{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:09:17Z","timestamp":1771006157023,"version":"3.50.1"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Cholecystokinin (CCK) release and gall bladder emptying in response to a fatty meal are completely abolished in coeliac disease. To determine the effect of lipid digestion on CCK release and gall bladder motility, six patients with untreated coeliac disease and a flat jejunal mucosa were studied on two separate days. After an overnight fast, the plasma CCK concentration and gall bladder volume were measured before and at regular intervals after the intraduodenal instillation of 60 ml corn oil (triglycerides) incubated with 40 ml saline or with 40 ml bile and pancreatic juice. The mean (SEM) concentration of free fatty acids in the aqueous phase of corn oil after incubation with bile and pancreatic juice (predigested corn oil) was 78 (35) mM compared with 0.1 (0.1) mM in the aqueous phase of corn oil incubated with saline (undigested corn oil). Integrated plasma CCK in response to predigested corn oil was significantly greater than that in response to undigested corn oil (101 (18) pM. 80 min v-2 (9) pM.80 min; p &lt; 0.005). Similarly, integrated gall bladder contraction in response to predigested corn oil was significantly larger than that after undigested corn oil (817 (210) ml. 80 min v-225 (243) ml. 80 min; p &lt; 0.05). In contrast to undigested corn oil, corn oil that has been predigested with bile and pancreatic juice induces plasma CCK secretion and gall bladder contraction in patients with untreated coeliac disease, presumably by generating and rendering soluble lipolytic products.<\/jats:p>","DOI":"10.1136\/gut.36.1.17","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"17-21","source":"Crossref","is-referenced-by-count":32,"title":["Effect of predigested fat on intestinal stimulation of plasma cholecystokinin and gall bladder motility in coeliac disease."],"prefix":"10.1136","volume":"36","author":[{"given":"W P","family":"Hopman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Rosenbusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Hectors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"ref_1","first-page":"1144","article-title":"Cholecystokinin bioactivity in human plasma. 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Gastroenterology 1985; 89: 1242-7.","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1172\/JCI114288","article-title":"Effects of a novel cholecystokinin receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans: implications for the physiology of CCK","volume":"84","author":"Liddle, R.A.; Gertz, B.A.; Kanyama, S.; Beccaria, L.; Coker, L.D.; Turnbull, T.A.","year":"1989","unstructured":"Liddle RA, Gertz BA, Kanyama S, Beccaria L, Coker LD, Turnbull TA, et al. Effects of a novel cholecystokinin receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans: implications for the physiology of CCK. J Clin Invest 1989; 84: 1220-5.","journal-title":"J Clin Invest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1172\/JCI114486","article-title":"Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man","volume":"85","author":"Hildebrand, P.; Beglinger, C.; Gyr, K.; Jansen, J.B.M.J.; Rovati, L.C.; Zuercher, M.","year":"1990","unstructured":"Hildebrand P, Beglinger C, Gyr K, Jansen JBMJ, Rovati LC, Zuercher M, et al. Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man. Jf Clin Invest 1990; 85: 640-6.","journal-title":"Jf Clin Invest"},{"key":"ref_5","first-page":"111","article-title":"Endocrine cells of the digestive system","volume-title":"Physiology of the gastrointestinal tract. Vol 1","author":"Solcia, E.; Capella, C.; Buffa, R.; Usellini, L.; Fiocca, R.; Sessa, F.","year":"1987","unstructured":"Solcia E, Capella C, Buffa R, Usellini L, Fiocca R, Sessa F. Endocrine cells of the digestive system. In: Johnson LR, ed. Physiology of the gastrointestinal tract. Vol 1. 2nd ed. New York: Raven Press, 1987: 111-30.","edition":"2nd ed"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0016-5085(85)90497-4","article-title":"Defective gallbladder emptying and cholecystokinin release in celiac disease","volume":"88","author":"Maton, P.N.; Selden, A.C.; Fitzpatick, M.L.; Chadwick, V.S.","year":"1985","unstructured":"Maton PN, Selden AC, Fitzpatick ML, Chadwick VS. Defective gallbladder emptying and cholecystokinin release in celiac disease. 