. Gastroenterology 1971; 61: 585-9 1.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"206","article-title":"Effect of sucralfate on the quality of experimental gastric ulcer healing - quantitative histologic assessment. alone. The trophic effect of the antacid on the ulcer margin and scar","volume-title":"was nearly abolished Gastroenterology 1993; 104","author":"Tamawski, A.; Ichikawa, Y.; Stachura, J.; Douglass, T.G.; Sarfeh, I.J.","unstructured":"Tamawski A, Ichikawa Y, Stachura J, Douglass TG, Sarfeh IJ. Effect of sucralfate on the quality of experimental gastric ulcer healing - quantitative histologic assessment. alone. The trophic effect of the antacid on the ulcer margin and scar was nearly abolished Gastroenterology 1993; 104: A206."},{"key":"ref_9","first-page":"636","article-title":"Influence of prostaglandins, by concomitant treatment with omeprazole. These results show that an acid environment is omeprazole, and indomethacin on healing of experimental gastric ulcers","volume-title":"the rat. Gastroenterology 1988; 95; necessary for the full expression of the trophic actions of antacid. These results are similar to","author":"Inauen, W.; Wyss, P.A.; Kayser, S.; Baumgartner, A.; Schurer-Maly, C.C.; Koelz, H.R.","unstructured":"Inauen W, Wyss PA, Kayser S, Baumgartner A, Schurer-Maly CC, Koelz HR, et al. Influence of prostaglandins, by concomitant treatment with omeprazole. These results show that an acid environment is omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. Gastroenterology 1988; 95: 636-41. necessary for the full expression of the trophic actions of antacid. These results are similar to"},{"key":"ref_10","article-title":"Simple gastroscopy technique in the rat","author":"Meyrat, P.; Baumgartner, A.; Kappeler, M.; Halter, F.","year":"1984","unstructured":"Meyrat P, Baumgartner A, Kappeler M, Halter F. Simple gastroscopy technique in the rat. Dig Dis Sci 1984; 29: 327-9. those reported in cytoprotection studies, showing that acidified antacid are several fold more","journal-title":"Dig Dis Sci; 29: 327-9. those reported in cytoprotection studies, showing that acidified antacid are several fold more"},{"issue":"1","key":"ref_11","first-page":"51","article-title":"A new endoscopic ulcer model in the rat: endoscopic ulcer induction by acetic acid and videoendoscopic assessment effective than non-acidified antacid.45 49 of healing by sequential morphometric analysis","volume":"49","author":"Schmassmann, A.; Varga, L.; Flogerzi, B.; Halter, F.","year":"1991","unstructured":"Schmassmann A, Varga L, Flogerzi B, Halter F. A new endoscopic ulcer model in the rat: endoscopic ulcer induction by acetic acid and videoendoscopic assessment effective than non-acidified antacid.45 49 of healing by sequential morphometric analysis. 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Digestion 1991; 49: 140-50.","journal-title":"Digestion"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.35.7.896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:33:38Z","timestamp":1765629218000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.35.7.896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1994,7,1]]},"published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1136\/gut.35.7.896"],"URL":"https:\/\/doi.org\/10.1136\/gut.35.7.896","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}