{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:42:29Z","timestamp":1788266549397,"version":"build-2803163510"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>This study evaluates the diagnostic accuracy of a faecal occult blood test and faecal alpha 1-antitrypsin in the investigation of patients with gastrointestinal symptoms or iron deficiency anaemia. One hundred and seventy nine patients with either iron deficiency anaemia (n = 67), changed bowel habit and aged &gt; 39 years (n = 107), or a history suggestive of melaena (n = 5) provided faecal samples. After investigation, 32 patients had a diagnosis of possible gastrointestinal bleeding and 139 patients had no evidence of gastrointestinal bleeding. Eight patients had a cause of enteric protein loss in the absence of gastrointestinal bleeding and were excluded from subsequent analysis. The faecal alpha 1-antitrypsin test was diagnostically more accurate than the guaiac test in identifying probable gastrointestinal bleeding (82% and 72% respectively, p &lt; 0.05). This faecal alpha 1-antitrypsin test was also more specific (83% and 72% respectively, p &lt; 0.05), but was not significantly more sensitive (78% and 72% respectively). The sensitivity of these tests was insufficient to recommend their use for most patients in this study.<\/jats:p>","DOI":"10.1136\/gut.36.1.87","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"87-89","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic value of a guaiac occult blood test and faecal alpha 1-antitrypsin."],"prefix":"10.1136","volume":"36","author":[{"given":"A","family":"Moran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Husband","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Asquith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/archinte.1990.00390170055013","article-title":"A comparative study of faecal occult blood tests for early detection of gastrointestinal pathology","volume":"150","author":"Stelling, H.P.; Maimon, H.N.; Smith, R.A.; Haddy, R.I.; Markert, R.J.","year":"1990","unstructured":"Stelling HP, Maimon HN, Smith RA, Haddy RI, Markert RJ. A comparative study of faecal occult blood tests for early detection of gastrointestinal pathology. Arch Intern Med 1990; 150: 1001-5.","journal-title":"Arch Intern Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0009-8981(93)90161-V","article-title":"Value of faecal alpha-l-antitrypsin, haemoglobin, and a chemical occult blood test in the investigation of gastrointestinal disease","volume":"217","author":"Moran, A.; Lawson, N.; Morrow, R.; Jones, A.F.; Asquith, P.","year":"1993","unstructured":"Moran A, Lawson N, Morrow R, Jones AF, Asquith P. Value of faecal alpha-l-antitrypsin, haemoglobin, and a chemical occult blood test in the investigation of gastrointestinal disease. 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Accuracy of faecal occult blood test interpretation","volume":"114","author":"Fleisher, M.; Winawer, S.J.; Zauber, A.G.; Smith, C.; Schwartz, M.K.","year":"1991","unstructured":"Fleisher M, Winawer SJ, Zauber AG, Smith C, Schwartz MK, and the National Polyp Study Work Group. Accuracy of faecal occult blood test interpretation. Ann Intern Med 1991; 114: 875-6.","journal-title":"Ann Intern Med"},{"key":"ref_5","first-page":"1816","article-title":"Protein-losing gastroenteropathies","volume-title":"Gastroenterology","author":"Waldmann, T.A.","year":"1985","unstructured":"Waldmann TA. Protein-losing gastroenteropathies. In: Berk JE. Bockus Gastroenterology. 4th ed. 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JAMA 1993; 269: 1262-7.","journal-title":"JAMA"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.36.1.87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:29:09Z","timestamp":1763742549000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.36.1.87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1995,1,1]]},"published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1136\/gut.36.1.87"],"URL":"https:\/\/doi.org\/10.1136\/gut.36.1.87","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}