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Diminished concentrations in patients with coeliac disease","volume":"69","author":"Calam, J.; Ellis, A.; Dockray, G.J.","year":"1982","unstructured":"Calam J, Ellis A, Dockray GJ. Identification and measurement of molecular variants of cholecystokinin in duodenal mucosa and plasma. Diminished concentrations in patients with coeliac disease. _J Clin Invest 1982; 69: 218-25.","journal-title":"_J Clin Invest"},{"key":"ref_9","volume-title":"Cholecystokinin abnormalities in coeliac disease [Abstract]. Gastroenterology 1978; 74: 1079","author":"Polak, J.M.; Bloom, SR, McCrossman; MV, Timson; CM, Johnston; DR, Hudson; D.","unstructured":"Polak JM, Bloom SR, McCrossman MV, Timson CM, Johnston DR, Hudson D, et al. Cholecystokinin abnormalities in coeliac disease [Abstract]. Gastroenterology 1978; 74: 1079."},{"key":"ref_10","first-page":"1178","article-title":"Canine pancreatic responses to intestinally perfused fat and products of fat digestion","volume":"226","author":"Meyer, J.H.; Jones, R.S.","year":"1974","unstructured":"Meyer JH, Jones RS. Canine pancreatic responses to intestinally perfused fat and products of fat digestion. AmJPhysiol 1974; 226: 1178-87.","journal-title":"AmJPhysiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1148\/radiology.154.1.3880611","article-title":"A computerized method for rapid quantification of gallbladder volume from real-time sonograms","volume":"154","author":"Hopman, W.P.M.; Brouwer, W.F.M.; Rosenbusch, G.; Jansen, J.B.M.J.; Lamers, C.B.H.W.","year":"1985","unstructured":"Hopman WPM, Brouwer WFM, Rosenbusch G, Jansen JBMJ, Lamers CBHW. A computerized method for rapid quantification of gallbladder volume from real-time sonograms. 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Digestion 1984; 29: 19-25.","journal-title":"Digestion"},{"key":"ref_14","first-page":"528","article-title":"Immunohistochemical identification of the cholecystokinin cell","volume-title":"the intestinal mucosa. Gastroenterology 1976","volume":"70","author":"Buffa, R.; Solcia, E.; Go, V.L.W.","unstructured":"Buffa R, Solcia E, Go VLW. Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa. Gastroenterology 1976; 70: 528-32."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1172\/JCI112534","article-title":"Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin","volume":"77","author":"Owyang, C.; Louie, D.S.; Tatum, D.","year":"1986","unstructured":"Owyang C, Louie DS, Tatum D. Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin. J Clin Invest 1986; 77: 2042-7.","journal-title":"J Clin Invest"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0167-0115(89)90181-X","article-title":"Effect of pancreatic enzyme supplementation on postprandial plasma cholecystokinin secretion in patients with pancreatic insufficiency","volume":"25","author":"Jansen, J.B.M.J.; Jebbink, M.C.W.; Mulders, H.J.A.; Lamers, C.B.H.W.","year":"1989","unstructured":"Jansen JBMJ, Jebbink MCW, Mulders HJA, Lamers CBHW. Effect of pancreatic enzyme supplementation on postprandial plasma cholecystokinin secretion in patients with pancreatic insufficiency. Regulatory Peptides 1989; 25: 333-42.","journal-title":"Regulatory Peptides"},{"key":"ref_17","first-page":"1311","article-title":"Feedback regulation of human pancreatic secretion. Effects of protease inhibition on duodenal delivery and small intestinal transit of pancreatic enzymes","volume":"98","author":"Layer, P.; Jansen, J.B.M.J.; Cherian, L.; Lamers, C.B.H.W.; Goebell, H.","year":"1990","unstructured":"Layer P, Jansen JBMJ, Cherian L, Lamers CBHW, Goebell H. Feedback regulation of human pancreatic secretion. Effects of protease inhibition on duodenal delivery and small intestinal transit of pancreatic enzymes. Gastroenterology 1990; 98: 1311-9.","journal-title":"Gastroenterology"},{"key":"ref_18","first-page":"1036","article-title":"Regulation of the release of cholecystokinin by bile salts","volume-title":"dogs and humans. Gastroenterology 1988; 94","author":"Gomez, G.; Upp, JR, LLuis; F, Alexander; RW, Poston; GJ, Greeley; GH, et at","unstructured":"Gomez G, Upp JR, LLuis F, Alexander RW, Poston GJ, Greeley GH, et at. Regulation of the release of cholecystokinin by bile salts in dogs and humans. Gastroenterology 1988; 94: 1036-46."