{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:44:22Z","timestamp":1768495462162,"version":"3.49.0"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:p>Between 1968 and 1991, the number of deaths from non-malignant oesophageal disease (NMOD) (International Classification of Diseases code 530), recorded by the Office of Population Censuses and Surveys (OPCS) in England and Wales, trebled in women, from 118 to 340 (5 to 13 per million) and doubled in men, from 131 to 251 (5.5 to 10 per million). Calculation of age specific death rates, shows the increase to result from a rise in mortality in those over 75 years and age standardised mortality confirms a rise in overall frequency from 2.9 to 7.0 deaths per million men and 5.2 to 13.1 per million women. Between 1974 and 1988 when specific diagnoses were coded, deaths from oesophageal ulcer rose from 1.5 to 2.5 per million. In men, the death rate from oesophageal stricture increased from 2.5 to 3 per million and in women from 3.5 to 6 per million. Mortality from oesophageal perforation did not change (1 per million). Some of these changes reflect the increasing age of the population in general, but further explanations are required. Review of 84 sets of case notes from a total of 281 inpatients whose coded diagnoses had included NMOD and who had died suggested that in 28 (33%) death was actually due to NMOD, and in seven of these endoscopic intervention was responsible. The certified underlying cause of death was compared with that suggested from case note review in 62 cases; death from NMOD was substantially underestimated. This study concludes that a rising death rate attributed to NMOD is underestimated on death certificates and that endoscopic intervention explains only a few of the cases.<\/jats:p>","DOI":"10.1136\/gut.36.4.488","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"488-491","source":"Crossref","is-referenced-by-count":21,"title":["Rising death rate from non-malignant disease of the oesophagus (NMOD) in England and Wales."],"prefix":"10.1136","volume":"36","author":[{"given":"M Z","family":"Panos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R P","family":"Walt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Langman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"ref_1","first-page":"438","article-title":"Open access upper alimentary endoscopy","volume":"4","author":"Gear, M.W.L.; Wilkinson, S.P.","year":"1989","unstructured":"Gear MWL, Wilkinson SP. Open access upper alimentary endoscopy. BrJrHosp Med 1989; 4: 438-44.","journal-title":"BrJrHosp Med"},{"key":"ref_2","article-title":"Population Censuses and Surveys. Registrar General's statistical reviews 1968-1973. Table 17","author":"Office of","unstructured":"Office of Population Censuses and Surveys. Registrar General's statistical reviews 1968-1973. Table 17. London: HMSO."},{"issue":"2","key":"ref_3","first-page":"1","article-title":"Population Censuses and Surveys. Registrar General's statistical reviews 1974-1988","volume":"2","author":"Office of","unstructured":"Office of Population Censuses and Surveys. Registrar General's statistical reviews 1974-1988. Table 2. Series DH2 no 1-15. London: HMSO.","journal-title":"Table"},{"key":"ref_4","article-title":"Accuracy of certification of cause of death. Studies on medical and population subjects","author":"Heasman, M.A.; Lipworth, L.","year":"1966","unstructured":"Heasman MA, Lipworth L. Accuracy of certification of cause of death. Studies on medical and population subjects. General Register Office 1966; No 20 HMSO: London.","journal-title":"General Register Office; HMSO"},{"key":"ref_5","article-title":"Population Censuses and Surveys. Registrar General's statistical reviews 1968-1973. Table 1. Estimated populations: total home and civilian by sex and age","author":"Office of","unstructured":"Office of Population Censuses and Surveys. Registrar General's statistical reviews 1968-1973. Table 1. Estimated populations: total home and civilian by sex and age. London: HMSO."},{"key":"ref_6","first-page":"14","article-title":"Population Censuses and Surveys. Registrar General's statistical reviews 1974-1982. Table 1. Series DH2 no 1-9. and 1983-1988 Table","volume":"1","author":"Office of","year":"1,","unstructured":"Office of Population Censuses and Surveys. Registrar General's statistical reviews 1974-1982. Table 1. Series DH2 no 1-9. and 1983-1988 Table 1, Series DH1 no 14-21. London: HMSO."},{"key":"ref_7","first-page":"489","article-title":"Rising frequency of ulcer perforation in elderly people in the United Kingdom","volume":"i:","author":"Walt, R.; Katschinski, B.; Logan, R.; Ashley, J.; Langman, M.","year":"1986","unstructured":"Walt R, Katschinski B, Logan R, Ashley J, Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1986; i: 489-92.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/gut.32.7.730","article-title":"Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study","volume":"32","author":"Holvoet, J.; Terriere, L.; Van Hee, W.; Verbist, L.; Fierens, E.; Hautekeete, M.L.","year":"1991","unstructured":"Holvoet J, Terriere L, Van Hee W, Verbist L, Fierens E, Hautekeete ML. Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study. Gut 1991; 32: 730-4.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(86)92927-2","article-title":"Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer","volume":"i:","author":"Somerville, K.W.; Faulkner, G.; Langman, M.J.S.","year":"1986","unstructured":"Somerville KW, Faulkner G, Langman MJS. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986; i: 462-4.","journal-title":"Lancet"},{"key":"ref_10","first-page":"497","article-title":"Gastrointestinal events in patients prescribed non-steroidal anti-inflammatory drugs: a controlled study using record linkage in Tayside","volume":"71","author":"Beardon, P.H.G.; Brown, S.V.; McDevitt, D.G.","year":"1989","unstructured":"Beardon PHG, Brown SV, McDevitt DG. Gastrointestinal events in patients prescribed non-steroidal anti-inflammatory drugs: a controlled study using record linkage in Tayside. Q3JMed 1989; 71: 497-505."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7326\/0003-4819-115-10-787","article-title":"Risk of serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs","volume":"115","author":"Gabriel, S.E.; Jaakkimainen, L.; Bombardier, C.","year":"1991","unstructured":"Gabriel SE, Jaakkimainen L, Bombardier C. Risk of serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991; 115: 787-96.","journal-title":"Ann Intern Med"},{"key":"ref_12","first-page":"1214","article-title":"Prevalence of oesophagitis in subjects on long term non-steroidal anti-inflammatory drugs","volume":"32","author":"Arnold, J.D.; Swift, G.L.; Williams, G.T.; Wilkins, W.E.; Morris, J.E.; Rhodes, J.","year":"1991","unstructured":"Arnold JD, Swift GL, Williams GT, Wilkins WE, Morris JE, Rhodes J. Prevalence of oesophagitis in subjects on long term non-steroidal anti-inflammatory drugs. Gut 1991; 32: A1214.","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/bmj.285.6336.167","article-title":"Nonsteroidal anti-inflammatory drugs and benign oesophageal strictures","volume":"285","year":"1982","unstructured":"Heller SR, Fellows 1W, Ogilvie AL, Atktinson M. Nonsteroidal anti-inflammatory drugs and benign oesophageal strictures. BMJ 1982; 285: 167-8.","journal-title":"BMJ"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.36.4.488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:06:05Z","timestamp":1757271965000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.36.4.488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1995,4,1]]},"published-print":{"date-parts":[[1995,4]]}},"alternative-id":["10.1136\/gut.36.4.488"],"URL":"https:\/\/doi.org\/10.1136\/gut.36.4.488","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}