{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:16:16Z","timestamp":1789787776726,"version":"4.0.1"},"reference-count":28,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Omeprazole is a powerful inhibitor of gastric acid and may suppress Helicobacter pylori by effecting the pKa of H pylori urease, by altering the pattern of infection, or by promoting overgrowth of other bacteria. At routine endoscopy H pylori was detected by histology and culture before and after four weeks' treatment with omeprazole, 40 mg each morning. A 13C-urea breath test was also done at t = 0, 2, 4, and 6 weeks. Thirty nine patients with duodenal ulcer (n = 25) or reflux oesophagitis (n = 14) were studied, of whom 29 of 39 had H pylori infection. During omeprazole treatment, 13C-urea breath test values fell significantly--mean (SEM) values before treatment and at four weeks were 23.0 (2.1) and 15.5 (2.7) per mil respectively, p &lt; 0.001. Before treatment H pylori was seen in 28 of 29 antral, 29 of 29 corpus, and 28 of 29 fundic biopsy specimens. After four weeks of omeprazole treatment, the histological density of H pylori in the antrum and corpus was reduced (p &lt; 0.001), while that in the fundus was increased. The migration of H pylori from the antrum to the fundus was associated with a corresponding decrease in the activity of antral gastritis. H pylori was not seen in antral biopsy specimens from 12 of 29 patients whose median excess delta 13CO2 excretion fell from 23.0 to 9.9 per mil. In the body mucosa, 26 of 29 specimens were still positive for H pylori and there was no significant change in the gastritis type. Two weeks after finishing treatment, the mean (SEM) excess delta 13CO2 excretion returned to levels before treatment. Omeprazole decreases antral H pylori colonisation but increases that in the fundus. The changes in the intragastric distribution of the organism are associated with concomitant changes in the activity of gastritis and are matched by a progressive fall in the excretion of delta 13CO2.<\/jats:p>","DOI":"10.1136\/gut.36.1.12","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"12-16","source":"Crossref","is-referenced-by-count":263,"title":["Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole."],"prefix":"10.1136","volume":"36","author":[{"given":"R P","family":"Logan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Misiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Gummett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q N","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0016-5085(88)90606-3","article-title":"Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment","volume":"94","author":"Rauws, E.A.; Langenberg, W.; Houthoff, H.J.; Zanen, H.G.; Tytgat, G.N.J.","year":"1988","unstructured":"Rauws EA, Langenberg W, Houthoff HJ, Zanen HG,Tytgat GNJ. Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gaseroenterology 1988; 94: 33-40.","journal-title":"Gaseroenterology"},{"issue":"1","key":"ref_2","first-page":"233","article-title":"Cure of duodenal ulcer with eradication of Helicobacter pyloni","volume":"335","author":"Rauws, E.A.J.; Tytgat, G.N.J.","year":"1990","unstructured":"Rauws EAJ, Tytgat GNJ. Cure of duodenal ulcer with eradication of Helicobacter pyloni. 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The Sydney system: a new classification of gastritis. _J Gastroenteral Hepatol 1991; 6: 207-52.","journal-title":"_J Gastroenteral Hepatol"},{"key":"ref_16","first-page":"435","article-title":"The effect of omeprazole on Helicobacter pylori and associated gastritis","volume":"5","author":"Daw, M.A.; Deegan, P.; O'Morain, C.","year":"1991","unstructured":"Daw MA, Deegan P, O'Morain C. The effect of omeprazole on Helicobacter pylori and associated gastritis. Alimentary Pharmacology and Therapy 1991; 5: 435-39.","journal-title":"Alimentary Pharmacology and Therapy"},{"key":"ref_17","first-page":"271","article-title":"Elimination of Helicobacter pylori under treatment with omeprazole","volume":"28","author":"Stolte, M.; Bethke, B.","year":"1990","unstructured":"Stolte M, Bethke B. Elimination of Helicobacter pylori under treatment with omeprazole. Z Gastroenterol (Verh) 1990; 28: 271-4.","journal-title":"Z Gastroenterol (Verh)"},{"key":"ref_18","first-page":"357","article-title":"Effect of omeprazole of H pylori after 2 weeks of treatment","volume":"23","author":"Arachimandritis, C.; Tjivras, M.; Davaris, P.; Fertakis, A.","year":"1991","unstructured":"Arachimandritis C, Tjivras M, Davaris P, Fertakis A. Effect of omeprazole of H pylori after 2 weeks of treatment. Italian Journal of Gastroenterology 1991; 23: 357-8.","journal-title":"Italian Journal of Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF01297022","article-title":"Effect of omeprazole on duodenal ulcer-associated antral gastritis and Helicobacter pylori","volume":"36","author":"Hui, W.M.; Lam, S.K.; Ho, J.; Lai, C.L.; Lok, A.S.F.; Ng, M.M.T.","year":"1991","unstructured":"Hui WM, Lam SK, Ho J, Lai CL, Lok ASF, Ng MMT, et al. 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Relationship between Helicobacter pylori infection and gastric and duodenal bacterial overgrowth. Gastroenterology 1993; 104: A81.","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1128\/AAC.35.3.490","article-title":"Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori","volume":"35","author":"Iwahi, T.; Satoh, H.; Nakao, M.; Iwasaki, T.; Yamazaki, T.; Kubo, K.","year":"1991","unstructured":"Iwahi T, Satoh H, Nakao M, Iwasaki T, Yamazaki T, Kubo K, et al. Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. 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European J3ournal of Gastroenterology Hepatology 1993; 5: 683-5."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.37.4.769","article-title":"Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H pylori cells","volume":"37","author":"Nagata, K.; Satoh, H.; Iwahi, T.; Shimoyama, T.; Tamura, T.","year":"1993","unstructured":"Nagata K, Satoh H, Iwahi T, Shimoyama T, Tamura T. Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H pylori cells. Antimicrobial Agents and Chemotherapy 1993; 37: 769-74.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/gut.34.2.181","article-title":"Development of a 14C-urea breath test in ferrets colonised with Helicobacter mustelae: effects of treatment with bismuth, antibiotics and urease inhibitors","volume":"34","author":"McColm, A.A.; Bagshaw, J.A.; O'Malley, C.F.O.","year":"1993","unstructured":"McColm AA, Bagshaw JA, O'Malley CFO. Development of a 14C-urea breath test in ferrets colonised with Helicobacter mustelae: effects of treatment with bismuth, antibiotics and urease inhibitors. 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Ann Intern Med 1991; 115: 266-9.","journal-title":"Ann Intern Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.36.1.12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:27:13Z","timestamp":1763749633000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.36.1.12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1995,1,1]]},"published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1136\/gut.36.1.12"],"URL":"https:\/\/doi.org\/10.1136\/gut.36.1.12","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}