{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:36:15Z","timestamp":1772757375523,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>Patients who have undergone gastric resection are at higher risk of developing gastric carcinoma than normal subjects, and bile reflux is believed to play a role in carcinogenesis. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. Helicobacter pylori is considered a major risk factor for gastric cancer in the intact stomach. It has been shown previously that antral cell proliferation is increased in H pylori gastritis and falls to normal levels after eradication of the organism. Little is known of corpus cell proliferation in H pylori gastritis or after gastric resection. Using in vitro bromodeoxyuridine labelling of endoscopic biopsy specimens we have found that corpus cell proliferation is increased in H pylori gastritis. Cell proliferation was greater in corpus biopsy specimens of resected stomachs than in H pylori gastritis. Subgroup analysis of patients who had undergone gastric resection indicated that those positive for H pylori had higher levels of cell proliferation than those negative for the organism. These findings provide further evidence that H pylori and bile have a role in gastric carcinogenesis and suggest that their presence has a synergistic effect on gastric epithelial cell proliferation.<\/jats:p>","DOI":"10.1136\/gut.36.3.351","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"351-353","source":"Crossref","is-referenced-by-count":47,"title":["Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection."],"prefix":"10.1136","volume":"36","author":[{"given":"D A","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N P","family":"Mapstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Quirke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A T","family":"Axon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1136\/gut.29.11.1588","article-title":"Mortality caused by stomach cancer after remote partial gastrectomy for benign conditions; 40 years of follow-up of an Amsterdam cohort of 2633 postgastrectomy patients","volume":"29","author":"Offerhaus, G.J.A.; Tersmette, A.C.; Huibregste, K.","year":"1988","unstructured":"Offerhaus GJA, Tersmette AC, Huibregste K, et al. 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Its effect on the production of experimental gastric cancer","volume":"115","author":"Weiman, T.J.; Max, M.H.; Vogles, C.R.; Burrows, G.H.","year":"1980","unstructured":"Weiman TJ, Max MH, Vogles CR, Burrows GH. Diversion of duodenal contents. Its effect on the production of experimental gastric cancer. Arch Surg 1980; 115: 959-61.","journal-title":"Arch Surg"},{"key":"ref_6","first-page":"19","article-title":"The multi-step theory of neoplasia","volume-title":"advances in histopathology. No 11","author":"Medline, A.; Farber, E.","year":"1981","unstructured":"Medline A, Farber E. The multi-step theory of neoplasia. In: Anthony PP, Sweeney RMN, eds. Recent advances in histopathology. No 11. Edinburgh: Churchill Livingstone, 1981: 19-34."},{"key":"ref_7","first-page":"16","article-title":"Infection and gastric carcinoma among Japanese Americans in Hawaii","volume":"325","author":"Nomura, A.; Stemmermann, G.N.; Chyou, P.; Kato, I.; PerezPerez, G.I.; Blaser, M.J.","year":"1991","unstructured":"Nomura A, Stemmermann GN, Chyou P, Kato I, PerezPerez GI, Blaser MJ. Infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991; 325: 16, 1132-6.","journal-title":"N Engl J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.302.6788.1302","article-title":"Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation","volume":"302","author":"Forman, D.; Newell, D.G.; Fullerton, F.; Yamell, J.W.G.; Stacey, A.R.; Wald, N.; Sitas, F.","year":"1991","unstructured":"Forman D, Newell DG, Fullerton F, Yamell JWG, Stacey AR, Wald N, Sitas F. 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An international association between Helicobacter pylori infection and gastric cancer. Lancet 1993; 341: 1359-62.","journal-title":"Lancet"},{"issue":"1","key":"ref_11","first-page":"12","article-title":"Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy","volume":"34","author":"Lynch, D.A.F.; Mapstone, N.P.; Clarke, A.M.T.; Jackson, P.; Dixon, M.F.; Quirke, P.","year":"1993","unstructured":"Lynch DAF, Mapstone NP, Clarke AMT, Jackson P, Dixon MF, Quirke P, et al. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. 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Gastric cell proliferation kinetics and bile reflux after partial gastrectomy. Am J Gastroenterol 1991; 86 (10): 1424-32.","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"ref_16","first-page":"197","article-title":"Correlation between cell proliferation in H pylori associated gastritis and histological scoring using the Sidney System","volume":"34","author":"Lynch, D.A.F.; Mapstone, N.P.; Lewis, F.; Dixon, M.F.; Quirke, P.; Axon, A.T.R.","year":"1993","unstructured":"Lynch DAF, Mapstone NP, Lewis F, Dixon MF, Quirke P, Axon ATR. Correlation between cell proliferation in H pylori associated gastritis and histological scoring using the Sidney System. Gut 1993; 34 (suppl 4): F197.","journal-title":"Gut"},{"key":"ref_17","first-page":"164","article-title":"Systemic mediators of inflammation","volume":"45","author":"Emery, P.; Salmon, M.","year":"1991","unstructured":"Emery P, Salmon M. Systemic mediators of inflammation. BrJ Hosp Med 1991; 45: 164-8.","journal-title":"BrJ Hosp Med"},{"key":"ref_18","first-page":"663","article-title":"Growth regulatory peptides in gastric mucosa","volume":"81","author":"Jankowski, J.; McMenemin, R.; Penston, Hopwood D.; J, Wormsley; K.G.","year":"1991","unstructured":"Jankowski J, McMenemin R, Hopwood D. Penston J, Wormsley KG. Growth regulatory peptides in gastric mucosa. 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