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Physiological studies showed deep, ultraslow waves and an absence of internal anal sphincter relaxation on rectal distension in the two most severely affected family members, suggesting the possibility of a neuropathic origin. Both of these patients had an abnormally high blood pressure. After treatment with a sustained release formulation of the calcium antagonist, nifedipine, their blood pressure returned to normal, anal tone was reduced, and the frequency and intensity of anal pain was suppressed. These together improved the quality of the patients' sleep, which had previously been very troubled because of night time attacks of anal pain.<\/jats:p>","DOI":"10.1136\/gut.36.4.581","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"581-584","source":"Crossref","is-referenced-by-count":48,"title":["Hereditary proctalgia fugax and constipation: report of a second family."],"prefix":"10.1136","volume":"36","author":[{"given":"A F","family":"Celik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Katsinelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N W","family":"Read","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M I","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T C","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"ref_1","first-page":"444","volume":"ii:","author":"fugax, Abrahams A.Proctalgia","year":"1935","unstructured":"Abrahams A. 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InterJf Colorectal Dis 1989; 4: 188-96.","journal-title":"InterJf Colorectal Dis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/gut.18.8.651","article-title":"Internal sphincter and the nature of the haemorrhoids","volume":"18","author":"Hancock, B.D.","year":"1977","unstructured":"Hancock BD. Internal sphincter and the nature of the haemorrhoids. Gut 1977; 18: 651-6.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/gut.18.8.651","article-title":"The internal sphincter and Lord's procedure for haemorrhoids","volume":"18","author":"Hancock, B.D.","year":"1977","unstructured":"Hancock BD. The internal sphincter and Lord's procedure for haemorrhoids. 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