},{"key":"ref_19","first-page":"1625","article-title":"Dorn 5, Koop H, Witzleb 5, Beglinger","volume":"36","author":"Koop, I.","year":"1991","unstructured":"Koop I, Dorn 5, Koop H, Witzleb 5, Beglinger C, Schafmayer A, et at. Dissociation of cholecystokinin and pancreaticobiliary response to intraduodenal bile acids and cholestyramine in humans. Dig Dis Sci 1991; 36: 1625-32.","journal-title":"C, Schafmayer A, et at. Dissociation; of cholecystokinin and pancreaticobiliary response to intraduodenal bile acids and cholestyramine in humans"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1136\/gut.30.6.866","article-title":"Reversible gall bladder dysfunction in severe pancreatic insufficiency","volume":"30","author":"Masclee, A.A.M.; Jansen, J.B.M.J.; Corstens, F.H.M.; Lamers, C.B.H.W.","year":"1989","unstructured":"Masclee AAM, Jansen JBMJ, Corstens FHM, Lamers CBHW. Reversible gall bladder dysfunction in severe pancreatic insufficiency. Gut 1989; 30: 866-72.","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI108493","article-title":"Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man","volume":"58","author":"Malagelada, JR, DiMagno; EP, Summerskill; WHJ, Go; V.L.W.","year":"1976","unstructured":"Malagelada JR, DiMagno EP, Summerskill WHJ, Go VLW. Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man. Jf Clin Invest 1976; 58: 493-9.","journal-title":"Jf Clin Invest"},{"key":"ref_22","first-page":"1008","article-title":"Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis","volume":"2","author":"Beardshall, K.; Frost, G.; Morarji, Y.; Domin, J.; Bloom, SR, Calam; J.","year":"1989","unstructured":"Beardshall K, Frost G, Morarji Y, Domin J, Bloom SR, Calam J. Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. Lancet 1989; 2: 1008-10.","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/00365528909092242","article-title":"Fat and pancreatic secretion","volume":"24","author":"Olsen 0, Schaffalitzky de Muckadell OB, Cantor P","year":"1989","unstructured":"Olsen 0, Schaffalitzky de Muckadell OB, Cantor P. Fat and pancreatic secretion. Scand Jf Gastroenterol 1989; 24: 74-80.","journal-title":"Scand Jf Gastroenterol"},{"key":"ref_24","first-page":"266","article-title":"Role of lipase in the regulation of upper gastrointestinal functions in man: nutrient specific effects - studies with THL, a new highly specific","volume-title":"lipase inhibitor [abstract]. Gastroenterology 1992; 102","author":"Fried, M.; Schwizer, W.; Asal, K.; Guzelhan, C.; Jansen, J.; Lamers, C.","unstructured":"Fried M, Schwizer W, Asal K, Guzelhan C, Jansen J, Lamers C, et al. Role of lipase in the regulation of upper gastrointestinal functions in man: nutrient specific effects - studies with THL, a new highly specific lipase inhibitor [abstract]. Gastroenterology 1992; 102: A266."},{"key":"ref_25","first-page":"1527","article-title":"Lipid digestion and absorption","volume-title":"Physiology of the gastrointestinal tract. Vol 2","author":"Shiau, Y.","year":"1987","unstructured":"Shiau Y. Lipid digestion and absorption. In: Johnson LR, ed. Physiology of the gastrointestinal tract. Vol 2. 2nd ed. New York: Raven Press, 1987: 1527-56.","edition":"2nd ed"},{"key":"ref_26","first-page":"25","article-title":"Impaired cholecystokinin-pancreozymin secretion, intraluminal dilution, and maldigestion","volume-title":"of fat in sprue. Gastroenterology 1972; 63","author":"DiMagno EP, Go VLW, Summerskill WHJ","unstructured":"DiMagno EP, Go VLW, Summerskill WHJ. Impaired cholecystokinin-pancreozymin secretion, intraluminal dilution, and maldigestion of fat in sprue. Gastroenterology 1972; 63: 25-32."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.36.1.17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:05:46Z","timestamp":1765649146000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.36.1.17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1995,1,1]]},"published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1136\/gut.36.1.17"],"URL":"https:\/\/doi.org\/10.1136\/gut.36.1.17","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}