{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:46:17Z","timestamp":1777063577954,"version":"3.51.4"},"reference-count":16,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>The functional response and phenotypic characterisation of peripheral blood T cells were studied in 41 patients with autoimmune gastritis--nine patients with autoimmune gastritis alone, 11 with untreated pernicious anaemia, and 21 with resolved pernicious anaemia who were taking vitamin B-12. Phenotypic analysis showed no changes in the CD4\/CD8 ratio in any group of patients. CD3+ cells were significantly decreased and CD16+ cells were significantly increased in patients with autoimmune gastritis alone. Phytohaemagglutinin induced T cell proliferation, with or without interleukin 2, was reduced in the three groups. T cell proliferation induced by phorbol myristate acetate was normal. Interleukin 2 production of phytohaemagglutinin-stimulated lymphocytes was normal in the three groups. Five patients with pernicious anaemia treated with vitamin B-12 were followed and persistent hypoproliferation of T cells in response to phytohaemagglutinin was observed. The follow up study of the phenotype of these patients showed a significant increase of the CD2+ CD3- lymphocyte population after six months' treatment. In conclusion, the three groups of autoimmune gastritis patients studied have a functional defect in T cells that is independent of B-12 treatment and of the presence of pernicious anaemia.<\/jats:p>","DOI":"10.1136\/gut.36.2.171","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"171-175","source":"Crossref","is-referenced-by-count":21,"title":["Functional defect of T cells in autoimmune gastritis."],"prefix":"10.1136","volume":"36","author":[{"given":"J A","family":"Vargas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Alvarez-Mon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Albillos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Fernandez-Corugedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Albarr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dur\u00e1ntez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,2,1]]},"reference":[{"key":"ref_1","first-page":"535","article-title":"Chronic gastritis and pernicious anemia","volume-title":"and immunopathology of the liver and gastrointestinal tract","author":"Strickland, R.G.","year":"1990","unstructured":"Strickland RG. Chronic gastritis and pernicious anemia. In: Targan SR, Shanahan F, eds. Immunology and immunopathology of the liver and gastrointestinal tract. Tokyo: Igaku-Shoin, 1990: 535-46."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/BF01071995","article-title":"A reappraisal of the nature and significance of chronic atrophic gastritis","volume":"18","author":"Strickland, R.G.; Mackay, I.R.","year":"1973","unstructured":"Strickland RG, Mackay IR. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis 1973; 18: 426-40.","journal-title":"Am J Dig Dis"},{"key":"ref_3","first-page":"482","article-title":"Natural history of autoimmune achlorhydric atrophic gastritis. A 1-15 year follow-up study","volume":"ii:","author":"Irvine, W.I.; Cullen, D.R.; Mawhinney, H.","year":"1974","unstructured":"Irvine WI, Cullen DR, Mawhinney H. Natural history of autoimmune achlorhydric atrophic gastritis. A 1-15 year follow-up study. 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